Systemic free fatty acid disposal into very low-Density lipoprotein triglycerides

Diabetes

Volumn 62, Issue 7, 2013, Pages 2386-2395

  Koutsari, Christina ^a   Mundi, Manpreet S ^a   Ali, Asem H ^a   Patterson, Bruce W ^b   Jensen, Michael D ^a  

^a Endocrine Research Unit   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLYCEROL; PALMITIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN TRIGLYCERIDE;

ABSORPTION; ADULT; ARTICLE; BODY MASS; CLEARANCE; CONTROLLED STUDY; FATTY ACID METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MALE; METABOLIC REGULATION; NORMAL HUMAN; OBESITY; POSTPRANDIAL STATE; PREMENOPAUSE; PRIORITY JOURNAL; RESTING ENERGY EXPENDITURE; TRIACYLGLYCEROL BLOOD LEVEL; VOLUNTEER; WALKING; BLOOD; BODY WEIGHT; ENERGY METABOLISM; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; BODY WEIGHT; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; OVERWEIGHT; POSTPRANDIAL PERIOD; TRIGLYCERIDES;

EID: 84883694303     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1557     Document Type: Article

References (52)

1. Havel RJ, Kane JP, Balasse EO, Segel N, Basso LV. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J Clin Invest 1970;49:2017-2035
2. Nielsen S, Guo ZK, Johnson CM, Hensrud DD, Jensen MD. Splanchnic lipolysis in human obesity. J Clin Invest 2004;113:1582-1588
3. Basso LV, Havel RJ. Hepatic metabolism of free fatty acids in normal and diabetic dogs. J Clin Invest 1970;49:537-547
4. Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 2008;134: 424-431
5. Parks EJ, Krauss RM, Christiansen MP, Neese RA, Hellerstein MK. Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J Clin Invest 1999;104:1087-1096
6. Vedala A, Wang W, Neese RA, Christiansen MP, Hellerstein MK. Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans. J Lipid Res 2006;47:2562-2574
7. Barrows BR, Parks EJ. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab 2006;91:1446-1452
8. Hodson L, Bickerton AS, McQuaid SE, et al. The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state. Diabetes 2007;56:2433- 2441
9. Eaton RP, Berman M, Steinberg D. Kinetic studies of plasma free fatty acid and triglyceride metabolism in man. J Clin Invest 1969;48:1560-1579
10. Koutsari C, Dumesic DA, Patterson BW, Votruba SB, Jensen MD. Plasma free fatty acid storage in subcutaneous and visceral adipose tissue in postabsorptive women. Diabetes 2008;57:1186-1194
11. Friedberg SJ, Klein RF, Trout DL, Bogdonoff MD, Estes EH Jr. The incorporation of plasma free fatty acids into plasma triglycerides in man. J Clin Invest 1961;40:1846-1855
12. Ryan WG, Schwartz TB. Dynamics of plasma triglyceride turnover in man. Metabolism 1965;14:1243-1254
13. Quarfordt SH, Frank A, Shames DM, Berman M, Steinberg D. Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets. J Clin Invest 1970;49: 2281-2297
14. Howard BV, Abbott WG, Egusa G, Taskinen MR. Coordination of very lowdensity lipoprotein triglyceride and apolipoprotein B metabolism in humans: effects of obesity and non-insulin-dependent diabetes mellitus. Am Heart J 1987;113:522-526
15. Mittendorfer B, Patterson BW, Klein S. Effect of sex and obesity on very-low density lipoprotein-triglyceride kinetcs. Am J Clin Nutr 2003;77:573-579
16. Mittendorfer B, Patterson BW, Klein S, Sidossis LS. VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity. Am J Physiol Endocrinol Metab 2003;284:E708-E715
17. Egusa G, Beltz WF, Grundy SM, Howard BV. Influence of obesity on the metabolism of apolipoprotein B in humans. J Clin Invest 1985;76:596-603
18. Kesäniemi YA, Beltz WF, Grundy SM. Comparisons of metabolism of apolipoprotein B in normal subjects, obese patients, and patients with coronary heart disease. J Clin Invest 1985;76:586-595
19. Carpentier A, Patterson BW, Leung N, Lewis GF. Sensitivity to acute insulin-mediated suppression of plasma free fatty acids is not a determinant of fasting VLDL triglyceride secretion in healthy humans. Diabetes 2002;51:1867-1875
20. Gormsen LC, Nellemann B, Sørensen LP, Jensen MD, Christiansen JS, Nielsen S. Impact of body composition on very-low-density lipoproteintriglycerides kinetics. Am J Physiol Endocrinol Metab 2009;296:E165-E173
21. Gormsen LC, Jensen MD, Schmitz O, Møller N, Christiansen JS, Nielsen S.Energy expenditure, insulin, and VLDL-triglyceride production in humans. J Lipid Res 2006;47:2325-2332
22. Sondergaard E, Rahbek I, Sørensen LP, et al. Effects of exercise on VLDLtriglyceride oxidation and turnover. Am J Physiol Endocrinol Metab 2011; 300:E939-E944
23. Nestel PJ, Whyte HM. Plasma free fatty acid and triglyceride turnover in obesity. Metabolism 1968;17:1122-1128
