Dendrimers in cancer therapeutics and diagnosis

Current Drug Metabolism

Volumn 13, Issue 8, 2012, Pages 1097-1109

  Guo, Rui ^a   Shi, Xiangyang ^a,b  

^a DONGHUA UNIVERSITY   (China)

^b UNIVERSITY OF MADEIRA   (Portugal)

Author keywords

Anticancer drug delivery; Cancer diagnosis; Dendrimer

Indexed keywords

BIOTIN; CAMPTOTHECIN; CARBON NANOTUBE; CETUXIMAB; DENDRIMER; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FERROUS SULFATE; FIBROBLAST GROWTH FACTOR RECEPTOR; FIRTECAN; FOLIC ACID; GADOLINIUM; GOLD NANOPARTICLE; IODINE; IOHEXOL; METHOTREXATE; PACLITAXEL; PENTETIC ACID; POLYAMIDOAMINE; QUANTUM DOT; RIBOFLAVIN; SILVER NANOPARTICLE; SUCCINIC ACID; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TITANIUM DIOXIDE; TRANSFERRIN RECEPTOR; TRASTUZUMAB;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOCOMPATIBILITY; BLOOD BRAIN BARRIER; CANCER CELL CULTURE; CANCER DIAGNOSIS; CANCER IMMUNOTHERAPY; CHEMICAL REACTION; COMPUTER ASSISTED TOMOGRAPHY; COVALENT BOND; CYTOTOXICITY; DRUG ABSORPTION; DRUG BINDING; DRUG CONFORMATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG SOLUBILITY; DRUG TOXICITY; ENDOCYTOSIS; FLUORESCENCE IMAGING; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; SEMICONDUCTOR; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STATIC ELECTRICITY; TUMOR GROWTH; UNSPECIFIED SIDE EFFECT; X RAY ABSORPTION SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; CONTRAST MEDIA; DENDRIMERS; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEMS; HUMANS; NANOSTRUCTURES; NEOPLASMS;

EID: 84868016738     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012802850010     Document Type: Article

References (138)

1. Alonso, M.J. Nanomedicines for overcoming biological barriers. Biomed. Pharmacother., 2004, 58(3), 168-172.
2. Peer, D.; Karp, J.M.; Hong, S.; FaroKhzad, O.C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol., 2007, 2(12), 751-760.
3. Kundu, P.P.; Sharma, V. Synthetic polymeric vectors in gene therapy. Curr. Opin. Solid State Mat. Sci., 2008, 12(5-6), 89-102.
4. Campolongo, M.J.; Tan, S.J.; Xu, J.F.; Luo, D. DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications. Adv. Drug Del. Rev., 2010, 62(6), 606-616.
5. Mornet, S.; Vasseur, S.; Grasset, F.; Duguet, E. Magnetic nanoparticle design for medical diagnosis and therapy. J. Mater. Chem., 2004, 14(14), 2161-2175.
6. El-Sayed, I.H.; Huang, X.H.; El-Sayed, M.A. Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer. Nano Lett., 2005, 5(5), 829-834.
7. Maxwell, D.J.; Taylor, J.R.; Nie, S.M. Self-assembled nanoparticle probes for recognition and detection of biomolecules. J. Am. Chem. Soc., 2002, 124(32), 9606-9612.
8. Medintz, I.L.; Uyeda, H.T.; Goldman, E.R.; Mattoussi, H. Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater., 2005, 4(6), 435-446.
9. Huang, X.H.; El-Sayed, I.H.; Qian, W.; El-Sayed, M.A. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Am. Chem. Soc., 2006, 128(6), 2115-2120.
10. Slowing, II; Trewyn, B.G.; Giri, S.; Lin, V.S.Y. Mesoporous silica nanoparticles for drug delivery and biosensing applications. Adv. Funct. Mater., 2007, 17(8), 1225-1236.
11. Wu, G.; Barth, R.F.; Yang, W.; Lee, R.J.; Tjarks, W.; Backer, M.V.; Backer, J.M. Boron containing macromolecules and nanovehicles as delivery agents for neutron capture therapy. Anticancer Agents Med. Chem., 2006, 6(2), 167-184.
12. Ideta, R.; Tasaka, F.; Jang, W.D.; Nishiyama, N.; Zhang, G.D.; Harada, A.; Yanagi, Y.; Tamaki, Y.; Aida, T.; Kataoka, K. Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano Lett., 2005, 5(12), 2426-2431.
13. Lee, C.C.; MacKay, J.A.; Frechet, J.M.J.; Szoka, F.C. Designing dendrimers for biological applications. Nat. Biotechnol., 2005, 23(12), 1517-1526.
14. Tomalia, D.A.; Frechet, J.M.J. Discovery of dendrimers and dendritic polymers: A brief historical perspective. J. Polym. Sci. Part A Polym. Chem., 2002, 40(16), 2719-2728.
