Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis

Chinese Journal of Cancer

Volumn 31, Issue 1, 2012, Pages 5-7

  Lu, Zhimin ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Cell cycle; Pyruvate kinase; Tumorigenesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA CATENIN; CYCLIN D1; DICKKOPF 1 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOENZYME; LACTIC ACID; OXYGEN; PYRUVATE KINASE; PYRUVATE KINASE ISOFORM M1; PYRUVATE KINASE ISOFORM M2; PYRUVIC ACID; UNCLASSIFIED DRUG; UVOMORULIN;

AEROBIC METABOLISM; ARTICLE; CANCER CELL; CARCINOGENESIS; CATALYSIS; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL PROLIFERATION; CYCLIN D1 GENE; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORT; GLYCOLYSIS; METABOLIC REGULATION; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TRANSACTIVATION; TUMOR GENE;

ANIMALS; BETA CATENIN; CELL CYCLE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; GLYCOLYSIS; HUMANS; ISOENZYMES; NEOPLASMS; PYRUVATE KINASE; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84856189114     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.011.10446     Document Type: Article

References (19)

1. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 2009,324(5930):1029-1033.
2. Altenberg B, Greulich KO. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics, 2004,84(6): 1014-1020.
3. Majumder PK, Febbo PG, Bikoff R, et al. mTOR inhibition reverses Aktdependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med, 2004,10(6):594-601.
4. Jurica MS, Mesecar A, Heath PJ, et al. The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure, 1998,6(2):195-210.
5. Mellati AA, Yucel M, Altinors N, et al. Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine. Cancer Biochem Biophys, 1992,13(1):33-41.
6. Guminska M, Stachurska MB, Ignacak J. Pyruvate kinase isoenzymes in chromatin extracts of Ehrlich ascites tumour, Morris hepatoma 7777 and normal mouse and rat livers. Biochim Biophys Acta, 1988,966(2):207-213.
7. Oremek GM, Teigelkamp S, Kramer W, et al. The pyruvate kinase isoenzyme tumor M2 (Tu M2-PK) as a tumor marker for renal carcinoma. Anticancer Res, 1999,19(4A):2599-2601.
8. Christofk HR, Vander Heiden MG, Harris MH, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature, 2008,452 (7184):230-233.
9. Anastasiou D, Poulogiannis G, Asara JM, et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science, 2011,334 (6060):1278-1283.
10. Hitosugi T, Kang S, Vander Heiden MG, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal, 2009,2(97):ra73.
11. Christofk HR, Vander Heiden MG, Wu N, et al. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature, 2008,452 (7184):181-186.
12. Luo W, Hu H, Chang R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-in ducible factor 1. Cell, 2011,145(5):732-744.
13. Yang W, Xia Y, Ji H, et al. Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature, 2011,480(7375): 118-122.
14. Huang H, He X. Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol, 2008,20(2):119-125.
15. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol, 1998,14(59-88.
16. Lu Z, Hunter T. Wnt-independent beta-catenin transactivation in tumor development. Cell Cycle, 2004,3(5):571-573.
17. Lu Z, Ghosh S, Wang Z, et al. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell, 2003,4(6):499-515.
18. Ji H, Wang J, Nika H, et al. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell, 2009,36(4):547-559.
19. Fang D, Hawke D, Zheng Y, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem, 2007,282(15):11221-11229.