Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Lai, Hsiao Lei ^a   Wang, Q Tian ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITIONAL SEX COMBS LIKE 2 PROTEIN; HISTONE H2A; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASLX2 GENE; CONTROLLED STUDY; EPIGENETIC REPRESSION; GENE REPRESSION; GENE TARGETING; HEART; HISTONE UBIQUITINATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ACETYLATION; ANIMALS; CELL LINE; CHROMATIN; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; GENETIC LOCI; HISTONES; HUMANS; METHYLATION; MICE; MYOCARDIUM; ORGAN SPECIFICITY; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEIN TRANSPORT; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN THIOLESTERASE; UBIQUITINATION; UBIQUITINS;

EID: 84883643064     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073983     Document Type: Article

References (57)

1. Kennison JA, (1995) The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet 29: 289-303. doi:10.1146/annurev.ge.29.120195.001445. PubMed: 8825476.
2. Gould A, (1997) Functions of mammalian Polycomb group and trithorax group related genes. Curr Opin Genet Dev 7: 488-494. doi:10.1016/S0959-437X(97)80075-5. PubMed: 9309179.
3. Ng RK, Gurdon JB, (2008) Epigenetic inheritance of cell differentiation status. Cell Cycle 7: 1173-1177. doi:10.4161/cc.7.9.5791. PubMed: 18418041.
4. Schuettengruber B, Cavalli G, (2009) Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development 136: 3531-3542. doi:10.1242/dev.033902. PubMed: 19820181.
5. Surface LE, Thornton SR, Boyer LA, (2010) Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell 7: 288-298. doi:10.1016/j.stem.2010.08.004. PubMed: 20804966.
6. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, et al. (2002) Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298: 1039-1043. doi:10.1126/science.1076997. PubMed: 12351676.
7. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D, (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16: 2893-2905. doi:10.1101/gad.1035902. PubMed: 12435631.
8. Cao R, Zhang Y, (2004) SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol Cell 15: 57-67. doi:10.1016/j.molcel.2004.06.020. PubMed: 15225548.
9. Montgomery ND, Yee D, Chen A, Kalantry S, Chamberlain SJ, et al. (2005) The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Boil 15: 942-947. doi:10.1016/j.cub.2005.11.027. PubMed: 15916951.
10. Pasini D, Bracken AP, Jensen MR, Denchi EL, Helin K, (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 23: 4061-4071. doi:10.1038/sj.emboj.7600402. PubMed: 15385962.
11. Margueron R, Justin N, Ohno K, Sharpe ML, Son J, et al. (2009) Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461: 762-767. doi:10.1038/nature08398. PubMed: 19767730.
12. Jurgens G, (1985) A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316: 153-155. doi:10.1038/316153a0.
13. Campbell RB, Sinclair DA, Couling M, Brock HW, (1995) Genetic interactions and dosage effects of Polycomb group genes of Drosophila. Mol Gen Genet 6: 291-300. PubMed: 7854314.
14. Scheuermann JC, de Ayala Alonso AG, Oktaba K, Ly-Hartig N, McGinty RK, et al. (2010) Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 465: 243-247. doi:10.1038/nature08966. PubMed: 20436459.
15. Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, et al. (1998) The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Development 125: 1207-1216. PubMed: 9477319.
16. Fisher CL, Berger J, Randazzo F, Brock HW, (2003) A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11. Gene 306: 115-126. doi:10.1016/S0378-1119(03)00430-X. PubMed: 12657473.
17. Katoh M, Katoh M, (2003) Identification and characterization of ASXL2 gene in silico. Int J Oncol 23: 845-850. PubMed: 12888926.
18. Katoh M, Katoh M, (2004) Identification and characterization of ASXL3 gene in silico. Int J Oncol 24: 1617-1622. PubMed: 15138607.
19. Baskind HA, Na L, Ma QH, Patel MP, Geenen DL, et al. (2009) Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx. PLOS ONE 4: e4750. doi:10.1371/journal.pone.0004750. PubMed: 19270745.
20. Méndez J, Stillman B, (2000) Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol 20: 8602-8612. doi:10.1128/MCB.20.22.8602-8612.2000. PubMed: 11046155.
21. Lai HL, Grachoff M, McGinley AL, Khan FF, Warren CM, et al. (2012) Maintenance of adult cardiac function requires the chromatin factor Asxl2. J Mol Cell Cardiol 53: 734-741. doi:10.1016/j.yjmcc.2012.08.014. PubMed: 23046516.
22. Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K, (2006) Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 20: 1123-1136. doi:10.1101/gad.381706. PubMed: 16618801.
23. Chen EP, Bittner HB, Akhter SA, Koch WJ, Davis RD, (2001) Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5. Ann Thorac Surg 71: 1320-1324. doi:10.1016/S0003-4975(00)01754-9. PubMed: 11308180.
24. Feng JJ, Marston S, (2009) Genotype-phenotype correlations in ACTA1 mutations that cause congenital myopathies. Neuromuscul Disord 19: 6-16. doi:10.1016/j.nmd.2008.09.005. PubMed: 18976909.
25. Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, et al. (2009) Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction. Nat Cell Biol 11: 46-55. doi:10.1038/ncb1811. PubMed: 19079247.
26. Huang ZM, Gold JI, Koch WJ, (2011) G protein-coupled receptor kinases in normal and failing myocardium. Front Biosci 17: 3047-3060.
27. Bernstein E, Duncan EM, Masui O, Heard E, Allis CD, et al. (2006) Mouse Polycomb proteins bind differentially to methylated Histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol 26: 2560-2569. doi:10.1128/MCB.26.7.2560-2569.2006. PubMed: 16537902.
28. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, et al. (2007) Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448: 553-560. doi:10.1038/nature06008. PubMed: 17603471.
29. Pan G, Tian S, Nie J, Yang C, Ruotti V, et al. (2007) Whole genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell, 1: 299-312. doi:10.1016/j.stem.2007.08.003. PubMed: 18371364.
30. Zhao XD, Han X, Chew JL, Liu J, Chiu KP, et al. (2007) Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 1: 286-298. doi:10.1016/j.stem.2007.08.004. PubMed: 18371363.
31. Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, et al. (2008) Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLOS Genet 4: e1000242. PubMed: 18974828.
32. Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, et al. (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454: 766-770. PubMed: 18600261.
33. Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, et al. (2008) Dissecting direct reprogramming through integrative genomic analysis. Nature 454: 49-55. doi:10.1038/nature07056. PubMed: 18509334.
34. Schuettengruber B, Ganapathi M, Leblanc B, Portoso M, Jaschek R, et al. (2009) Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLOS Biol 7: e13. doi:10.1371/journal.pbio.1000013. PubMed: 19143474.
35. Milne TA, Sinclair DA, Brock HW, (1999) The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. Mol Gen Genet 261: 753-761. doi:10.1007/s004380050018. PubMed: 10394912.
36. Fisher CL, Lee I, Bloyer S, Bozza S, Chevalier J, et al. (2010) Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Dev Biol 347: 9-15. doi:10.1016/j.ydbio.2010.06.029. PubMed: 20599889.
37. Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, et al. (2012) Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis. Nat Genet 22: 343-347. PubMed: 22267199.
38. Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D, (2008) Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol 28: 2718-2731. doi:10.1128/MCB.02017-07. PubMed: 18285464.
39. Nekrasov M, Klymenko T, Fraterman S, Papp B, Oktaba K, et al. (2007) Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J 26: 4078-4088. doi:10.1038/sj.emboj.7601837. PubMed: 17762866.
40. Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, et al. (2012) ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 14: 180-193.
41. O'Connell S, Wang L, Robert S, Jones CA, Saint R, et al. (2001) Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein. J Biol Chem 276: 43065-43073. doi:10.1074/jbc.M104294200. PubMed: 11571280.
42. Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, et al. (2008) Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol 28: 1862-1872. doi:10.1128/MCB.01589-07. PubMed: 18086877.
43. Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, et al. (2010) The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol 30: 5071-5085. doi:10.1128/MCB.00396-10. PubMed: 20805357.
44. Lee SW, Cho YS, Na JM, Park UH, Kang M, et al. (2010) ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem 285: 18-29. doi:10.1074/jbc.M109.065862. PubMed: 19880879.
45. Cho YS, Kim EJ, Park UH, Sin HS, Um SJ, (2006) Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor. J Biol Chem 281: 17588-17598. doi:10.1074/jbc.M512616200. PubMed: 16606617.
46. Aravind L, Iyer LM, (2012) The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Cell Cycle 11: 119-131. doi:10.4161/cc.11.1.18475. PubMed: 22186017.
47. Brown JL, Mucci D, Whiteley M, Dirksen ML, Kassis JA, (1998) The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol Cell 1: 1057-1064. doi:10.1016/S1097-2765(00)80106-9. PubMed: 9651589.
48. Brown JL, Fritsch C, Mueller J, Kassis JA, (2003) The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development 130: 285-294. doi:10.1242/dev.00204. PubMed: 12466196.
49. Mohd-Sarip A, Venturini F, Chalkley GE, Verrijzer CP, (2002) Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression. Mol Cell Biol 22: 7473-7483. doi:10.1128/MCB.22.21.7473-7483.2002. PubMed: 12370294.
50. Atchison L, Ghias A, Wilkinson F, Bonini N, Atchison ML, (2003) Transcription factor YY1 functions as a PcG protein in vivo. EMBO J 22: 1347-1358. doi:10.1093/emboj/cdg124. PubMed: 12628927.
51. Kim SY, Paylor SW, Magnuson T, Schumacher A, (2006) Juxtaposed Polycomb complexes co-regulate vertebral identity. Development 133: 4957-4968. doi:10.1242/dev.02677. PubMed: 17107999.
52. Fisher CL, Randazzo F, Humphries RK, Brock HW, (2006) Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family. Gene 369: 109-118. doi:10.1016/j.gene.2005.10.033. PubMed: 16412590.
53. Bischoff K, Ballew AC, Simon MA, O'Reilly AM, (2009) Wing defects in Drosophila xenicid mutant clones are caused by C-terminal deletion of Additional sex combs (Asx). PLOS ONE 4: e8106. doi:10.1371/journal.pone.0008106. PubMed: 19956620.
54. Bienz M, (2006) The PHD finger, a nuclear protein-interaction domain. Trends Biochem Sci 31: 35-40. doi:10.1016/j.tibs.2005.11.001. PubMed: 16297627.
55. Li H, Ilin S, Wang W, Duncan EM, Wysocka J, et al. (2006) Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature 442: 91-95. PubMed: 16728978.
56. Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, et al. (2006) A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 442: 86-90. PubMed: 16728976.
57. Petruk S, Smith ST, Sedkov Y, Mazo A, (2008) Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity. Development 135: 2383-2390. doi:10.1242/dev.023275. PubMed: 18550707.