Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis

American Journal of Pathology

Volumn 172, Issue 5, 2008, Pages 1171-1173

  Fink, Mitchell P ^a,b,c  

^a Logical Therapeutics Inc ^*  (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOTANSHINONE; DROTRECOGIN; ETACRYNIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; NAFAMSTAT MESILATE; NICOTINE; NICOTINIC RECEPTOR BLOCKING AGENT; PROTEIN ANTIBODY; TANSHINONE; TUMOR NECROSIS FACTOR; UROCORTIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANTIINFLAMMATORY ACTIVITY; CELL MEMBRANE PERMEABILITY; DIARRHEA; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DRUG MECHANISM; HUMAN; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ISOLATION; PROTEIN SECRETION; SEPSIS; TACHYCARDIA; UNSPECIFIED SIDE EFFECT;

EID: 43449112677     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.080161     Document Type: Note

References (42)

1. MM Levy MP Fink JC Marshall E Abraham D Angus D Cook J Cohen SM Opal JL Vincent G Ramsay SCCM/ESICM/ACCP/ATS/SIS 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Crit Care Med 31 2003 1250 1256
2. GS Martin DM Mannino S Eaton M Moss The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 2003 1546 1554
3. DC Angus WT Linde-Zwirble J Lidicker G Clermont J Carcillo MR Pinsky Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 2001 1303 1310
4. A Chorny M Delgado Neuropeptides rescue mice from lethal sepsis by downregulating the secretion of the late-acting inflammatory mediator high mobility group box 1 Am J Pathol 172 2008 1287 1292
5. EW Johns Studies on histones. 7. Preparative methods for histone fractions from calf thymus Biochem J 92 1964 55 59
6. V Aleporou-Marinou H Marinou T Patargias A mini review of the high mobility group proteins of insects Biochem Genet 41 2003 291 304
7. GH Goodwin C Sanders EW Johns A new group of chromatin-associated proteins with a high content of acidic and basic amino acids Eur J Biochem 38 1973 14 19
8. C Sanders A method for the fractionation of the high-mobility-group non-histone chromosomal proteins Biochem Biophys Res Commun 78 1977 1034 1042
9. JO Thomas AA Travers HMG1 and 2, and related ‘architectural’ DNA-binding proteins Trends Biochem Sci 26 2001 167 174
10. P Prendergast SA Onate K Christensen DP Edwards Nuclear accessory factors enhance the binding of progesterone receptor to specific target DNA J Steroid Biochem Mol Biol 48 1994 1 13
11. CC Zhang S Krieg DJ Shapiro HMG-1 stimulates estrogen response element binding by estrogen receptor from stably transfected HeLa cells Mol Endocrinol 13 1999 632 643
12. M Ciubotaru DG Schatz Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination Mol Cell Biol 24 2004 8727 8744
13. M Stros E Muselikova-Polanska S Pospisilova F Strauss High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops Biochemistry 43 2004 7215 7225
14. H Wang O Bloom M Zhang JM Vishnubhakat M Ombrellino J Che A Frazier H Yang S Ivanova L Borovikova KR Manogue E Faist E Abraham J Andersson U Andersson PE Molina NN Abumrad A Sama KJ Tracey HMG-1 as a late mediator of endotoxin lethality in mice Science 285 1999 248 251
15. H Yang M Ochani J Li M Tanovic HE Harris S Susarla L Ulloa H Wang R DiRaimo CJ Czura H Wang HS Warren MP Fink MJ Fenton U Andersson KJ Tracey Reversing established sepsis with antagonists of endogenous HMGB1 Proc Natl Acad Sci USA 101 2004 296 301
16. U Andersson H Wang K Palmblad AC Aveberger O Bloom H Erlandsson-Harris A Janson R Kokkola M Zhang H Yang KJ Tracey High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes J Exp Med 192 2001 565 570
17. PL Sappington R Yang H Yang KJ Tracey RL Delude MP Fink HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice Gastroenterology 123 2002 790 802
18. SH Zuckerman J Shellhaas LD Butler Differential regulation of lipopolysaccharide-induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis Eur J Immunol 19 1989 301 305
19. SH Zuckerman GF Evans LD Butler Endotoxin tolerance: independent regulation of interleukin-1 and tumor necrosis factor expression Infect Immun 59 1991 2774 2780
