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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 19, 2013, Pages 5259-5263

A high-yield route to synthesize the P-glycoprotein radioligand [ 11C]N-desmethyl-loperamide and its parent radioligand [ 11C]loperamide

(3) Wang, Min a Gao, Mingzhang a Zheng, Qi Huang a

a INDIANA UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

11C N Desmethyl loperamide ( 11C dLop) 11C Loperamide; Automation; Brain imaging; P glycoprotein (P gp); Positron emission tomography (PET)

Indexed keywords

LOPERAMIDE C 11; MULTIDRUG RESISTANCE PROTEIN; N DESMETHYL LOPERAMIDE C 11; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRECURSOR; RADIOCHEMISTRY; SOLID PHASE EXTRACTION;

AUTOMATION; BRAIN IMAGING; P-GLYCOPROTEIN (P-GP); POSITRON EMISSION TOMOGRAPHY (PET); [(11)C]LOPERAMIDE; [(11)C]N-DESMETHYL-LOPERAMIDE ([(11)C]DLOP);

CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIGANDS; LOPERAMIDE; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; RADIOPHARMACEUTICALS; SOLID PHASE EXTRACTION;

EID: 84883490493 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.08.024 Document Type: Article

Times cited : (11)

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