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Volumn 64, Issue 11, 2012, Pages 1614-1620

Progesterone pharmacokinetics in the mouse: Implications for potential stroke therapy

Author keywords

brain; pharmacokinetics; plasma; progesterone; stroke

Indexed keywords

DIMETHYL SULFOXIDE; PROGESTERONE;

EID: 84867581389     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01537.x     Document Type: Article
Times cited : (13)

References (50)
  • 2
    • 5344258196 scopus 로고    scopus 로고
    • Is stroke the most common cause of disability
    • Adamson J, et al,. Is stroke the most common cause of disability ? J Stroke Cerebrovasc Dis 2004; 13: 171-177.
    • (2004) J Stroke Cerebrovasc Dis , vol.13 , pp. 171-177
    • Adamson, J.1
  • 3
    • 65249125762 scopus 로고    scopus 로고
    • Sex differences in stroke epidemiology a systematic review
    • Appelros P, et al,. Sex differences in stroke epidemiology a systematic review. Stroke 2009; 40: 1082-1090.
    • (2009) Stroke , vol.40 , pp. 1082-1090
    • Appelros, P.1
  • 4
    • 0025755590 scopus 로고
    • Estrogen and coronary heart disease in women
    • Barrett-Connor E, Bush TL,. Estrogen and coronary heart disease in women. JAMA 1991; 265: 1861-1867.
    • (1991) JAMA , vol.265 , pp. 1861-1867
    • Barrett-Connor, E.1    Bush, T.L.2
  • 5
    • 0001846234 scopus 로고
    • The incidence, prevalence and mortality of cardiovascular disease
    • Schlant R.C. Alexander R.W. eds. New York: McGraw-Hill Inc
    • Kannel WB, Thom TJ,. The incidence, prevalence and mortality of cardiovascular disease. In:, Schlant RC, Alexander RW, eds. The Heart. New York: McGraw-Hill Inc, 1994: 185-197.
    • (1994) The Heart , pp. 185-197
    • Kannel, W.B.1    Thom, T.J.2
  • 6
    • 0027217784 scopus 로고
    • Cardiovascular health and disease in women
    • Wenger N, et al,. Cardiovascular health and disease in women. N Engl J Med 1993; 329: 247-256.
    • (1993) N Engl J Med , vol.329 , pp. 247-256
    • Wenger, N.1
  • 7
    • 33747622760 scopus 로고    scopus 로고
    • Estrogen and experimental ischemic stroke: A systematic review
    • Gibson CL, et al,. Estrogen and experimental ischemic stroke: a systematic review. J Cereb Blood Flow Metab 2006; 26: 1103-1113.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 1103-1113
    • Gibson, C.L.1
  • 8
    • 0033976986 scopus 로고    scopus 로고
    • Neuroprotective effects of female gonadal steroids in reproductively senescent female rats
    • Alkayed NJ, et al,. Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 2000; 31: 161-168.
    • (2000) Stroke , vol.31 , pp. 161-168
    • Alkayed, N.J.1
  • 9
    • 3042773856 scopus 로고    scopus 로고
    • Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice
    • Gibson CL, Murphy S,. Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 2004; 24: 805-813.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 805-813
    • Gibson, C.L.1    Murphy, S.2
  • 10
    • 0030607198 scopus 로고    scopus 로고
    • Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats
    • Jiang N, et al,. Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res 1996; 735: 101-107.
    • (1996) Brain Res , vol.735 , pp. 101-107
    • Jiang, N.1
  • 11
    • 0034016139 scopus 로고    scopus 로고
    • Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia
    • Kumon Y, et al,. Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia. J Neurosurg 2000; 92: 848-852.
    • (2000) J Neurosurg , vol.92 , pp. 848-852
    • Kumon, Y.1
  • 12
    • 0036791875 scopus 로고    scopus 로고
    • Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats
    • Murphy SJ, et al,. Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats. J Cereb Blood Flow Metab 2002; 22: 1181-1188.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1181-1188
    • Murphy, S.J.1
  • 13
    • 18144409121 scopus 로고    scopus 로고
    • Progesterone supresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia
    • Gibson CL, et al,. Progesterone supresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischemia. Exp Neurol 2005; 193: 522-530.
