Activation of the JAK/STAT pathway in human neutrophils by NDMA

Turkish Journal of Biology

Volumn 37, Issue 5, 2013, Pages 629-637

  Ratajczak Wrona, Wioletta ^a   Jablonska, Ewa ^a   Garley, Marzena ^a   Jablonski, Jakub ^a   Radziwon, Piotr ^b   Iwaniuk, Agnieszka ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b Regional Centre for Transfusion Medicine   (Poland)

Author keywords

Inducible nitric oxide synthase; JAK STAT; N nitrosodimethylamine; Neutrophils; Nitric oxide; Superoxide anion radical

Indexed keywords

EID: 84883541869     PISSN: 13000152     EISSN: 13036092     Source Type: Journal    
DOI: 10.3906/biy-1302-60     Document Type: Article

References (43)

1. Aiub CA, Gadermaier G, Oliveira I, Felzenszwalb I, Ferreira F, Pinto LFR, Eckl P (2011). N-Nitrosodimethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. Toxicol Lett 206: 139-143.
2. Beck KF, Eberhardt W, Frank S, Huwiler A, Messmer UK, Mühl H, Pfeilschifter J (1999). Inducible NO synthase: role in cellular signalling. J Exp Biol 202: 645-653.
3. Chanda S, Rakholiya K, Dholakia K, Baravalia Y (2013). Antimicrobial, antioxidant, and synergistic properties of two nutraceutical plants: Terminalia catappa L. and Colocasia esculenta L. Turk J Biol 37: 81-91.
4. Chatterjee-Kishore M, Wright KL, Ting JP, Stark GR (2000). How Statl mediates constitutive gene expression: a complex of unphosphorylated Statl and IRFI supports transcription of the LMP2 gene. Embo J 19: 4111-4122.
5. Chen CW, Chao Y, Chang YH, Hsu MJ, Lin WW (2002). Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid. Brit J Pharmacol 137: 1011-1020.
6. Dai R, Philips RA, Karpuzoglu E, Khan D, Ahmed SA (2009). Estrogen regulates transcription factors STAT-1 and NF-κB to promote inducible nitric oxide synthase and inflammatory responses. J Immunol 183: 6998-7005.
7. Demir E, Bülent K, Marcos R, Cenkci SK, Çetin H (2013). Investigation of the genotoxic and antigenotoxic properties of essential oils obtained from two Origanum species by Drosophila wing SMART assay. Turk J Biol 37: 129-138.
8. Demirci C, Dar KA, Uyaner I, (2001). Nitric oxide synthase in the skeletal muscle and arterioles of rats with streptozotosininduced diabetes mellitus. Turk J Biol 25: 159-169.
9. Dent G, Munoz NM, Zhu X, Ruhlmann E, Magnussen H, Leff AR, Rabe KF (2000). Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. Immunology 100: 231-237.
10. Dobo KL, Eastmond DA, Grosovsky AJ (1997). The influence of cellular apoptotic capacity on N-nitrosodimethylamineinduced loss of heterozygosity mutations in human cells. Carcinogenesis 18: 1701-1707.
11. Freitas MC, Uchida Y, Zhao D, Ke B, Busuttil RW, Kupiec-Weglinski JW (2010). Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion. Liver Transplant 16: 600-610.
12. Glavin OA, Mikhailenko PM, Zaletok SP, Gulua L (2008). Effects of green and black tea biocomposites on endogenous synthesis, metabolism, and genotoxic effect of carcinogenic N-nitrosodimethylamine. Exp Oncol 30: 306-314.
13. Greenhalgh CJ, Hilton DJ (2001). Negative regulation of cytokine signaling. J Leukocyte Biol 70: 348-356.
14. Haspel RL, Darnell JE (1999). A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. P Natl Acad Sci USA 96: 10188-10193.
15. Ihle JN (2001). The Stat family in cytokine signaling. Curr Opin Cell Biol 13: 211-217.
16. Jablonski J, Jablonska E, Iwanowska J, Marcinczyk M, MoniuszkoJakoniuk J (2006). The influence of human neutrophils on N-nitrosodimethylamine (NDMA) synthesis. Immunopharm Immunot 28: 93-102.
17. Kleinert H, Wallerath T, Fritz G, Ihrig-Biedert I, Rodriguez-Pascual F, Geller DA, Forstermann U (1998). Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1, and NF-kappaB-signaling pathways. Brit J Pharmacol 125: 193-201.
18. Konuk M, Şahin T, Ciǧerci IH, Fidan AF, Korcan SE (2012). Effects of α-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in subchronic thinner-addicted rats. Turk J Biol 36: 702-710.
19. Levy DE, Darnell JE (2002). Stats: transcriptional control and biological impact. Nat Rev Mol Cell Bio 3: 651-662.
20. Lirk P, Hoffmann G, Rieder J (2002). Inducible nitric oxide synthase - time for reappraisal. Curr Drug Targets 1: 89-108.
