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Volumn 10, Issue 9, 2013, Pages 3484-3496

Mechanism of cationic phosphorus dendrimer toxicity against murine neural cell lines

Author keywords

Apoptosis; cationic phosphorus dendrimers; cell viability; cytotoxicity; necrosis

Indexed keywords

CASPASE 3; CATIONIC PHOSPHORUS DENDRIMER; CYTOCHROME C; DENDRIMER; PHOSPHORUS DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84883565434     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4003255     Document Type: Article
Times cited : (35)

References (78)
  • 1
    • 60749099362 scopus 로고    scopus 로고
    • Dendrimers as versatile platform in drug delivery applications
    • Svenson, S. Dendrimers as versatile platform in drug delivery applications Eur. J. Pharm. Biopharm. 2009, 71, 445-462
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 445-462
    • Svenson, S.1
  • 2
    • 78650316044 scopus 로고    scopus 로고
    • Biomedical applications of dendrimers: A tutorial
    • Mintzer, M. A.; Grinstaff, M. W. Biomedical applications of dendrimers: a tutorial Chem. Soc. Rev. 2010, 40, 173-190
    • (2010) Chem. Soc. Rev. , vol.40 , pp. 173-190
    • Mintzer, M.A.1    Grinstaff, M.W.2
  • 4
    • 0036922118 scopus 로고    scopus 로고
    • The specific contribution of phosphorus in dendrimer chemistry
    • Majoral, J.-P.; Caminade, A.-M.; Maraval, V. The specific contribution of phosphorus in dendrimer chemistry Chem. Commun. 2002, 21, 2929-2942
    • (2002) Chem. Commun. , vol.21 , pp. 2929-2942
    • Majoral, J.-P.1    Caminade, A.-M.2    Maraval, V.3
  • 5
    • 18444366502 scopus 로고    scopus 로고
    • Water-soluble phosphorus-containing dendrimers
    • Caminade, A.-M.; Majoral, J.-P. Water-soluble phosphorus-containing dendrimers Prog. Polym. Sci. 2005, 30, 491-505
    • (2005) Prog. Polym. Sci. , vol.30 , pp. 491-505
    • Caminade, A.-M.1    Majoral, J.-P.2
  • 6
    • 0002397728 scopus 로고
    • Photochemical and thermal rearrangement of heavier main-group element azides
    • Bertrand, G.; Majoral, J.-P.; Baceiredo, A. Photochemical and thermal rearrangement of heavier main-group element azides Acc. Chem. Res. 1986, 19, 17-23
    • (1986) Acc. Chem. Res. , vol.19 , pp. 17-23
    • Bertrand, G.1    Majoral, J.-P.2    Baceiredo, A.3
  • 8
    • 33845470880 scopus 로고
    • Synthesis and structure of the first cyclodiphosphazene. Dimerization of a phosphonitrile:P.tplbond.N
    • Baceiredo, A.; Bertrand, G.; Majoral, J.-P.; Sicard, G.; Jaud, J.; Galy, J. Synthesis and structure of the first cyclodiphosphazene. Dimerization of a phosphonitrile:P.tplbond.N J. Am. Chem. Soc. 1984, 106, 6088-6089
    • (1984) J. Am. Chem. Soc. , vol.106 , pp. 6088-6089
    • Baceiredo, A.1    Bertrand, G.2    Majoral, J.-P.3    Sicard, G.4    Jaud, J.5    Galy, J.6
  • 9
    • 37349024800 scopus 로고    scopus 로고
    • Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly
    • Hernandez-Lopez, J.-L.; Khor, H. L.; Caminade, A.-M.; Majoral, J.-P.; Mittler, S.; Knoll, W.; Kim, D. H. Bioactive multilayer thin films of charged N,N-disubstituted hydrazine phosphorus dendrimers fabricated by layer-by-layer self-assembly Thin Solid Films 2008, 516, 1256-1264
    • (2008) Thin Solid Films , vol.516 , pp. 1256-1264
    • Hernandez-Lopez, J.-L.1    Khor, H.L.2    Caminade, A.-M.3    Majoral, J.-P.4    Mittler, S.5    Knoll, W.6    Kim, D.H.7
  • 14
    • 0242473739 scopus 로고    scopus 로고
    • Water-soluble polycationic dendrimers with a phosphoramidothioate backbone: Preliminary studies of cytotoxicity and oligonucleotide/plasmid delivery in human cell culture
