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Volumn 9, Issue 9, 2013, Pages 544-556

Advances in understanding the pathogenesis of primary Sjögren's syndrome

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B CELL ACTIVATING FACTOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 14; TOLL LIKE RECEPTOR;

EID: 84883448195     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2013.110     Document Type: Review
Times cited : (327)

References (142)
  • 1
    • 31544442739 scopus 로고    scopus 로고
    • Epidemiology of primary Sjogren's syndrome in north-west Greece, 1982-2003
    • Alamanos, Y. et al. Epidemiology of primary Sjogren's syndrome in north-west Greece, 1982-2003. Rheumatology (Oxford) 45, 187-191 (2006).
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 187-191
    • Alamanos, Y.1
  • 2
    • 1542357595 scopus 로고    scopus 로고
    • Estimating the prevalence among Caucasian women of primary Sjogren's syndrome in two general practices in Birmingham, UK
    • Bowman, S. J., Ibrahim, G. H., Holmes, G., Hamburger, J. & Ainsworth, J. R. Estimating the prevalence among Caucasian women of primary Sjogren's syndrome in two general practices in Birmingham, UK. Scand. J. Rheumatol. 33, 39-43 (2004).
    • (2004) Scand. J. Rheumatol. , vol.33 , pp. 39-43
    • Bowman, S.J.1    Ibrahim, G.H.2    Holmes, G.3    Hamburger, J.4    Ainsworth, J.R.5
  • 5
    • 77955160246 scopus 로고    scopus 로고
    • Pathogenesis of Sjögren's syndrome and therapeutic consequences
    • Mariette, X. & Gottenberg, J. E. Pathogenesis of Sjögren's syndrome and therapeutic consequences. Curr. Opin. Rheumatol. 22, 471-477 (2010).
    • (2010) Curr. Opin. Rheumatol. , vol.22 , pp. 471-477
    • Mariette, X.1    Gottenberg, J.E.2
  • 6
    • 17244372491 scopus 로고    scopus 로고
    • Activation of the type i interferon system in primary Sjögren's syndrome: A possible etiopathogenic mechanism
    • Bave, U. et al. Activation of the type I interferon system in primary Sjögren's syndrome: a possible etiopathogenic mechanism. Arthritis Rheum. 52, 1185-1195 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1185-1195
    • Bave, U.1
  • 7
    • 84855445128 scopus 로고    scopus 로고
    • Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: Increased serum levels of interleukin-21 and its expression in the labial salivary glands
    • Kang, K. Y. et al. Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands. Arthritis Res. Ther. 13, R179 (2011).
    • (2011) Arthritis Res. Ther. , vol.13
    • Kang, K.Y.1
  • 8
    • 44849084239 scopus 로고    scopus 로고
    • Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways
    • Ittah, M. et al. Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways. Eur. J. Immunol. 38, 1058-1064 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1058-1064
    • Ittah, M.1
  • 9
    • 37149055953 scopus 로고    scopus 로고
    • Association of an IRF5 gene functional polymorphism with Sjögren's syndrome
    • Miceli-Richard, C. et al. Association of an IRF5 gene functional polymorphism with Sjögren's syndrome. Arthritis Rheum. 56, 3989-3994 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 3989-3994
    • Miceli-Richard, C.1
  • 10
    • 67650074526 scopus 로고    scopus 로고
    • The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjögren's syndrome
    • Miceli-Richard, C. et al. The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjögren's syndrome. Arthritis Rheum. 60, 1991-1997 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 1991-1997
    • Miceli-Richard, C.1
  • 11
    • 59149104204 scopus 로고    scopus 로고
    • Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome
    • Nordmark, G. et al. Additive effects of the major risk alleles of IRF5 and STAT4 in primary Sjögren's syndrome. Genes Immun. 10, 68-76 (2009).
    • (2009) Genes Immun , vol.10 , pp. 68-76
    • Nordmark, G.1
  • 12
    • 77954886593 scopus 로고    scopus 로고
    • STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling
    • Gestermann, N. et al. STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and could be involved in type 1 interferon pathway signaling. Genes Immun. 11, 432-438 (2010).
    • (2010) Genes Immun , vol.11 , pp. 432-438
    • Gestermann, N.1
  • 13
    • 42549147098 scopus 로고    scopus 로고
    • Variant form of STAT4 is associated with primary Sjögren's syndrome
    • Korman, B. D. et al. Variant form of STAT4 is associated with primary Sjögren's syndrome. Genes Immun. 9, 267-270 (2008).
