Functional conservation of Asxl2, a murine homolog for the Drosophila Enhancer of trithorax and polycombgroup gene Asx

PLoS ONE

Volumn 4, Issue 3, 2009, Pages

  Baskind, Heather A ^a   Na, Lucy ^a   Ma, Quanhong ^a   Patel, Mayur P ^a   Geenen, David L ^a   Wang, Q Tian ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITIONAL SEX COMBS; DROSOPHILA PROTEIN; HISTONE; POLYCOMB GROUP PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ASXL2; TRITHORAX PROTEIN; UNCLASSIFIED DRUG; ADDITIONAL SEX COMBS PROTEIN, DROSOPHILA; ASXL2 PROTEIN, MOUSE; LYSINE; NONHISTONE PROTEIN; REPRESSOR PROTEIN; TRITHORAX PROTEIN, DROSOPHILA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CARDIOMEGALY; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE LOSS; GENETIC CONSERVATION; GENETIC TRANSFORMATION; HEART FUNCTION; HISTOLOGY; HOMOZYGOSITY; LIFESPAN; MOUSE; MUSCULOSKELETAL DEVELOPMENT; NEOCORTEX; NONHUMAN; OOCYTE DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; RETINA DEVELOPMENT; SPERMATOGONIUM; SURVIVAL RATE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; ANIMAL; ANIMAL EMBRYO; CYTOLOGY; DROSOPHILA MELANOGASTER; GENE TRANSFER; GENETICS; HEART; METABOLISM; METHYLATION; NEWBORN; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETON; WESTERN BLOTTING;

ANIMALIA; MAMMALIA; MURINAE; MUS;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CHROMOSOMAL PROTEINS, NON-HISTONE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, MAMMALIAN; GENE TRANSFER TECHNIQUES; HEART; HISTONES; LYSINE; METHYLATION; MICE; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKELETON;

EID: 62749165324     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004750     Document Type: Article

References (50)