    • Maszewska, M.; Leclaire, J.; Cieslak, M.; Nawrot, B.; Okruszek, A.; Caminade, A.-M.; Majoral, J.-P. Water-soluble polycationic dendrimers with a phosphoramidothioate backbone: preliminary studies of cytotoxicity and oligonucleotide/plasmid delivery in human cell culture Oligonucleotides 2003, 13, 193-205
    • (2003) Oligonucleotides , vol.13 , pp. 193-205
    • Maszewska, M.1    Leclaire, J.2    Cieslak, M.3    Nawrot, B.4    Okruszek, A.5    Caminade, A.-M.6    Majoral, J.-P.7
  • 25
    • 84868016738 scopus 로고    scopus 로고
    • Dendrimers in cancer therapeutics and diagnosis
    • Guo, R.; Shi, X. Dendrimers in cancer therapeutics and diagnosis Curr. Drug. Metab. 2012, 13, 1097-1109
    • (2012) Curr. Drug. Metab. , vol.13 , pp. 1097-1109
    • Guo, R.1    Shi, X.2
  • 26
    • 84871660526 scopus 로고    scopus 로고
    • Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons
    • Majd, S.; Chegini, F.; Chataway, T.; Zhou, X.-F.; Gai, W. Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons Neurotoxicol. Res. 2013, 23, 69-78
    • (2013) Neurotoxicol. Res. , vol.23 , pp. 69-78
    • Majd, S.1    Chegini, F.2    Chataway, T.3    Zhou, X.-F.4    Gai, W.5
  • 27
    • 84868341385 scopus 로고    scopus 로고
    • Synthesis, characterization and brain targeting potential of paclitaxel loaded thiamine-PPI nanoconjugates
    • Patel, S. K.; Gajbhiye, V.; Jain, N. K. Synthesis, characterization and brain targeting potential of paclitaxel loaded thiamine-PPI nanoconjugates J. Drug Target. 2012, 20, 841-849
    • (2012) J. Drug Target. , vol.20 , pp. 841-849
    • Patel, S.K.1    Gajbhiye, V.2    Jain, N.K.3
  • 28
    • 84883596195 scopus 로고    scopus 로고
    • Surface functionalization regulates PAMAM dendrimer toxicity on Blood Brain Barrier cells and the modulation of key inflammatory receptors on microglia
    • in press
    • Bertero, A.; Boni, A.; Gemmi, M.; Gagliardi, M.; Bifone, A.; Bardi, G. Surface functionalization regulates PAMAM dendrimer toxicity on Blood Brain Barrier cells and the modulation of key inflammatory receptors on microglia. Nanotoxicology 2013, in press.
    • (2013) Nanotoxicology
    • Bertero, A.1    Boni, A.2    Gemmi, M.3    Gagliardi, M.4    Bifone, A.5    Bardi, G.6
  • 31
    • 0036533531 scopus 로고    scopus 로고
    • Mitochondrial and nonmitochondrial reduction of MTT: Interaction of MTT with TMRE, JC-1, and NAO mitochondrial fluorescent probes
    • Bernas, T.; Dobrucki, J. Mitochondrial and nonmitochondrial reduction of MTT: interaction of MTT with TMRE, JC-1, and NAO mitochondrial fluorescent probes Cytometry 2002, 47, 236-242
    • (2002) Cytometry , vol.47 , pp. 236-242
    • Bernas, T.1    Dobrucki, J.2
  • 32
    • 33646828379 scopus 로고    scopus 로고
    • Use of spectroscopic probes for detection of reactive oxygen species
    • Bartosz, G. Use of spectroscopic probes for detection of reactive oxygen species Clin. Chim. Acta 2006, 368, 53-76
    • (2006) Clin. Chim. Acta , vol.368 , pp. 53-76
    • Bartosz, G.1
  • 33
    • 46649101286 scopus 로고    scopus 로고
    • A method for measuring mitochondrial mass and activity
    • Agnello, M.; Morici, G.; Rinaldi, A. M. A method for measuring mitochondrial mass and activity Cytotechnology 2008, 56, 145-149
    • (2008) Cytotechnology , vol.56 , pp. 145-149
    • Agnello, M.1    Morici, G.2    Rinaldi, A.M.3
  • 34
    • 0030612749 scopus 로고    scopus 로고
    • JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