24. Magkos F, Patterson BW, Mohammed BS, Klein S, Mittendorfer B. Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab 2007;92:1311-1318
25. Lewis GF, Uffelman KD, Szeto LW, Weller B, Steiner G. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J Clin Invest 1995;95:158-166
26. Koutsari C, Ali AH, Mundi MS, Jensen MD. Storage of circulating free fatty acid in adipose tissue of postabsorptive humans: quantitative measures and implications for body fat distribution. Diabetes 2011;60:2032-2040
27. Koutsari C, Mundi MS, Ali AH, Jensen MD. Storage rates of circulating free fatty acid into adipose tissue during eating or walking in humans. Diabetes 2012;61:329-338
28. Koutsari C, Ali AH, Mundi MS, Jensen MD. Measuring plasma fatty acid oxidation with intravenous bolus injection of 3H- and 14C-fatty acid. J Lipid Res 2013;54:254-264
29. Miles JM, Ellman MG, McClean KL, Jensen MD. Validation of a new method for determination of free fatty acid turnover. Am J Physiol 1987; 252:E431-E438
30. Persson X-MT, Blachnio-Zabielska AU, Jensen MD. Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res 2010;51:2761-2765
31. Nielsen S, Guo Z, Albu JB, Klein S, O'Brien PC, Jensen MD. Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest 2003;111:981-988
32. Humphreys SM, Fisher RM, Frayn KN. Micro-method for measurement of sub-nanomole amounts of triacylglycerol. Ann Clin Biochem 1990;27:597-598
33. Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, Klein S. Use of stable isotopically labeled tracers to measure very low density lipoproteintriglyceride turnover. J Lipid Res 2002;43:223-233
34. Sørensen LP, Gormsen LC, Nielsen S. VLDL-TG kinetics: A dual isotope study for quantifying VLDL-TG pool size, production rates, and fractional oxidation in humans. Am J Physiol Endocrinol Metab 2009;297:E1324- E1330
35. Iozzo P, Bucci M, Roivainen A, et al. Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals. Gastroenterology 2010;139:846-856, 856, e1-e6
36. Marinou K, Adiels M, Hodson L, Frayn KN, Karpe F, Fielding BA. Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men. Br J Nutr 2011;105:857-865
37. Kanaley JA, Shadid S, Sheehan MT, Guo Z, Jensen MD. Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans. J Physiol 2009;587:5939-5950
38. Shadid S, Koutsari C, Jensen MD. Direct free fatty acid uptake into human adipocytes in vivo: relation to body fat distribution. Diabetes 2007;56:1369- 1375
39. Søndergaard E, Gormsen LC, Nellemann B, Jensen MD, Nielsen S. Body composition determines direct FFA storage pattern in overweight women. Am J Physiol Endocrinol Metab 2012;302:E1599-E1604
40. Ali AH, Koutsari C, Mundi M, et al. Free fatty acid storage in human visceral and subcutaneous adipose tissue: role of adipocyte proteins. Diabetes 2011;60:2300-2307
41. Taghibiglou C, Carpentier A, Van Iderstine SC, et al. Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model [erratum appears in J Biol Chem 2001;276: 20804]. J Biol Chem 2000;275:8416-8425
42. Adiels M, Westerbacka J, Soro-Paavonen A, et al. Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia 2007;50:2356-2365
43. Sørensen LP, Andersen IR, Søndergaard E, et al. Basal and insulin mediated VLDL-triglyceride kinetics in type 2 diabetic men. Diabetes 2011;60:88-96
44. Sondergaard E, Sorensen LP, Rahbek I, Gormsen LC, Christiansen JS, Nielsen S. Postprandial VLDL-triacylglycerol secretion is not suppressed in obese type 2 diabetic men. Diabetologia 2012;55:2733-2740
45. Morio B, Holmbäck U, Gore D, Wolfe RR. Increased VLDL-TAG turnover during and after acute moderate-intensity exercise. Med Sci Sports Exerc 2004;36:801-806
46. Ahlborg G, Felig P, Hagenfeldt L, Hendler R, Wahren J. Substrate turnover during prolonged exercise in man. Splanchnic and leg metabolism of glucose, free fatty acids, and amino acids. J Clin Invest 1974;53:1080-1090
47. Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007;56:1010-1013
48. Sparks JD, Cianci J, Jokinen J, Chen LS, Sparks CE. Interleukin-6 mediates hepatic hypersecretion of apolipoprotein B. Am J Physiol Gastrointest Liver Physiol 2010;299:G980-G989
49. Gill JMR, Brown JC, Bedford D, et al. Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis 2004;176:49-56
50. Wolfe RR, Chinkes DL. Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis. Hoboken, NJ, John Wiley & Sons, 2005
51. Fabbrini E, Magkos F, Mohammed BS, et al. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci USA 2009;106:15430-15435
52. Nielsen S, Karpe F. Determinants of VLDL-triglycerides production. Curr Opin Lipidol 2012;23:321-326.