-
2
-
-
0027333411
-
Tumor cell interactions with the extracellular matrix during invasion and metastasis
-
Stetler-Stevenson WG, Aznavoorian S, Liotta LA,. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol 1993; 9: 541-73.
-
(1993)
Annu Rev Cell Biol
, vol.9
, pp. 541-573
-
-
Stetler-Stevenson, W.G.1
Aznavoorian, S.2
Liotta, L.A.3
-
3
-
-
67649811051
-
Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain
-
Lorger M, Krueger JS, O'Neal M, et al. Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain. Proc Natl Acad Sci USA 2009; 106: 10666-71.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 10666-10671
-
-
Lorger, M.1
Krueger, J.S.2
O'Neal, M.3
-
4
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo W, Giancotti FG,. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816-26.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
5
-
-
0037145037
-
Integrins: Bidirectional, allosteric signaling machines
-
Hynes RO,. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110: 673-87.
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
6
-
-
33845329178
-
Signalling via integrins: Implications for cell survival and anticancer strategies
-
Hehlgans S, Haase M, Cordes N,. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 2007; 1775: 163-80.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 163-180
-
-
Hehlgans, S.1
Haase, M.2
Cordes, N.3
-
7
-
-
72949119124
-
Integrins in cancer: Biological implications and therapeutic opportunities
-
Desgrosellier JS, Cheresh DA,. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 2010; 10: 9-22.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
8
-
-
0037278885
-
Integrin adhesion receptors in tumor metastasis
-
Felding-Habermann B,. Integrin adhesion receptors in tumor metastasis. Clin Exp Metastasis 2003; 20: 203-13.
-
(2003)
Clin Exp Metastasis
, vol.20
, pp. 203-213
-
-
Felding-Habermann, B.1
-
9
-
-
0036796781
-
Get a ligand, get a life: Integrins, signaling and cell survival
-
Stupack DG, Cheresh DA,. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 2002; 115: 3729-38.
-
(2002)
J Cell Sci
, vol.115
, pp. 3729-3738
-
-
Stupack, D.G.1
Cheresh, D.A.2
-
10
-
-
38449113305
-
Integrin-mediated adhesion: Tipping the balance between chemosensitivity and chemoresistance
-
Zutter MM,. Integrin-mediated adhesion: tipping the balance between chemosensitivity and chemoresistance. Adv Exp Med Biol 2007; 608: 87-100.
-
(2007)
Adv Exp Med Biol
, vol.608
, pp. 87-100
-
-
Zutter, M.M.1
-
11
-
-
60549101931
-
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis
-
Ricono JM, Huang M, Barnes LA, et al. Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis. Cancer Res 2009; 69: 1383-91.
-
(2009)
Cancer Res
, vol.69
, pp. 1383-1391
-
-
Ricono, J.M.1
Huang, M.2
Barnes, L.A.3
-
12
-
-
33644888822
-
Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: A novel functional target for gefitinib
-
Matsuo M, Sakurai H, Ueno Y, et al. Activation of MEK/ERK and PI3K/Akt pathways by fibronectin requires integrin alphav-mediated ADAM activity in hepatocellular carcinoma: a novel functional target for gefitinib. Cancer Sci 2006; 97: 155-62.
-
(2006)
Cancer Sci
, vol.97
, pp. 155-162
-
-
Matsuo, M.1
Sakurai, H.2
Ueno, Y.3
-
13
-
-
0034672112
-
Colon cancer cells adhesion and spreading on autocrine laminin-10 is mediated by multiple integrin receptors and modulated by EGF receptor stimulation
-
Pouliot N, Connolly LM, Moritz RL, et al. Colon cancer cells adhesion and spreading on autocrine laminin-10 is mediated by multiple integrin receptors and modulated by EGF receptor stimulation. Exp Cell Res 2000; 261: 360-71.
-
(2000)
Exp Cell Res
, vol.261
, pp. 360-371
-
-
Pouliot, N.1
Connolly, L.M.2
Moritz, R.L.3
-
14
-
-
67650770190
-
Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
-
Somanath PR, Malinin NL, Byzova TV,. Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis. Angiogenesis 2009; 12: 177-85.
