[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1569-1574

  Wang, Min ^a   Gao, Mingzhang ^a   Miller, Kathy D ^a   Sledge, George W ^a   Zheng, Qi Huang ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Mammalian target of rapamycin (mTOR); Phosphoinositide 3 kinase (PI3K); Positron emission tomography (PET)

Indexed keywords

GSK 2126458 C 11; GSK 2126458 F 18; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; 2,4 DIFLUORO N (2 (METHYLOXY) 5 (4 (4 PYRIDAZINYL) 6 QUINOLINYL) 3 PYRIDINYL)BENZENESULFONAMIDE; 2,4-DIFLUORO-N-(2-(METHYLOXY)-5-(4-(4-PYRIDAZINYL)-6-QUINOLINYL)-3-PYRIDINYL)BENZENESULFONAMIDE; CARBON; DIAGNOSTIC AGENT; FLUORODEOXYGLUCOSE F 18; MTOR PROTEIN, HUMAN; QUINOLINE DERIVATIVE; SULFONAMIDE; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CANCER DIAGNOSIS; CHEMICAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; SOLID PHASE EXTRACTION; CHEMISTRY; HUMAN; METABOLISM; NEOPLASM; SCINTISCANNING;

MAMMALIA;

CARBON RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; POSITRON-EMISSION TOMOGRAPHY; QUINOLINES; RADIOPHARMACEUTICALS; SULFONAMIDES; TOR SERINE-THREONINE KINASES;

EID: 84856675492     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.136     Document Type: Article

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