    • (2008) Genes Immun , vol.9 , pp. 267-270
    • Korman, B.D.1
  • 14
    • 84883446867 scopus 로고    scopus 로고
    • Identification of multiple sjögren's syndrome susceptibility loci [abstract OP0020]
    • Lessard, C. J. et al. Identification of multiple Sjögren's syndrome susceptibility loci [abstract OP0020]. Ann.Rheum. Dis. 72 (Suppl. 3), 54 (2013).
    • (2013) Ann.Rheum. Dis. , vol.72 , Issue.SUPPL. 3 , pp. 54
    • Lessard, C.J.1
  • 15
    • 84875934940 scopus 로고    scopus 로고
    • The critical importance of epigenetics in autoimmunity
    • Lu, Q. The critical importance of epigenetics in autoimmunity. J. Autoimmun. 41, 1-5 (2013).
    • (2013) J. Autoimmun. , vol.41 , pp. 1-5
    • Lu, Q.1
  • 16
    • 79551656688 scopus 로고    scopus 로고
    • MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjögren's syndrome
    • Alevizos, I., Alexander, S., Turner, R. J. & Illei, G. G. MicroRNA expression profiles as biomarkers of minor salivary gland inflammation and dysfunction in Sjögren's syndrome. Arthritis Rheum. 63, 535-544 (2011).
    • (2011) Arthritis Rheum , vol.63 , pp. 535-544
    • Alevizos, I.1    Alexander, S.2    Turner, R.J.3    Illei, G.G.4
  • 17
    • 0018775078 scopus 로고
    • Immune interferon in the circulation of patients with autoimmune disease
    • Hooks, J. J. et al. Immune interferon in the circulation of patients with autoimmune disease. N. Engl. J. Med. 301, 5-8 (1979).
    • (1979) N. Engl. J. Med. , vol.301 , pp. 5-8
    • Hooks, J.J.1
  • 18
    • 33644530664 scopus 로고    scopus 로고
    • Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome
    • Gottenberg, J. E. et al. Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome. Proc. Natl Acad. Sci. USA 103, 2770-2775 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 2770-2775
    • Gottenberg, J.E.1
  • 19
    • 18644364840 scopus 로고    scopus 로고
    • Gene expression profiling of minor salivary glands clearly distinguishes primary Sjögren's syndrome patients from healthy control subjects
    • Hjelmervik, T. O., Petersen, K., Jonassen, I., Jonsson, R. & Bolstad, A. I. Gene expression profiling of minor salivary glands clearly distinguishes primary Sjögren's syndrome patients from healthy control subjects. Arthritis Rheum. 52, 1534-1544 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1534-1544
    • Hjelmervik, T.O.1    Petersen, K.2    Jonassen, I.3    Jonsson, R.4    Bolstad, A.I.5
  • 20
    • 67349105006 scopus 로고    scopus 로고
    • Peripheral blood gene expression profiling in Sjögren's syndrome
    • Emamian, E. S. et al. Peripheral blood gene expression profiling in Sjögren's syndrome. Genes Immun. 10, 285-296 (2009).
    • (2009) Genes Immun , vol.10 , pp. 285-296
    • Emamian, E.S.1
  • 21
    • 70350488070 scopus 로고    scopus 로고
    • Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3
    • Iwakiri, D. et al. Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3. J. Exp. Med. 206, 2091-2099 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 2091-2099
    • Iwakiri, D.1
  • 22
    • 58149170722 scopus 로고    scopus 로고
    • Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function
    • Deshmukh, U. S., Nandula, S. R., Thimmalapura, P. R., Scindia, Y. M. & Bagavant, H. Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function. J. Oral Pathol. Med. 38, 42-47 (2009).
    • (2009) J. Oral Pathol. Med. , vol.38 , pp. 42-47
    • Deshmukh, U.S.1    Nandula, S.R.2    Thimmalapura, P.R.3    Scindia, Y.M.4    Bagavant, H.5
  • 24
    • 80054060025 scopus 로고    scopus 로고
    • Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like disease
    • Nandula, S. R., Scindia, Y. M., Dey, P., Bagavant, H. & Deshmukh, U. S. Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like disease. Oral Dis. 17, 801-807 (2011).
    • (2011) Oral Dis , vol.17 , pp. 801-807
    • Nandula, S.R.1    Scindia, Y.M.2    Dey, P.3    Bagavant, H.4    Deshmukh, U.S.5
  • 25
    • 0030897928 scopus 로고    scopus 로고
    • Retrovirus in salivary glands from patients with Sjögren's syndrome
    • Yamano, S. et al. Retrovirus in salivary glands from patients with Sjögren's syndrome. J. Clin. Pathol. 50, 223-230 (1997).