15. Shi, X.Y.; Lee, I.; Chen, X.S.; Shen, M.W.; Xiao, S.L.; Zhu, M.F.; Baker, J.R.; Wang, S.H. Influence of dendrimer surface charge on the bioactivity of 2-methoxyestradiol complexed with dendrimers. Soft Matter, 2010, 6(11), 2539-2545.
16. Kolhatkar, R.B.; Swaan, P.; Ghandehari, H. Potential oral delivery of 7-Ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers. Pharm. Res., 2008, 25(7), 1723-1729.
17. Guo, R.; Wang, H.; Peng, C.; Shen, M.W.; Pan, M.J.; Cao, X.Y.; Zhang, G.X.; Shi, X.Y. X-ray attenuation property of dendrimer-entrapped gold nanoparticles. J. Phys. Chem. C, 2010, 114(1), 50-56.
18. Shi, X.; Wang, S.H.; Meshinchi, S.; Van Antwerp, M.E.; Bi, X.D.; Lee, I.H.; Baker, J.R. Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and Imaging. Small, 2007, 3, 1245-1252.
19. Thiagarajan, G.; Ray, A.; Malugin, A.; Ghandehari, H. PAMAM-camptothecin conjugate inhibits proliferation and induces nuclear fragmentation in colorectal carcinoma cells. Pharm. Res., 2010, 27(11), 2307-2316.
20. Bi, X.; Shi, X.; Majoros, I.J.; Shukla, R.; Baker, J.R. Multifunctional poly(amidoamine) dendrimer-taxol conjugates: Synthesis, characterization and stability. J. Comput. Theor. Nanosci., 2007, 4(6), 1179-1187.
21. Majoros, I.J.; Thomas, T.P.; Mehta, C.B.; Baker, J.R. Poly(amidoamine) dendrimer-based multifunctional engineered nanodevice for cancer therapy. J. Med. Chem., 2005, 48(19), 5892-5899.
22. Shukla, R.; Thomas, T.P.; Peters, J.; Kotlyar, A.; Myc, A.; Baker Jr, J.R. Tumor angiogenic vasculature targeting with PAMAM dendrimer-RGD conjugates. Chem. Commun., 2005, (46), 5739-5741.
23. Zhang, Y.H.; Thomas, T.P.; Desai, A.; Zong, H.; Leroueil, P.R.; Majoros, I.J.; Baker, J.R. Targeted dendrimeric anticancer prodrug: A methotrexate-folic acid-poly(amidoamine) conjugate and a novel, rapid, "one pot" synthetic approach. Bioconjugate Chem., 2010, 21(3), 489-495.
24. Thomas, T.P.; Choi, S.K.; Li, M.-H.; Kotlyar, A.; Baker Jr, J.R. Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery. Bioorg. Med. Chem. Lett., 2010, 20(17), 5191-5194.
25. Cheng, Z.L.; Thorek, D.L.J.; Tsourkas, A. Porous polymersomes with encapsulated Gd-labeled dendrimers as highly efficient MRI contrast agents. Adv. Funct. Mater., 2009, 19(23), 3753-3759.
26. Shi, X.; Wang, S.H.; Swanson, S.D.; Ge, S.; Cao, Z.; Van Antwerp, M.E.; Landmark, K.J.; Baker, J.R., Jr. Dendrimer-functionalized shell-crosslinked iron oxide nanoparticles for in vivo magnetic resonance imaging of tumors. Adv. Mater., 2008, 20(9), 1671-1678.
27. Shi, X.Y.; Sun, K.; Balogh, L.P.; Baker, J.R. Synthesis, characterization, and manipulation of dendrimer-stabilized iron sulfide nanoparticles. Nanotechnology, 2006, 17(18), 4554-4560.
28. Esfand, R.; Tomalia, D.A. Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov. Today, 2001, 6(8), 427-436.
29. Huang, J.; Gao, F.; Tang, X.X.; Yu, J.H.; Wang, D.X.; Liu, S.Y.; Li, Y.P. Liver-targeting doxorubicin-conjugated polymeric prodrug with pH-triggered drug release profile. Polym. Int., 2010, 59(10), 1390-1396.
30. He, H.; Li, Y.; Jia, X.R.; Du, J.; Ying, X.; Lu, W.L.; Lou, J.N.; Wei, Y. PEGylated poly(amidoamine) dendrimer-based dualtargeting carrier for treating brain tumors. Biomaterials, 2010, 32(2), 478-487.
31. Kojima, C.; Kono, K.; Maruyama, K.; Takagishi, T. Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs. Bioconjugate Chem., 2000, 11(6), 910-917.
32. Chen, W.T.; Thirumalai, D.; Shih, T.T.F.; Chen, R.C.; Tu, S.Y.; Lin, C.I.; Yang, P.C. Dynamic contrast-enhanced folate-receptortargeted MR imaging using a Gd-loaded PEG-dendrimer-folate conjugate in a mouse xenograft tumor model. Mol. Imag. Biol., 2010, 12(2), 145-154.
