Interleukin-1β-induced iNOS expression in human lung carcinoma A549 cells: Involvement of STAT and MAPK pathways

Indian Journal of Experimental Biology

Volumn 49, Issue 11, 2011, Pages 840-847

  Ravichandran, Kameswaran ^a   Tyagi, Alpna ^a   Deep, Gagan ^a,b   Agarwal, Chapla ^a,b   Agarwal, Rajesh ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Human lung carcinoma; iNOS; Interleukin 1 ; MAPK; STAT

Indexed keywords

3,3',4,5'-TETRAHYDROXYSTILBENE; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE 1; NOS2 PROTEIN, HUMAN; PICEATANNOL; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STILBENE DERIVATIVE;

ARTICLE; CARCINOMA; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG TUMOR; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CARCINOMA; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JANUS KINASE 1; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STILBENES;

EID: 80355141481     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Jemal A, Siegel R, Xu J & Ward E, Cancer statistics, 2010, CA Cancer J Clin, 60 (2010) 277.
2. Schachter E N & Neuman T, Targeted therapies for the prevention of lung cancer, Drugs Today (Barc), 43 (2007) 897.
3. Amir E, Hughes S, Blackhall F, Thatcher N, Ostoros G, Timar J, Tovari J, Kovacs G & Dome B, Targeting blood vessels for the treatment of non-small cell lung cancer, Curr Cancer Drug Targets, 8 (2008) 392.
4. Harichand-Herdt S & Ramalingam S S, Targeted therapy for the treatment of non-small cell lung cancer: focus on inhibition of epidermal growth factor receptor, Semin Thorac Cardiovasc Surg, 20 (2008) 217.
5. Kisley L R, Barrett B S, Bauer A K, Dwyer-Nield L D, Barthel B, Meyer A M, Thompson D C & Malkinson A M, Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis, Cancer Res, 62 (2002) 6850.
6. Liu C Y, Wang C H, Chen T C, Lin H C, Yu C T & Kuo H P, Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer, Br J Cancer, 78 (1998) 534.
7. Chen G G, Lee T W, Xu H, Yip J H, Li M, Mok T S & Yim A P, Increased inducible nitric oxide synthase in lung carcinoma of smokers, Cancer, 112 (2008) 372.
8. Chittezhath M, Deep G, Singh R P, Agarwal C & Agarwal R, Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells, Mol Cancer Ther, 7 (2008) 1817.
9. Singh R P, Deep G, Chittezhath M, Kaur M, Dwyer-Nield L D, Malkinson A M & Agarwal R, Effect of silibinin on the growth and progression of primary lung tumors in mice, J Natl Cancer Inst, 98 (2006) 846.
10. Fitzpatrick B, Mehibel M, Cowen R L & Stratford I J, iNOS as a therapeutic target for treatment of human tumors, Nitric Oxide, 19 (2008) 217.
11. Watanabe K, Kawamori T, Nakatsugi S & Wakabayashi K, COX-2 and iNOS, good targets for chemoprevention of colon cancer, Biofactors, 12 (2000) 129.
12. Masri F A, Comhair S A, Koeck T, Xu W, Janocha A, Ghosh S, Dweik R A, Golish J, Kinter M, Stuehr D J, Erzurum S C & Aulak K S, Abnormalities in nitric oxide and its derivatives in lung cancer, Am J Respir Crit Care Med, 172 (2005) 597.
13. Ohshima H & Bartsch H, Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis, Mutat Res, 305 (1994) 253.
14. Liu R H & Hotchkiss J H, Potential genotoxicity of chronically elevated nitric oxide: a review, Mutat Res, 339 (1995) 73.
15. Kanwar J R, Kanwar R K, Burrow H & Baratchi S, Recent advances on the roles of NO in cancer and chronic inflammatory disorders, Curr Med Chem, 16 (2009) 2373.
16. Sharma S, Wilkinson B P, Gao P & Steele V E, Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system, Neoplasia, 4 (2002) 332.
17. Zhu Y M, Webster S J, Flower D & Woll P J, Interleukin-8/CXCL8 is a growth factor for human lung cancer cells, Br J Cancer, 91 (2004) 1970.
18. Tauler J & Mulshine J L, Lung cancer and inflammation: interaction of chemokines and hnRNPs, Curr Opin Pharmacol, 9 (2009) 384.
