-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987-996.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
-
2
-
-
32944469010
-
Changing paradigms-an update on the multidisciplinary management of malignant glioma
-
Stupp R, Hegi Me, van den Bent MJ, et al. Changing paradigms-an update on the multidisciplinary management of malignant glioma. Oncologist. 2006;11:165-180.
-
(2006)
Oncologist
, vol.11
, pp. 165-180
-
-
Stupp, R.1
Hegi, M.2
van den Bent, M.J.3
-
3
-
-
13444275480
-
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion
-
Bellail AC, Hunter SB, Brat DJ, Tan C, Van Meir eG. Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int J Biochem Cell Biol. 2004;36:1046-1069.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 1046-1069
-
-
Bellail, A.C.1
Hunter, S.B.2
Brat, D.J.3
Tan, C.4
Meir eG, V.5
-
5
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol. 2004;5:816-826.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
6
-
-
0033556841
-
The role of integrins in the malignant phenotype of gliomas
-
Uhm JH, Gladson CL, Rao JS. The role of integrins in the malignant phenotype of gliomas. Front Biosci. 1999;4:D188-D199.
-
(1999)
Front Biosci
, vol.4
-
-
Uhm, J.H.1
Gladson, C.L.2
Rao, J.S.3
-
7
-
-
26444496192
-
Angiogenesis and apoptosis in glioma: Two arenas for promising new therapies
-
Bogler O, Mikkelsen T. Angiogenesis and apoptosis in glioma: two arenas for promising new therapies. J Cell Biochem. 2005;96:16-24.
-
(2005)
J Cell Biochem
, vol.96
, pp. 16-24
-
-
Bogler, O.1
Mikkelsen, T.2
-
8
-
-
17844367105
-
Alpha(v)beta3 and alpha(v) beta5 integrin expression in glioma periphery
-
Bello L, Francolini M, Marthyn P, et al. Alpha(v)beta3 and alpha(v) beta5 integrin expression in glioma periphery. Neurosurgery. 2001; 49:380-390.
-
(2001)
Neurosurgery
, vol.49
, pp. 380-390
-
-
Bello, L.1
Francolini, M.2
Marthyn, P.3
-
9
-
-
0028940958
-
Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors
-
Gladson CL, Wilcox JN, Sanders L, Gillespie GY, Cheresh DA. Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J Cell Sci. 1995;108(pt 3):947-956.
-
(1995)
J Cell Sci
, vol.108
, Issue.PART 3
, pp. 947-956
-
-
Gladson, C.L.1
Wilcox, J.N.2
Sanders, L.3
Gillespie, G.Y.4
Cheresh, D.A.5
-
10
-
-
0026334978
-
Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells
-
Gladson CL, Cheresh DA. Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells. J Clin Invest. 1991;88:1924-1932.
-
(1991)
J Clin Invest
, vol.88
, pp. 1924-1932
-
-
Gladson, C.L.1
Cheresh, D.A.2
-
11
-
-
33646894819
-
Glioma cell integrin expression and their interactions with integrin antagonists: Research article
-
3A:325-A340
-
Mattern RH, Read SB, Pierschbacher MD, et al. Glioma cell integrin expression and their interactions with integrin antagonists: research article. Cancer Ther. 2005;3A:325-A340.
-
(2005)
Cancer Ther
-
-
Mattern, R.H.1
Read, S.B.2
Pierschbacher, M.D.3
-
12
-
-
0029846478
-
-
Gladson CL. expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors. J Neuropathol Exp Neurol. 1996;55:1143-1149.
-
Gladson CL. expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors. J Neuropathol Exp Neurol. 1996;55:1143-1149.
-
-
-
-
13
-
-
0042165831
-
Alpha v integrin inhibitors and cancer therapy
-
Tucker GC. Alpha v integrin inhibitors and cancer therapy. Curr Opin Investig Drugs. 2003;4:722-731.
-
(2003)
Curr Opin Investig Drugs
, vol.4
, pp. 722-731
-
-
Tucker, G.C.1
-
14
-
-
33751191637
-
Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells
-
Maubant S, Saint-Dizier D, Boutillon M, et al. Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells. Blood. 2006;108:3035-3044.
