Energy expenditure, sex, and endogenous fuel availability in humans

Journal of Clinical Investigation

Volumn 111, Issue 7, 2003, Pages 981-988

  Nielsen, Søoren ^a   Guo, ZengKui ^a   Albu, Jeanine B ^b   Klein, Samuel ^c   O'Brien, Peter C ^a   Jensen, Michael D ^a  

^a MAYO CLINIC   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; FATTY ACID; GROWTH HORMONE; INSULIN; NORADRENALIN; PALMITIC ACID;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BODY COMPOSITION; CALORIMETRY; CLEARANCE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GLUCOSE TRANSPORT; GROWTH HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; LIPID TRANSPORT; MALE; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; RESPIRATORY QUOTIENT; SEX DIFFERENCE;

EID: 0037380644     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16253     Document Type: Article

References (42)

1. Unger, R.H. 1995. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes. 44:863-869.
2. Bjorntorp, P. 1990. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis. 10:493-496.
3. Paolisso, G., et al. 1995. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia. 38:1213-1217.
4. Ferrannini, E., Barrett, E.J., Bevilacqva, S., and DeFronzo, R.A. 1983. Effect of fatty acids on glucose production and utilization in man. J. Clin. Invest. 72:1737-1747.
5. Lewis, G.F., Uffelman, K.D., Szeto, L.W., Weller, B., and Steiner, G. 1995. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J. Clin. Invest. 95:158-166.
6. Steinberg, H.O., et al. 1997. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J. Clin. Invest. 100:1230-1239.
7. Zhou, Y.P., and Grill, V.E. 1994. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J. Clin. Invest. 93:870-876.
8. 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J. Clin. Invest. 97:126-132.
9. Jensen, M.D. 1995. Gender differences in regional fatty acid metabolism before and after meal ingestion. J. Clin. Invest. 96:2297-2303.
10. Kanaley, J.A., Mottram, C.D., Scanlon, P.D., and Jensen, M.D. 1995. Fatty acid kinetic responses to running above or below lactate threshold. J. Appl. Physiol. 79:439-447.
11. Issekutz, B., Jr., Bortz, W.M., Miller, H.I., and Paul, P. 1967. Turnover rate of plasma FFA in humans and in dogs. Metabolism. 16:1001-1009.
12. Bjorntorp, P., Bergman, H., and Varnauskas, E. 1969. Plasma free fatty acid turnover rate in obesity. Acta. Med. Scand. 185:351-356.
13. Jensen, M.D., Haymond, M.W., Rizza, R.A., Cryer, P.E., and Miles, J.M. 1989. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 83:1168-1173.
14. Bjorntorp, P., Bergman, H., Varnauskas, E., and Lindholm, B. 1969. Lipid mobilization in relation to body composition in man. Metabolism. 18:841-851.
15. Birkenhäger, J.C., and Tjabbes, T. 1969. Turnover rate of plasma FFA and rate of esterification of plasma FFA to plasma triglycerides in obese humans before and after weight reduction. Metabolism. 18:18-32.
16. Hagenfeldt, L. 1975. Turnover of individual free fatty acids in man. Fed. Proc. 34:2246-2249.
17. Nestel, P.J., and Whyte, H.M. 1968. Plasma free fatty acid and triglyceride turnover in obesity. Metabolism. 17:1122-1128.
18. Tanner, J.M. 1949. Fallacy of per-weight and per-surface area standards, and their relation to spurious correlation. J. Appl. Physiol. 2:1-15.
19. Bogardus, C., et al. 1986. Familial dependence of the resting metabolic rate. N. Engl. J. Med. 315:96-100.
20. Ferraro, R., et al. 1992. Lower sedentary metabolic rate in women compared with men. J. Clin. Invest. 90:780-784.
