Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5

Annals of Thoracic Surgery

Volumn 71, Issue 4, 2001, Pages 1320-1324

  Chen, Edward P ^a,b   Bittner, Hartmuth B ^a   Akhter, Shahab A ^a   Koch, Walter J ^a   Davis, R Duane ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEART FAILURE; HEART HEMODYNAMICS; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART PERFORMANCE; HEART PRELOAD; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROKE; TRANSGENIC MOUSE;

ANIMALS; CARDIAC OUTPUT; HEART RATE; HEMODYNAMIC PROCESSES; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; MYOCARDIUM; PROTEIN-SERINE-THREONINE KINASES; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; STROKE VOLUME;

EID: 0035060068     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(00)01754-9     Document Type: Article

References (16)

1. Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts
2. 1-adrenergic receptors in the failing human heart
3. G protein-coupled receptor kinases
4. Structure and mechanism of the G protein-coupled receptor kinases
5. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases
6. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice
7. Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts
8. A work-performing heart preparation for myocardial performance analysis in murine hearts
9. Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations
10. G-protein-coupled receptor kinases and the heart
11. Cardiac function in mice overexpressing the β-Adrenergic Receptor Kinase or a βARK inhibitor
12. Adenylyl cyclase and G protein receptor kinase expression during development of heart failure
13. Enhanced GRK5 expression in the hearts of cardiomyopathic hamsters, J2N-k
14. Physiologic effects of extracellular superoxide dismutase transgene overexpression on myocardial function after ischemia and reperfusion injury
15. 2-adrenergic receptor
16. Linearity of the Frank-Starling relationship in the intact heart: The concept of preload recruitable stroke work