[11C]Olanzapine, radiosynthesis and lipophilicity of a new potential PET 5-HT2 and D2 receptor radioligand

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 1953-1956

  Gao, Mingzhang ^a   Shi, Zenas ^a   Wang, Min ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

11C Olanzapine; Brain imaging; Dopamine receptor; Positron emission tomography (PET); Radiosynthesis; Serotonin receptor

Indexed keywords

DOPAMINE 2 RECEPTOR; OLANZAPINE; PIPERAZINE DERIVATIVE; RACLOPRIDE; RADIOLIGAND; SEROTONIN 2 RECEPTOR; SETOPERONE; BENZODIAZEPINE DERIVATIVE; CARBON; LIGAND;

ARTICLE; BLOOD BRAIN BARRIER; CATALYST; CHEMICAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; SOLID PHASE EXTRACTION; SUBSTITUTION REACTION; SYNTHESIS; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECT; METABOLISM; STRUCTURE ACTIVITY RELATION;

BENZODIAZEPINES; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN, 5-HT2; SOLID PHASE EXTRACTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875216529     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.02.045     Document Type: Article

References (27)

1. F.P. Bymaster, D.O. Calligaro, J.F. Falcone, R.D. Marsh, N.A. Moore, N.C. Tye, P. Seeman, and D.T. Wong Neuropsychopharmacology 14 1996 87
2. S. Kapur, R.B. Zipursky, and G. Remington Am. J. Psychiatry 156 1999 286
3. S. Nyberg, L. Farde, and C. Halldin Neuropsychopharmacology 16 1997 1
4. S. Kapur, R.B. Zipursky, G. Remington, C. Jones, J. DaSilva, A.A. Wilson, and S. Houle Am. J. Psychiatry 155 1998 921
5. Chakrabarti, J. K.; Hotten, T. M.; Tupper, D. E. US Patent No. 5229382, 1993.
6. Chakrabarti, J. K.; Hotten, T. M.; Tupper, D. E. US Patent No. 5627178, 1997.
7. A. Leyva-Pérez, J.R. Cabrero-Antonino, and A. Corma Tetrahedron 66 2010 8203
8. D.M. Jewett Int. J. Radiat. Appl. Instrum. A 43 1992 1383
9. B.H. Mock, G.K. Mulholland, and M.T. Vavrek Nucl. Med. Biol. 26 1999 467
10. Q.-H. Zheng, and G.K. Mulholland Nucl. Med. Biol. 23 1996 981
11. K.K. Yoder, G.D. Hutchins, B.H. Mock, X. Fei, W.L. Winkle, B.D. Gitter, P.R. Territo, and Q.-H. Zheng Nucl. Med. Biol. 36 2009 11
12. M. Wang, M. Gao, K.D. Miller, G.W. Sledge, G.D. Hutchins, and Q.-H. Zheng Nucl. Med. Biol. 37 2010 763
13. M. Gao, M. Wang, B.H. Mock, B.E. Glick-Wilson, K.K. Yoder, G.D. Hutchins, and Q.-H. Zheng Appl. Radiat. Isot. 68 2010 1079
14. M. Wang, M. Gao, K.D. Miller, and Q.-H. Zheng Steroids 76 2011 1331
15. M. Wang, M. Gao, K.D. Miller, G.W. Sledge, and Q.-H. Zheng Bioorg. Med. Chem. Lett. 22 2012 1569
16. B.H. Mock, Q.-H. Zheng, and T.R. DeGrado J. Labelled Compd. Radiopharm. 48 2005 S225
17. B.H. Mock, B.E. Glick-Wilson, Q.-H. Zheng, and T.R. DeGrado J. Labelled Compd. Radiopharm. 48 2005 S224
18. M. Wang, M. Gao, and Q.-H. Zheng Appl. Radiat. Isot. 70 2012 965
19. M. Wang, M. Gao, and Q.-H. Zheng Bioorg. Med. Chem. Lett. 23 2013 524
20. Q.-H. Zheng, and B.H. Mock Biomed. Chromatogr. 19 2005 671
21. J.E. Haky, and A.M. Young J. Liq. Chromatogr. 7 1984 675
22. X. Fei, and Q.-H. Zheng J. Liq. Chromatogr. Relat. Technol. 28 2005 939
23. M. Gao, B.H. Mock, G.D. Hutchins, and Q.-H. Zheng Nucl. Med. Biol. 32 2005 543
24. M. Gao, M. Wang, G.D. Hutchins, and Q.-H. Zheng Bioorg. Med. Chem. Lett. 20 2010 2529
25. M. Wang, M. Gao, B.L. Steele, B.E. Glick-Wilson, C. Brown-Proctor, A. Shekhar, G.D. Hutchins, and Q.-H. Zheng Bioorg. Med. Chem. Lett. 22 2012 4713
26. X. Fei, B.H. Mock, T.R. DeGrado, J.-Q. Wang, B.E. Glick-Wilson, M.L. Sullivan, G.D. Hutchins, and Q.-H. Zheng Synth. Commun. 34 2004 1897
27. C.A. Mathis, Y. Wang, D.P. Holt, G.-F. Huang, M.L. Debnath, and W.E. Klunk J. Med. Chem. 46 2003 2740