-
(2009)
Angiogenesis
, vol.12
, pp. 177-185
-
-
Somanath, P.R.1
Malinin, N.L.2
Byzova, T.V.3
-
15
-
-
0030814976
-
Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF
-
Schneller M, Vuori K, Ruoslahti E,. Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. EMBO J 1997; 16: 5600-7.
-
(1997)
EMBO J
, vol.16
, pp. 5600-5607
-
-
Schneller, M.1
Vuori, K.2
Ruoslahti, E.3
-
16
-
-
77952932498
-
Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma
-
Barbolina MV, Kim M, Liu Y, et al. Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma. Mol Cancer Res 2010; 8: 653-64.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 653-664
-
-
Barbolina, M.V.1
Kim, M.2
Liu, Y.3
-
17
-
-
0025012050
-
Integrin distribution in malignant melanoma: Association of the beta 3 subunit with tumor progression
-
Albelda SM, Mette SA, Elder DE, et al. Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. Cancer Res 1990; 50: 6757-64.
-
(1990)
Cancer Res
, vol.50
, pp. 6757-6764
-
-
Albelda, S.M.1
Mette, S.A.2
Elder, D.E.3
-
18
-
-
0026631151
-
Involvement of integrin alpha v gene expression in human melanoma tumorigenicity
-
Felding-Habermann B, Mueller BM, Romerdahl CA, et al. Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J Clin Invest 1992; 89: 2018-22.
-
(1992)
J Clin Invest
, vol.89
, pp. 2018-2022
-
-
Felding-Habermann, B.1
Mueller, B.M.2
Romerdahl, C.A.3
-
20
-
-
0028984231
-
An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice
-
Mitjans F, Sander D, Adan J, et al. An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. J Cell Sci 1995; 108: 2825-38.
-
(1995)
J Cell Sci
, vol.108
, pp. 2825-2838
-
-
Mitjans, F.1
Sander, D.2
Adan, J.3
-
21
-
-
0029937529
-
Integrin alpha v beta 3 expression by bone-residing breast cancer metastases
-
Liapis H, Flath A, Kitazawa S,. Integrin alpha V beta 3 expression by bone-residing breast cancer metastases. Diagn Mol Pathol 1996; 5: 127-35.
-
(1996)
Diagn Mol Pathol
, vol.5
, pp. 127-135
-
-
Liapis, H.1
Flath, A.2
Kitazawa, S.3
-
22
-
-
0242668787
-
Expression of alphav integrin family in gastric carcinomas: Increased alphavbeta6 is associated with lymph node metastasis
-
Kawashima A, Tsugawa S, Boku A, et al. Expression of alphav integrin family in gastric carcinomas: increased alphavbeta6 is associated with lymph node metastasis. Pathol Res Pract 2003; 199: 57-64.
-
(2003)
Pathol Res Pract
, vol.199
, pp. 57-64
-
-
Kawashima, A.1
Tsugawa, S.2
Boku, A.3
-
23
-
-
0029610677
-
Definition of two angiogenic pathways by distinct alpha v integrins
-
Friedlander M, Brooks PC, Shaffer RW, et al. Definition of two angiogenic pathways by distinct alpha v integrins. Science 1995; 270: 1500-2.
-
(1995)
Science
, vol.270
, pp. 1500-1502
-
-
Friedlander, M.1
Brooks, P.C.2
Shaffer, R.W.3
-
24
-
-
0037017835
-
Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo
-
Buerkle MA, Pahernik SA, Sutter A, et al. Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo. Br J Cancer 2002; 86: 788-95.
-
(2002)
Br J Cancer
, vol.86
, pp. 788-795
-
-
Buerkle, M.A.1
Pahernik, S.A.2
Sutter, A.3
-
25
-
-
0028972105
-
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin
-
Brooks PC, Stromblad S, Klemke R, et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J Clin Invest 1995; 96: 1815-22.
-
(1995)
J Clin Invest
, vol.96
, pp. 1815-1822
-
-
Brooks, P.C.1
Stromblad, S.2
Klemke, R.3
-
27
-
-
0033549864
-
N-methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists
-
Dechantsreiter MA, Planker E, Matha B, et al. N-methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem 1999; 42: 3033-40.
