Subnormal cytokine profile in the tear fluid of keratoconus patients

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Jun, Albert S ^a   Cope, Leslie ^a   Speck, Caroline ^b   Feng, Xiaojun ^a   Lee, Seakwoo ^a   Meng, Huan ^a   Hamad, Abdel ^a   Chakravarti, Shukti ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; RANTES; TUMOR NECROSIS FACTOR ALPHA; AUTACOID;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; CORNEA PERMEABILITY; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOMEOSTASIS; HUMAN; IMMUNOASSAY; INFLAMMATION; KERATOCONUS; LACRIMAL FLUID LEVEL; MALE; MULTIPLEX IMMUNOBEAD ASSAY; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; TISSUE DEGENERATION; BLOOD; CASE CONTROL STUDY; CHEMISTRY; CORNEA; IMMUNOLOGY; LACRIMAL FLUID; MIDDLE AGED; PHYSIOLOGY;

ADULT; CASE-CONTROL STUDIES; CORNEA; CYTOKINES; FEMALE; HOMEOSTASIS; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-17; KERATOCONUS; MALE; MIDDLE AGED; TEARS; YOUNG ADULT;

EID: 79551533688     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016437     Document Type: Article

References (41)

1. Krachmer JH, Feder RS, Belin MW (1984) Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 28: 293-322.
2. Yue BY, Sugar J, Benveniste K (1984) Heterogeneity in keratoconus: possible biochemical basis. Proc Soc Exp Biol Med 175: 336-341.
3. Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42: 297-319.
4. Olivares Jimenez JL, Guerrero Jurado JC, Bermudez Rodriguez FJ, Serrano Laborda D (1997) Keratoconus: age of onset and natural history. Optom Vis Sci 74: 147-151.
5. Galin MA, Berger R (1958) Atopy and keratoconus. Am J Ophthalmol 45: 904-906.
6. Kemp EG, Lewis CJ (1982) Immunoglobulin patterns in keratoconus with particular reference to total and specific IgE levels. Br J Ophthalmol 66: 717-720.
7. Rahi A, Davies P, Ruben M, Lobascher D, Menon J (1977) Keratoconus and coexisting atopic disease. Br J Ophthalmol 61: 761-764.
8. Lema I, Duran JA (2005) Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 112: 654-659.
9. Lema I, Sobrino T, Duran JA, Brea D, Diez-Feijoo E (2009) Subclinical keratoconus and inflammatory molecules fromtears. Br J Ophthalmol 93: 820-824.
10. Fabre EJ, Bureau J, Pouliquen Y, Lorans G (1991) Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. Curr Eye Res 10: 585-592.
11. Li S, Sack R, Vijmasi T, Sathe S, Beaton A, et al. (2008) Antibody protein arrayanalysis of the tear film cytokines. Optom Vis Sci 85: 653-660.
12. Carreno E, Enriquez-de-Salamanca A, Teson M, Garcia-Vazquez C, Stern ME, et al. (2010) Cytokine and chemokine levels in tears from healthy subjects. Acta Ophthalmol.
13. Lema I, Duran JA, Ruiz C, Diez-Feijoo E, Acera A, et al. (2008) Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects. Cornea 27: 758-763.
14. Paul WE, Zhu J (2010) How are T(H)2-type immune responses initiated and amplified? Nat Rev Immunol 10: 225-235.
15. Wills-Karp M, Finkelman FD (2008) Untangling the complex web of IL-4- and IL-13-mediated signaling pathways. Sci Signal 1: pe55.
16. Leonardi A, Curnow SJ, Zhan H, Calder VL (2006) Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures. Clin Exp Allergy 36: 777-784.
17. Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE (1999) The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 17: 701-738.
18. Bhogal RK, Bona CA (2008) Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13. Int Rev Immunol 27: 472-496.
19. Aoudjehane L, Pissaia A, Jr., Scatton O, Podevin P, Massault PP, et al. (2008) Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway. Lab Invest 88: 973-985.
20. Chwa M, Atilano SR, Reddy V, Jordan N, Kim DW, et al. (2006) Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts. Invest Ophthalmol Vis Sci 47: 1902-1910.
21. Kenney MC, Brown DJ (2003) The cascade hypothesis of keratoconus. Cont Lens Anterior Eye 26: 139-146.
22. Fini ME, Yue BY, Sugar J (1992) Collagenolytic/gelatinolytic metalloproteinases in normal and keratoconus corneas. Curr Eye Res 11: 849-862.
23. Fukuchi T, Yue BY, Sugar J, Lam S (1994) Lysosomal enzyme activities in conjunctival tissues of patients with keratoconus. Arch Ophthalmol 112: 1368-1374.
24. Steinman L (2007) A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 13: 139-145.
25. Awasthi A, Murugaiyan G, Kuchroo VK (2008) Interplay between effector Th17 and regulatory T cells. J Clin Immunol 28: 660-670.
26. Imanishi J, Kamiyama K, Iguchi I, Kita M, Sotozono C, et al. (2000) Growth factors: importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res 19: 113-129.
27. Long Q, Chu R, Zhou X, Dai J, Chen C, et al. (2006) Correlation between TGF-beta1 in tears and corneal haze following LASEK and epi-LASIK. J Refract Surg 22: 708-712.
28. Saika S (2006) TGFbeta pathobiology in the eye. Lab Invest 86: 106-115.
29. Wynn TA (2005) T(H)-17: a giant step from T(H)1 and T(H)2. Nat Immunol 6: 1069-1070.
30. Yagi Y, Andoh A, Inatomi O, Tsujikawa T, Fujiyama Y (2007) Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts. J Gastroenterol 42: 746-753.
31. Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, et al. (2007) IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation. Am J Physiol Heart Circ Physiol 293: H3356-3365.
32. Sylvester J, Liacini A, Li WQ, Zafarullah M (2004) Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, -13 and aggrecanase-1 genes in articular chondrocytes. Cell Signal 16: 469-476.
33. Bamba S, Andoh A, Yasui H, Araki Y, Bamba T, et al. (2003) Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17. J Gastroenterol 38: 548-554.
34. Rifas L, Arackal S (2003) T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism. Arthritis Rheum 48: 993-1001.
35. Qiu Z, Dillen C, Hu J, Verbeke H, Struyf S, et al. (2009) Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes. Immunobiology 214: 835-842.
36. Katsifis GE, Moutsopoulos NM, Wahl SM (2007) T lymphocytes in Sjogren's syndrome: contributors to and regulators of pathophysiology. Clin Rev Allergy Immunol 32: 252-264.
37. De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD 3rd, Fang B, et al. (2009) IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol 2: 243-253.
38. Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, et al. (2009) Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol 182: 1247-1252.
39. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC (2010) Desiccating Stress Promotes Th17 Differentiation by Ocular Surface Tissues through a Dendritic Cell-Mediated Pathway. Invest Ophthalmol Vis Sci.
40. Lema I, Brea D, Rodriguez-Gonzalez R, Diez-Feijoo E, Sobrino T (2010) Proteomic analysis of the tear film in patients with keratoconus. Mol Vis 16: 2055-2061.
41. Pannebaker C, Chandler HL, Nichols JJ (2010) Tear proteomics in keratoconus. Mol Vis 16: 1949-1957.