33. Zhang, W.-L.; Li, N.; Huang, J.; Yu, J.-H.; Wang, D.-X.; Li, Y.-P.; Liu, S.-Y. Gadolinium-conjugated FA-PEG-PAMAM-COOH nanoparticles as potential tumor-targeted circulation-prolonged macromolecular MRI contrast agents. J. Appl. Polym. Sci., 2010, 118(3), 1805-1814.
34. Liu, H.; Wang, H.; Guo, R.; Cao, X.; Zhao, J.; Luo, Y.; Shen, M.; Zhang, G.; Shi, X. Size-controlled synthesis of dendrimer-stabilized silver nanoparticles for X-ray computed tomography imaging applications. Polym. Chem., 2010, 1(10), 1677-1683.
35. Li, Z.; Huang, P.; Lin, J.; He, R.; Liu, B.; Zhang, X.; Yang, S.; Xi, P.; Zhang, X.; Ren, Q.; Cui, D. Arginine-glycine-aspartic acid-conjugated dendrimer-modified quantum dots for targeting and imaging melanoma. J. Nanosci. Nanotechnol., 2010, 10, 1-9.
36. Myc, A.; Kukowska-Latallo, J.; Cao, P.; Swanson, B.; Battista, J.; Dunham, T.; Baker, J.R. Targeting the efficacy of a dendrimer-based nanotherapeutic in heterogeneous xenograft tumors in vivo. Anti-Cancer Drugs, 2010, 21(2), 186-192.
37. Jiang, Y.Y.; Tang, G.T.; Zhang, L.H.; Kong, S.Y.; Zhu, S.J.; Pei, Y.Y. PEGylated PAMAM dendrimers as a potential drug delivery carrier: in vitro and in vivo comparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex. J. Drug Targeting, 2010, 18(5), 389-403.
38. Ke, W.L.; Zhao, Y.S.; Huang, R.Q.; Jiang, C.; Pei, Y.Y. Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. J. Pharm. Sci., 2008, 97(6), 2208-2216.
39. Caminade, A.M.; Turrin, C.O.; Majoral, J.P. Dendrimers and DNA: Combinations of two special topologies for nanomaterials and biology. Chem. Eur. J., 2008, 14(25), 7422-7432.
40. Dufès, C.; Uchegbu, I.F.; Schätzlein, A.G. Dendrimers in gene delivery. Adv. Drug Del. Rev., 2005, 57(15), 2177-2202.
41. Wolinsky, J.B.; Grinstaff, M.W. Therapeutic and diagnostic applications of dendrimers for cancer treatment. Adv. Drug Del. Rev., 2008, 60(9), 1037-1055.
42. Cheng, Z.L.; Thorek, D.L.J.; Tsourkas, A. Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T-1 magnetic resonance imaging contrast agent. Angew. Chem. Int. Ed., 2010, 49(2), 346-350.
43. Landmark, K.J.; DiMaggio, S.; Ward, J.; Kelly, C.V.; Vogt, S.; Hong, S.; Kotlyar, A.; Myc, A.; Thomas, T.P.; Penner-Hahn, J.E.; Baker, J.R.; Holl, M.M.B.; Orr, B.G. Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugated dendrimers. ACS Nano, 2008, 2(4), 773-783.
44. Wang, H.; Zheng, L.; Peng, C.; Guo, R.; Shen, M.; Shi, X.; Zhang, G. Computed tomography imaging of cancer cells using acetylated dendrimer-entrapped gold nanoparticles. Biomaterials, 2011, 32(11), 2979-2988.
45. Morgan, M.T.; Nakanishi, Y.; Kroll, D.J.; Griset, A.P.; Carnahan, M.A.; Wathier, M.; Oberlies, N.H.; Manikumar, G.; Wani, M.C.; Grinstaff, M.W. Dendrimer-encapsulated camptothecins: Increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro. Cancer Res., 2006, 66(24), 11913-11921.
46. Wang, Y.; Guo, R.; Cao, X.Y.; Shen, M.W.; Shi, X.Y. Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials, 2011, 32(12), 3322-3329.
47. Han, L.; Huang, R.; Li, J.; Liu, S.; Huang, S.; Jiang, C. Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer. Biomaterials, 2011, 32(4), 1242-1252.
48. Bhadra, D.; Bhadra, S.; Jain, S.; Jain, N.K. A PEGylated dendritic nanoparticulate carrier of fluorouracil. Int. J. Pharm., 2003, 257(1-2), 111-124.
49. Devarakonda, B.; Hill, R.A.; de Villiers, M.M. The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine. Int. J. Pharm., 2004, 284(1-2), 133-140.