    • Salvioli, S.; Ardizzoni, A.; Franceschi, C.; Cossarizza, A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis FEBS Lett. 1997, 411, 77-82
    • (1997) FEBS Lett. , vol.411 , pp. 77-82
    • Salvioli, S.1    Ardizzoni, A.2    Franceschi, C.3    Cossarizza, A.4
  • 35
    • 70449519057 scopus 로고    scopus 로고
    • Chlorophenols and chlorocatechols induce apoptosis in human lymphocytes (in vitro)
    • Michałowicz, J.; Sicińska, P. Chlorophenols and chlorocatechols induce apoptosis in human lymphocytes (in vitro) Toxicol. Lett. 2009, 191, 246-252
    • (2009) Toxicol. Lett. , vol.191 , pp. 246-252
    • Michałowicz, J.1    Sicińska, P.2
  • 37
    • 1642575107 scopus 로고    scopus 로고
    • Genistein arrests hepatoma cells at G2/M phase: Involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1
    • Chang, K.-L.; Kung, M.-L.; Chow, N.-H.; Su, S.-J. Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1 Biochem. Pharmacol. 2004, 67, 717-726
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 717-726
    • Chang, K.-L.1    Kung, M.-L.2    Chow, N.-H.3    Su, S.-J.4
  • 38
    • 18444366502 scopus 로고    scopus 로고
    • Water-soluble phosphorus-containing dendrimers
    • Caminade, A.-M.; Majoral, J.-P. Water-soluble phosphorus-containing dendrimers Prog. Polym. Sci. 2005, 30, 491-505
    • (2005) Prog. Polym. Sci. , vol.30 , pp. 491-505
    • Caminade, A.-M.1    Majoral, J.-P.2
  • 39
    • 78650400785 scopus 로고    scopus 로고
    • Time evolution of the aggregation process of peptides involved in neurodegenerative diseases and preventing aggregation effect of phosphorus dendrimers studied by EPR
    • Ottaviani, M. F.; Mazzeo, R.; Cangiotti, M.; Fiorani, L.; Majoral, J.-P.; Caminade, A.-M.; Pedziwiatr, E.; Bryszewska, M.; Klajnert, B. Time evolution of the aggregation process of peptides involved in neurodegenerative diseases and preventing aggregation effect of phosphorus dendrimers studied by EPR Biomacromolecules 2010, 11, 3014-3021
    • (2010) Biomacromolecules , vol.11 , pp. 3014-3021
    • Ottaviani, M.F.1    Mazzeo, R.2    Cangiotti, M.3    Fiorani, L.4    Majoral, J.-P.5    Caminade, A.-M.6    Pedziwiatr, E.7    Bryszewska, M.8    Klajnert, B.9
  • 40
    • 84861125786 scopus 로고    scopus 로고
    • Peripheral functionalization of dendrimers regulates internalization and intracellular trafficking in living cells
    • Albertazzi, L.; Fernandez-Villamarin, M.; Riguera, R.; Fernandez-Megia, E. Peripheral functionalization of dendrimers regulates internalization and intracellular trafficking in living cells Bioconjugate Chem. 2012, 23, 1059-1068
    • (2012) Bioconjugate Chem. , vol.23 , pp. 1059-1068
    • Albertazzi, L.1    Fernandez-Villamarin, M.2    Riguera, R.3    Fernandez-Megia, E.4
  • 41
    • 84869010924 scopus 로고    scopus 로고
    • Endocytic uptake and intracellular trafficking of bis-MPA-based hyperbranched copolymer micelles in breast cancer cells
    • Zeng, X.; Zhang, Y.; Nyström, A. M. Endocytic uptake and intracellular trafficking of bis-MPA-based hyperbranched copolymer micelles in breast cancer cells Biomacromolecules 2012, 13, 3814-3822
    • (2012) Biomacromolecules , vol.13 , pp. 3814-3822
    • Zeng, X.1    Zhang, Y.2    Nyström, A.M.3
  • 42
    • 77955982005 scopus 로고    scopus 로고
    • Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells
    • Mukherjee, S. P.; Lyng, F. M.; Garcia, A.; Davoren, M.; Byrne, H. J. Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells Toxicol. Appl. Pharmacol. 2010, 248, 259-268
    • (2010) Toxicol. Appl. Pharmacol. , vol.248 , pp. 259-268
    • Mukherjee, S.P.1    Lyng, F.M.2    Garcia, A.3    Davoren, M.4    Byrne, H.J.5
