Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas

Experimental Eye Research

Volumn 104, Issue , 2012, Pages 74-81

  Dudakova, Lubica ^a   Liskova, Petra ^a   Trojek, Tomas ^b   Palos, Michalis ^c   Kalasova, Sarka ^a   Jirsova, Katerina ^a  

^a Charles University in Prague and General University Hospital in Prague   (Czech Republic)

^b CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Cornea; Culture; Enzyme activity; Immunohistochemistry; Keratoconus; Keratocytes; Lysyl oxidase

Indexed keywords

3 AMINOPROPIONITRILE; HYDROGEN PEROXIDE; PROTEIN LYSINE 6 OXIDASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; FIBROBLAST; FLUOROMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATOCONUS; MALE; PATHOGENESIS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AMINO ACID OXIDOREDUCTASES; CELLS, CULTURED; CONJUNCTIVA; CORNEA; CORNEAL KERATOCYTES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; KERATOCONUS; LIMBUS CORNEAE; MALE; MIDDLE AGED; PROTEIN-LYSINE 6-OXIDASE; YOUNG ADULT;

EID: 84867659231     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2012.09.005     Document Type: Article

References (49)

1. Avetisov S.E., Mamikonian V.R., Novikov I.A. The role of tear acidity and Cu-cofactor of lysyl oxidase activity in the pathogenesis of keratoconus. Vestn. Oftalmol. 2011, 127(2):3-8.
2. Berulava T., Horsthemke B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur. J. Hum. Genet. 2010, 18(9):1054-1056.
3. Bisceglia L., De Bonis P., Pizzicoli C., Fischetti L., Laborante A., Di Perna M., Giuliani F., Delle Noci N., Buzzonetti L., Zelante L. Linkage analysis in keratoconus: replication of locus 5q21.2 and identification of other suggestive loci. Invest. Ophthalmol. Vis. Sci. 2009, 50(3):1081-1086.
4. Buss D.G., Giuliano E.A., Sharma A., Mohan R.R. Isolation and cultivation of equine corneal keratocytes, fibroblasts and myofibroblasts. Vet. Ophthalmol. 2010, 13(1):37-42.
5. Bykhovskaya Y., Li X., Epifantseva I., Haritunians T., Siscovick D., Aldave A., Szczotka-Flynn L., Iyengar S.K., Taylor K.D., Rotter J.I., Rabinowitz Y.S. Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies. Invest. Ophthalmol. Vis. Sci. 2012, 53(7):4152-4157.
6. Bystrom B., Carracedo S., Behndig A., Gullberg D., Pedrosa-Domellöf F. Alpha11 integrin in the human cornea: importance in development and disease. Invest. Ophthalmol. Vis. Sci. 2009, 50(11):5044-5053.
7. Choi J.A., Kim M.S. Progression of keratoconus by longitudinal assessment with corneal topography. Invest. Ophthalmol. Vis. Sci. 2012, 53(2):927-935.
8. Coral K., Angayarkanni N., Madhavan J., Bharathselvi M., Ramakrishnan S., Nandi K., Rishi P., Kasinathan N., Krishnakumar S. Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment. Invest. Ophthalmol. Vis. Sci. 2008, 49(11):4746-4752.
9. Cristina Kenney M., Brown D.J. The cascade hypothesis of keratoconus. Cont. Lens Anterior Eye 2003, 26(3):139-146.
10. Csiszar K. Lysyl oxidases: a novel multifunctional amine oxidase family. Prog. Nucleic Acid Res. Mol. Biol. 2001, 70:1-32.
11. Daxer A., Fratzl P. Collagen fibril orientation in the human corneal stroma and its implication in keratoconus. Invest. Ophthalmol. Vis. Sci. 1997, 38(1):121-129.
12. De Bonis P., Laborante A., Pizzicoli C., Stallone R., Barbano R., Longo C., Mazzilli E., Zelante L., Bisceglia L. Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus. Mol. Vis. 2011, 17:2482-2494.
