Transcription factor YY1 functions as a PcG protein in vivo

EMBO Journal

Volumn 22, Issue 6, 2003, Pages 1347-1358

  Atchison, Lakshmi ^a   Ghias, Ayesha ^b   Wilkinson, Frank ^b   Bonini, Nancy ^b   Atchison, Michael L ^b  

^a CHESTNUT HILL COLLEGE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Development; Polycomb group; Repression; Transcription; YY1

Indexed keywords

DNA; DNA BINDING PROTEIN; GLUTATHIONE TRANSFERASE; HEAT SHOCK PROTEIN 70; PCG PROTEIN; POLYCOMB GROUP PROTEIN; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG;

ARTICLE; DNA PROTEIN COMPLEX; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; IMMUNOBLOTTING; LARVAL DEVELOPMENT; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSGENE;

ALCOHOL OXIDOREDUCTASES; ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; ERYTHROID-SPECIFIC DNA-BINDING FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GENES, REPORTER; HOMEODOMAIN PROTEINS; LARVA; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSGENES; YY1 TRANSCRIPTION FACTOR;

VERTEBRATA;

EID: 0037451302     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg124     Document Type: Article

References (70)

1. Akasaka, T., Kanno, M., Balling, R., Taniguchi, M. and Koseki, H. (1996) A role for mel-18, a polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development, 122, 1513-1522.
2. Akasaka, T. et al. (1997) The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity, 7, 135-146.
3. Akasaka, T. et al. (2001) Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development, 128, 1587-1597.
4. Alkema, M.J., van der Lugt, N.M.T., Bobeldijk, R.C., Berns, A. and van Lohuizen, M. (1995) Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. Nature, 374, 724-727.
5. Austen, M., Luscher, B. and Luscher-Firzlaff, J.M. (1997) Characterization of the transcriptional regulator YY1. J. Biol. Chem., 272, 1709-1717.
6. Beinz, M. and Muller, J. (1995) Transcriptional silencing of homeotic genes in Drosophila. BioEssays, 17, 775-784.
7. Bel, S., Core, N., Djaball, M., Kieboo, K., van der Lugt, N., Alkema, M.J. and Van Lohuizen, M. (1998) Genetic interactions and dosage effects of Polycomb group genes in mice. Development, 125, 3543-3551.
8. Brock, H.W. and van Lohuizen, M. (2001) The Polycomb group - no longer an exclusive club? Curr. Opin. Genet. Dev., 11, 175-181.
9. Brown, J.L., Mucci, D., Whiteley, M., Dirksen, M.-L. and Kassis, J.A. (1998) The Drosophila polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol. Cell, 1, 1057-1064.
10. Bushmeyer, S.M. and Atchison, M.L. (1998) Identification of YY1 sequences necessary for association with the nuclear matrix and for transcriptional repression functions. J. Cell. Biochem., 68, 484-499.
11. Bushmeyer, S., Park, K. and Atchison, M.L. (1995) Characterization of functional domains within the multifunctional transcription factor, YY1. J. Biol. Chem., 270, 30213-30220.
12. Busturia, S., Lloyd, A., Bejarano, F., Zavortink, M. and Sakonju, S. (2001) The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression. Development, 128, 2163-2173.
13. Chinnadurai, G. (2002) CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell, 9, 213-224.
14. Donohoe, M.E., Zhang, X., McGinnis, L., Biggers, J., Li, E. and Shi, Y. (1999) Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol. Cell. Biol., 19, 7237-7244.
15. Duncan, I. and Lewis, E.B. (1982) Genetic Control of Body Segment Differentiation in Drosophila. Alan R. Liss, Inc., New York, NY.
16. Francis, N.J. and Kingston, R.E. (2001) Mechanisms of transcriptional memory. Nat. Rev. Mol. Cell Biol., 2, 409-421.
17. Fritsch, C. (2002) Funktionelle analyse des Polycomb gruppen proteins pleiohomeotic in Drosophila. Dissertation Thesis, der Fakultät für Biologie der Eberhard Karls Universität Tübingen, Tübingen, Germany.
18. Fritsch, C., Brown, J.L., Kassis, J.A. and Muller, J. (1999) The DNA-binding Polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene. Development, 126, 3905-3913.
19. Galvin, K.M. and Shi, Y. (1997) Multiple mechanisms of transcriptional repression by YY1. Mol. Cell. Biol., 17, 3723-3732.