    • (1997) J. Clin. Pathol. , vol.50 , pp. 223-230
    • Yamano, S.1
  • 26
    • 71249087529 scopus 로고    scopus 로고
    • Primary Sjögren's syndrome: Pathophysiological, clinical and therapeutic advances
    • Gottenberg, J. E. Primary Sjögren's syndrome: pathophysiological, clinical and therapeutic advances. Joint Bone Spine 76, 591-594 (2009).
    • (2009) Joint Bone Spine , vol.76 , pp. 591-594
    • Gottenberg, J.E.1
  • 27
    • 0032433666 scopus 로고    scopus 로고
    • Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice
    • Fleck, M., Kern, E. R., Zhou, T., Lang, B. & Mountz, J. D. Murine cytomegalovirus induces a Sjögren's syndrome-like disease in C57Bl/6-lpr/lpr mice. Arthritis Rheum. 41, 2175-2184 (1998).
    • (1998) Arthritis Rheum , vol.41 , pp. 2175-2184
    • Fleck, M.1    Kern, E.R.2    Zhou, T.3    Lang, B.4    Mountz, J.D.5
  • 28
    • 79960246157 scopus 로고    scopus 로고
    • A failure of TNFAIP3 negative regulation maintains sustained NF-κB activation in Sjögren's syndrome
    • Sisto, M. et al. A failure of TNFAIP3 negative regulation maintains sustained NF-κB activation in Sjögren's syndrome. Histochem. Cell Biol. 135, 615-625 (2011).
    • (2011) Histochem. Cell Biol. , vol.135 , pp. 615-625
    • Sisto, M.1
  • 29
    • 77956996600 scopus 로고    scopus 로고
    • Defective feedback regulation of NF-κB underlies Sjögren's syndrome in mice with mutated κb enhancers of the IκBα promoter
    • Peng, B. et al. Defective feedback regulation of NF-κB underlies Sjögren's syndrome in mice with mutated κB enhancers of the IκBα promoter. Proc. Natl Acad. Sci. USA 107, 15193-15198 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15193-15198
    • Peng, B.1
  • 30
    • 0033428703 scopus 로고    scopus 로고
    • Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
    • Mackay, F. et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 190, 1697-1710 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1697-1710
    • Mackay, F.1
  • 31
    • 9144234090 scopus 로고    scopus 로고
    • TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma
    • Batten, M. et al. TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J. Immunol. 172, 812-822 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 812-822
    • Batten, M.1
  • 32
    • 0037310430 scopus 로고    scopus 로고
    • The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome
    • Mariette, X. et al. The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome. Ann. Rheum. Dis. 62, 168-171 (2003).
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 168-171
    • Mariette, X.1
  • 33
    • 34247230559 scopus 로고    scopus 로고
    • Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndrome
    • Daridon, C. et al. Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndrome. Arthritis Rheum. 56, 1134-1144 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 1134-1144
    • Daridon, C.1
  • 34
    • 38149090131 scopus 로고    scopus 로고
    • B-cell activating factor of the tumour necrosis factor family expression in blood monocytes and T cells from patients with primary Sjögren's syndrome
    • Lavie, F. et al. B-cell activating factor of the tumour necrosis factor family expression in blood monocytes and T cells from patients with primary Sjögren's syndrome. Scand. J. Immunol. 67, 185-192 (2008).
    • (2008) Scand. J. Immunol. , vol.67 , pp. 185-192
    • Lavie, F.1
  • 35
    • 0036732753 scopus 로고    scopus 로고
    • DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    • Litinskiy, M. B. et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 3, 822-829 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 822-829
    • Litinskiy, M.B.1
  • 36
    • 67649948121 scopus 로고    scopus 로고
    • B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation
    • Ittah, M. et al. B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation. Eur. J. Immunol. 39, 1271-1279 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1271-1279
    • Ittah, M.1
  • 37
    • 79952009770 scopus 로고    scopus 로고
    • Induction of B cell-activating factor by viral infection is a general phenomenon, but the types of viruses and mechanisms depend on cell type
    • Ittah, M. et al. Induction of B cell-activating factor by viral infection is a general phenomenon, but the types of viruses and mechanisms depend on cell type. J. Innate Immun. 3, 200-207 (2011).
