Storage of circulating free fatty acid in adipose tissue of postabsorptive humans: Quantitative measures and implications for body fat distribution

Diabetes

Volumn 60, Issue 8, 2011, Pages 2032-2040

  Koutsari, Christina ^a   Ali, Asem H ^a,b   Mundi, Manpreet S ^a   Jensen, Michael D ^a  

^a MAYO CLINIC   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; DIACYLGLYCEROL ACYLTRANSFERASE; LONG CHAIN FATTY ACID COENZYME A LIGASE; PALMITIC ACID;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY FAT DISTRIBUTION; COMPUTER ASSISTED TOMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PREMENOPAUSE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUBCUTANEOUS FAT;

ADULT; ANTIGENS, CD36; BODY FAT DISTRIBUTION; COENZYME A LIGASES; DIACYLGLYCEROL O-ACYLTRANSFERASE; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; MALE; PALMITATES; SEX CHARACTERISTICS; SUBCUTANEOUS FAT; SUBCUTANEOUS FAT, ABDOMINAL; THIGH;

EID: 80052860294     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0154     Document Type: Article

References (45)

1. Kim S, Popkin BM. Commentary: understanding the epidemiology of overweight and obesity: a real global public health concern (discussion 81-82). Int J Epidemiol 2006;35:60-67 (Pubitemid 43205444)
2. Pischon T, Boeing H, Hoffmann K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med 2008;359:2105-2120
3. Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease. Am J Clin Nutr 1956;4:20-34
4. Basu A, Basu R, Shah P, Vella A, Rizza RA, Jensen MD. Systemic and regional free fatty acid metabolism in type 2 diabetes. Am J Physiol Endocrinol Metab 2001;280:E1000-E1006
5. Nielsen S, Guo ZK, Johnson CM, Hensrud DD, Jensen MD. Splanchnic lipolysis in human obesity. J Clin Invest 2004;113:1582-1588 (Pubitemid 39071681)
6. Shadid S, Koutsari C, Jensen MD. Direct free fatty acid uptake into human adipocytes in vivo: relation to body fat distribution. Diabetes 2007;56:1369-1375 (Pubitemid 46715629)
7. Koutsari C, Dumesic DA, Patterson BW, Votruba SB, Jensen MD. Plasma free fatty acid storage in subcutaneous and visceral adipose tissue in postabsorptive women. Diabetes 2008;57:1186-1194
8. Hannukainen JC, Kalliokoski KK, Borra RJ, et al. Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men. Obesity (Silver Spring) 2010;18:261-265
9. Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002; 45:1201-1210
10. Birkenhäger JC, Tjabbes T. Turnover rate of plasma FFA and rate of esterification of plasma FFA to plasma triglycerides in obese humans before and after weight reduction. Metabolism 1969;18:18-32
11. Campbell PJ, Carlson MG, Nurjhan N. Fat metabolism in human obesity. Am J Physiol 1994;266:E600-E605
12. Horowitz JF, Coppack SW, Paramore D, Cryer PE, Zhao G, Klein S. Effect of short-term fasting on lipid kinetics in lean and obese women. Am J Physiol 1999;276:E278-E284 (Pubitemid 29100583)
13. McQuaid SE, Hodson L, Neville MJ, et al. Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes 2011;60:47-55
14. Hamilton JA, Kamp F. How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes 1999;48:2255-2269
15. Frohnert BI, Bernlohr DA. Regulation of fatty acid transporters in mammalian cells. Prog Lipid Res 2000;39:83-107 (Pubitemid 30145443)
16. Hajri T, Abumrad NA. Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu Rev Nutr 2002;22:383-415 (Pubitemid 35221466)
17. Doege H, Stahl A. Protein-mediated fatty acid uptake: novel insights from in vivo models. Physiology (Bethesda) 2006;21:259-268 (Pubitemid 44156858)
18. Kampf JP, Parmley D, Kleinfeld AM. Free fatty acid transport across adipocytes is mediated by an unknown membrane protein pump. Am J Physiol Endocrinol Metab 2007;293:E1207-E1214 (Pubitemid 350106586)
19. Gargiulo CE, Stuhlsatz-Krouper SM, Schaffer JE. Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane. J Lipid Res 1999;40:881-892 (Pubitemid 29220529)
20. Lobo S, Wiczer BM, Smith AJ, Hall AM, Bernlohr DA. Fatty acid metabolism in adipocytes: functional analysis of fatty acid transport proteins 1 and 4. J Lipid Res 2007;48:609-620 (Pubitemid 46397464)