21. Jensen, M.D., et al. 1993. Assessment of body composition with use of dual-energy x-ray absorptiometry: evaluation and comparison with other methods. Mayo Clin. Proc. 68:867-873.
22. Jensen, M.D., Kanaley, J.A., Reed, J.E., and Sheedy, P.F. 1995. Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry. Am. J. Clin. Nutr. 61:274-278.
23. Di Girolamo, M., Mendlinger, S., and Fertig, J.W. 1971. A simple method to determine fat cell size and number in four mammalian species. Am. J. Physiol. 221:850-858.
24. 13C] palmitate. J. Lipid Res. 38:1888-1895.
25. Kury, D., and Keller, U. 1991. Trimethylsilyl-O-methyloxime derivatives for the measurement of [6,6-2H2]-D-glucose-enriched plasma samples by gas chromatography-mass spectrometry. J. Chrom. 572:302-306.
26. Jensen, M.D., Caruso, M., Heiling, V., and Miles, J.M. 1989. Insulin regulation of lipolysis in nondiabetic and IDDM subjects. Diabetes. 38:1595-1601.
27. Wolfe, R.R., Allsop, J.R., and Burke, J.F. 1979. Glucose metabolism in man: responses to intravenous glucose infusion. Metabolism. 28:210-220.
28. Causon, R.C., Carruthers, M.E., and Rodnight, R. 1981. Assay of plasma catecholamines by liquid chromatography with electrochemical detection. Anal. Biochem. 116:223-226.
29. Klein, S., and Wolfe, R.R. 1990. Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer. J. Clin. Invest. 86:1403-1408.
30. Mittendorfer, B., Patterson, B.W., and Klein, S. 2003. Effect of sex and obesity on very-low density lipoprotein-triglyceride kinetics. Am. J. Clin. Nutr. 77:573-579.
31. Kanaley, J.A., Cryer, P.E., and Jensen, M.D. 1993. Fatty acid kinetic responses to exercise. Effects of obesity, body fat distribution, and energy-restricted diet. J. Clin. Invest. 92:255-261.
32. Tarnopolsky, M.A., Atkinson, S.A., Phillips, S.M., and MacDougall, J.D. 1995. Carbohydrate loading and metabolism during exercise in men and women. J. Appl. Physiol. 78:1360-1368.
33. Kissebah, A.H., et al. 1982. Relation of body fat distribution to metabolic complications of obesity. J. Clin. Endocrinol. Metab. 54:254-260.
34. Boden, G., et al. 1991. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J. Clin. Invest. 88:960-966.
35. Segerlantz, M., Bramnert, M., Manhem, P., Laurila, E., and Groo, L.C. 2001. Inhibition of the rise in FFA by acipimox partially prevents GH-induced insulin resistance in GH-deficient adults. J. Clin. Endocrinol. Metab. 86:5813-5818.
36. Kelly, D.E., Reilly, J.P., Veneman, T., and Mandarino, L.J. 1990. Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans. Am. J. Physiol. 258:E923-E928.
37. Hubinger, A., Knode, O., Susanto, F., Reinauer, H., and Gries, F.A. 1997. Effects of the carnitine-acyltransferase inhibitor etomoxir on insulin sensitivity, energy expenditure and substrate oxidation in NIDDM. Horm. Metab. Res. 29:436-439.
38. Stein, D.T., et al. 1996. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J. Clin. Invest. 97:2728-2735.
39. Casanueva, F., Villanueva, L., Penalva, A., Vila, T., and Cabezas-Cerrato, J. 1981. Free fatty acid inhibition of exercise-induced growth hormone secretion. Horm. Metab. Res. 13:348-350.
40. Samra, J.S., et al. 1998. Peripheral fat metabolism during infusion of an exogenous triacylglycerol emulsion. Int. J. Obes. Relat. Metab. Disord. 22:806-812.
41. Dobbins, R.L., et al. 1998. A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion. J. Clin. Invest. 101:2370-2376.
42. Andreorti, A.C., et al. 1994. Acute pharmacologic blockade of lipolysis normalizes nocturnal growth hormone levels and pulsatility in obese subjects. Metabolism. 43:1207-1213.