20. Garcia, E., Marcos-Gutierrez, C., del Mar Lorente, M., Moreno, J.C. and Vidal, M. (1999) RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex and with the transcription factor YY1. EMBO J., 18, 3404-3418.
21. Girton, J.R. and Jeon, S.H. (1994) Novel embryonic and adult homeotic phenotypes are produced by pleiohomeotic mutations in Drosophila. Dev. Biol., 161, 393-407.
22. Gualberto, A., LePage, D., Pons, G., Mader, S.L., Park, K., Atchison, M.L. and Walsh, K. (1992) Functional antagonism between YY1 and the serum response factor. Mol. Cell. Biol., 12, 4209-4214.
23. Hildebrand, J.D. and Soriano, P. (2002) Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol., 22, 5296-5307.
24. Hyde-DeRuyscher, R.P., Jennings, E. and Shenk, T. (1995) DNA binding sites for the transcriptional activator/repressor YY1. Nucleic Acids Res., 23, 4457-4465.
25. Jacobs, J.J.L., Kieboom, K., Marino, S., DePinho, R.A. and van Lohuizen, M. (1999) The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature, 397, 164-168.
26. Jones, C.A., Ng, J., Peterson, A.J., Morgan, K., Simon, J. and Jones, R. (1998) The Drosophila esc and E(z) proteins are direct partners in Polycomb Group-mediated repression. Mol. Cell. Biol., 18, 2825-2834.
27. Jurgens, G. (1985) A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature, 316, 153-155.
28. Kennison, J.A. (1993) Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet., 9, 75-78.
29. Lee, J.-S., Galvin, K.M., See, R.H., Eckner, R., Livingston, D., Moran, E. and Shi, Y. (1995) Relief of YY1 transcriptional repression by adenovirus E1A is mediated by EIA-associated protein p300. Genes Dev., 9, 1188-1198.
30. Lee, T.-C., Zhang, Y. and Schwartz, R.J. (1994) Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis. Oncogene, 9, 1047-1052.
31. Lessard, J., Schumacher, A., Thorsteinsdottir, U., van Lohuizen, M., Magnuson, T. and Sauvageau, G. (1999) Functional antagonism of the Polycomb Group genes eed and Bmi1 in hematopoietic cell proliferation. Genes Dev., 13, 2691-2703.
32. Levine, S.S., Weiss, A., Erdjument-Bromage, H., Shao, Z., Tempst, P. and Kingston, R.E. (2002) The core of the Polycomb Repressive Complex is compositionally and functionally conserved in flies and humans. Mol. Cell. Biol., 22, 6070-6078.
33. Lu, S.-Y., Rodriguez, M. and Liao, W.S.L. (1994) YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-κB during acute-phase response. Mol. Cell. Biol., 14, 6253-6263.
34. McKeon, J. and Brock, H.W. (1991) Interactions of the Polycomb group of genes with homeotic loci of Drosophila. Rouxs Arch. Dev. Biol., 199, 387-396.
35. Mihaly, J., Mishra, R.K. and Karch, F. (1998) A conserved sequence motif in Polycomb response elements. Mol. Cell, 1, 1065-1066.
36. Mishra, R.K., Mihaly, J., Barges, S., Spierer, A., Karch, F., Hagstrom, K., Schweinsberg, S.E. and Schedl, P. (2001) The iab-7 Polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activitiy. Mol. Cell. Biol., 21, 1311-1318.
37. Mohd-Sarip, A., Venturini, F., Chalkley, G.E. and Verrijzer, C.P. (2002) Pleiohomeotic can link Polycomb to DNA and mediate transcriptional repression. Mol. Cell. Biol., 22, 7473-7483.
38. Muller, J. (1995) Transcriptional silencing by the polycomb protein in Drosophila embryos. EMBO J., 6, 1209-1220.
39. Muller, J., Guant, S. and Lawrence,P.A. (1995) Function of the polycomb protein is conserved in mice and flies. Development, 121, 2847-2852.
40. Nateson, S. and Gilman, M.Z. (1993) DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev., 7, 2497-2509.
41. Ng, J., Hart, C.M., Morgan, K. and Simon, J.A. (2000) A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC. Mol. Cell. Biol., 20, 3069-3078.
42. O'Carroll, D., Erhardt, S., Pagani, M., Barton, S.C., Surani, M.A. and Jenuwein, T. (2001) The Polycomb-Group gene Ezh2 is required for early mouse development. Mol. Cell. Biol., 21, 4330-4336.
43. O'Kane, C.J. and Gehring, W.J. (1987) Detection in situ of genomic regulatory elements in Drosophila. Proc. Natl Acad. Sci. USA, 84, 9123-9127.
44. Park, K. and Atchison, M.L. (1991) Isolation of a candidate repressor/activator, NF-E1 (YY-1, δ), that binds to the immunoglobulin κ 3′ enhancer and the immunoglobulin heavy-chain μE1 site. Proc. Natl Acad. Sci. USA, 88, 9804-9808.
