Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB pathway

Acta Pharmacologica Sinica

Volumn 29, Issue 2, 2008, Pages 245-251

  Xue, Yang ^a   Wang, Ying ^a   Feng, De Chun ^a   Xiao, Bao Guo ^b   Xu, Ling Yun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Cytokine; Microglia; NF B; Nitric oxide; Superoxide anion; Tetrandrine

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NITRIC OXIDE; SUPEROXIDE; TETRANDRINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GEL MOBILITY SHIFT ASSAY; IN VITRO STUDY; MICROGLIA; NONHUMAN; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZYLISOQUINOLINES; CYTOKINES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MICROGLIA; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 38749147302     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00734.x     Document Type: Article

References (40)

1. Ho LJ, Lai JH. Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders. Curr Drug Metab 2004 5 : 181 92.
2. Xie QM, Tang HF, Chen JQ, Bian RL. Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta Pharmacol Sin 2002 23 : 1107 13.
3. Lai JH. Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta Pharmacol Sin 2002 23 : 1093 101.
4. Rao MR. Effects of tetrandrine on cardiac and vascular remodeling. Acta Pharmacol Sin 2002 23 : 1075 85.
5. Shi X, Mao Y, Saffiotti U, Wang L, Rojanasakul Y, Leonard SS, et al. Antioxidant activity of tetrandrine and its inhibition of quartz-induced lipid peroxidation. J Toxicol Environ Health 1995 46 : 233 48.
6. Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X, et al. Tetrandrine inhibits signal-induced NF-kappa B activation in rat alveolar macrophages. Biochem Biophys Res Commun 1997 231 : 99 102.
7. Ho LJ, Chang DM, Lee TC, Chang ML, Lai JH. Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells. Eur J Pharmacol 1999 367 : 389 98.
8. Ferrante A, Seow WK, Rowan-Kelly B, Thong YH. Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) by human monocytes. Clin Exp Immunol 1990 80 : 232 5.
9. Wang B, Yang L, Yan HL, Wang M, Xiao JG. Effect of tetrandrine on calcium-dependent tumour necrosis factor-alpha production in glia-neurone mixed cultures. Basic Clin Pharmacol Toxicol 2005 97 : 244 8.
10. Gremo F, Sogos V, Ennas MG, Meloni A, Persichini T, Colasanti M, et al. Features and functions of human microglia cells. Adv Exp Med Biol 1997 429 : 79 97.
11. Ryu JK, Shin WH, Kim J, Joe EH, Lee YB, Cho KG, et al. Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia. Glia 2002 38 : 15 23.
12. Iadecola C, Zhang F, Xu S, Casey R, Ross ME. Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 1995 15 : 378 84.
13. Paresce DM, Chung H, Maxfield FR. Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by micro-glial cells. J Biol Chem 1997 272 : 29390 7.
14. Bal-Price A, Brown GC. Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem 2000 75 : 1455 64.
15. Combs CK, Karlo JC, Kao SC, Landreth GE. Beta-amyloid stimulation of microglia and monocytes results in TNF-alpha-depen-dent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001 21 : 1179 88.
16. Xiao BG, Diab A, Zhu J, van der Meide P, Link H. Astrocytes induce hyporesponses of myelin basic protein-reactive T and B cell function. J Neuroimmunol 1998 89 : 113 21.
17. Griess P. Bemerkungen zu der abhandlung der H. H. Weselsky und Benedikt "Ueber einige azoverbindungen". Chem Ber 1879 12 : 426 8.
18. McDonald DR, Brunden KR, Landreth GE. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci 1997 17 : 2284 94.
19. Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, et al. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 2006 281 : 21362 8.
20. Le W, Rowe D, Xie W, Ortiz I, He Y, Appel SH. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci 2001 21 : 8447 55.
21. Brown GC, Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol 2003 27 : 325 55.
22. Liu B, Jiang JW, Wilson BC, Du L, Yang SN, Wang J Y, et al. Systemic infusion of naloxone reduces degeneration of rat sub-stantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. J Pharmacol Exp Ther 2000 295 : 125 32.
23. Liu B, Du L, Hong JS. Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. J Pharmacol Exp Ther 2000 293 : 607 17.
24. Kowalski J, Labuzek K, Herman ZS. Flupentixol and trifluperidol reduce secretion of tumor necrosis factor-α and nitric oxide by rat microglial cells. Neurochem Int 2003 1289 : 1 6.
25. Li R, Huang YG, Fang D, Le WD. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci Res 2004 78 : 723 31.
26. Kondo Y, Takano F, Hojo H. Inhibitory effect of bisbenzyliso-quinoline alkaloids on nitric oxide production in activated macrophages. Biochem Pharmacol 1993 46 : 1887 92.
27. Lai JH, Ho LJ, Kwan CY, Chang DM, Lee TC. Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology. Transplantation 1999 68 : 1383 92.
28. Castranova V. Generation of oxygen radicals and mechanisms of injury prevention. Environ Health Perspect 1994 Suppl 10 : 65 8.
29. Bal-Price A, Matthias A, Brown GC. Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production. J Neurochem 2002 80 : 73 80.
30. Riobo NA, Clementi E, Melani M, Boveris A, Cadenas E, Moncada S, et al. Nitric oxide inhibits mitochondrial NADH: ubiquinone reductase activity through peroxynitrite formation. Biochem J 2001 359 : 139 45.
31. Seow WK, Ferrante A, Li SY, Thong YH. Antiphagocytic and antioxidant properties of plant alkaloid tetrandrine. Int Arch Allergy Appl Immunol 1988 85 : 404 9.
32. Grau GE, Lou J. TNF in vascular pathology: the importance of platelet-endothelial interactions. Res Immunol 1993 144 : 355 63.
33. Satoh J, Kastrukoff LF, Kim SU. Cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in cultured human oligodendrocytes and astrocytes. J Neuropathol Exp Neurol 1991 50 : 215 26.
34. McManus CM, Brosnan CF, Berman JW. Cytokine induction of MIP-1α and MIP-1β in human fetal microglia. J Immunol 1998 160 : 1449 55.
35. Hayashi M, Luo Y, Laning J, Strieter RM, Dorf ME. Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells. J Neuroimmunol 1995 60 : 143 50.
36. Hurwitz AA, Lyman WD, Berman JW. Tumor necrosis factor α and transforming growth factor? upregulate astrocyte expression of monocyte chemoattractant protein-1. J Neuroimmunol 1995 57 : 193 8.
37. Louis JC, Magal E, Takayama S, Varon S. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 1993 259 : 689 92.
38. Klein MA, Moller JC, Jones LL, Bluethmann H, Kreutzberg GW, Raivich G. Impaired neuroglial activation in interleukin-6-deficient mice. Glia 1997 19 : 227 33.
39. Ho LJ, Juan TY, Chao P, Wu WL, Chang DM, Chang SY, et al. Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell. Br J Pharmacol 2004 143 : 919 27.
40. Chen F, Sun S, Kuhn DC, Lu Y, Gaydos LJ, Shi X, et al. Tetrandrine inhibits signal-induced NF-kappa B activation in rat alveolar macrophages. Biochem Biophys Res Commun 1997 231 : 99 102.