13. Diebold Y., Calonge M., Fernández N., Lázaro M.C., Callejo S., Herreras J.M., Pastor J.C. Characterization of epithelial primary cultures from human conjunctiva. Graefes Arch. Clin. Exp. Ophthalmol. 1997, 235(5):268-276.
14. Espana E.M., Kawakita T., Liu C.Y., Tseng S.C. CD-34 expression by cultured human keratocytes is downregulated during myofibroblast differentiation induced by TGF-beta1. Invest. Ophthalmol. Vis. Sci. 2004, 45(9):2985-2991.
15. Guo Y., Pischon N., Palamakumbura A.H., Trackman P.C. Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells. Am. J. Physiol. Cell. Physiol. 2007, 292(6):C2095-C2102.
16. Hayes S., Boote C., Tuft S.J., Quantock A.J., Meek K.M. A study of corneal thickness, shape and collagen organisation in keratoconus using videokeratography and X-ray scattering techniques. Exp. Eye Res. 2007, 84(3):423-434.
17. Hein S., Yamamoto S.Y., Okazaki K., Jourdan-LeSaux C., Csiszar K., Bryant-Greenwood G.D. Lysyl oxidases: expression in the fetal membranes and placenta. Placenta 2001, 22(1):49-57.
18. Jester J.V., Barry-Lane P.A., Cavanagh H.D., Petroll W.M. Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes. Cornea 1996, 15(5):505-516.
19. Jester J.V., Huang J., Fisher S., Spiekerman J., Chang J.H., Wright W.E., Shay J.W. Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Invest. Ophthalmol. Vis. Sci. 2003, 44(5):1850-1858.
20. Kagan H.M., Vaccaro C.A., Bronson R.E., Tang S.S., Brody J.S. Ultrastructural immunolocalization of lysyl oxidase in vascular connective tissue. J. Cell. Biol. 1986, 103(3):1121-1128.
21. Kanellopoulos A.J. Long term results of a prospective randomized bilateral eye comparison trial of higher fluence, shorter duration ultraviolet A radiation, and riboflavin collagen cross linking for progressive keratoconus. Clin. Ophthalmol. 2012, 6:97-101.
22. Kennedy R.H., Bourne W.M., Dyer J.A. A 48-year clinical and epidemiologic study of keratoconus. Am. J. Ophthalmol. 1986, 101(3):267-273.
23. Kenney M.C., Chwa M., Atilano S.R., Tran A., Carballo M., Saghizadeh M., Vasiliou V., Adachi W., Brown D.J. Increased levels of catalase and cathepsin V/L2 but decreased TIMP-1 in keratoconus corneas: evidence that oxidative stress plays a role in this disorder. Invest. Ophthalmol. Vis. Sci. 2005, 46(3):823-832.
24. Kenney M.C., Chwa M., Lin B., Huang G.H., Ljubimov A.V., Brown D.J. Identification of cell types in human diseased corneas. Cornea 2001, 20(3):309-316.
25. Krachmer J.H., Feder R.S., Belin M.W. Keratoconus and related noninflammatory corneal thinning disorders. Surv. Ophthalmol. 1984, 28(4):293-322.
26. Kuivaniemi H. Partial characterization of lysyl oxidase from several human tissues. Biochem. J. 1985, 230(3):639-643.
27. Kuivaniemi H., Peltonen L., Palotie A., Kaitila I., Kivirikko K.I. Abnormal copper metabolism and deficient lysyl oxidase activity in a heritable connective tissue disorder. J. Clin. Invest. 1982, 69(3):730-733.
28. Maatta M., Vaisanen T., Vaisanen M.R., Pihlajaniemi T., Tervo T. Altered expression of type XIII collagen in keratoconus and scarred human cornea: increased expression in scarred cornea is associated with myofibroblast transformation. Cornea 2006, 25(4):448-453.
