Proteomic analysis of the tear film in patients with keratoconus

Molecular Vision

Volumn 16, Issue , 2010, Pages 2055-2061

  Lema, Isabel ^a   Brea, David ^a   Rodríguez González, Raquel ^a   Díez Feijoo, Elío ^a   Sobrino, Tomás ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 GLYCOPROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; LACTOFERRIN; UNCLASSIFIED DRUG; ZICN ALPHA2 GLYCOPROTEIN;

ADULT; ARTICLE; BIOMICROSCOPY; CASE CONTROL STUDY; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; FEMALE; HUMAN; KERATOCONUS; KERATOMETRY; MALE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEOMICS; SCHIRMER TEST; TEAR FILM; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CASE-CONTROL STUDIES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EYE PROTEINS; FEMALE; HUMANS; KERATOCONUS; MALE; MOLECULAR WEIGHT; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEARS;

EID: 78149486003     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 1984; 28:293-322.
2. Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42:297-319.
3. Dobbins KR, Price FW Jr, Whitson WE. Trends in the indications for penetrating keratoplasty in the midwestern United States. Cornea 2000; 19:813-6.
4. Tuft SJ, Moodaley LC, Gregory WM, Davison CR, Buckley RJ. Prognostic factors for the progression of keratoconus. Ophthalmology 1994; 101:439-47.
5. Kaldawy RM, Wagner J, Ching S, Seigel GM. Evidence of apoptotic cell death in keratoconus. Cornea 2002; 21:206-9.
6. Erie JC, Patel SV, McLaren JW, Nau CB, Hodge DO, Bourne WM. Keratocyte density in keratoconus. A confocal microscopy study(a). Am J Ophthalmol 2002; 134:689-95.
7. Wilson SE, He YG, Weng J, Li Q, McDowall AW, Vital M, Chwang EL. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res 1996; 62:325-7.
8. Rahi A, Davies P, Ruben M, Lobascher D, Menon J. Keratoconus and coexisting atopic disease. Br J Ophthalmol 1977; 61:761-4.
9. Chandler JW. Immunology of the ocular surface. Int Ophthalmol Clin 1985; 25:13-23.
10. Bonini S, Lambiase A, Sgrulletta R, Bonini S. Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis. Curr Opin Allergy Clin Immunol 2003; 3:381-7.
11. Zhou L, Sawaguchi S, Twining SS, Sugar J, Feder RS, Yue BY. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest Ophthalmol Vis Sci 1998; 39:1117-24.
12. Collier SA, Madigan MC, Penfold PL. Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas. Curr Eye Res 2000; 21:662-8.
13. Lema I, Duran JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 2005; 112:654-9.
14. de Freitas Campos C, Cole N, Van Dyk D, Walsh BJ, Diakos P, Almeida D, Torrecilhas A, Laus JL, Willcox MD. Proteomic analysis of dog tears for potential cancer markers. Res Vet Sci 2008; 85:349-52.
15. Ananthi S, Chitra T, Bini R, Prajna NV, Lalitha P, Dharmalingam K. Comparative analysis of the tear protein profile in mycotic keratitis patients. Mol Vis 2008; 14:500-7.
16. de Souza GA, Godoy LM, Mann M. Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors. Genome Biol 2006; 7:R72.
17. Zadnik K, Barr JT, Gordon MO, Edrington TB. Biomicroscopic signs and disease severity in keratoconus. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group. Cornea 1996; 15:139-46.
18. Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal Chem 1996; 68:850-8.
19. Green-Church KB, Nichols KK, Kleinholz NM, Zhang L, Nichols JJ. Investigation of the human tear film proteome using multiple proteomic approaches. Mol Vis 2008; 14:456-70.
20. Flanagan JL, Willcox MD. Role of lactoferrin in the tear film. Biochimie 2009; 91:35-43.
21. Puddu P, Valenti P, Gessani S. Immunomodulatory effects of lactoferrin on antigen presenting cells. Biochimie 2009; 91:11-8.
22. Choe YH, Lee SW. Effect of lactoferrin on the production of tumor necrosis factor-alpha and nitric oxide. J Cell Biochem 1999; 76:30-6.
23. Mattsby-Baltzer I, Roseanu A, Motas C, Elverfors J, Engberg I, Hanson LA. Lactoferrin or a fragment thereof inhibits the endotoxin-induced interleukin-6 response in human monocytic cells. Pediatr Res 1996; 40:257-62.
24. Håversen L, Ohlsson BG, Hahn-Zoric M, Hanson LA, Mattsby-Baltzer I. Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cell Immunol 2002; 220:83-95.
25. Shoham A, Hadziahmetovic M, Dunaief JL, Mydlarski MB, Schipper HM. Oxidative stress in diseases of the human cornea. Free Radic Biol Med 2008; 45:1047-55.
26. Russell ST, Zimmerman TP, Domin BA, Tisdale MJ. Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha- (2)-glycoprotein. Biochim Biophys Acta 2004; 1636:59-68.
27. Hassan MI, Waheed A, Yadav S, Singh TP, Ahmad F. Zinc alpha 2-glycoprotein: a multidisciplinary protein. Mol Cancer Res 2008; 6:892-906.
28. Baker GR, Morton M, Rajapaska RS, Bullock M, Gullu S, Mazzi B, Ludgate M. Altered tear composition in smokers and patients with Graves ophthalmopathy. Arch Ophthalmol 2006; 124:1451-6.
29. Chandler JW. Ocular surface immunology. In: Pepose JS, Holland GN, Wilhelmus KR, editors. Ocular infection and immunity. St Louis: Mosby; 1996. p. 104-11.
30. Bonini S, Lambiase A, Juhas T, Rama P. Inflammatory immune-associated diseases of the cornea. In: Ben Ezra D, editor. Ocular inflammation: basic and clinical concepts. London: Martin Dunitz; 1999. p. 151-68.
31. Lema I, Sobrino T, Durán JA, Brea D, Díez-Feijoo E. Subclinical keratoconus and inflammatory molecules from tears. Br J Ophthalmol 2009; 93:820-4.
32. Srivastava OP, Chandrasekaran D, Pfister RR. Molecular changes in selected epithelial proteins in human keratoconus corneas compared to normal corneas. Mol Vis 2006; 12:1615-25.