    • (2011) J. Innate Immun. , vol.3 , pp. 200-207
    • Ittah, M.1
  • 38
    • 84875958991 scopus 로고    scopus 로고
    • Prevalence of interferon type i signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression
    • Brkic, Z. et al. Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression. Ann. Rheum. Dis. 72, 728-735 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 728-735
    • Brkic, Z.1
  • 39
    • 0021945723 scopus 로고
    • Human B lymphoma cell line producing B cell growth factor
    • Ambrus, J. L. Jr & Fauci, A. S. Human B lymphoma cell line producing B cell growth factor. J. Clin. Invest. 75, 732-739 (1985).
    • (1985) J. Clin. Invest. , vol.75 , pp. 732-739
    • Ambrus Jr., J.L.1    Fauci, A.S.2
  • 40
    • 33749509230 scopus 로고    scopus 로고
    • Development of autoimmunity in IL-14α-transgenic mice
    • Shen, L. et al. Development of autoimmunity in IL-14α-transgenic mice. J. Immunol. 177, 5676-5686 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 5676-5686
    • Shen, L.1
  • 41
    • 59349087482 scopus 로고    scopus 로고
    • IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans
    • Shen, L. et al. IL-14 alpha, the nexus for primary Sjögren's disease in mice and humans. Clin. Immunol. 130, 304-312 (2009).
    • (2009) Clin. Immunol. , vol.130 , pp. 304-312
    • Shen, L.1
  • 42
    • 84883458348 scopus 로고    scopus 로고
    • Stages of Sjögren's syndrome defined by immune mediators [abstract 515]
    • Suresh, L., Ambrus, J. J. & Shen, L. Stages of Sjögren's syndrome defined by immune mediators [abstract 515]. Arthritis Rheum. 64 (Suppl. 10), S225 (2012).
    • (2012) Arthritis Rheum. , vol.64 , Issue.SUPPL. 10
    • Suresh, L.1    Ambrus, J.J.2    Shen, L.3
  • 43
    • 0033017601 scopus 로고    scopus 로고
    • Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjögren's syndrome
    • Halse, A., Tengner, P., Wahren-Herlenius, M., Haga, H. & Jonsson, R. Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjögren's syndrome. Scand. J. Immunol. 49, 533-538 (1999).
    • (1999) Scand. J. Immunol. , vol.49 , pp. 533-538
    • Halse, A.1    Tengner, P.2    Wahren-Herlenius, M.3    Haga, H.4    Jonsson, R.5
  • 44
    • 0034039608 scopus 로고    scopus 로고
    • Increased serum levels of interleukin 10 in Sjögren's syndrome; Correlation with increased IgG1
    • Perrier, S. et al. Increased serum levels of interleukin 10 in Sjögren's syndrome; correlation with increased IgG1. J. Rheumatol. 27, 935-939 (2000).
    • (2000) J. Rheumatol. , vol.27 , pp. 935-939
    • Perrier, S.1
  • 45
    • 14044259331 scopus 로고    scopus 로고
    • Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: Implications for Burkitt's lymphoma
    • Ogden, C. A. et al. Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma. J. Immunol. 174, 3015-3023 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3015-3023
    • Ogden, C.A.1
  • 46
    • 78049527643 scopus 로고    scopus 로고
    • Regulatory B cells in autoimmunity: Developments and controversies
    • Mauri, C. & Blair, P. A. Regulatory B cells in autoimmunity: developments and controversies. Nat. Rev. Rheumatol. 6, 636-643 (2010).
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 636-643
    • Mauri, C.1    Blair, P.A.2
  • 47
    • 78751469622 scopus 로고    scopus 로고
    • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells
    • Iwata, Y. et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 117, 530-541 (2011).
    • (2011) Blood , vol.117 , pp. 530-541
    • Iwata, Y.1
  • 48
    • 0036092482 scopus 로고    scopus 로고
    • Classification criteria for Sjögren's syndrome: A revised version of the European criteria proposed by the American-European Consensus Group
    • Vitali, C. et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann. Rheum. Dis. 61, 554-558 (2002).
    • (2002) Ann. Rheum. Dis. , vol.61 , pp. 554-558
    • Vitali, C.1
  • 49
    • 33748320925 scopus 로고    scopus 로고
    • Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block
    • Clancy, R. M. et al. Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block. J. Clin. Invest. 116, 2413-2422 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2413-2422
    • Clancy, R.M.1
  • 50
    • 0032430377 scopus 로고    scopus 로고
    • Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndrome
    • Tengner, P., Halse, A. K., Haga, H. J., Jonsson, R. & Wahren-Herlenius, M. Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndrome. Arthritis Rheum. 41, 2238-2248 (1998).