21. Coleman RA, Lee DP. Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 2004;43:134-176 (Pubitemid 37492937)
22. Jensen MD, Kanaley JA, Reed JE, Sheedy PF. Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry. Am J Clin Nutr 1995;61:274-278
23. Tchoukalova YD, Harteneck DA, Karwoski RA, Tarara J, Jensen MD. A quick, reliable, and automated method for fat cell sizing. J Lipid Res 2003; 44:1795-1801 (Pubitemid 37185892)
24. Miles JM, Ellman MG, McClean KL, Jensen MD. Validation of a new method for determination of free fatty acid turnover. Am J Physiol 1987;252:E431-E438
25. Nielsen S, Guo Z, Albu JB, Klein S, O'Brien PC, Jensen MD. Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest 2003;111:981-988 (Pubitemid 36397474)
26. Persson X-MT, Blachnio-Zabielska AU, Jensen MD. Rapid measurement of plasma free fatty acid concentration and isotopic enrichment using LC/MS. J Lipid Res 2010;51:2761-2765
27. Allred CC, Krennmayr T, Koutsari C, Zhou L, Ali AH, Jensen MD. A novel ELISA for measuring CD36 protein in human adipose tissue. J Lipid Res 2011;52:408-415
28. Hall AM, Smith AJ, Bernlohr DA. Characterization of the acyl-CoA synthetase activity of purified murine fatty acid transport protein 1. J Biol Chem 2003;278:43008-43013 (Pubitemid 37345914)
29. Coleman RA. Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine. Methods Enzymol 1992;209:98-104
30. Hou XG, Moser S, Sarr MG, Thompson GB, Que FG, Jensen MD. Visceral and subcutaneous adipose tissue diacylglycerol acyltransferase activity in humans. Obesity (Silver Spring) 2009;17:1129-1134
31. Koutsari C, Basu R, Rizza RA, Nair KS, Khosla S, Jensen MD. Nonoxidative free fatty acid disposal is greater in young women than men. J Clin Endocrinol Metab 2011;96:541-547
32. Romanski SA, Nelson RM, Jensen MD. Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans. Am J Physiol Endocrinol Metab 2000;279:E455-E462
33. Votruba SB, Jensen MD. Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Am J Physiol Endocrinol Metab 2006;291: E1115-E1123
34. Mårin P, Rebuffé-Scrive M, Björntorp P. Uptake of triglyceride fatty acids in adipose tissue in vivo in man. Eur J Clin Invest 1990;20:158-165 (Pubitemid 20126654)
35. Mårin P, Lönn L, Andersson B, et al. Assimilation of triglycerides in subcutaneous and intraabdominal adipose tissues in vivo in men: effects of testosterone. J Clin Endocrinol Metab 1996;81:1018-1022 (Pubitemid 26083964)
36. Martin ML, Jensen MD. Effects of body fat distribution on regional lipolysis in obesity. J Clin Invest 1991;88:609-613
37. Guo ZK, Hensrud DD, Johnson CM, Jensen MD. Regional postprandial fatty acid metabolism in different obesity phenotypes. Diabetes 1999;48: 1586-1592 (Pubitemid 29356867)
38. Bickerton AS, Roberts R, Fielding BA, et al. Preferential uptake of dietary fatty acids in adipose tissue and muscle in the postprandial period. Diabetes 2007;56:168-176
39. McQuaid SE, Humphreys SM, Hodson L, Fielding BA, Karpe F, Frayn KN. Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids. Diabetes 2010;59:2465-2473
40. Sacchetti M, Saltin B, Osada T, van Hall G. Intramuscular fatty acid metabolism in contracting and non-contracting human skeletal muscle. J Physiol 2002;540:387-395 (Pubitemid 35175011)
41. Kanaley JA, Shadid S, Sheehan MT, Guo ZK, Jensen MD. Relationship between plasma FFA, intramyocellular triglycerides and long-chain acylcarnitines in resting humans. J Physiol 2009;587:5939-5950
42. Febbraio M, Abumrad NA, Hajjar DP, et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 1999;274:19055-19062
43. Tchoukalova Y, Koutsari C, Jensen M. Committed subcutaneous preadipocytes are reduced in human obesity. Diabetologia 2007;50:151-157 (Pubitemid 46035863)
44. Tchoukalova YD, Sarr MG, Jensen MD. Measuring committed preadipocytes in human adipose tissue from severely obese patients by using adipocyte fatty acid binding protein. Am J Physiol Regul Integr Comp Physiol 2004;287:R1132-R1140 (Pubitemid 39391058)
45. Rasouli N, Yao-Borengasser A, Varma V, et al. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans. Arterioscler Thromb Vasc Biol 2009;29:1328-1335