50. Yang, K.; Weng, L.A.; Cheng, Y.Y.; Zhang, H.F.; Zhang, J.H.; Wu, Q.L.; Xu, T.W. Host-guest chemistry of dendrimer-drug complexes. 6. fully acetylated dendrimers as biocompatible drug vehicles using dexamethasone 21-phosphate as a model drug. J. Phys. Chem. B, 2011, 115(10), 2185-2195.
51. Gupta, U.; Agashe, H.B.; Asthana, A.; Jain, N.K. Dendrimers: Novel polymeric nanoarchitectures for solubility enhancement. Biomacromolecules, 2006, 7(3), 649-658.
52. Quintana, A.; Raczka, E.; Piehler, L.; Lee, I.; Myc, A.; Majoros, I.; Patri, A.K.; Thomas, T.; Mule, J.; Baker, J.R. Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm. Res., 2002, 19(9), 1310-1316.
53. Vijayalakshmi, N.; Ray, A.; Malugin, A.; Ghandehari, H. Carboxyl-terminated PAMAM-SN38 conjugates: Synthesis, characterization, and in vitro evaluation. Bioconjugate Chem., 2010, 21(10), 1804-1810.
54. Shukla, R.; Thomas, T.P.; Desai, A.M.; Kotlyar, A.; Park, S.J.; Baker Jr, J.R. HER2 specific delivery of methotrexate by dendrimer conjugated anti-HER2 mAb. Nanotechnology, 2008, 19(29).
55. Thomas, T.P.; Shukla, R.; Kotlyar, A.; Kukowska-Latallo, J.; Baker Jr, J.R. Dendrimer-based tumor cell targeting of fibroblast growth factor-1. Bioorg. Med. Chem. Lett., 2010, 20(2), 700-703.
56. Li, Z.; Huang, P.; Zhang, X.; Lin, J.; Yang, S.; Liu, B.; Gao, F.; Xi, P.; Ren, Q.; Cui, D. RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol. Pharmaceutics, 2010, 7, 94-104.
57. Patri, A.K.; Kukowska-Latallo, J.F.; Baker, J.R. Targeted drug delivery with dendrimers: Comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Adv. Drug Del. Rev., 2005, 57(15), 2203-2214.
58. Sun, X.; Dong, S.; Wang, E. One-step preparation and characterization of poly(propyleneimine) dendrimer-protected silver nano-clusters. Macromolecules, 2004, 37, 7105-7108.
59. Sutton, A.; Franc, G.; Kakkar, A. Silver metal nanoparticles: Facile dendrimer-assisted size-controlled synthesis and selective catalytic reduction of chloronitrobenzenes. J. Polym. Sci. Part A: Polym. Chem., 2009, 47, 4482-4493.
60. Auten, B.J.; Hahn, B.P.; Vijayaraghavan, G.; Stevenson, K.J.; Chandler, B.D. Preparation and characterization of 3 nm magnetic NiAu nanoparticles. J. Phys. Chem. C, 2008, 112(14), 5365-5372.
61. Weir, M.G.; Knecht, M.R.; Frenkel, A.I.; Crooks, R.M. Structural analysis of PdAu dendrimer-encapsulated bimetallic nanoparticles. Langmuir, 2010, 26(2), 1137-1146.
62. Satoh, N.; Nakashima, T.; Kamikura, K.; Yamamoto, K. Quantum size effect in TiO2 nanoparticles prepared by finely controlled metal assembly on dendrimer templates. Nat. Nanotechnol., 2008, 3(2), 106-111.
63. Sooklal, K.; Hanus, L.H.; Ploehn, H.J.; Murphy, C.J. A blueemitting CdS/dendrimer nanocomposite. Adv. Mater., 1998, 10(14), 1083-1087.
64. Triulzi, R.C.; Micic, M.; Giordani, S.; Serry, M.; Chiou, W.-A.; Leblanc, R.M. Immunoasssay based on the antibody-conjugated PAMAM-dendrimer-gold quantum dot complex. Chem. Commun., 2006, (48), 5068-5070.
65. Campos, B.B.; Algarra, M.; da Silva, J. Fluorescent properties of a hybrid cadmium sulfide-dendrimer nanocomposite and its quenching with nitromethane. J. Fluoresc., 2010, 20(1), 143-151.
66. Shen, M.W.; Shi, X.Y. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications. Nanoscale, 2010, 2(9), 1596-1610.
67. Shi, X.Y.; Lee, I.; Baker, J.R. Acetylation of dendrimer-entrapped gold and silver nanoparticles. J. Mater. Chem., 2008, 18(5), 586-593.
68. Shen, M.W.; Sun, K.; Shi, X.Y. Hydroxylated dendrimer-stabilized gold and silver nanoparticles: Spontaneous formation, characterization, and surface properties. Curr. Nanosci., 2010, 6(3), 307-314.
69. Wisher, A.C.; Bronstein, I.; Chechik, V. Thiolated PAMAM den-drimer-coated CdSe/ZnSe nanoparticles as protein transfection agents. Chem. Commun., 2006, (15), 1637-1639.