19. Landvik N E, Hart K, Skaug V, Stangeland L B, Haugen A & Zienolddiny S, A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer, Carcinogenesis, 30 (2009) 1186.
20. Kimura Y N, Watari K, Fotovati A, Hosoi F, Yasumoto K, Izumi H, Kohno K, Umezawa K, Iguchi H, Shirouzu K, Takamori S, Kuwano M & Ono M, Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis, Cancer Sci, 98 (2007) 2009.
21. Cheng C Y, Hsieh H L, Sun C C, Lin C C, Luo S F & Yang C M, IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells, J Cell Physiol, 219 (2009) 183.
22. Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z & Matsumoto K, The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway, Nature, 398 (1999) 252.
23. Cao Z, Xiong J, Takeuchi M, Kurama T & Goeddel D V, TRAF6 is a signal transducer for interleukin-1, Nature, 383 (1996) 443.
24. Kang J H, Chang S Y, Jang H J, Kim D B, Ryu G R, Ko S H, Jeong I K, Jo Y H & Kim M J, Exendin-4 inhibits interleukin-1beta-induced iNOS expression at the protein level, but not at the transcriptional and posttranscriptional levels, in RINm5F beta-cells, J Endocrinol, 202 (2009) 65.
25. Gonzalez F J, Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress, Biochem J, 394 (2006) e3.
26. Kwon S & George S C, Synergistic cytokine-induced nitric oxide production in human alveolar epithelial cells, Nitric Oxide, 3 (1999) 348.
27. Zi X, Feyes D K & Agarwal R, Anticarcinogenic effect of a flavonoid antioxidant, silymarin, in human breast cancer cells MDA-MB 468: induction of G1 arrest through an increase in Cip1/p21 concomitant with a decrease in kinase activity of cyclin-dependent kinases and associated cyclins, Clin Cancer Res, 4 (1998) 1055.
28. Muller M M, Schreiber E, Schaffner W & Matthias P, Rapid test for in vivo stability and DNA binding of mutated octamer binding proteins with 'mini-extracts' prepared from transfected cells, Nucleic Acids Res, 17 (1989) 6420.
29. Singh R P & Agarwal R, Inducible nitric oxide synthasevascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents, Curr Cancer Drug Targets, 7 (2007) 475.
30. Li Y, Du H, Qin Y, Roberts J, Cummings O W & Yan C, Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung, Cancer Res, 67 (2007) 8494.
31. Mossman B T, Lounsbury K M & Reddy S P, Oxidants and signaling by mitogen-activated protein kinases in lung epithelium, Am J Respir Cell Mol Biol, 34 (2006) 666.
32. Cicenas J, The potential role of Akt phosphorylation in human cancers, Int J Biol Markers, 23 (2008) 1.
33. Karin M, Nuclear factor-kappaB in cancer development and progression, Nature, 441 (2006) 431.
34. Semenza G L, Targeting HIF-1 for cancer therapy, Nat Rev Cancer, 3 (2003) 721.
35. Walser T, Cui X, Yanagawa J, Lee J M, Heinrich E, Lee G, Sharma S & Dubinett S M, Smoking and lung cancer: the role of inflammation, Proc Am Thorac Soc, 5 (2008) 811.
36. Ho C & Laskin J, EGFR-directed therapies to treat nonsmall-cell lung cancer, Expert Opin Investig Drugs, 18 (2009) 1133.
37. Orucevic A, Bechberger J, Green A M, Shapiro R A, Billiar T R & Lala P K, Nitric-oxide production by murine mammary adenocarcinoma cells promotes tumor-cell invasiveness, Int J Cancer, 81 (1999) 889.
38. Ramasamy K, Dwyer-Nield L D, Serkova N J, Hasebroock K M, Tyagi A, Raina K, Singh R P, Malkinson A M & Agarwal R, Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/-mice: potential of real-time micro-CT in lung cancer chemoprevention studies, Clin Cancer Res, 17 (2011) 753.
39. Shields P G, Molecular epidemiology of smoking and lung cancer, Oncogene, 21 (2002) 6870.
40. Lee G, Walser T C & Dubinett S M, Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer, Curr Opin Pulm Med, 15 (2009) 303.
41. Saijo Y, Tanaka M, Miki M, Usui K, Suzuki T, Maemondo M, Hong X, Tazawa R, Kikuchi T, Matsushima K & Nukiwa T, Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: In vivo analysis of tumor-stromal interaction, J Immunol, 169 (2002) 469.