Paclitaxel/tetrandrine coloaded nanoparticles effectively promote the apoptosis of gastric cancer cells based on "oxidation therapy"

Molecular Pharmaceutics

Volumn 9, Issue 2, 2012, Pages 222-229

  Li, Xiaolin ^a,b   Lu, Xiaowei ^b   Xu, Huae ^b   Zhu, Zhenshu ^c,d   Yin, Haitao ^a   Qian, Xiaoping ^a   Li, Rutian ^a   Jiang, Xiqun ^c   Liu, Baorui ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

^d CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

antitumor; nanoparticle; oxidation therapy; paclitaxel; tetrandrine

Indexed keywords

NANOPARTICLE; PACLITAXEL; REACTIVE OXYGEN METABOLITE; TETRANDRINE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG STABILITY; ENCAPSULATION; ENDOCYTOSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATION THERAPY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH CANCER;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZYLISOQUINOLINES; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; DRUG SYNERGISM; GENES, BCL-2; HUMANS; NANOPARTICLES; PACLITAXEL; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; STOMACH NEOPLASMS; VITAMIN E;

EID: 84863131190     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2002736     Document Type: Article

References (32)

1. Sakamoto, J.; Matsui, T.; Kodera, Y. Paclitaxel chemotherapy for the treatment of gastric cancer Gastric Cancer 2009, 12, 69-78
2. Woodward, E. J.; Twelves, C. Scheduling of taxanes: a review Curr. Clin. Pharmacol. 2010, 5, 226-231
3. Dorr, R. T. Pharmacology and toxicology of Cremophor EL diluent Ann. Pharmacother. 1994, 28, S11-S14
4. Bissery, M. C.; Nohynek, G.; Sanderink, G. J.; Lavelle, F. Docetaxel (Taxotere): A review of preclinical and clinical experience. Part I: Preclinical experience. Anticancer Drugs 1995. 6, 339-355, 363-368.
5. Wei, X.; Gong, C.; Gou, M.; Fu, S.; Guo, Q.; Shi, S.; Luo, F.; Guo, G.; Qiu, L.; Qian, Z. Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system Int. J. Pharm. 2009, 381, 1-18
6. van Vlerken, L. E.; Vyas, T. K.; Amiji, M. M. Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery Pharm. Res. 2007, 24, 1405-1414 (Pubitemid 46988224)
7. Uhrich, K. E.; Cannizzaro, S. M.; Langer, R. S.; Shakesheff, K. M. Polymeric systems for controlled drug release Chem. Rev. 1999, 99, 3181-3198 (Pubitemid 129583051)
8. Jain, R. K.; Stylianopoulos, T. Delivering nanomedicine to solid tumors Nat. Rev. Clin. Oncol. 2010, 7, 653-664
9. Laurent, A.; Nicco, C.; Chéreau, C.; Goulvestre, C.; Alexandre, J.; Alves, A.; Lévy, E.; Goldwasser, F.; Panis, Y.; Soubrane, O.; Weill, B.; Batteux, F. Controlling tumor growth by modulating endogenous production of reactive oxygen species Cancer Res. 2005, 65, 948-956 (Pubitemid 40216456)
10. Alexandre, J.; Batteux, F.; Nicco, C.; Chéreau, C.; Laurent, A.; Guillevin, L.; Weill, B.; Goldwasser, F. Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo Int. J. Cancer 2006, 119, 41-48
11. Ramanathan, B.; Jan, K. Y.; Chen, C. H.; Hour, T. C.; Yu, H. J.; Pu, Y. S. Resistance to paclitaxel is proportional to cellular total antioxidant capacity Cancer Res. 2005, 65, 8455-8460 (Pubitemid 41330613)
12. Wenzel, U.; Nickel, A.; Daniel, H. alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation Apoptosis 2005, 10, 359-368 (Pubitemid 40603489)
13. Fang, J.; Sawa, T.; Akaike, T.; Maeda, H. Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide Cancer Res. 2002, 62, 3138-3143 (Pubitemid 34602406)
14. Wu, J. M.; Chen, Y.; Chen, J. C.; Lin, T. Y.; Tseng, S. H. Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice Cancer Lett. 2010, 287, 187-195
15. Kuo, P. L.; Lin, C. C. Tetrandrine-induced cell cycle arrest and apoptosis in HepG2 cells Life Sci. 2003, 73, 243-252
