An alternative method for the quantitation of neuronal damage after experimental middle cerebral artery occlusion in rats: Analysis of behavioral deficit

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 4, 1996, Pages 705-713

  Aronowski, Jaroslaw ^a   Samways, Emma ^a   Strong, Roger ^a   Rhoades, Howard M ^a   Grotta, James C ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Behavioral dysfunction; Focal ischemia; Motor performance; Neurological deficit; Neuroprotective therapy

Indexed keywords

APTIGANEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; CELL DAMAGE; COMMON CAROTID ARTERY; CONTROLLED STUDY; HYPOTHESIS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; REPRODUCIBILITY; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0029882764     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199607000-00022     Document Type: Article

References (26)

1. Aronowski J, Samways E, Strong R, Grotta JC (1994) A graded bioassay for demonstration of brain rescue from experimental acute ischemia. Stroke 25:2235-2240
2. Earth TM, Jones TA, Schauert T (1990) Functional subdivisions of the rat somatic sensorimotor cortex. Behav Brain Res 39:73-95
3. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of neurologic examination. Stroke 17:472-476
4. Bharucha VA, Wakade CG, Mahadik SP, Karpiak SE (1991) GM1 ganglioside treatment reduces functional deficit associated with cortical focal ischemia. Exp Neurol 114:136-139
5. Brint S, Jacewicz M, Kiessling M, Tanabe J, Pulsinelli W (1988) Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries. J Cereb Blood Flow Metab 8:474-485
6. Coyle P (1986) Different susceptibilities to cerebral infarction in spontaneously hypertensive (SHR) and normotensive Sprague-Dawley rats. Stroke 17:520-525
7. DeGraba T, Ostrow P, Grotta JC (1993) Threshold of calcium disturbances after focal cerebral ischemia in rats -implications of the windows of therapeutic opportunity. Stroke 24:1212-1217
8. DeGraba TJ, Ostrow P, Hanson S, Grotta JC (1994) Motor performance, histologie damage, and calcium influx in rats tested with NBQX after focal ischemia. J Cereb Blood Flow Metab 14:262-268
9. De Lean A, Munson PJ, Rodbard D (1978) Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235:E97-E102
10. Dixon CA, Clifton GL, Lighthall JW, Yaghmai AA, Hayes RL (1991) A controlled cortical impact model of traumatic brain injury in the rat. J Neurosci Methods 39:253-262
11. Finkbeiner S, Stevens CF (1988) Applications of quantitative measurements for assessing glutamate neurotoxicity. Proc Natl Acad Sci USA 85:4071-4074
12. Grabowski M, Brundin P, Johansson BB (1993) Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats. Stroke 24:889-895
13. Grotta JC, Pettigrew LC, Reid C, Rosenbaum D, McCandless D, Rhoades H (1988) Studies on the efficacy and mechanism of action of a calcium blocker after global cerebral ischemia. Stroke 19:447-454
14. Grotta JC, Picone CM, Ostrow PT, Strong RA, Earls RM, Yao LP, Rhoades HM, Dedman JR (1990) CGS 19755, a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann Neurol 27:612-619
15. Jacewicz M (1992) The hypertensive rat and predisposition to cerebral infarction. Hypertension 19:47-48
16. Kaplan B, Brint S, Tanabe J, Jacewicz M, Wand X-J, Pulsinelli W (1991) Temporal threshold of neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke 22: 1031-1039
17. Kolb B, Whishaw IQ (1983) Dissociation of the contribution of the prefrontal, motor and parietal cortex to the control of movement in the rat: an experimental review. Can J Psychol 37:211-232
18. Markgraf CG, Green EJ, Hurwitz BE, Morikawa E, Dietrich WD, McCabe PM, Ginsberg MD, Schneiderman N (1992) Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats. Brain Res 575:238-246
19. Menzies SA, Hoff JT, Betz AL (1992) Middle cerebral artery occlusion in rat: a neurological and pathological evaluation of a reproducible model. Neurosurgery 31:100-107
20. Minematsu K, Yamaguchi T, Omae T (1992) Spectacular shrinking deficit: rapid recovery from a major hemispheric syndrome by migration of an embolus. Neurology 42:157-162
21. Minematsu K, Fisher M, Li L, Davis MA, Knapp AG, Cotter RE, McBurney RN, Sotak CH (1993) Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI. Neurology 43:397-403
22. Persson L, Hardemark H-G, Bolander HG, Hillered L, Olsson Y (1989) Neurologic and neuropathologic outcome after middle cerebral artery occlusion in rat. Stroke 20:641-645
23. Schallert T, Whishaw IQ (1984) Bilateral cutaneous stimulation of the somatosensory system in hemi-decorticated rats. Behav Neurosci 98:518-540
24. Tang D-I, Geller NL, Pocock SJ (1993) On the design and analysis of randomized clinical trials with multiple endpoints. Biometrics 49:23-30
25. Wahl F, Allix M, Plotkine M, Boulu RG (1992) Neurological and behavioral outcomes of focal cerebral ischemia in rats. Stroke 23:267-272
26. Zivin JA, Waud DR (1992) Quantal bioassay and stroke. Stroke 23:767-773