Measuring mitochondrial metabolism in rat brain in vivo using MR Spectroscopy of hyperpolarized [2-13C]pyruvate

NMR in Biomedicine

Volumn 26, Issue 10, 2013, Pages 1197-1203

  Park, Jae Mo ^a,b   Josan, Sonal ^b,c   Grafendorfer, Thomas ^d   Yen, Yi Fen ^b   Hurd, Ralph E ^d   Spielman, Daniel M ^a,b   Mayer, Dirk ^b,c  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c SRI INTERNATIONAL   (United States)

^d GE HEALTHCARE   (United States)

Author keywords

Brain; Dichloroacetate; Glutamate; Hyperpolarized 13C; MRS; Pyruvate; Tricarboxylic acid cycle metabolism

Indexed keywords

DICHLOROACETATE; GLUTAMATE; HYPERPOLARIZED; MRS; PYRUVATES; TRICARBOXYLIC ACID CYCLE;

AMINO ACIDS; BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; RATS;

METABOLISM;

ACETYLCARNITINE; CARBON 13; CITRIC ACID; DICHLOROACETIC ACID; LACTIC ACID; PYRUVIC ACID; PYRUVIC ACID C 13; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ARTICLE; BRAIN METABOLISM; BRAIN MITOCHONDRION; CITRIC ACID CYCLE; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT;

RATTUS;

BRAIN; DICHLOROACETATE; GLUTAMATE; HYPERPOLARIZED 13C; MRS; PYRUVATE; TRICARBOXYLIC ACID CYCLE METABOLISM;

ANIMALS; BRAIN; CARBON ISOTOPES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA; PYRUVATES; RATS; RATS, WISTAR; TIME FACTORS;

EID: 84883747844     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.2935     Document Type: Article

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