Proteomic and gene expression patterns of keratoconus

Indian Journal of Ophthalmology

Volumn 61, Issue 8, 2013, Pages 389-391

  Ghosh, Arkasubhra ^a   Zhou, Lei ^b   Ghosh, Anuprita ^a   Shetty, Rohit ^a   Beuerman, Roger ^b,c  

^a Narayana Nethralaya ^*  (India)

^b DUKE UNIVERSITY   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Deregulation; ectasia; gene expression; keratoconus; mass spectroscopy; proteomics; signaling pathways

Indexed keywords

EYE PROTEIN;

CONFERENCE PAPER; CORNEA; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KERATOCONUS; METABOLISM; PHYSIOLOGY; PROTEOMICS;

CORNEA; EYE PROTEINS; GENE EXPRESSION REGULATION; HUMANS; KERATOCONUS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOMICS;

EID: 84883703607     PISSN: 03014738     EISSN: 19983689     Source Type: Journal    
DOI: 10.4103/0301-4738.116056     Document Type: Conference Paper

References (26)

1. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998;42:297-319. (Pubitemid 28092771)
2. Rabinowitz YS. The genetics of keratoconus. Ophthalmol Clin North Am 2003;16:607-20. (Pubitemid 38044995)
3. Cristina Kenney M, Brown DJ. The cascade hypothesis of keratoconus. Cont Lens Anterior Eye 2003;26:139-46. (Pubitemid 37098779)
4. Balasubramanian SA, Mohan S, Pye DC, Willcox MD. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol 2012;90:e303-9.
5. Jun. AS, Cope L, Speck C, Feng X, Lee S, Meng H. et al. Subnormal cytokine profile in the tear fluid of keratoconus patients. PloS One 2011;6:e16437.
6. Lema I, Duran JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 2005;112:654-9. (Pubitemid 41108867)
7. Lema I, Sobrino T, Duran JA, Brea D, Diez-Fe?oo E. Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 2009;93:820-4.
8. Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, et al. Proteome profiling of corneal epithelium and Identification of marker proteins for keratoconus, a pilot study. Exp Eye Res 2006;82:201-9. (Pubitemid 43122106)
9. Srivastava, O P, Chandrasekaran D, Pfister RR. Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas. Mol Vis 2006;12:1615-25. (Pubitemid 46043921)
10. Brouillard F, Fritsch J, Edelman A, Ollero M. Contribution of proteomics to the study of the role of cytokeratins in disease and physiopathology. Proteomics Clin Appl 2008;2:264-85. (Pubitemid 351284905)
11. Zhou L, Zhao SZ, Koh SK, Chen L, Vaz C, Tanavde V, et al. In-depth analysis of the human tear proteome. J Proteomics 2012;75:3877-85.
12. de Souza GA, Godoy LM, Mann M. Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors. Genome Biol 2006;7:R72.
13. Pannebaker C, Chandler HL, Nichols JJ. Tear proteomics in keratoconus. Mol Vis 2010;16:1949-57.
14. Lema I, Brea D, Rodriguez-Gonzalez R, Diez-Fe?oo E, Sobrino T. Proteomic analysis of the tear film in patients with keratoconus. Mol Vis 2010;16:2055-61.
15. Joseph R, Srivastava OP, Pfister RR. Differential epithelial and stromal protein profiles in keratoconus and normal human corneas. Exp Eye Res 2011;92:282-98.
16. Balasubramanian SA, Pye DC, Willcox MD. Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus. Exp Eye Res 2012;96:132-7.
17. Nielsen K, Birkenkamp-Demtroder K, Ehlers N, Orntoft TF. Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays. Invest Ophthalmol Vis Sci 2003;44:2466-76. (Pubitemid 36618403)
18. Matthews FJ, Cook SD, Majid MA, Dick AD, Smith VA. Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus. Exp Eye Re 2007;84:1125-34. (Pubitemid 46770726)
19. Kenney MC, Chwa M, Atilano SR, Tran A, Carballo M, Saghizadeh M, et al. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: Evidence that oxidative stress plays a role in this disorder. Invest Ophthalmol Vis Sci 2005;46:823-32. (Pubitemid 41327143)
20. Dudakova L, Liskova P, Trojek T, Palos M, Kalasova S, Jirsova K. Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas. Exp Eye Res 2012;104:74-81.
21. Katoh Y, Katoh M. Comparative integromics on angiopoietin family members. Int J Mol Med 2006;17:1145-9.
22. Suton G, Madigan M, Roufas A, McAvoy J. Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: A novel finding highlighting a new potential focus for keratoconus research and treatment. Clin Experiment Ophthalmol 2010;38:43-8.
23. Lema I, Duran JA, Ruiz C, Diez-Fe?oo E, Acera A, Merayo J. Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects. Cornea 2008;27:758-63.
24. Nemet AY, Vinker S, Bahar I, Kaiserman I. The association of keratoconus with immune disorders. Cornea 2010;29:1261-4.
25. Yue BY, Sugar J, Schrode K. Histochemical studies of keratoconus. Curr Eye Res 1988;7:81-6. (Pubitemid 18036330)
26. Jacq PL, Sale Y, Cochener B, Lozach P, Colin J. Keratoconus, changes in corneal topography and allergy. Study of 3 groups of patients. J Fr Ophtalmol 1997;20:97-102. (Pubitemid 27104137)