  • 43
    • 34848888660 scopus 로고    scopus 로고
    • Endocytosis and interaction of poly(amidoamine) dendrimers with Caco-2 cells
    • Kitchens, K. M.; Foraker, A. B.; Kolhatkar, R. B.; Swaan, P. W.; Ghandehari, H. Endocytosis and interaction of poly(amidoamine) dendrimers with Caco-2 cells Pharm. Res. 2007, 24, 2138-2145
    • (2007) Pharm. Res. , vol.24 , pp. 2138-2145
    • Kitchens, K.M.1    Foraker, A.B.2    Kolhatkar, R.B.3    Swaan, P.W.4    Ghandehari, H.5
  • 44
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • Circu, M. L.; Aw, T. Y. Reactive oxygen species, cellular redox systems, and apoptosis Free Radical Biol. Med. 2010, 48, 749-762
    • (2010) Free Radical Biol. Med. , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 46
    • 34249873498 scopus 로고    scopus 로고
    • Interactions between U-937 human macrophages and poly(propyleneimine) dendrimers
    • Kuo, J.-H. S.; Jan, M.-S.; Lin, Y.-L. Interactions between U-937 human macrophages and poly(propyleneimine) dendrimers J. Controlled Release 2007, 120, 51-59
    • (2007) J. Controlled Release , vol.120 , pp. 51-59
    • Kuo, J.-H.S.1    Jan, M.-S.2    Lin, Y.-L.3
  • 47
    • 77953691199 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells
    • Naha, P. C.; Davoren, M.; Lyng, F. M.; Byrne, H. J. Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells Toxicol. Appl. Pharmacol. 2010, 246, 91-99
    • (2010) Toxicol. Appl. Pharmacol. , vol.246 , pp. 91-99
    • Naha, P.C.1    Davoren, M.2    Lyng, F.M.3    Byrne, H.J.4
  • 48
    • 65449170822 scopus 로고    scopus 로고
    • The decrease of PAMAM dendrimer-induced cytotoxicity by PEGylation via attenuation of oxidative stress
    • Wang, W.; Xiong, W.; Wan, J.; Sun, X.; Xu, H.; Yang, X. The decrease of PAMAM dendrimer-induced cytotoxicity by PEGylation via attenuation of oxidative stress Nanotechnology 2009, 20, 105103
    • (2009) Nanotechnology , vol.20 , pp. 105103
    • Wang, W.1    Xiong, W.2    Wan, J.3    Sun, X.4    Xu, H.5    Yang, X.6
  • 49
    • 84873734071 scopus 로고    scopus 로고
    • Polyamidoamine dendrimer nanoparticle cytotoxicity, oxidative stress, caspase activation and inflammatory response: Experimental observation and numerical simulation
    • Mukherjee, S. P.; Byrne, H. J. Polyamidoamine dendrimer nanoparticle cytotoxicity, oxidative stress, caspase activation and inflammatory response: experimental observation and numerical simulation Nanomedicine 2012, 9, 202-211
    • (2012) Nanomedicine , vol.9 , pp. 202-211
    • Mukherjee, S.P.1    Byrne, H.J.2
  • 50
    • 0037718255 scopus 로고    scopus 로고
    • Evaluation of the probes 2",7-"dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation
    • Myhre, O.; Andersen, J. M.; Aarnes, H.; Fonnum, F. Evaluation of the probes 2",7-"dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation Biochem. Pharmacol. 2003, 65, 1575-1582
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1575-1582
    • Myhre, O.1    Andersen, J.M.2    Aarnes, H.3    Fonnum, F.4
  • 51
    • 84856556021 scopus 로고    scopus 로고
    • There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells
    • Brown, G. C.; Borutaite, V. There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells Mitochondrion 2012, 12, 1-4
    • (2012) Mitochondrion , vol.12 , pp. 1-4
    • Brown, G.C.1    Borutaite, V.2
  • 52
    • 0037125237 scopus 로고    scopus 로고
    • Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells
    • Giovannini, C.; Matarrese, P.; Scazzocchio, B.; Sanchez, M.; Masella, R.; Malorni, W. Mitochondria hyperpolarization is an early event in oxidized low-density lipoprotein-induced apoptosis in Caco-2 intestinal cells FEBS Lett. 2002, 523, 200-206
    • (2002) FEBS Lett. , vol.523 , pp. 200-206
    • Giovannini, C.1    Matarrese, P.2    Scazzocchio, B.3    Sanchez, M.4    Masella, R.5    Malorni, W.6
  • 53
    • 0033694728 scopus 로고    scopus 로고
    • Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells
    • Sánchez-Alcázar, J. A.; Ault, J. G.; Khodjakov, A.; Schneider, E. Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells Cell Death Differ. 2000, 7, 1090-1100
    • (2000) Cell Death Differ. , vol.7 , pp. 1090-1100
    • Sánchez-Alcázar, J.A.1    Ault, J.G.2    Khodjakov, A.3    Schneider, E.4
  • 54
    • 69449091125 scopus 로고    scopus 로고
    • Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction
    • Lee, J.-H.; Cha, K. E.; Kim, M. S.; Hong, H. W.; Chung, D. J.; Ryu, G.; Myung, H. Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction Toxicol. Lett. 2009, 190, 202-207
    • (2009) Toxicol. Lett. , vol.190 , pp. 202-207
    • Lee, J.-H.1    Cha, K.E.2    Kim, M.S.3    Hong, H.W.4    Chung, D.J.5    Ryu, G.6    Myung, H.7
  • 55
    • 33646389796 scopus 로고    scopus 로고
    • Bioenergetic aspects of apoptosis, necrosis and mitoptosis
    • Skulachev, V. P. Bioenergetic aspects of apoptosis, necrosis and mitoptosis Apoptosis 2006, 11, 473-485
    • (2006) Apoptosis , vol.11 , pp. 473-485
    • Skulachev, V.P.1
  • 56
    • 4444240180 scopus 로고    scopus 로고
    • A mitochondrial oscillator dependent on reactive oxygen species
    • Cortassa, S.; Aon, M. A.; Winslow, R. L.; O'Rourke, B. A mitochondrial oscillator dependent on reactive oxygen species Biophys. J. 2004, 87, 2060-2073
    • (2004) Biophys. J. , vol.87 , pp. 2060-2073
    • Cortassa, S.1    Aon, M.A.2    Winslow, R.L.3    O'Rourke, B.4
  • 57
    • 39749123276 scopus 로고    scopus 로고
    • Apoptosis and necrosis: Detection, discrimination and phagocytosis
    • Krysko, D. V.; Vanden Berghe, T.; D'Herde, K.; Vandenabeele, P. Apoptosis and necrosis: detection, discrimination and phagocytosis Methods 2008, 44, 205-221
    • (2008) Methods , vol.44 , pp. 205-221
    • Krysko, D.V.1    Vanden Berghe, T.2    D'Herde, K.3    Vandenabeele, P.4
  • 58
    • 0002372072 scopus 로고    scopus 로고
    • Using ethidium bromide to probe the interactions between DNA and dendrimers
    • Chen, W.; Turro, N. J.; Tomalia, D. A. Using ethidium bromide to probe the interactions between DNA and dendrimers Langmuir 2000, 16, 15-19
    • (2000) Langmuir , vol.16 , pp. 15-19
    • Chen, W.1    Turro, N.J.2    Tomalia, D.A.3
  • 60
    • 76249098974 scopus 로고    scopus 로고
    • Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers
    • Parimi, S.; Barnes, T. J.; Callen, D. F.; Prestidge, C. A. Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers Biomacromolecules 2010, 11, 382-389
    • (2010) Biomacromolecules , vol.11 , pp. 382-389
    • Parimi, S.1    Barnes, T.J.2    Callen, D.F.3    Prestidge, C.A.4
  • 61
    • 70449360521 scopus 로고    scopus 로고
    • Watching DNA condensation induced by poly(amido amine) dendrimers with time-resolved cryo-TEM
    • Carnerup, A. M.; Ainalem, M.-L.; Alfredsson, V.; Nylander, T. Watching DNA condensation induced by poly(amido amine) dendrimers with time-resolved cryo-TEM Langmuir 2009, 25, 12466-12470
    • (2009) Langmuir , vol.25 , pp. 12466-12470
    • Carnerup, A.M.1    Ainalem, M.-L.2    Alfredsson, V.3    Nylander, T.4
  • 63
    • 17144384416 scopus 로고    scopus 로고