    • (2005) Exp Neurol , vol.193 , pp. 522-530
    • Gibson, C.L.1
  • 14
    • 34548089961 scopus 로고    scopus 로고
    • Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion
    • Sayeed I, et al,. Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 2007; 25: 151-159.
    • (2007) Restor Neurol Neurosci , vol.25 , pp. 151-159
    • Sayeed, I.1
  • 15
    • 61849137768 scopus 로고    scopus 로고
    • Direct inhibition of the mitochondrial permeability transition pore: A possible mechanism for better neuroprotective effects of allopregnanolone over progesterone
    • Sayeed I, et al,. Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism for better neuroprotective effects of allopregnanolone over progesterone. Brain Res 2009; 1263: 165-173.
    • (2009) Brain Res , vol.1263 , pp. 165-173
    • Sayeed, I.1
  • 16
    • 63349089474 scopus 로고    scopus 로고
    • Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats
    • Ishrat T, et al,. Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischemia in rats. Brain Res 2009; 1257: 94-101.
    • (2009) Brain Res , vol.1257 , pp. 94-101
    • Ishrat, T.1
  • 17
    • 0032724682 scopus 로고    scopus 로고
    • Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat
    • Chen J, Chopp M,. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 1999; 171: 24-30.
    • (1999) J Neurol Sci , vol.171 , pp. 24-30
    • Chen, J.1    Chopp, M.2
  • 18
    • 38849190685 scopus 로고    scopus 로고
    • Progesterone for the treatment of experimental brain injury; A systematic review
    • Gibson CL, et al,. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2007; 131: 318-328.
    • (2007) Brain , vol.131 , pp. 318-328
    • Gibson, C.L.1
  • 19
    • 0034046613 scopus 로고    scopus 로고
    • The etiology of female breast cancer
    • Sharpe C, Boivin JF,. The etiology of female breast cancer. Med Princ Pract 2000; 9: 1-24.
    • (2000) Med Princ Pract , vol.9 , pp. 1-24
    • Sharpe, C.1    Boivin, J.F.2
  • 20
    • 0016242603 scopus 로고
    • Physiological and psychological effects of progesterone in man
    • Little BC, et al,. Physiological and psychological effects of progesterone in man. J Nerv Ment Dis 1974; 159: 256-262.
    • (1974) J Nerv Ment Dis , vol.159 , pp. 256-262
    • Little, B.C.1
  • 21
    • 0022000112 scopus 로고
    • Bioequivalence evaluation of new megestrol-acetate formulations in humans
    • Gaver RC, et al,. Bioequivalence evaluation of new megestrol-acetate formulations in humans. Semin Oncol 1985; 12: 17-19.
    • (1985) Semin Oncol , vol.12 , pp. 17-19
    • Gaver, R.C.1
  • 22
    • 36049044777 scopus 로고    scopus 로고
    • Progesterone: Review of safety for clinical studies
    • Goletiani NV, et al,. Progesterone: review of safety for clinical studies. Exp Clin Psychopharmacol 2007; 15: 427-444.
    • (2007) Exp Clin Psychopharmacol , vol.15 , pp. 427-444
    • Goletiani, N.V.1
  • 23
    • 33947165175 scopus 로고    scopus 로고
    • ProTECT: A randomized clinical trial of progresterone for acute traumatic brain injury
    • Wright DW, et al,. ProTECT: a randomized clinical trial of progresterone for acute traumatic brain injury. Ann Emerg Med 2007; 49: 391-402.
    • (2007) Ann Emerg Med , vol.49 , pp. 391-402
    • Wright, D.W.1
  • 24
    • 43249131666 scopus 로고    scopus 로고
    • Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: A randomized controlled trial
    • R61
    • Xiao GM, et al,. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care 2008; 12: R61.
    • (2008) Crit Care , vol.12
    • Xiao, G.M.1
  • 25
    • 0034102549 scopus 로고    scopus 로고
    • Progesterone exacerbates striatal stroke injury in progesterone deficient female animals
    • Murphy SJ, et al,. Progesterone exacerbates striatal stroke injury in progesterone deficient female animals. Stroke 2000; 31: 1173-1178.
    • (2000) Stroke , vol.31 , pp. 1173-1178
    • Murphy, S.J.1
  • 26
    • 78049280232 scopus 로고    scopus 로고
    • Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice
    • Coomber B, Gibson CL,. Sustained levels of progesterone prior to the onset of cerebral ischemia are not beneficial to female mice. Brain Res 2010; 1361: 124-132.