-
(1999)
J Med Chem
, vol.42
, pp. 3033-3040
-
-
Dechantsreiter, M.A.1
Planker, E.2
Matha, B.3
-
28
-
-
0842333243
-
Alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro
-
Nisato RE, Tille JC, Jonczyk A, et al. alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro. Angiogenesis 2003; 6: 105-19.
-
(2003)
Angiogenesis
, vol.6
, pp. 105-119
-
-
Nisato, R.E.1
Tille, J.C.2
Jonczyk, A.3
-
29
-
-
0035149747
-
Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist
-
MacDonald TJ, Taga T, Shimada H, et al. Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery 2001; 48: 151-7.
-
(2001)
Neurosurgery
, vol.48
, pp. 151-157
-
-
Macdonald, T.J.1
Taga, T.2
Shimada, H.3
-
30
-
-
64249086909
-
Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency
-
Mikkelsen T, Brodie C, Finniss S, et al. Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency. Int J Cancer 2009; 124: 2719-27.
-
(2009)
Int J Cancer
, vol.124
, pp. 2719-2727
-
-
Mikkelsen, T.1
Brodie, C.2
Finniss, S.3
-
31
-
-
84964875096
-
Matched rabbit monoclonal antibodies against alphav-series integrins reveal a novel alphavbeta3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors
-
Goodman SL, Grote HJ, Wilm C,. Matched rabbit monoclonal antibodies against alphav-series integrins reveal a novel alphavbeta3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors. Biol Open 2012; 1: 329-40.
-
(2012)
Biol Open
, vol.1
, pp. 329-340
-
-
Goodman, S.L.1
Grote, H.J.2
Wilm, C.3
-
32
-
-
67349189805
-
Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung
-
Prudkin L, Liu DD, Ozburn NC, et al. Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung. Mod Pathol 2009; 22: 668-78.
-
(2009)
Mod Pathol
, vol.22
, pp. 668-678
-
-
Prudkin, L.1
Liu, D.D.2
Ozburn, N.C.3
-
33
-
-
54849376500
-
CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma
-
Monnier Y, Farmer P, Bieler G, et al. CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res 2008; 68: 7323-31.
-
(2008)
Cancer Res
, vol.68
, pp. 7323-7331
-
-
Monnier, Y.1
Farmer, P.2
Bieler, G.3
-
34
-
-
16344378769
-
Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression
-
Cowden Dahl KD, Robertson SE, Weaver VM, et al. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Mol Biol Cell 2005; 16: 1901-12.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 1901-1912
-
-
Cowden Dahl, K.D.1
Robertson, S.E.2
Weaver, V.M.3
-
35
-
-
77955472749
-
A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis
-
Tchaicha JH, Mobley AK, Hossain MG, et al. A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Oncogene 2010; 29: 4460-72.
-
(2010)
Oncogene
, vol.29
, pp. 4460-4472
-
-
Tchaicha, J.H.1
Mobley, A.K.2
Hossain, M.G.3
-
36
-
-
84856284021
-
Defective retinal vascular endothelial cell development as a consequence of impaired integrin alphaVbeta8-mediated activation of transforming growth factor-beta
-
Arnold TD, Ferrero GM, Qiu H, et al. Defective retinal vascular endothelial cell development as a consequence of impaired integrin alphaVbeta8-mediated activation of transforming growth factor-beta. J Neurosci 2012; 32: 1197-206.
-
(2012)
J Neurosci
, vol.32
, pp. 1197-1206
-
-
Arnold, T.D.1
Ferrero, G.M.2
Qiu, H.3
-
37
-
-
0037192933
-
The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1
-
Mu D, Cambier S, Fjellbirkeland L, et al. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol 2002; 157: 493-507.