    • Mechanism of cell death induced by cationic dendrimers in RAW 264.7 murine macrophage-like cells
    • Kuo, J.-H. S.; Jan, M.-S.; Chiu, H. W. Mechanism of cell death induced by cationic dendrimers in RAW 264.7 murine macrophage-like cells J. Pharm. Pharmacol. 2005, 57, 489-496
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 489-496
    • Kuo, J.-H.S.1    Jan, M.-S.2    Chiu, H.W.3
  • 67
    • 7544242594 scopus 로고    scopus 로고
    • The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholinesterase activity
    • Klajnert, B.; Sadowska, M.; Bryszewska, M. The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholinesterase activity Bioelectrochemistry 2004, 65, 23-26
    • (2004) Bioelectrochemistry , vol.65 , pp. 23-26
    • Klajnert, B.1    Sadowska, M.2    Bryszewska, M.3
  • 69
    • 0033045065 scopus 로고    scopus 로고
    • Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells
    • Li, Y. Z.; Li, C. J.; Pinto, A. V.; Pardee, A. B. Release of mitochondrial cytochrome C in both apoptosis and necrosis induced by beta-lapachone in human carcinoma cells Mol. Med. 1999, 5, 232
    • (1999) Mol. Med. , vol.5 , pp. 232
    • Li, Y.Z.1    Li, C.J.2    Pinto, A.V.3    Pardee, A.B.4
  • 70
    • 85047697158 scopus 로고    scopus 로고
    • Release of intact, monomeric cytochrome c from apoptotic and necrotic cells
    • Jemmerson, R.; LaPlante, B.; Treeful, A. Release of intact, monomeric cytochrome c from apoptotic and necrotic cells Cell Death Differ. 2002, 9, 538-548
    • (2002) Cell Death Differ. , vol.9 , pp. 538-548
    • Jemmerson, R.1    Laplante, B.2    Treeful, A.3
  • 72
    • 84873996482 scopus 로고    scopus 로고
    • Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells
    • Teng, C.-L. J.; Yu, C.-T. R.; Hwang, W.-L.; Tsai, J.-R.; Liu, H.-C.; Hwang, G.-Y.; Hsu, S.-L. Effector mechanisms of sunitinib-induced G1 cell cycle arrest, differentiation, and apoptosis in human acute myeloid leukaemia HL60 and KG-1 cells Ann. Hematol. 2013, 92, 301-313
    • (2013) Ann. Hematol. , vol.92 , pp. 301-313
    • Teng, C.-L.J.1    Yu, C.-T.R.2    Hwang, W.-L.3    Tsai, J.-R.4    Liu, H.-C.5    Hwang, G.-Y.6    Hsu, S.-L.7
  • 73
    • 84872824063 scopus 로고    scopus 로고
    • Triptolide induces S phase arrest via the inhibition of cyclin e and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells
    • Hung, F.-M.; Chen, Y.-L.; Huang, A.-C.; Hsiao, Y.-P.; Yang, J.-S.; Chung, M.-T.; Chueh, F.-S.; Lu, H.-F.; Chung, J.-G. Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells Oncol. Rep. 2013, 29, 1053-1060
    • (2013) Oncol. Rep. , vol.29 , pp. 1053-1060
    • Hung, F.-M.1    Chen, Y.-L.2    Huang, A.-C.3    Hsiao, Y.-P.4    Yang, J.-S.5    Chung, M.-T.6    Chueh, F.-S.7    Lu, H.-F.8    Chung, J.-G.9
  • 75
    • 2042421495 scopus 로고    scopus 로고
    • Incorporation of fluorescent probes into PAMAM dendrimers
    • Domański, D. M.; Klajnert, B.; Bryszewska, M. Incorporation of fluorescent probes into PAMAM dendrimers Bioelectrochemistry 2004, 63, 193-197
    • (2004) Bioelectrochemistry , vol.63 , pp. 193-197
    • Domański, D.M.1    Klajnert, B.2    Bryszewska, M.3
  • 78
    • 36849034047 scopus 로고    scopus 로고
    • Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability
    • Kolhatkar, R. B.; Kitchens, K. M.; Swaan, P. W.; Ghandehari, H. Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability Bioconjugate Chem. 2007, 18, 2054-2060
    • (2007) Bioconjugate Chem. , vol.18 , pp. 2054-2060
    • Kolhatkar, R.B.1    Kitchens, K.M.2    Swaan, P.W.3    Ghandehari, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.