70. Pan, B.F.; Cui, D.X.; Xu, P.; Ozkan, C.; Feng, G.; Ozkan, M.; Huang, T.; Chu, B.F.; Li, Q.; He, R.; Hu, G.H. Synthesis and characterization of polyamidoamine dendrimer-coated multi-walled carbon nanotubes and their application in gene delivery systems. Nanotechnology, 2009, 20(12), 9.
71. Pan, B.F.; Gao, F.; Ao, L.M.; Tian, H.Y.; He, R.; Cui, D.X. Controlled self-assembly of thiol-terminated poly(amidoamine) den-drimer and gold nanoparticles. Colloids Surf. A Physicochem. Eng. Aspects, 2005, 259(1-3), 89-94.
72. Wang, S.; Shi, X.; Van Antwerp, M.; Cao, Z.; Swanson, S.D.; Bi, X.; Baker, J.R., Jr. Dendrimer-functionalized iron oxide nanoparticles for specific targeting and imaging of cancer cells. Adv. Funct. Mater., 2007, 17, 3043-3050.
73. Rosario-Amorin, D.; Wang, X.; Gaboyard, M.; Clerac, R.; Nlate, S.; Heuze, K. Dendron-functionalized core-shell superparamagnetic nanoparticles: magnetically recoverable and reusable catalysts for Suzuki C-C cross-coupling reactions. Chem. Eur. J., 2009, 15(46), 12636-12643.
74. Heuze, K.; Rosario-Amorin, D.; Nlate, S.; Gaboyard, M.; Boutercd, A.; Clerac, R. Efficient strategy to increase the surface functionalization of core-shell superparamagnetic nanoparticles using dendron grafting. New J. Chem., 2008, 32(3), 383-387.
75. Pan, B.F.; Cui, D.X.; Sheng, Y.; Ozkan, C.G.; Gao, F.; He, R.; Li, Q.; Xu, P.; Huang, T. Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system. Cancer Res., 2007, 67(17), 8156-8163.
76. Venuganti, V.V.K.; Perumal, O.P. Effect of poly(amidoamine) (PAMAM) dendrimer on skin permeation of 5-fluorouracil. Int. J. Pharm., 2008, 361(1-2), 230-238.
77. Khandare, J.J.; Jayant, S.; Singh, A.; Chandna, P.; Wang, Y.; Vorsa, N.; Minko, T. Dendrimer versus linear conjugate: Influence of polymeric architecture on the delivery and anticancer effect of paclitaxel. Bioconjugate Chem., 2006, 17(6), 1464-1472.
78. Kono, K.; Kojima, C.; Hayashi, N.; Nishisaka, E.; Kiura, K.; Wataral, S.; Harada, A. Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin. Biomaterials, 2008, 29(11), 1664-1675.
79. Majoros, I.J.; Myc, A.; Thomas, T.; Mehta, C.B.; Baker, J.R. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: Synthesis, characterization, and functionality. Biomacromolecules, 2006, 7(2), 572-579.
80. Singh, P.; Gupta, U.; Asthana, A.; Jain, N.K. Folate and folate-PEG-PAMAM dendrimers: Synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice. Bioconjugate Chem., 2008, 19(11), 2239-2252.
81. Choi, S.K.; Thomas, T.; Li, M.H.; Kotlyar, A.; Desai, A.; Baker, J.R. Light-controlled release of caged doxorubicin from folate receptor-targeting PAMAM dendrimer nanoconjugate. Chem. Commun., 2010, 46(15), 2632-2634.
82. Majoros, I.J.; Williams, C.R.; Becker, A.; Baker, J.R. Methotrexate delivery via folate targeted dendrimer-based nanotherapeutic platform. Wiley Interdiscip. Rev.-Nanomed. Nanobiotechnol., 2009, 1(5), 502-510.
83. Hong, S.; Leroueil, P.R.; Majoros, I.J.; Orr, B.G.; Baker Jr, J.R.; Banaszak Holl, M.M. The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform. Chem. Biol., 2007, 14(1), 107-115.
84. Thomas, T.P.; Majoros, I.J.; Kotlyar, A.; Kukowska-Latallo, J.F.; Bielinska, A.; Myc, A.; Baker, J.R. Targeting and inhibition of cell growth by an engineered dendritic nanodevice. J. Med. Chem., 2005, 48(11), 3729-3735.
85. Yang, W.; Cheng, Y.; Xu, T.; Wang, X.; Wen, L.-p. Targeting cancer cells with biotin-dendrimer conjugates. Eur. J. Med. Chem., 2009, 44(2), 862-868.
86. Shukla, R.; Thomas, T.P.; Peters, J.L.; Desai, A.M.; Kukowska-Latallo, J.; Patri, A.K.; Kotlyar, A.; Baker Jr, J.R. HER2 specific tumor targeting with dendrimer conjugated anti-HER2 mAb. Bioconjugate Chem., 2006, 17(5), 1109-1115.