    • (2010) Brain Res , vol.1361 , pp. 124-132
    • Coomber, B.1    Gibson, C.L.2
  • 27
    • 48849089052 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: Past, present and future
    • Ginsberg MD,. Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology 2008; 55: 363-389.
    • (2008) Neuropharmacology , vol.55 , pp. 363-389
    • Ginsberg, M.D.1
  • 28
    • 0032511643 scopus 로고    scopus 로고
    • The neurosteroids, progesterone and 3 alpha,5 alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats
    • Frye CA, et al,. The neurosteroids, progesterone and 3 alpha,5 alpha-THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Res 1998; 808: 72-83.
    • (1998) Brain Res , vol.808 , pp. 72-83
    • Frye, C.A.1
  • 29
    • 0024841883 scopus 로고
    • Mean time parameters in pharmacokinetics - Definition, computation and clinical implications.2
    • Vengpedersen P,. Mean time parameters in pharmacokinetics-definition, computation and clinical implications.2. Clin Pharmacokinet 1989; 17: 424-440.
    • (1989) Clin Pharmacokinet , vol.17 , pp. 424-440
    • Vengpedersen, P.1
  • 31
    • 0002344081 scopus 로고
    • Pharmacokinetics
    • Glenny H. Nelmes P. eds. London: Blackwell Scientific Publications
    • Martin BK,. Pharmacokinetics. In:, Glenny H, Nelmes P, eds. Handbook of Clinical Drug Research. London: Blackwell Scientific Publications, 1986: 59-93.
    • (1986) Handbook of Clinical Drug Research , pp. 59-93
    • Martin, B.K.1
  • 32
    • 0026690043 scopus 로고
    • Progesterone treatment attenuates brain edema following contusion injury in male and female rats
    • Roof RL, et al,. Progesterone treatment attenuates brain edema following contusion injury in male and female rats. Restor Neurol Neurosci 1992; 4: 425-427.
    • (1992) Restor Neurol Neurosci , vol.4 , pp. 425-427
    • Roof, R.L.1
  • 33
    • 0029878565 scopus 로고    scopus 로고
    • Progesterone rapidly decreases brain edema: Treatment delayed up to 24 hours is still effective
    • Roof RL, et al,. Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp Neurol 1996; 138: 246-251.
    • (1996) Exp Neurol , vol.138 , pp. 246-251
    • Roof, R.L.1
  • 34
    • 34547838202 scopus 로고    scopus 로고
    • Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility
    • Beckley EH, Finn DA,. Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility. Pharmacol Biochem Behav 2007; 87: 412-419.
    • (2007) Pharmacol Biochem Behav , vol.87 , pp. 412-419
    • Beckley, E.H.1    Finn, D.A.2
  • 35
    • 79959711271 scopus 로고    scopus 로고
    • Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice
    • Gibson CL, et al,. Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice. Brain 2011; 134: 2125-2133.
    • (2011) Brain , vol.134 , pp. 2125-2133
    • Gibson, C.L.1
  • 36
    • 5444275187 scopus 로고    scopus 로고
    • Dynamic aspects of acute tolerance to allopregnanolone evaluated using anaesthesia threshold in male rats
    • Zhu D, et al,. Dynamic aspects of acute tolerance to allopregnanolone evaluated using anaesthesia threshold in male rats. Br J Anaesth 2004; 93: 560-567.
    • (2004) Br J Anaesth , vol.93 , pp. 560-567
    • Zhu, D.1
  • 37
    • 0034477199 scopus 로고    scopus 로고
    • Steroid synthesis and metabolism in the nervous system: Trophic and protective effects
    • Schumacher M, et al,. Steroid synthesis and metabolism in the nervous system: trophic and protective effects. J Neurocytol 2000; 29: 307-326.
    • (2000) J Neurocytol , vol.29 , pp. 307-326
    • Schumacher, M.1
  • 38
    • 0018750857 scopus 로고
    • Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone
    • Pardridge WM, Mietus LJ,. Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone. J Clin Invest 1979; 64: 145-154.
    • (1979) J Clin Invest , vol.64 , pp. 145-154
    • Pardridge, W.M.1    Mietus, L.J.2
  • 39
    • 0016740846 scopus 로고
    • The metabolic clearance rate, head and brain extractions, and brain distribution and metabolism of progesterone in anesthetized, female monkey (Macaca mulatta)
