Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells

Toxicology

Volumn 300, Issue 3, 2012, Pages 138-148

  Yang, Xue Jiao ^a   Lu, Hui Yuan ^a   Li, Zi Yin ^a   Bian, Qian ^c   Qiu, Liang Lin ^a   Li, Zhong ^a   Liu, Qizhan ^a   Li, Jianmin ^b   Wang, Xinru ^a   Wang, Shou Lin ^a  

^a Nanjing Medical University   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Aflatoxin B 1; BEAS 2B cells; Cytochrome P450 2A13; Cytotoxicity; Metabolic activation; Mitochondrial signaling pathway

Indexed keywords

AFLATOXIN B1; CASPASE 3; CYTOCHROME P450; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; METHOXSALEN; NICOTINE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BRONCHIAL EPITHELIUM CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; METABOLIC ACTIVATION; PRIORITY JOURNAL;

AFLATOXIN B1; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BRONCHI; CELL LINE; CELL SURVIVAL; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; MITOCHONDRIA; PLASMIDS; TIME FACTORS; TRANSFECTION;

EID: 84864064045     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.06.010     Document Type: Article

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