87. Wu, G.; Barth, R.F.; Yang, W.; Kawabata, S.; Zhang, L.; Green-Church, K. Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates. Mol. Cancer Ther., 2006, 5(1), 52-59.
88. Oh, S.; Kim, B.J.; Singh, N.P.; Lai, H.; Sasaki, T. Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide. Cancer Lett., 2009, 274(1), 33-39.
89. Han, L.A.; Huang, R.Q.; Liu, S.H.; Huang, S.X.; Jiang, C. Peptide-conjugated PAMAM for targeted doxorubicin delivery to transferrin teceptor overexpressed tumors. Mol. Pharmaceutics, 2010, 7(6), 2156-2165.
90. Shukla, R.; Hill, E.; Shi, X.; Kim, J.; Muniz, M.C.; Sun, K.; Baker, J.R. Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles. Soft Matter, 2008, 4(11), 2160-2163.
91. Hui, H.; Fan, X.D.; Cao, Z.L. Thermo- and pH-sensitive dendrimer derivatives with a shell of poly (N,N-dimethylaminoethyl methacrylate) and study of their controlled drug release behavior. Polymer, 2005, 46(22), 9514-9522.
92. Lai, P.S.; Lou, P.J.; Peng, C.L.; Pai, C.L.; Yen, W.N.; Huang, M.Y.; Young, T.H.; Shieh, M.J. Doxorubicin delivery by polyamidoamine dendrimer conjugation and photochemical internalization for cancer therapy. J. Control. Release, 2007, 122(1), 39-46.
93. Zhu, S.J.; Hong, M.H.; Tang, G.T.; Qian, L.L.; Lin, J.Y.; Jiang, Y.Y.; Pei, Y.Y. Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: The effects of PEGylation degree and drug conjugation style. Biomaterials, 2010, 31(6), 1360-1371.
94. Zhu, S.; Hong, M.; Zhang, L.; Tang, G.; Jiang, Y.; Pei, Y. PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation. Pharm. Res., 2010, 27(1), 161-174.
95. Boisselier, E.; Diallo, A.K.; Salmon, L.; Ornelas, C.; Ruiz, J.; Astruc, D. Encapsulation and stabilization of gold nanoparticles with "Click" polyethyleneglycol dendrimers. J. Am. Chem. Soc., 2010, 132(8), 2729-2742.
96. Yamamoto, D.; Watanabe, S.; Miyahara, M.T. Coordination and reduction processes in the synthesis of dendrimer-encapsulated Pt nanoparticles. Langmuir, 2010, 26(4), 2339-2345.
97. Uzun, K.; Cevik, E.; Senel, M.; Sozeri, H.; Baykal, A.; Abasiyanik, M.F.; Toprak, M.S. Covalent immobilization of invertase on PAMAM-dendrimer modified superparamagnetic iron oxide nanoparticles. J. Nanopart. Res., 2010, 12(8), 3057-3067.
98. Criscione, J.M.; Le, B.L.; Stern, E.; Brennan, M.; Rahner, C.; Papademetris, X.; Fahmy, T.M. Self-assembly of pH-responsive fluorinated dendrimer-based particulates for drug delivery and non-invasive imaging. Biomaterials, 2009, 30(23-24), 3946-3955.
99. Fayad, Z.A.; Fallon, J.T.; Shinnar, M.; Wehrli, S.; Dansky, H.M.; Poon, M.; Badimon, J.J.; Charlton, S.A.; Fisher, E.A.; Breslow, J.L.; Fuster, V. Noninvasive in vivo high-resolution magnetic resonance imaging of atherosclerotic lesions in genetically engineered mice. Circulation, 1998, 98(15), 1541-1547.
100. Langereis, S.; Dirksen, A.; Hackeng, T.M.; van Genderen, M.H.P.; Meijer, E.W. Dendrimers and magnetic resonance imaging. New J. Chem., 2007, 31(7), 1152-1160.
101. Lei, X.G.; Jockusch, S.; Turro, N.J.; Tomalia, D.A.; Ottaviani, M.F. EPR characterization of gadolinium(III)-containing-PAMAM-dendrimers in the absence and in the presence of paramagnetic probes. J. Colloid Interface Sci., 2008, 322(2), 457-464.
102. Menjoge, A.R.; Kannan, R.M.; Tomalia, D.A. Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications. Drug Discov. Today, 2010, 15(5-6), 171-185.
103. Margerum, L.D.; Campion, B.K.; Koo, M.; Shargill, N.; Lai, J.-J.; Marumoto, A.; Christian Sontum, P. Gadolinium(III) DO3A macrocycles and polyethylene glycol coupled to dendrimers Effect of molecular weight on physical and biological properties of macro-molecular magnetic resonance imaging contrast agents. J. Alloys Compd., 1997, 249(1-2), 185-190.