    • Billiar RB, et al,. The metabolic clearance rate, head and brain extractions, and brain distribution and metabolism of progesterone in anesthetized, female monkey (Macaca mulatta). Brain Res 1975; 94: 99-113.
    • (1975) Brain Res , vol.94 , pp. 99-113
    • Billiar, R.B.1
  • 40
    • 0017111437 scopus 로고
    • Head extractions, brain and pituitary uptake and metabolism of progesterone and 5alpha-dihydroprogesterone in anesthetized, female rabbits
    • Johnson WA, et al,. Head extractions, brain and pituitary uptake and metabolism of progesterone and 5alpha-dihydroprogesterone in anesthetized, female rabbits. Brain Res 1976; 111: 147-155.
    • (1976) Brain Res , vol.111 , pp. 147-155
    • Johnson, W.A.1
  • 41
    • 0035660086 scopus 로고    scopus 로고
    • Brain androgen and progesterone metabolizing enzymes: Biosynthesis, distribution and function
    • Lephart ED, et al,. Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Res Rev 2001; 37: 25-37.
    • (2001) Brain Res Rev , vol.37 , pp. 25-37
    • Lephart, E.D.1
  • 42
    • 33645002699 scopus 로고    scopus 로고
    • Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    • Sayeed I, et al,. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Ann Emerg Med 2006; 47: 381-389.
    • (2006) Ann Emerg Med , vol.47 , pp. 381-389
    • Sayeed, I.1
  • 43
    • 84875238449 scopus 로고    scopus 로고
    • Progestogen matabolism
    • Lobo R.A. et al., ed. San Diego: Academic Press
    • Lobo RA, et al,. Progestogen matabolism. In:, Lobo RA, et al., ed. Menopause: Biology and Pathobiology. San Diego: Academic Press, 2000: 422-434.
    • (2000) Menopause: Biology and Pathobiology , pp. 422-434
    • Lobo, R.A.1
  • 44
    • 0016137733 scopus 로고
    • Progesterone and estradiol-17beta concentrations in peripheral plasma during pregnancy in mouse
    • McCormac JT, Greenwal GS,. Progesterone and estradiol-17beta concentrations in peripheral plasma during pregnancy in mouse. J Endocrinol 1974; 62: 101-107.
    • (1974) J Endocrinol , vol.62 , pp. 101-107
    • McCormac, J.T.1    Greenwal, G.S.2
  • 45
    • 0016240465 scopus 로고
    • Serum progesterone levels in the pregnant and postpartum laboratory mouse
    • Virgo BB, Bellward GD,. Serum progesterone levels in the pregnant and postpartum laboratory mouse. Endocrinology 1974; 95: 1486-1490.
    • (1974) Endocrinology , vol.95 , pp. 1486-1490
    • Virgo, B.B.1    Bellward, G.D.2
  • 46
    • 0343742584 scopus 로고    scopus 로고
    • Brain neurosteroids during the mouse oestrous cycle
    • Corpechot C, et al,. Brain neurosteroids during the mouse oestrous cycle. Brain Res 1997; 766: 276-280.
    • (1997) Brain Res , vol.766 , pp. 276-280
    • Corpechot, C.1
  • 47
    • 9144223250 scopus 로고    scopus 로고
    • The resistance to ischemia of white and gray matter after stroke
    • Falcao ALE, et al,. The resistance to ischemia of white and gray matter after stroke. Ann Neurol 2004; 56: 695-701.
    • (2004) Ann Neurol , vol.56 , pp. 695-701
    • Falcao, A.L.E.1
  • 48
    • 33644698763 scopus 로고    scopus 로고
    • Is white matter involved in patients entered into typical trials of neuroprotection?
    • Ho PW, et al,. Is white matter involved in patients entered into typical trials of neuroprotection? Stroke 2005; 36: 2742-2744.
    • (2005) Stroke , vol.36 , pp. 2742-2744
    • Ho, P.W.1
  • 49
    • 19544376511 scopus 로고    scopus 로고
    • Neuroprotection for ischemic stroke: Two decades of success and failure
    • Cheng YD, et al,. Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRX 2004; 1: 36-45.
    • (2004) NeuroRX , vol.1 , pp. 36-45
    • Cheng, Y.D.1
  • 50
    • 0041659304 scopus 로고    scopus 로고
    • Animal models of stroke: Do they have value for discovering neuroprotective agents?
    • Green AR, et al,. Animal models of stroke: do they have value for discovering neuroprotective agents? Trends Pharmacol Sci 2003; 24: 402-408.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 402-408
    • Green, A.R.1


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