20. H Wang H Liao M Ochani M Justiniani X Lin L Yang Y Al-Abed H Wang C Metz EJ Miller KJ Tracey L Ulloa Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis Nat Med 10 2004 1216 1221
21. L Ulloa M Ochani H Yang D Halperin R Yang CJ Czura MP Fink KJ Tracey Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation Proc Natl Acad Sci USA 99 2002 12351 12356
22. B Rendon-Mitchell M Ochani J Li J Han H Wang S Susarla C Czura RA Mitchell G Chen AE Sama KJ Tracey H Wang IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism J Immunol 170 2003 3890 3897
23. S Gardella C Andrei D Ferrera LV Lotti MR Torrisi ME Bianchi A Rubartelli The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway EMBO Rep 3 2002 995 1001
24. T Bonaldi F Talamo P Scaffidi D Perrera A Porto A Bachi A Rubartelli A Agresti ME Bianchi Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion EMBO J 22 2003 5551 5560
25. C Semino G Angelini A Poggi A Rubartelli NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1 Blood 106 2005 609 616
26. IE Dumitriu P Baruah ME Bianchi AA Manfredi P Rovere-Querini Requirement of HMGB1 and RAGE for the maturation of human plasmacytoid dendritic cells Eur J Immunol 35 2005 2184 2190
27. H Wang JM Vishnubhakat O Bloom M Zhang M Ombrellino A Sama KJ Tracey Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes Surgery 126 2002 389 392
28. S Liu DB Stolz PL Sappington CA Macias ME Killeen JJ Tenhunen RL Delude MP Fink HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers Am J Physiol 290 2006 C990 C999
29. VA Pavlov M Ochani LH Yang M Gallowitsch-Puerta K Ochani X Lin J Levi WR Parrish M Rosas-Ballina CJ Czura GJ Larosa EJ Miller KJ Tracey Y Al-Abed Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis Crit Care Med 35 2007 1139 1144
30. G Chen J Li X Qiang CJ Czura M Ochani K Ochani L Ulloa H Yang KJ Tracey P Wang AE Sama H Wang Suppression of HMGB1 release by stearoyl lysophosphatidylcholine: an additional mechanism for its therapeutic effects in experimental sepsis J Lipid Res 46 2005 623 627
31. S Hagiwara H Iwasaka S Matumoto T Noguchi Nafamostat mesilate inhibits high-mobility group box 1 by lipopolysaccharide stimulation in murine macrophage raw 264.7 Shock 27 2007 429 435
32. W Li J Li M Ashok R Wu D Chen L Yang H Yang KJ Tracey P Wang AE Sama H Wang A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1 J Immunol 178 2007 3856 3864
33. ME Killeen JA Englert DB Stolz M Song Y Han RL Delude JA Kellum MP Fink The phase 2 enzyme inducers, ethacrynic acid. DL-sulforaphane and oltipraz, inhibit LPS-induced HMGB1 secretion by RAW 2647 cells J Pharmacol Exp Ther 316 2006 1070 1079
34. CJ Czura SG Friedman KJ Tracey Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway J Endotoxin Res 9 2003 409 413
35. JM Huston M Gallowitsch-Puerta M Ochani K Ochani R Yuan M Rosas-Ballina M Ashok RS Goldstein S Chavan VA Pavlov CN Metz H Yang CJ Czura H Wang KJ Tracey Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis Crit Care Med 35 2007 2762 2768
36. GR Bernard J-L Vincent PF Laterre SP LaRosa J-F Dhainaut A Lopez-Rodriguez JS Steingrub GE Garber JD Helterbrand EW Ely CJ Fisher Jr Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 344 2001 699 709
37. V Costa JM Brophy Drotrecogin alfa (activated) in severe sepsis: a systematic review and new cost-effectiveness analysis BMC Anesthesiol 7 2007 5
38. EE Castelli CM Culley MP Fink Challenge and rechallenge: drotrecogin alfa (activated)-induced prolongation of activated partial thromboplastin time in a patient with severe sepsis Pharmacotherapy 25 2005 1147 1150
39. S Kanji MM Perreault C Chant D Williamson L Burry Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study Intensive Care Med 33 2007 517 523
40. AF Mackenzie Activate protein C: do more survive? Intensive Care Med 31 2005 1624 1626
41. J Keller JC Mueller-Wolf K Ahmadi-Simab C Fibbe U Rosien P Layer Do elevated plasma vasoactive intestinal polypeptide (VIP) levels cause small intestinal motor disturbances in humans? Dig Dis Sci 50 2005 276 282
42. ME Davis CJ Pemberton TG Yandle JG Laichbury MT Rademaker MG Nicholls CM Frampton AM Richards Urocortin-1 infusion in normal humans Clin Endocrinol Metab 89 2004 1402 1409