104. Wiener, E.C.; Brechbiel, M.W.; Brothers, H.; Magin, R.L.; Gansow, O.A.; Tomalia, D.A.; Lauterbur, P.C. Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents. Magn. Reson. Med., 1994, 31(1), 1-8.
105. Sato, N.; Kobayashi, H.; Hiraga, A.; Saga, T.; Togashi, K.; Konishi, J.; Brechbiel, M.W. Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores. Magn. Reson. Med., 2001, 46(6), 1169-1173.
106. Xu, H.; Regino, C.A.S.; Bernardo, M.; Koyama, Y.; Kobayashi, H.; Choyke, P.L.; Brechbiel, M.W. Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: New bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry. J. Med. Chem., 2007, 50(14), 3185-3193.
107. Kobayashi, H.; Kawamoto, S.; Saga, T.; Sato, N.; Hiraga, A.; Konishi, J.; Togashi, K.; Brechbiel, M.W. Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: Reference to pharmacokinetic properties of den-drimer-based MR contrast agents. J. Magn. Reson. Imaging, 2001, 14(6), 705-713.
108. Kobayashi, H.; Sato, N.; Hiraga, A.; Saga, T.; Nakamoto, Y.; Ueda, H.; Konishi, J.; Togashi, K.; Brechbiel, M.W. 3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties. Magn. Reson. Med., 2001, 45(3), 454-460.
109. Kobayashi, H.; Kawamoto, S.; Jo, S.-K.; Bryant, H.L.; Brechbiel, M.W.; Star, R.A. Macromolecular MRI contrast agents with small dendrimers: Pharmacokinetic differences between sizes and cores. Bioconjugate Chem., 2003, 14(2), 388-394.
110. Kobayashi, H.; Brechbiel, M.W. Nano-sized MRI contrast agents with dendrimer cores. Adv. Drug Del. Rev., 2005, 57(15), 2271-2286.
111. Nwe, K.; Xu, H.; Regino, C.A.S.; Bernardo, M.; Ileva, L.; Riffle, L.; Wong, K.J.; Brechbiel, M.W. A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives. Bioconjugate Chem., 2009, 20(7), 1412-1418.
112. Nwe, K.; Bryant, L.H.; Brechbiel, M.W. Poly(amidoamine) den-drimer based MRI contrast agents exhibiting enhanced relaxivities derived via metal preligation techniques. Bioconjugate Chem., 2010, 21(6), 1014-1017.
113. Swanson, S.D.; Kukowska-Latallo, J.F.; Patri, A.K.; Chen, C.Y.; Ge, S.; Cao, Z.Y.; Kotlyar, A.; East, A.T.; Baker, J.R. Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. Int. J. Nanomed., 2008, 3(2), 201-210.
114. De Leon-Rodriguez, L.M.; Lubag, A.; Udugamasooriya, D.G.; Proneth, B.; Brekken, R.A.; Sun, X.K.; Kodadek, T.; Sherry, A.D. MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)(8)-dendron for targeting. J. Am. Chem. Soc., 2010, 132(37), 12829-12831.
115. Shi, X.; Thomas, T.P.; Myc, L.A.; Kotlyar, A.; Baker, J.R., Jr. Synthesis, characterization, and intracellular uptake of carboxylterminated poly(amidoamine) dendrimer-stabilized iron oxide nanoparticles. Phys. Chem. Chem. Phys., 2007, 9, 5712 - 5720.
116. Ogawa, M.; Nitahara, S.; Aoki, H.; Ito, S.; Narazaki, M.; Matsuda, T. Fluorinated polymer nanoparticles as a novel 19F MRI contrast agent prepared by dendrimer-initiated living radical polymerization. Macromol. Chem. Phys., 2010, 211(12), 1369-1376.
117. Rabin, O.; Perez, J.M.; Grimm, J.; Wojtkiewicz, G.; Weissleder, R. An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles. Nat. Mater., 2006, 5(2), 118-122.
118. Kim, D.; Park, S.; Lee, J.H.; Jeong, Y.Y.; Jon, S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging. J. Am. Chem. Soc., 2007, 129(24), 7661-7665.
119. Popovtzer, R.; Agrawal, A.; Kotov, N.A.; Popovtzer, A.; Balter, J.; Carey, T.E.; Kopelman, R. Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett., 2008, 8(12), 4593-4596.
120. Aviv, H.; Bartling, S.; Kieslling, F.; Margel, S. Radiopaque iodinated copolymeric nanoparticles for X-ray imaging applications. Biomaterials, 2009, 30(29), 5610-5616.
121. Joshi, N.S.; Bansal, P.N.; Stewart, R.C.; Snyder, B.D.; Grinstaff, M.W. Effect of contrast agent charge on visualization of articular cartilage using computed tomography: exploiting electrostatic interactions for improved sensitivity. J. Am. Chem. Soc., 2009, 131(37), 13234-13235.