1. Duncan I (1996) How do single homeotic genes control multiple segment identities? Bioessays 18(2): 91-94.
2. Deschamps J, van Nes J (2005) Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development 132(13): 2931-2942.
3. Pearson JC, Lemons D, McGinnis W (2005) Modulating Hox gene functions during animal body patterning. Nat Rev Genet 6(12): 893-904.
4. Schwartz YB, Pirrotta V (2007) Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet 8(1): 9-22.
5. Orlando V (2003) Polycomb, epigenomes, and control of cell identity. Cell 112(5): 99-606.
6. Levine SS, King I, Kingston RE (2004) Division of labor in polycomb group repression. Trends Biochem Sci 29(9): 478-485.
7. Ringrose L, Paro R (2007) Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development 134(2): 223-232.
8. Müller J, Kassis J (2006) Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Curr Opin Genet Dev 16(5): 476-484.
9. Brown JL, Mucci D, Whiteley M, Dirksen ML, Kassis JA (1998) The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol Cell 1: 1057-1064.
10. Brown JL, Fritsch C, Muller J, Kassis JA (2003) The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development 130: 285-294.
11. Klymenko T, Papp B, Fischle W, Köcher T, Schelder M, et al. (2006) A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev 20(9): 1110-1122.
12. Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, et al. (2002) Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111(2): 185-196.
13. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 16(22): 2893-2905.
14. Müller J, Hart C, Francis NJ, Vargas ML, Sengupta A, et al. (2002) Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111(2): 197-208.
15. Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, et al. (2002) Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298(5595): 1039-1043.
16. Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, et al. (2003) Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 17(15): 1870-1881.
17. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, et al. (2004) Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol 24(13): 5639-49.
18. Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, et al. (2005) Genomic maps and comparative analysis of histone modifications in human and mouse. Cell 120: 169-181.
19. Schneider R, Bannister AJ, Myers FA, Thorne AW, Crane-Robinson C, et al. (2004) Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol 6: 73-77.
20. Papoulas O, Beek SJ, Moseley SL, McCallum CM, Sarte M, et al. (1998) The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes. Development 125(20): 3955-66.
21. Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, et al. (2002) ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell 10(5): 1119-1128.
22. Kennison JA (1995) The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet 29: 289-303.
23. Gildea JJ, Lopez R, Shearn A (2000) A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics 156(2): 645-663.
24. Lopez A, Higuet D, Rosset R, Deutsch J, Peronnet F (2001) corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae. Mol Genet Genomics 266(4): 572-583.
25. Decoville M, Giacomello E, Leng M, Locker D (2001) DSP1, an HMG-like protein, is involved in the regulation of homeotic genes. Genetics 157(1): 237-244.
26. Salvaing J, Lopez A, Boivin A, Deutsch JS, Peronnet F (2003) The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor. Nucleic Acids Res 31(11): 2873-2882.
27. Déjardin J, Rappailles A, Cuvier O, Grimaud C, Decoville M, et al. (2005) Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1. Nature 434(7032): 533-538.
28. Salvaing J, Decoville M, Mouchel-Vielh E, Bussière M, Daulny A, et al. (2006) Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene: understanding the role of Enhancers of trithorax and Polycomb. BMC Biol 4(9).
29. Horard B, Tatout C, Poux S, Pirrotta V (2000) Structure of a polycomb response element and in vitro binding of polycomb group complexes containing GAGA factor. Mol Cell Biol 20(9): 3187-3197.
30. Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, et al. (1998) The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Development 125(7): 1207-1216.
31. Breen TR, Duncan IM (1986) Maternal expression of genes that regulate the Bithorax complex of Drosophila melanogaster. Dev Biol 118: 442-456.
32. Sinclair DA, Campbell RB, Nicholls F, Slade E, Brock HW (1992) Genetic analysis of the additional sex combs locus of Drosophila melanogaster. Genetics 130(4): 817-825.
33. Milne TA, Sinclair DA, Brock HW (1999) The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. Mol Gen Genet 261(4-5): 753-761.
34. Fisher CL, Randazzo F, Humphries RK, Brock HW (2006) Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family. Gene 15(369): 109-118.
35. Katoh M, Katoh M (2003) Identification and characterization of ASXL2 gene in silico. Int J Oncol 23(3): 845-850.
36. Katoh M, Katoh M (2004) Identification and characterization of ASXL3 gene in silico. Int J Oncol 24(6): 1617-1622.
37. Available: http://www.genetrap.org/.
38. Bel S, Core N, Djabali M, Kieboom K, Van der Lugt N, et al. (1998) Genetic interactions and dosage effects of Polycomb group genes in mice. Development 125(18): 3543-3551.
39. Lorente M, Perez C, Sánchez C, Donohoe M, Shi Y, et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev 123(4): 312-320.
40. Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, et al. (2006) Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes Dev 20(17): 2397-2409.
41. Ramocki MB, Dowling J, Grinberg I, Kimonis VE, Cardoso C, et al. (2003) Reciprocal fusion transcripts of two novel Zn-finger genes in a female with absence of the corpus callosum, ocular colobomas and a balanced translocation between chromosomes 2p24 and 9q32. European J Human Gen 11: 527-534.
42. Coré N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, et al. (1997) Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 124(3): 721-729.
43. van der Lugt NM, Domen J, Linders K, van Roon M, Robanus-Maandag E, et al. (1994) Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8(7): 757-769.
44. Alkema MJ, Bronk M, Verhoeven E, Otte A, van't Veer LJ, et al. (1997) Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev 11(2): 226-240.
45. Kurzhals RL, Tie F, Stratton CA, Harte PJ (2007) Drosophila ESC-like can substitute for ESC and become required for Polycomb silencing if ESC is absent. Dev Biol 313: 293-306.
46. McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB (2007) DNA Methylation and Complete Transcriptional Silencing of Cancer Genes Persist after Depletion of EZH2. Cancer Res 67: 5097-5102.
47. Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, et al. (2002) The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. J Clin Invest 110(2): 177-184.
48. Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, et al. (2002) Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110(4): 479-488.
49. Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, et al. (2007) Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med 13: 324-331.
50. Durand JB (1999) Genetic basis of cardiomyopathy. Curr Opin Cardiol 14: 225-229.