16. Jin, Q.; Kang, C.; Soh, Y.; Sohn, N. W.; Lee, J.; Cho, Y. H.; Baik, H. H.; Kang, I. Tetrandrine cytotoxicity and its dual effect on oxidative stress-induced apoptosis through modulating cellular redox states in Neuro 2a mouse neuroblastoma cells Life Sci. 2002, 71, 2053-2066
17. Janga, B. C.; Lima, K. J.; Paikb, J. H.; Choc, J. W.; Baeka, W. K. Tetrandrine-induced apoptosis is mediated by activation of caspases and PKC-d in U937 cells Biochem. Pharmacol. 2004, 67, 1819-1829
18. Wei, J.; Liu, B.; Wang, L.; Qian, X.; Ding, Y.; Yu, L. Synergistic interaction between tetrandrine and chemotherapeutic agents and influence of tetrandrine on chemotherapeutic agent-associated genes in human gastric cancer cell lines Cancer Chemother. Pharmacol. 2007, 60, 703-711 (Pubitemid 47247282)
19. Li, X.; Zhen, D.; Lu, X.; Xu, H.; Shao, Y.; Xue, Q.; Hu, Y.; Liu, B.; Sun, W. Enhanced cytotoxicity and activation of ROSdependent c-Jun NH2-terminal kinase and caspase-3 by low doses of tetrandrine-loaded nanoparticles in Lovo cells - a possible Trojan strategy against cancer Eur. J. Pharm. Biopharm. 2010, 75, 334-340
20. Li, X.; Li, R.; Qian, X.; Ding, Y.; Tu, Y.; Guo, R.; Hu, Y.; Jiang, X.; Guo, W.; Liu, B. Superior antitumor efficiency of cisplatin-loaded nanoparticles by intratumoral delivery with decreased tumor metabolism rate Eur. J. Pharm. Biopharm. 2008, 70, 726-734
21. Chou, T. C.; Talalay, P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Adv. Enzyme Regul. 1984, 22, 27-55
22. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 1983, 65, 55-63 (Pubitemid 14203433)
23. Shao, J.; Zheng, D.; Jiang, Z.; Xu, H.; Hu, Y.; Li, X.; Lu, X. Curcumin delivery by methoxy polyethylene glycol-poly(caprolactone) nanoparticles inhibits the growth of C6 glioma cells Acta. Biochim. Biophys. Sin. (Shanghai) 2011, 43, 267-274
24. Shao, J.; Li, X.; Lu, X.; Jiang, C.; Hu, Y.; Li, Q.; You, Y.; Fu, Z. Enhanced growth inhibition effect of resveratrol incorporated into biodegradable nanoparticles against glioma cells is mediated by the induction of intracellular reactive oxygen species levels Colloids Surf., B 2009, 72, 40-47
25. Kirshner, J. R.; He, S.; Balasubramanyam, V.; Kepros, J.; Yang, C. Y.; Zhang, M.; Du, Z.; Barsoum, J.; Bertin, J. Elesclomol induces cancer cell apoptosis through oxidative stress Mol. Cancer Ther. 2008, 7, 2319-2327
26. Vobo?ilová, J.; N?mcová-Fürstová, V.; Neubauerová, J.; Ojima, I.; Zanardi, I.; Gut, I.; Ková?, J. Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells Invest. New Drugs 2011, 29, 411-423
27. Xu, R.; Nakano, K.; Iwasaki, H.; Kumagai, M.; Wakabayashi, R.; Yamasaki, A.; Suzuki, H.; Mibu, R.; Onishi, H.; Katano, M. Dual blockade of phosphatidylinositol 3?-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer Cancer Lett. 2011, 306, 151-160
28. Szanto, A.; Bognar, Z.; Szigeti, A.; Szabo, A.; Farkas, L.; Gallyas, F., Jr. Critical role of bad phosphorylation by Akt in cytostatic resistance of human bladder cancer cells Anticancer Res. 2009, 29, 159-164
29. Kim, S. H.; Juhnn, Y. S.; Song, Y. S. Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells Ann. N.Y. Acad. Sci. 2007, 1095, 82-89
30. Mabuchi, S.; Ohmichi, M.; Kimura, A.; Hisamoto, K.; Hayakawa, J.; Nishio, Y.; Adachi, K.; Takahashi, K.; Arimoto-Ishida, E.; Nakatsuji, Y.; Tasaka, K.; Murata, Y. Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel J. Biol. Chem. 2002, 277, 33490-33500 (Pubitemid 34984873)
31. Wang, Y. F.; Chen, C. Y.; Chung, S. F.; Chiou, Y. H.; Lo, H. R. Involvement of oxidative stress and caspase activation in paclitaxel-induced apoptosis of primary effusion lymphoma cells Cancer Chemother. Pharmacol. 2004, 54, 322-330
32. Wang, L. G.; Liu, X. M.; Kreis, W.; Budman, D. R. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review Cancer Chemother. Pharmacol. 1999, 44, 355-361 (Pubitemid 29455579)