-
(2006)
Blood
, vol.108
, pp. 3035-3044
-
-
Maubant, S.1
Saint-Dizier, D.2
Boutillon, M.3
-
16
-
-
0033021996
-
Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death
-
Uhm JH, Dooley NP, Kyritsis AP, Rao JS, Gladson CL. Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin Cancer Res. 1999;5:1587-1594.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1587-1594
-
-
Uhm, J.H.1
Dooley, N.P.2
Kyritsis, A.P.3
Rao, J.S.4
Gladson, C.L.5
-
17
-
-
34249087162
-
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
-
Nabors LB, Mikkelsen T, Rosenfeld SS, et al. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol. 2007;25:1651-1657.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1651-1657
-
-
Nabors, L.B.1
Mikkelsen, T.2
Rosenfeld, S.S.3
-
18
-
-
57149108506
-
Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
-
Reardon DA, Fink KL, Mikkelsen T, et al. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol. 2008;26:5610-5617.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5610-5617
-
-
Reardon, D.A.1
Fink, K.L.2
Mikkelsen, T.3
-
19
-
-
56749119313
-
Phase I/IIa trial of cilengitide (eMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma
-
Stupp R, Goldbrunner R, Neyns B, et al. Phase I/IIa trial of cilengitide (eMD121974) and temozolomide with concomitant radiotherapy, followed by temozolomide and cilengitide maintenance therapy in patients with newly diagnosed glioblastoma. J Clin Oncol. 2007;25:2000.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2000
-
-
Stupp, R.1
Goldbrunner, R.2
Neyns, B.3
-
20
-
-
51449124031
-
Cilengitide: An integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme
-
Reardon DA, Nabors LB, Stupp R, Mikkelsen T. Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs. 2008;17:1225-1235.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1225-1235
-
-
Reardon, D.A.1
Nabors, L.B.2
Stupp, R.3
Mikkelsen, T.4
-
21
-
-
0033549864
-
N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists
-
Dechantsreiter MA, Planker e, Matha B, et al. N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999;42:3033-3040.
-
(1999)
J Med Chem
, vol.42
, pp. 3033-3040
-
-
Dechantsreiter, M.A.1
Planker2
Matha, B.3
-
22
-
-
0031767393
-
Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses
-
Weller M, Rieger J, Grimmel C, et al. Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses. Int J Cancer. 1998;79:640-644.
-
(1998)
Int J Cancer
, vol.79
, pp. 640-644
-
-
Weller, M.1
Rieger, J.2
Grimmel, C.3
-
23
-
-
0032977124
-
Frequent co-alterations of TP53, p16/ CDKN2A, p14ARF, PTeN tumor suppressor genes in human glioma cell lines
-
Ishii N, Maier D, Merlo A, et al. Frequent co-alterations of TP53, p16/ CDKN2A, p14ARF, PTeN tumor suppressor genes in human glioma cell lines. Brain Pathol. 1999;9:469-479.
-
(1999)
Brain Pathol
, vol.9
, pp. 469-479
-
-
Ishii, N.1
Maier, D.2
Merlo, A.3
-
24
-
-
0344441926
-
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death
-
Wischhusen J, Naumann U, Ohgaki H, Rastinejad F, Weller M. CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death. Oncogene. 2003;22:8233-8245.
-
(2003)
Oncogene
, vol.22
, pp. 8233-8245
-
-
Wischhusen, J.1
Naumann, U.2
Ohgaki, H.3
Rastinejad, F.4
Weller, M.5
-
25
-
-
0035833368
-
Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells
-
Glaser T, Wagenknecht B, Weller M. Identification of p21 as a target of cycloheximide-mediated facilitation of CD95-mediated apoptosis in human malignant glioma cells. Oncogene. 2001;20:4757-4767.
-
(2001)
Oncogene
, vol.20
, pp. 4757-4767
-
-
Glaser, T.1
Wagenknecht, B.2
Weller, M.3
-
26
-
-
0031758283
-
Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing
-
Wagenknecht B, Schulz JB, Gulbins e, Weller M. Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing. Cell Death Differ. 1998;5:894-900.
-
(1998)
Cell Death Differ
, vol.5
, pp. 894-900
-
-
Wagenknecht, B.1
Schulz, J.B.2
Gulbins3
Weller, M.4
-
27
-
-
33645105856
-
O6-Methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells
-
Hermisson M, Klumpp A, Wick W, et al. O6-Methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells. J Neurochem. 2006;96:766-776.
