Cytochrome P450 2A13 is an efficient enzyme in metabolic activation of aflatoxin G1 in human bronchial epithelial cells

Archives of Toxicology

Volumn 87, Issue 9, 2013, Pages 1697-1707

  Zhang, Zhan ^a   Yang, Xuejiao ^a,b   Wang, Yun ^a   Wang, Xichen ^a   Lu, Huiyuan ^a   Zhang, Xiaoming ^a   Xiao, Xue ^a   Li, Shushu ^a   Wang, Xinru ^a   Wang, Shou Lin ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Jiaojiang District Center for Disease Control and Prevention of Taizhou   (China)

Author keywords

Aflatoxin G1; BEAS 2B cells; Cytochrome P450 2A13; Cytotoxicity; DNA damage; Metabolic activation

Indexed keywords

AFLATOXIN G1; ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CASPASE 3; CHECKPOINT KINASE 2; CYTOCHROME P450; CYTOCHROME P450 2A13; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BRONCHIAL EPITHELIUM CELL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME MECHANISM; EPITHELIUM CELL; HUMAN; HUMAN CELL; METABOLIC ACTIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION;

AFLATOXIN B1; AFLATOXINS; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL TRANSPORT; BIOTRANSFORMATION; BRONCHI; CELL NUCLEUS; CELL SURVIVAL; CLONE CELLS; DEOXYGUANOSINE; DNA DAMAGE; HISTONES; HUMANS; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA; RNA INTERFERENCE; S PHASE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84883551030     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1108-3     Document Type: Article

References (42)

