Synthesis of (Z)-2-((1H-indazol-3-yl)methylene)-6-[11C]methoxy- 7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one as a new potential PET probe for imaging of the enzyme PIM1

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4342-4346

  Gao, Mingzhang ^a   Wang, Min ^a   Miller, Kathy D ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

(Z) 2 ((1H Indazol 3 yl)methylene) 6 11C methoxy 7 (piperazin 1 ylmethyl)benzofuran 3(2H) one ( 11C 4); Alzheimer's disease; Cancer; Positron emission tomography (PET); Proviral integration site in moloney murine leukemia virus kinase 1 (PIM1); Radiosynthesis

Indexed keywords

2 [(1H INDAZOL 3 YL)METHYLENE] 6 METHOXY 7 (PIPERAZIN 1 YLMETHYL)BENZOFURAN 3(2H) ONE C 11; BENZOFURAN DERIVATIVE; CARBON 11; LEUKEMIA VIRUS KINASE 1; PHOSPHOTRANSFERASE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY;

ANIMALS; BENZOFURANS; CARBON ISOTOPES; HUMANS; INDAZOLES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN KINASE INHIBITORS; RADIOPHARMACEUTICALS;

MOLONEY MURINE LEUKEMIA VIRUS;

EID: 84879690744     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.091     Document Type: Article

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