-
(2006)
J Neurochem
, vol.96
, pp. 766-776
-
-
Hermisson, M.1
Klumpp, A.2
Wick, W.3
-
28
-
-
18744432267
-
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells
-
Bähr O, Rieger J, Duffner F, et al. P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells. Brain Pathol. 2003;13:482-494.
-
(2003)
Brain Pathol
, vol.13
, pp. 482-494
-
-
Bähr, O.1
Rieger, J.2
Duffner, F.3
-
29
-
-
0035422775
-
Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand
-
Naumann U, Kügler S, Wolburg H, et al. Chimeric tumor suppressor 1, a p53-derived chimeric tumor suppressor gene, kills p53 mutant and p53 wild-type glioma cells in synergy with irradiation and CD95 ligand. Cancer Res. 2001;61:5833-5842.
-
(2001)
Cancer Res
, vol.61
, pp. 5833-5842
-
-
Naumann, U.1
Kügler, S.2
Wolburg, H.3
-
30
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 2002;296: 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
31
-
-
0023187867
-
A rapid in vitro assay for quantitating the invasive potential of tumor cells
-
Albini A, Iwamoto Y, Kleinman HK, et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res. 1987;47:3239-3245.
-
(1987)
Cancer Res
, vol.47
, pp. 3239-3245
-
-
Albini, A.1
Iwamoto, Y.2
Kleinman, H.K.3
-
32
-
-
34347234200
-
The chemoinvasion assay: A method to assess tumor and endothelial cell invasion and its modulation
-
Albini A, Benelli R. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat Protoc. 2007;2:504-511.
-
(2007)
Nat Protoc
, vol.2
, pp. 504-511
-
-
Albini, A.1
Benelli, R.2
-
33
-
-
0036076552
-
ATP luminescencebased motility-invasion assay
-
passim
-
de la Monte SM, Lahousse SA, Carter J, Wands JR. ATP luminescencebased motility-invasion assay. Biotechniques. 2002;33:98-100, 102, 104 passim.
-
(2002)
Biotechniques
, vol.33
-
-
de la Monte, S.M.1
Lahousse, S.A.2
Carter, J.3
Wands, J.R.4
-
34
-
-
73249130732
-
-
Webb J. effects of more than one inhibitor. In: Webb JL, ed. Enzymes and Metabolic Inhibitors. 1. New York: Academic Press; 1963: 487-512.
-
Webb J. effects of more than one inhibitor. In: Webb JL, ed. Enzymes and Metabolic Inhibitors. Vol. 1. New York: Academic Press; 1963: 487-512.
-
-
-
-
35
-
-
0034867240
-
Molecular determinants of glioma cell migration and invasion
-
Wild-Bode C, Weller M, Wick W. Molecular determinants of glioma cell migration and invasion. J Neurosurg. 2001;94:978-984.
-
(2001)
J Neurosurg
, vol.94
, pp. 978-984
-
-
Wild-Bode, C.1
Weller, M.2
Wick, W.3
-
36
-
-
0348049844
-
Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines
-
Cordes N, Hansmeier B, Beinke C, Meineke V, van Beuningen D. Irradiation differentially affects substratum-dependent survival, adhesion, and invasion of glioblastoma cell lines. Br J Cancer. 2003;89:2122-2132.
-
(2003)
Br J Cancer
, vol.89
, pp. 2122-2132
-
-
Cordes, N.1
Hansmeier, B.2
Beinke, C.3
Meineke, V.4
van Beuningen, D.5
-
37
-
-
33845329178
-
Signalling via integrins: Implications for cell survival and anticancer strategies
-
Hehlgans S, Haase M, Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta. 2007;1775:163-180.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 163-180
-
-
Hehlgans, S.1
Haase, M.2
Cordes, N.3
-
38
-
-
20044372154
-
MGMT gene silencing and bene-fit from temozolomide in glioblastoma
-
Hegi Me, Diserens AC, Gorlia T, et al. MGMT gene silencing and bene-fit from temozolomide in glioblastoma. N Engl J Med. 2005;352:997-1003.
-
(2005)
N Engl J Med
, vol.352
, pp. 997-1003
-
-
Hegi, M.1
Diserens, A.C.2
Gorlia, T.3
|