21. Liu L, McBride KM, Reich NC (2005). STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3. P Natl Acad Sci USA 102: 8150-8155.
22. McCord JM, Fridovich I (1969). The utility of superoxide dismutase in studying free radical reactions and radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem 244: 6056-6063.
23. Murray PJ (2007). The JAK-STAT signaling pathway: input and output integration. J Immunol 178: 2623-2629.
24. Nakashima O, Terada Y, Inoshita S, Kuwahara M, Sasaki S, Marumo F (1999). Inducible nitric oxide synthase can be induced in the absence of active nuclear factor-kb in rat mesangial cells: involvement of the Janus kinase 2 signaling pathway. J Am Soc Nephrol 10: 721-729.
25. Pranada AL, Metz S, Herrmann A, Heinrich PC, Müller-Newen G (2004). Real-time analysis of STAT3 nucleocytoplasmic shuttling. J Biol Chem 279: 15114-15123.
26. Ratajczak-Wrona W, Jablonska E, Garley M, Jablonski J, Radziwon P (2011). Effect of N- nitrosodimethylamine on inducible nitric oxide synthase expression and production of nitric oxide by neutrophils and mononuclear cells: the role of JNK signalling pathway. APMIS 119: 431-441.
27. Ratajczak-Wrona W, Jablonska E, Garley M, Jablonski J, Radziwon P, Iwaniuk A (2013a). The role of MAP kinases in the induction of iNOS expression in neutrophils exposed to NDMA: the involvement transcription factors. Adv Med Sci 58 (in press: the print version will be published in December 2013 in Volume 58 DOI: 10.2478/v10039-012-0074-y).
28. Ratajczak-Wrona W, Jablonska E, Garley M, Jablonski J, Radziwon P, Iwaniuk A (2013b). Role of AP-1 family proteins in regulation of inducible nitric oxide synthase (iNOS) in human neutrophils. J Immunotoxicol 10: 32-39.
29. Ratajczak-Wrona W, Jablonska E, Garley M, Jablonski J, Radziwon P (2013c). Role of ERK1/2 kinase in the expression of iNOS by NDMA in human neutrophils. Indian J Exp Biol 51: 73-80.
30. Ravichandran K, Tyagi A, Gagan D, Chapla A, Agarwal R (2011). Interleukin-1β-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways. Indian J Exp Biol 49: 840-847.
31. Reich NC, Liu L (2006). Tracking STAT nuclear traffic. Nat Rev Immunol 6: 602-612.
32. Sareila O, Korhonen R, Karpanniemi O, Nieminen R, Kankaanranta H, Moilanen E (2006). JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages. Mediat Inflamm 2: 16161-16168.
33. Schmidt N, Pautz A, Art J, Rauschkolb P, Jung M, Erkel G, Goldring MB, Kleinert H (2010). Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochem Pharmacol 79: 722-732.
34. Schulz K, Kerber S, Kelm M (1999). Reevaluation of the Griess method for determining NO/NO2 - in aqueous and protein containing samples. Nitric Oxide-Biol Ch 3: 225-234.
35. Sehgal PB, Kumar V, Guo G, Murray WC (2003). Different patterns of regulation of Tyr-phosphorylated STAT1 and STAT3 in human hepatoma Hep3B cells by the phosphatase inhibitor orthovanadate. Arch Biochem Biophys 412: 242-250.
36. Simon AR, Rai U, Fanburg BL, Cochran BH (1998). Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol 275: C1640-C1652.
37. Sohn HY, Krotz F, Zahler S, Gloe T, Keller M, Theisen K, Schiele TM, Klauss V, Pohl U (2003). Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation. Cardiovasc Res 57: 804-815.
38. Tricker AR, Preussmann R (1991). Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat Res 259: 277-289.
39. Vermeer IT, Engels LG, Pachen DM, Dallinga JW, Kleinjans JC, van Maanen JM (2001). Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole. Gastroenterology 121: 517-527.
40. Waller G, Goscinski A (1999). Endogenous synthesis of N-nitrosoamine and the long-lasting antiulcer treatment. Pol Gastroenterol 6: 421-426 (article in Polish with an abstract in English).
41. Yamaoka K, Saharinen P, Pesu M, Holt VE, Silvennoinen O, O'Shea JJ (2004). The Janus kinases (Jaks). Genome Biol 5: 253-259.
42. Zeilmaker MJ, Bakker MI, Schothorst R, Slob W (2010). Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals. Toxicol Sci 116: 323-335.
43. Zeman K, Tchorzewski H, Majewska E (1988). Simple and fast method of simultaneous isolation of lymphocytes and the polymorphonuclear cells from peripheral blood. Immunol Pol 13: 217-220 (article in Polish).