The human insulin mRNA is partly translated via a cap- and eIF4A-independent mechanism

Biochemical and Biophysical Research Communications

Volumn 412, Issue 4, 2011, Pages 693-698

  Fred, Rikard G ^a   Sandberg, Monica ^a   Pelletier, Jerry ^b   Welsh, Nils ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

BSA; Cap independent translation; DETA NO; EIF4A; EIF4F; Hippuristanol; Human islets of Langerhans; Insulin biosynthesis; IRES; ITAF; KRBH; Nitric oxide; Polypyrimidine tract binding protein (PTB); PTB; TCA; UTR

Indexed keywords

3,3 BIS(2 AMINOETHYL) 1 HYDROXY 2 OXOTRIAZENE; GLUCOSE; HIPPURISTANOL; HYPERGLYCEMIC AGENT; INITIATION FACTOR 4A; INSULIN; MESSENGER RNA; POLYPYRIMIDINE TRACT BINDING PROTEIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INSULIN SYNTHESIS; ISOTOPE LABELING; NITROSATIVE STRESS; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN BINDING; RNA BINDING; RNA TRANSLATION; STARVATION;

EID: 80052620715     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.08.030     Document Type: Article

References (22)

1. Wajchenberg B.L. Beta-cell failure in diabetes and preservation by clinical treatment. Endocr. Rev. 2007, 28:187-218.
2. Wicksteed B., Herbert T.P., Alarcon C., Lingohr M.K., Moss L.G., Rhodes C.J. Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation. J. Biol. Chem. 2001, 276:22553-22558.
3. Pain V.M. Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 1996, 236:747-771.
4. Spriggs K.A., Stoneley M., Bushell M., Willis A.E. Re-programming of translation following cell stress allows IRES-mediated translation to predominate. Biol. Cell 2008, 100:27-38.
5. Spriggs K.A., Cobbold L.C., Ridley S.H., Coldwell M., Bottley A., Bushell M., Willis A.E., Siddle K. The human insulin receptor mRNA contains a functional internal ribosome entry segment. Nucleic Acids Res. 2009, 37:5881-5893.
6. Petersen C.P., Bordeleau M.E., Pelletier J., Sharp P.A. Short RNAs repress translation after initiation in mammalian cells. Mol. Cell 2006, 21:533-542.
7. Bordeleau M.E., Mori A., Oberer M., Lindqvist L., Chard L.S., Higa T., Belsham G.J., Wagner G., Tanaka J., Pelletier J. Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A. Nat. Chem. Biol. 2006, 2:213-220.
8. Fred R.G., Bang-Berthelsen C.H., Mandrup-Poulsen T., Grunnet L.G., Welsh N. High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS ONE 2010, 5:e10843.
9. Tillmar L., Carlsson C., Welsh N. Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence. J. Biol. Chem. 2002, 277:1099-1106.
10. Lindqvist L., Oberer M., Reibarkh M., Cencic R., Bordeleau M.E., Vogt E., Marintchev A., Tanaka J., Fagotto F., Altmann M., Wagner G., Pelletier J. Selective pharmacological targeting of a DEAD box RNA helicase. PLoS ONE 2008, 3:e1583.
11. Permutt A., Chirgwin J., Giddings S., Kakita K., Rotwein P. Insulin biosynthesis and diabetes mellitus. Clin. Biochem. 1981, 14:230-236.
12. Cabrera O., Berman D.M., Kenyon N.S., Ricordi C., Berggren P.O., Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc. Natl. Acad. Sci. USA 2006, 103:2334-2339.
13. Rhodes C.J., Taylor K.W. Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets. Diabetologia 1984, 27:601-603.
14. Eizirik D.L., Korbutt G.S., Hellerstrom C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J. Clin. Invest. 1992, 90:1263-1268.
15. Mitchell S.A., Spriggs K.A., Bushell M., Evans J.R., Stoneley M., Le Quesne J.P., Spriggs R.V., Willis A.E. Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry. Genes Dev. 2005, 19:1556-1571.
16. Mitchell S.A., Spriggs K.A., Coldwell M.J., Jackson R.J., Willis A.E. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol. Cell 2003, 11:757-771.
17. Paraskevas S., Aikin R., Maysinger D., Lakey J.R., Cavanagh T.J., Agapitos D., Wang R., Rosenberg L. Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal. Ann. Surg. 2001, 233:124-133.
18. Eizirik D.L., Darville M.I. Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 2001, 50(Suppl 1):S64-69.
19. Petegnief V., Font-Nieves M., Martin M.E., Salinas M., Planas A.M. Nitric oxide mediates NMDA-induced persistent inhibition of protein synthesis through dephosphorylation of eukaryotic initiation factor 4E-binding protein 1 and eukaryotic initiation factor 4G proteolysis. Biochem. J. 2008, 411:667-677.
20. Morley S.J., Coldwell M.J., Clemens M.J. Initiation factor modifications in the preapoptotic phase. Cell Death Differ. 2005, 12:571-584.
21. Kim Y.M., Son K., Hong S.J., Green A., Chen J.J., Tzeng E., Hierholzer C., Billiar T.R. Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: nitric oxide induces phosphorylation of initiation factor eIF-2 alpha. Mol. Med. 1998, 4:179-190.
22. Cai C.Q., Guo H., Schroeder R.A., Punzalan C., Kuo P.C. Nitric oxide-dependent ribosomal RNA cleavage is associated with inhibition of ribosomal peptidyl transferase activity in ANA-1 murine macrophages. J. Immunol. 2000, 165:3978-3984.