Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2- 13C 2]pyruvate in vivo

NMR in Biomedicine

Volumn 25, Issue 2, 2012, Pages 305-311

  Chen, Albert P ^a   Hurd, Ralph E ^b   Schroeder, Marie A ^c,d   Lau, Angus Z ^d,e   Gu, Yi Ping ^d   Lam, Wilfred W ^d   Barry, Jennifer ^d   Tropp, James ^b   Cunningham, Charles H ^d,e  

^a GE HEALTHCARE   (Canada)

^b GE HEALTHCARE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

13C MRS; 1,2 13C 2 pyruvate; DNP; Heart; Metabolism; PH

Indexed keywords

13C MRS; DNP; EX-VIVO; HYPERPOLARIZED; IN-VIVO; KREBS CYCLE; MR SPECTROSCOPY; PARTIAL VIEWS; PYRUVATE METABOLISM; PYRUVATES; RF PULSE; SINGLE-DOSE;

CARBON DIOXIDE; HEART; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PH; PHYSIOLOGY;

METABOLISM;

CARBON 13; CARBON DIOXIDE; GLUTAMIC ACID; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; EX VIVO STUDY; HEART PERFUSION; HYPERPOLARIZATION; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; BICARBONATES; CARBON DIOXIDE; CARBON ISOTOPES; CITRIC ACID CYCLE; HYDROGEN-ION CONCENTRATION; MYOCARDIUM; PHANTOMS, IMAGING; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID; SUS SCROFA;

EID: 84855982701     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1749     Document Type: Article

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