1. Bao Z, He XY, Ding X, Prabhu S, Hong JY (2005) Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug Metab Dispos 33(2):258-261 (Pubitemid 40216593)
2. Carvajal M, Berumen J, Guardado-Estrada M (2012) The presence of aflatoxin B(1)-FAPY adduct and human papilloma virus in cervical smears from cancer patients in Mexico. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29(2):258-268
3. Debbabi H, Ghosh S, Kamath AB et al (2005) Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4 + T cells. Am J Physiol Lung Cell Mol Physiol 289(2):L274-L279 (Pubitemid 41008910)
4. Ding X, Kaminsky LS (2003) Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149-173 (Pubitemid 37372638)
5. Espinoza LA, Tenzin F, Cecchi AO, Chen Z, Witten ML, Smulson ME (2006) Expression of JP-8-induced inflammatory genes in AEII cells is mediated by NF-kappaB and PARP-1. Am J Respir Cell Mol Biol 35(4):479-487 (Pubitemid 44477648)
6. Funamizu N, Lacy CR, Fujita K et al (2012) Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS ONE 7(5):e37424
7. Guo Z, Kumagai A, Wang SX, Dunphy WG (2000) Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev 14(21):2745-2756 (Pubitemid 32531201)
8. Gursoy-Yuzugullu O, Yuzugullu H, Yilmaz M, Ozturk M (2011) Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. Liver Int 31(4):561-571
9. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY (2006) Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. Int J Cancer 118(11):2665-2671 (Pubitemid 43673342)
10. IARC (2002) Aflatoxin. In: IARC (ed) Monograph evaluation of carcinogenic risk to humans. Some traditional herbal medicines. Some Mycotoxins, Naphthalene and Styrene, pp 171-300
11. Kannan S, Wu M (2006) Respiratory stem cells and progenitors: overview, derivation, differentiation, carcinogenesis, regeneration and therapeutic application. Curr Stem Cell Res Ther 1(1):37-46
12. Kemp MG, Lindsey-Boltz LA, Sancar A (2011) The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) are stimulated by bulky adduct-containing DNA. J Biol Chem 286(22):19237-19246
13. Khan MR, Alothman ZA, Ghfar AA, Wabaidur SM (2013) Analysis of aflatoxins in nonalcoholic beer using liquid-liquid extraction and ultraperformance LC-MS/MS. J Sep Sci 36(3):572-577
14. Lewis CW, Smith JE, Anderson JG, Freshney RI (1999) Increased cytotoxicity of food-borne mycotoxins toward human cell lines in vitro via enhanced cytochrome p450 expression using the MTT bioassay. Mycopathologia 148(2):97-102 (Pubitemid 32046415)
15. Liao W, McNutt MA, Zhu WG (2009) The comet assay: a sensitive method for detecting DNA damage in individual cells. Methods 48(1):46-53
16. Mah LJ, El-Osta A, Karagiannis TC (2010) GammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 24(4):679-686
17. Massey TE, Smith GB, Tam AS (2000) Mechanisms of aflatoxin B1 lung tumorigenesis. Exp Lung Res 26(8):673-683 (Pubitemid 32044585)
18. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 97(19):10389-10394
19. Mushtaq M, Sultana B, Anwar F, Khan MZ, Ashrafuzzaman M (2012) Occurrence of aflatoxins in selected processed foods from Pakistan. Int J Mol Sci 13(7):8324-8337
20. Peng T, Li LQ, Peng MH et al (2007) Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1 - a multi-center and multi-biomarker study. Carcinogenesis 28(11):2347-2354 (Pubitemid 350111593)
21. Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM (2000) Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem 275(13):9390-9395 (Pubitemid 30185164)
22. Roos WP, Kaina B (2012) DNA damage-induced apoptosis: from specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett 332(2):237-248
23. Sak A, Stuschke M (2010) Use of gammaH2AX and other biomarkers of double-strand breaks during radiotherapy. Semin Radiat Oncol 20(4):223-231
24. Sato K, Tomioka H, Shimizu T, Gonda T, Ota F, Sano C (2002) Type II alveolar cells play roles in macrophage-mediated host innate resistance to pulmonary mycobacterial infections by producing proinflammatory cytokines. J Infect Dis 185(8):1139-1147 (Pubitemid 34297772)
25. Serrano MA, Li Z, Dangeti M, et al. (2013) DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. Oncogene 32(19):2452-2562
26. Shen Y, White E (2001) p53-dependent apoptosis pathways. Adv Cancer Res 82:55-84 (Pubitemid 32613382)
27. Shen HM, Ong CN, Lee BL, Shi CY (1995) Aflatoxin B1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA. Carcinogenesis 16(2):419-422
28. Shen HT, Zhang XH, Huang XH et al (2005) Histogenesis of lung adenocarcinoma induced by oral adminstration of mycotoxins in mice. Wei Sheng Yan Jiu 34(3):341-344
29. Shen H, Lv P, Xing X et al (2012) Impairment of alveolar type-II cells involved in the toxicity of Aflatoxin G(1) in rat lung. Food Chem Toxicol 50(9):3222-3228
30. Stecklein SR, Kumaraswamy E, Behbod F et al (2012) BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. Proc Natl Acad Sci USA 109(34):13650-13655
31. Stoimenov I, Schultz N, Gottipati P, Helleday T (2011) Transcription inhibition by DRB potentiates recombinational repair of UV lesions in mammalian cells. PLoS ONE 6(5):e19492
32. Tam AS, Devereux TR, Patel AC, Foley JF, Maronpot RR, Massey TE (2003) Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors. Carcinogenesis 24(1):121-132 (Pubitemid 36196729)
33. von Weymarn LB, Zhang QY, Ding X, Hollenberg PF (2005) Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis 26(3):621-629 (Pubitemid 41214152)
34. von Weymarn LB, Brown KM, Murphy SE (2006) Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism. J Pharmacol Exp Ther 316(1):295-303 (Pubitemid 41832609)
35. Wu Y, Qi X, Gong L et al (2012) Identification of BC005512 as a DNA damage responsive murine endogenous retrovirus of GLN family involved in cell growth regulation. PLoS ONE 7(4):e35010
36. Yang XJ, Lu HY, Li ZY et al (2012) Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells. Toxicology 300(3):138-148
37. Zgheib O, Huyen Y, DiTullio RA Jr et al (2005) ATM signaling and 53BP1. Radiother Oncol 76(2):119-122 (Pubitemid 41725436)
38. Zhang X, Wang F, Wang J et al (2003) Experimental lung carcinoma induced by fungi and mycotoxins-a review. Beijing Da Xue Xue Bao 35(1):4-6
39. Zhang J, Willers H, Feng Z et al (2004) Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 24(2):708-718 (Pubitemid 38057922)
40. Zhang D, Li P, Zhang Q et al (2009) Production of ultrasensitive generic monoclonal antibodies against major aflatoxins using a modified two-step screening procedure. Anal Chim Acta 636(1):63-69
41. Zhang D, Li P, Zhang Q, Zhang W (2011) Ultrasensitive nanogold probe-based immunochromatographic assay for simultaneous detection of total aflatoxins in peanuts. Biosens Bioelectron 26(6):2877-2882
42. Zhu W, Dutta A (2006) An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Mol Cell Biol 26(12):4601-4611 (Pubitemid 43877578)