-
(2002)
J Cell Biol
, vol.157
, pp. 493-507
-
-
Mu, D.1
Cambier, S.2
Fjellbirkeland, L.3
-
38
-
-
79951838032
-
TGF-beta sequestration by mesangial cell integrin alphavbeta8: A novel mechanism of glomerular endothelial cell regulation
-
Pozzi A, Zent R,. TGF-beta sequestration by mesangial cell integrin alphavbeta8: a novel mechanism of glomerular endothelial cell regulation. Am J Pathol 2011; 178: 485-9.
-
(2011)
Am J Pathol
, vol.178
, pp. 485-489
-
-
Pozzi, A.1
Zent, R.2
-
39
-
-
27344444684
-
Vascular development of the brain requires beta8 integrin expression in the neuroepithelium
-
Proctor JM, Zang K, Wang D, et al. Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci 2005; 25: 9940-8.
-
(2005)
J Neurosci
, vol.25
, pp. 9940-9948
-
-
Proctor, J.M.1
Zang, K.2
Wang, D.3
-
40
-
-
70249086983
-
Defining the role of integrin alphavbeta6 in cancer
-
Bandyopadhyay A, Raghavan S,. Defining the role of integrin alphavbeta6 in cancer. Curr Drug Targets 2009; 10: 645-52.
-
(2009)
Curr Drug Targets
, vol.10
, pp. 645-652
-
-
Bandyopadhyay, A.1
Raghavan, S.2
-
41
-
-
38949212117
-
Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET
-
Beer AJ, Niemeyer M, Carlsen J, et al. Patterns of alphavbeta3 expression in primary and metastatic human breast cancer as shown by 18F-Galacto-RGD PET. J Nucl Med 2008; 49: 255-9.
-
(2008)
J Nucl Med
, vol.49
, pp. 255-259
-
-
Beer, A.J.1
Niemeyer, M.2
Carlsen, J.3
-
42
-
-
33746513396
-
Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone
-
Sloan EK, Pouliot N, Stanley KL, et al. Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res 2006; 8: R20.
-
(2006)
Breast Cancer Res
, vol.8
-
-
Sloan, E.K.1
Pouliot, N.2
Stanley, K.L.3
-
43
-
-
0033982574
-
Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice
-
Huang X, Griffiths M, Wu J, et al. Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice. Mol Cell Biol 2000; 20: 755-9.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 755-759
-
-
Huang, X.1
Griffiths, M.2
Wu, J.3
-
44
-
-
0036152857
-
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
-
Reynolds LE, Wyder L, Lively JC, et al. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 2002; 8: 27-34.
-
(2002)
Nat Med
, vol.8
, pp. 27-34
-
-
Reynolds, L.E.1
Wyder, L.2
Lively, J.C.3
-
45
-
-
79952741178
-
Cilengitide: The first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation
-
Mas-Moruno C, Rechenmacher F, Kessler H,. Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation. Anticancer Agents Med Chem 2010; 10: 753-68.
-
(2010)
Anticancer Agents Med Chem
, vol.10
, pp. 753-768
-
-
Mas-Moruno, C.1
Rechenmacher, F.2
Kessler, H.3
-
46
-
-
80052751118
-
Cilengitide induces autophagy-mediated cell death in glioma cells
-
Lomonaco SL, Finniss S, Xiang C, et al. Cilengitide induces autophagy-mediated cell death in glioma cells. Neuro Oncol 2011; 13: 857-65.
-
(2011)
Neuro Oncol
, vol.13
, pp. 857-865
-
-
Lomonaco, S.L.1
Finniss, S.2
Xiang, C.3
-
47
-
-
0037051697
-
Alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
-
Taga T, Suzuki A, Gonzalez-Gomez I, et al. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer 2002; 98: 690-7.
-
(2002)
Int J Cancer
, vol.98
, pp. 690-697
-
-
Taga, T.1
Suzuki, A.2
Gonzalez-Gomez, I.3
-
48
-
-
73249136703
-
Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro
-
Maurer GD, Tritschler I, Adams B, et al. Cilengitide modulates attachment and viability of human glioma cells, but not sensitivity to irradiation or temozolomide in vitro. Neuro Oncol 2009; 11: 747-56.
-
(2009)
Neuro Oncol
, vol.11
, pp. 747-756
-
-
Maurer, G.D.1
Tritschler, I.2
Adams, B.3
|