29. Meek K.M., Tuft S.J., Huang Y., Gill P.S., Hayes S., Newton R.H., Bron A.J. Changes in collagen orientation and distribution in keratoconus corneas. Invest. Ophthalmol. Vis. Sci. 2005, 46(6):1948-1956.
30. Merjava S., Neuwirth A., Mandys V., Jirsova K. Cytokeratins 8 and 18 in adult human corneal endothelium. Exp. Eye Res. 2009, 89(3):426-431.
31. Mizobe Y., Oikawa D., Tsuyama S., Akimoto Y., Hamasu K., Onitsuka E., Sato M., Takahata Y., Morimatsu F., Furuse M. mRNA expression of lysyl oxidase and matrix metalloproteinase-12 in mouse skin. Biosci. Biotechnol. Biochem. 2008, 72(11):3067-3070.
32. Moll R., Franke W.W., Schiller D.L., Geiger B., Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982, 31(1):11-24.
33. Molnar J., Fong K.S., He Q.P., Hayashi K., Kim Y., Fong S.F., Fogelgren B., Szauter K.M., Mink M., Csiszar K. Structural and functional diversity of lysyl oxidase and the LOX-like proteins. Biochim. Biophys. Acta 2003, 1647(1-2):220-224.
34. Nielsen K., Birkenkamp-Demtröder K., Ehlers N., Orntoft T.F. Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays. Invest. Ophthalmol. Vis. Sci. 2003, 44(6):2466-2476.
35. Nishioka T., Eustace A., West C. Lysyl oxidase: from basic science to future cancer treatment. Cell. Struct. Funct. 2012, 37(1):75-80.
36. Palamakumbura A.H., Trackman P.C. A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. Anal. Biochem. 2002, 300(2):245-251.
37. Rabinowitz Y.S. Keratoconus. Surv. Ophthalmol. 1998, 42(4):297-319.
38. Rodriguez C., Rodriguez-Sinovas A., Martinez-Gonzalez J. Lysyl oxidase as a potential therapeutic target. Drug News Perspect. 2008, 21(4):218-224.
39. Rucker R.B., Romero-Chapman N., Wong T., Lee J., Steinberg F.M., McGee C., Clegg M.S., Reiser K., Kosonen T., Uriu-Hare J.Y., Murphy J., Keen C.L. Modulation of lysyl oxidase by dietary copper in rats. J. Nutr. 1996, 126(1):51-60.
40. Sethi A., Mao W., Wordinger R.J., Clark A.F. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 2011, 52(8):5240-5250.
41. Sethi A., Wordinger R.J., Clark A.F. Focus on molecules: lysyl oxidase. Exp. Eye Res. 2012 Feb 19, (Epub ahead of print).
42. Schlotzer-Schrehardt U. Genetics and genomics of pseudoexfoliation syndrome/glaucoma. Middle East. Afr. J. Ophthalmol. 2011, 18(1):30-36.
43. Schoster J.V., Stuhr C., Kiorpes A. Tear copper and its association with liver copper concentrations in six adult ewes. Can. J. Vet. Res. 1995, 59(2):129-134.
44. Tang S.S., Trackman P.C., Kagan H.M. Reaction of aortic lysyl oxidase with beta-aminopropionitrile. J. Biol. Chem. 1983, 258(7):4331-4338.
45. Trackman P.C., Bedell-Hogan D., Tang J., Kagan H.M. Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor. J. Biol. Chem. 1992, 267(12):8666-8671.
46. Udar N., Atilano S.R., Brown D.J., Holguin B., Small K., Nesburn A.B., Kenney M.C. SOD1: a candidate gene for keratoconus. Invest. Ophthalmol. Vis. Sci. 2006, 47(8):3345-3351.
47. Uzel M.I., Scott I.C., Babakhanlou-Chase H., Palamakumbura A.H., Pappano W.N., Hong H.H., Greenspan D.S., Trackman P.C. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. J. Biol. Chem. 2001, 276(25):22537-22543.
48. Werman M.J., Bhathena S.J., Turnlund J.R. Dietary copper intake influences skin lysyl oxidase in young men. J. Nutr. Bichem. 1997, 8:201-204.
49. Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr. Opin. Ophthalmol. 2006, 17(4):356-360.