45. Paro, R. (1993) Mechanisms of heritable gene repression during development of Drosophila. Curr. Opin. Cell Biol., 5, 999-1005.
46. Pirrotta, V. (1997a) Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. Trends Genet., 13, 314-318.
47. Pirrotta, V. (1997b) PcG complexes and chromatin silencing. Curr. Opin. Genet. Dev., 7, 249-258.
48. Pirrotta, V. (1999) Polycomb silencing and the maintenance of stable chromatin states. Results Probl. Cell Differ., 25, 205-228.
49. Poortinga, G., Watanabe, M. and Parkhurst, S.M. (1998) Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and Hairy-mediated transcriptional repression. EMBO J., 17, 2067-2078.
50. Poux, S., McCabe, D. and Pirrotta, V. (2001a) Recruitment of components of Polycomb Group chromatin complexes in Drosophila. Development, 128, 75-85.
51. Poux, S., Melfi, R. and Pirrotta, V. (2001b) Establishment of Polycomb silencing requires a transient interaction between PC and ESC. Genes Dev., 15, 2509-2514.
52. Rubin, G.M. and Spradling, A.C. (1982) Genetic transformation of Drosophila with transposable element vectors. Science, 218, 348-353.
53. Satijn, D.P. and Otte, A.P. (1999) Polycomb group protein complexes: do different complexes regulate distinct target genes? Biochim. Biophys. Acta, 1447, 1-16.
54. Satijn, D.P., Hamer, K.M., den Blaauwen, J. and Otte, A.P. (2001) The polycomb group protein EED interacts with YY1 and both proteins induce neural tissue in Xenopus embryos. Mol. Cell. Biol., 21, 1360-1369.
55. Schumacher, A. and Magnuson, T. (1997) Murine polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet., 13, 167-170.
56. Schumacher, A., Faust, C. and Magnuson, T. (1996) Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature, 383, 250-253.
57. Sewalt, R.G.A.B., Gunster, M.J., van der Vlag, J., Satijn, D.P.E. and Otte, A.P. (1999) C-terminal binding protein is a transcriptional repressor that interacts with a specific class of vertebrate Polycomb proteins. Mol. Cell. Biol., 19, 777-787.
58. Shao, Z., Raible, F., Mollaaghababa, R., Guyon, J.R., Wu, C., Bender, W. and Kingston, R.E. (1999) Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell, 98, 37-46.
59. Shi, Y., Seto, E., Chang, L.-S. and Shenk, T. (1991) Transcriptional repression by YY1, a human GLI-Kruppel-related protein and relief of repression by adenovirus E1A protein.Cell, 67, 377-388.
60. Shi, Y., Lee, J. and Galvin, K.M. (1997) Everything you have ever wanted to know about Yin Yang1. Biochim. Biophys. Acta, 1332, F49-F66.
61. Shrivastava, A. and Calame, K. (1994) An analysis of genes regulated by the multi-functional transcriptional regulatory Yin Yang-1. Nucleic Acids Res., 22, 5151-5155.
62. Simon, J., Chiang, A. and Bender, W. (1992) Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products. Development, 114, 493-505.
63. Thomas, M.J. and Seto, E. (1999) Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene, 236, 197-208.
64. Tie, F., Furuyama, T. and Harte, P.J. (1998) The Drosophila Polycomb-Group proteins ESC and E(Z) bind directly to each other and co-localize at multiple chromosomal sites. Development, 125, 3438-3496.
65. Tie, F., Furuyama, T., Prasad-Sinha, J., Jane, E. and Harte, P.J. (2001) The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development, 128, 275-286.
66. van der Lugt, N.M.T. et al. (1994) Posterior transformation, neurological abnormalities and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev., 8, 757-769.
67. Yang, W.-M., Inouye, C., Zeng, Y., Bearss, D. and Seto, E. (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl Acad. Sci. USA, 93, 12845-12850.
68. Yao, Y.-L., Yang, W.-M. and Seto, E. (2001) Regulation of transcription factor YY1 by acetylation and deacetylation. Mol. Cell. Biol., 21, 5979-5991.
69. Ye, J., Zhang, X. and Dong, Z. (1996) Characterization of the human granulocyte-macrophage colony-stimulating factor gene promoter: an AP1 complex and an Sp1-related complex transactivate the promoter activity that is suppressed by a YY1 complex. Mol. Cell. Biol., 16, 157-167.
70. Zhou, Q., Gedrich, R.W. and Engel, D.A. (1995) Transcriptional repression of the c-fos gene by YY1 is mediated by direct interaction with ATF/CREB. J. Virol., 69, 4323-4330.