ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes

Acta Pharmacologica Sinica

Volumn 34, Issue 9, 2013, Pages 1229-1236

  Qi, Xin Ming ^a   Miao, Ling Ling ^a   Cai, Yan ^a   Gong, Li Kun ^a   Ren, Jin ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytochrome P450; Mitochondria; Reactive oxygen species; Tetrandrine

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASCORBIC ACID; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 2E1; GLUTATHIONE; PROADIFEN; REACTIVE OXYGEN METABOLITE; TETRANDRINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; GENE OVEREXPRESSION; LIVER CELL; LIVER TOXICITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEPLETION; RAT;

ANIMALS; BENZYLISOQUINOLINES; CELL LINE, TRANSFORMED; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 ENZYME SYSTEM; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; MALE; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84883708045     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.62     Document Type: Article

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