122. de Vries, A.; Custers, E.; Lub, J.; van den Bosch, S.; Nicolay, K.; Grull, H. Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents. Biomaterials, 2010, 31(25), 6537-6544.
123. Hallouard, F.; Anton, N.; Choquet, P.; Constantinesco, A.; Vandamme, T. Iodinated blood pool contrast media for preclinical X-ray imaging applications - a review. Biomaterials, 2010, 31(24), 6249-6268.
124. Kojima, C.; Umeda, Y.; Ogawa, M.; Harada, A.; Magata, Y.; Kono, K. X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer. Nanotechnology, 2010, 21(24), 245104.
125. Yordanov, A.T.; Lodder, A.L.; Woller, E.K.; Cloninger, M.J.; Patronas, N.; Milenic, D.; Brechbiel, M.W. Novel iodinated dendritic nanoparticles for computed tomography (CT) imaging. Nano Lett., 2002, 2(6), 595-599.
126. Fu, Y.J.; Nitecki, D.E.; Maltby, D.; Simon, G.H.; Berejnoi, K.; Raatschen, H.J.; Yeh, B.M.; Shames, D.M.; Brasch, R.C. Dendritic iodinated contrast agents with PEG-cores for CT imaging: Synthesis and preliminary characterization. Bioconjugate Chem., 2006, 17(4), 1043-1056.
127. Peng, C.; Wang, H.; Guo, R.; Shen, M.; Cao, X.; Zhu, M.; Zhang, G.; Shi, X. Acetylation of dendrimer-entrapped gold nanoparticles: Synthesis, stability, and X-ray attenuation properties. J. Appl. Polym. Sci., 2011, 119(3), 1673-1682.
128. Michalet, X.; Pinaud, F.F.; Bentolila, L.A.; Tsay, J.M.; Doose, S.; Li, J.J.; Sundaresan, G.; Wu, A.M.; Gambhir, S.S.; Weiss, S. Quantum dots for live cells, in vivo imaging, and diagnostics. Science, 2005, 307(5709), 538-544.
129. Huang, J.M.; Sooklal, K.; Murphy, C.J.; Ploehn, H.J. Polyamine-quantum dot nanocomposites: Linear versus starburst stabilizer architectures. Chem. Mater., 1999, 11(12), 3595-3601.
130. Wu, X.C.; Bittner, A.M.; Kern, K. Synthesis, photoluminescence, and adsorption of CdS/dendrimer nanocomposites. J. Phys. Chem. B, 2004, 109(1), 230-239.
131. Lemon, B.I.; Crooks, R.M. Preparation and characterization of dendrimer-encapsulated CdS semiconductor quantum dots. J. Am. Chem. Soc., 2000, 122(51), 12886-12887.
132. Priyam, A.; Blumling, D.E.; Knappenberger, K.L. Synthesis, characterization, and self-organization of dendrimer-encapsulated HgTe quantum dots. Langmuir, 2010, 26(13), 10636-10644.
133. Zhao, Y.; Liu, S.; Li, Y.; Jiang, W.; Chang, Y.; Pan, S.; Fang, X.; Wang, Y.A.; Wang, J. Synthesis and grafting of folate-PEG-PAMAM conjugates onto quantum dots for selective targeting of folate-receptor-positive tumor cells. J. Colloid Interface Sci., 2010, 350(1), 44-50.
134. Li, Z.; Huang, P.; He, R.; Lin, J.; Yang, S.; Zhang, X.; Ren, Q.; Cui, D. Aptamer-conjugated dendrimer-modified quantum dots for cancer cell targeting and imaging. Mater. Lett., 2010, 64(3), 375-378.
135. Kobayashi, H.; Wu, C.C.; Kim, M.K.; Paik, C.H.; Carrasquillo, J.A.; Brechbiel, M.W. Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody. Bioconjugate Chem., 1999, 10(1), 103-111.
136. Sato, N.; Park, C.W.; Kim, H.S.; Han, E.S.; Wong, K.J.; Paik, R.S.; Park, L.S.; Yao, Z.S.; Carrasquillo, J.A.; Paik, C.H. Synthesis of dendrimer-based biotin radiopharmaceuticals to enhance whole-body clearance. Nucl. Med. Biol., 2003, 30(6), 617-625.
137. Almutairi, A.; Rossin, R.; Shokeen, M.; Hagooly, A.; Ananth, A.; Capoccia, B.; Guillaudeu, S.; Abendschein, D.; Anderson, C.J.; Welch, M.J.; Frechet, J.M.J. Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis. Proc. Natl. Acad. Sci. U. S. A., 2009, 106(3), 685-690.
138. Zhang, Y.Q.; Sun, Y.H.; Xu, X.P.; Zhang, X.Z.; Zhu, H.; Huang, L.L.; Qi, Y.J.; Shen, Y.M. Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates. J. Med. Chem., 2010, 53(8), 3262-3272.