-
1
-
-
13844255273
-
Molecular biology and genetics of Alzheimer's disease
-
DOI 10.1016/j.crvi.2004.10.013, PII S1631069104002604
-
St George-Hyslop PH, Petit A (2005) Molecular biology and genetics of Alzheimer's disease. C R Biol 328(2):119-130. (Pubitemid 40247057)
-
(2005)
Comptes Rendus - Biologies
, vol.328
, Issue.2
, pp. 119-130
-
-
St G.-Hyslop, P.H.1
Petit, A.2
-
2
-
-
84863939887
-
Presenilins and γ-secretase: Structure, function, and role in Alzheimer Disease
-
De Strooper B, Iwatsubo T, Wolfe MS (2012) Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harb Perspect Med 2(1):a006304.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.1
-
-
De Strooper, B.1
Iwatsubo, T.2
Wolfe, M.S.3
-
3
-
-
80755145989
-
Presenilins in synaptic function and disease
-
Ho A, Shen J (2011) Presenilins in synaptic function and disease. Trends Mol Med 17(11):617-624.
-
(2011)
Trends Mol Med
, vol.17
, Issue.11
, pp. 617-624
-
-
Ho, A.1
Shen, J.2
-
4
-
-
11144354609
-
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
-
DOI 10.1016/S0896-6273(04)00182-5, PII S0896627304001825
-
Saura CA, et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42(1):23-36. (Pubitemid 38456965)
-
(2004)
Neuron
, vol.42
, Issue.1
, pp. 23-36
-
-
Saura, C.A.1
Choi, S.-Y.2
Beglopoulos, V.3
Malkani, S.4
Zhang, D.5
Rao, B.S.S.6
Chattarji, S.7
Kelleher III, R.J.8
Kandel, E.R.9
Duff, K.10
Kirkwood, A.11
Shen, J.12
-
5
-
-
84883766736
-
Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons
-
Wu B, Yamaguchi H, Lai FA, Shen J (2013) Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proc Natl Acad Sci USA 110:15091-15096.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 15091-15096
-
-
Wu, B.1
Yamaguchi, H.2
Lai, F.A.3
Shen, J.4
-
6
-
-
77953268759
-
Presynaptic roles of intracellular Ca(2+) stores in signalling and exocytosis
-
Nizami S, et al. (2010) Presynaptic roles of intracellular Ca(2+) stores in signalling and exocytosis. Biochem Soc Trans 38(2):529-535.
-
(2010)
Biochem Soc Trans
, vol.38
, Issue.2
, pp. 529-535
-
-
Nizami, S.1
-
7
-
-
0038573741
-
Presence and functional significance of presynaptic ryanodine receptors
-
DOI 10.1016/S0301-0082(03)00053-4
-
Bouchard R, Pattarini R, Geiger JD (2003) Presence and functional significance of presynaptic ryanodine receptors. Prog Neurobiol 69(6):391-418. (Pubitemid 36869008)
-
(2003)
Progress in Neurobiology
, vol.69
, Issue.6
, pp. 391-418
-
-
Bouchard, R.1
Pattarini, R.2
Geiger, J.D.3
-
8
-
-
50249135503
-
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
-
Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci 31(9):454-463.
-
(2008)
Trends Neurosci
, vol.31
, Issue.9
, pp. 454-463
-
-
Bezprozvanny, I.1
Mattson, M.P.2
-
9
-
-
33748140720
-
2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
-
DOI 10.1016/j.cell.2006.06.059, PII S0092867406010257
-
Tu H, et al. (2006) Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126(5):981-993. (Pubitemid 44310781)
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 981-993
-
-
Tu, H.1
Nelson, O.2
Bezprozvanny, A.3
Wang, Z.4
Lee, S.-F.5
Hao, Y.-H.6
Serneels, L.7
De Strooper, B.8
Yu, G.9
Bezprozvanny, I.10
-
10
-
-
0032972683
-
Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5- trisphosphate-mediated calcium signaling in Xenopus oocytes
-
DOI 10.1046/j.1471-4159.1999.0721061.x
-
Leissring MA, Paul BA, Parker I, Cotman CW, LaFerla FM (1999) Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes. J Neurochem 72(3):1061-1068. (Pubitemid 29085020)
-
(1999)
Journal of Neurochemistry
, vol.72
, Issue.3
, pp. 1061-1068
-
-
Leissring, M.A.1
Paul, B.A.2
Parker, I.3
Cotman, C.W.4
Laferla, F.M.5
-
11
-
-
46249123354
-
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production
-
DOI 10.1083/jcb.200706171
-
Green KN, et al. (2008) SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol 181(7):1107-1116. (Pubitemid 351915486)
-
(2008)
Journal of Cell Biology
, vol.181
, Issue.7
, pp. 1107-1116
-
-
Green, K.N.1
Demuro, A.2
Akbari, Y.3
Hitt, B.D.4
Smith, I.F.5
Parker, I.6
LaFerla, F.M.7
-
12
-
-
0036830947
-
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease
-
LaFerla FM (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat Rev Neurosci 3(11):862-872.
-
(2002)
Nat Rev Neurosci
, vol.3
, Issue.11
, pp. 862-872
-
-
LaFerla, F.M.1
-
13
-
-
67949086707
-
Presenilins are essential for regulating neurotransmitter release
-
Zhang C, et al. (2009) Presenilins are essential for regulating neurotransmitter release. Nature 460(7255):632-636.
-
(2009)
Nature
, vol.460
, Issue.7255
, pp. 632-636
-
-
Zhang, C.1
-
14
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee JH, et al. (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141(7):1146-1158.
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1146-1158
-
-
Lee, J.H.1
-
15
-
-
34547479273
-
Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content
-
DOI 10.1111/j.1471-4159.2007.04627.x
-
Hamid R, et al. (2007) Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. J Neurochem 102(4):1264-1275. (Pubitemid 47174237)
-
(2007)
Journal of Neurochemistry
, vol.102
, Issue.4
, pp. 1264-1275
-
-
Hamid, R.1
Kilger, E.2
Willem, M.3
Vassallo, N.4
Kostka, M.5
Bornhovd, C.6
Reichert, A.S.7
Kretzschmar, H.A.8
Haass, C.9
Herms, J.10
-
16
-
-
33947201115
-
Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease
-
De Strooper B (2007) Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease. EMBO Rep 8(2):141-146.
-
(2007)
EMBO Rep
, vol.8
, Issue.2
, pp. 141-146
-
-
De Strooper, B.1
-
17
-
-
77954602182
-
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity
-
Heilig EA, Xia W, Shen J, Kelleher RJ III (2010) A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem 285(29):22350-22359.
-
(2010)
J Biol Chem
, vol.285
, Issue.29
, pp. 22350-22359
-
-
Heilig, E.A.1
Xia, W.2
Shen, J.3
Kelleher III, R.J.4
-
18
-
-
84859520482
-
Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice
-
Watanabe H, Xia D, Kanekiyo T, Kelleher RJ III, Shen J (2012) Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci 32(15):5085-5096.
-
(2012)
J Neurosci
, vol.32
, Issue.15
, pp. 5085-5096
-
-
Watanabe, H.1
Xia, D.2
Kanekiyo, T.3
Kelleher III, R.J.4
Shen, J.5
-
19
-
-
84880442012
-
Transdominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production
-
Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ III (2013) Transdominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. J Neurosci 33(28):11606-11617.
-
(2013)
J Neurosci
, vol.33
, Issue.28
, pp. 11606-11617
-
-
Heilig, E.A.1
Gutti, U.2
Tai, T.3
Shen, J.4
Kelleher III, R.J.5
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