    • (1998) Arthritis Rheum , vol.41 , pp. 2238-2248
    • Tengner, P.1    Halse, A.K.2    Haga, H.J.3    Jonsson, R.4    Wahren-Herlenius, M.5
  • 51
    • 67549099572 scopus 로고    scopus 로고
    • Quantitative assessment of antibodies to ribonucleoproteins in primary Sjögren syndrome: Correlation with B-cell biomarkers and disease activity
    • Candon, S., Gottenberg, J. E., Bengoufa, D., Chatenoud, L. & Mariette, X. Quantitative assessment of antibodies to ribonucleoproteins in primary Sjögren syndrome: correlation with B-cell biomarkers and disease activity. Ann. Rheum. Dis. 68, 1208-1212 (2009).
    • (2009) Ann. Rheum. Dis. , vol.68 , pp. 1208-1212
    • Candon, S.1    Gottenberg, J.E.2    Bengoufa, D.3    Chatenoud, L.4    Mariette, X.5
  • 52
    • 0028809117 scopus 로고
    • Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens la (SS-B) and Ro (SS-A)
    • Topfer, F., Gordon, T. & McCluskey, J. Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc. Natl Acad. Sci. USA 92, 875-879 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 875-879
    • Topfer, F.1    Gordon, T.2    McCluskey, J.3
  • 53
    • 80155173180 scopus 로고    scopus 로고
    • Molecular signature of a public clonotypic autoantibody in primary sjögren's syndrome: A "forbidden" clone in systemic autoimmunity
    • Lindop, R. et al. Molecular signature of a public clonotypic autoantibody in primary Sjögren's syndrome: a "forbidden" clone in systemic autoimmunity. Arthritis Rheum. 63, 3477-3486 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 3477-3486
    • Lindop, R.1
  • 54
    • 84883447199 scopus 로고    scopus 로고
    • Long-term humoral autoimmunity to Ro60 in primary Sjögren's syndrome is driven by clonal succession [abstract 2676]
    • Lindop, R. et al. Long-term humoral autoimmunity to Ro60 in primary Sjögren's syndrome is driven by clonal succession [abstract 2676]. Arthritis Rheum. 64 (Suppl. 10), S1135 (2012).
    • (2012) Arthritis Rheum. , vol.64 , Issue.SUPPL. 10
    • Lindop, R.1
  • 55
    • 0035152101 scopus 로고    scopus 로고
    • Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome
    • Amft, N. et al. Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. Arthritis Rheum. 44, 2633-2641 (2001).
    • (2001) Arthritis Rheum , vol.44 , pp. 2633-2641
    • Amft, N.1
  • 56
    • 84866534641 scopus 로고    scopus 로고
    • Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice
    • Bombardieri, M. et al. Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice. J. Immunol. 189, 3767-3776 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 3767-3776
    • Bombardieri, M.1
  • 57
    • 0242663585 scopus 로고    scopus 로고
    • Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome
    • Salomonsson, S. et al. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome. Arthritis Rheum. 48, 3187-3201 (2003).
    • (2003) Arthritis Rheum , vol.48 , pp. 3187-3201
    • Salomonsson, S.1
  • 58
    • 78149414259 scopus 로고    scopus 로고
    • The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation
    • Winter, S. et al. The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation. J. Mol. Med. (Berl.) 88, 1169-1180 (2010).
    • (2010) J. Mol. Med. (Berl.) , vol.88 , pp. 1169-1180
    • Winter, S.1
  • 59
    • 84863605611 scopus 로고    scopus 로고
    • Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients
    • Maehara, T. et al. Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients. Clin. Exp. Immunol. 169, 89-99 (2012).
    • (2012) Clin. Exp. Immunol. , vol.169 , pp. 89-99
    • Maehara, T.1
  • 60
    • 84883451204 scopus 로고    scopus 로고
    • Salivary gland epithelial cells are capable to directly induce the differentiation of IL-21-secreting follicular helper CD4 T cells in primary Sjögren's syndrome [abstract]
    • Gong, Y. et al. Salivary gland epithelial cells are capable to directly induce the differentiation of IL-21-secreting follicular helper CD4 T cells in primary Sjögren's syndrome [abstract]. Arthritis Rheum. 63 (Suppl. 10), 774 (2011).
    • (2011) Arthritis Rheum. , vol.63 , Issue.SUPPL. 10 , pp. 774
    • Gong, Y.1
  • 61
    • 79953160964 scopus 로고    scopus 로고
    • Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target
    • Dong, W., Zhu, P., Wang, Y. & Wang, Z. Follicular helper T cells in systemic lupus erythematosus: a potential therapeutic target. Autoimmun. Rev. 10, 299-304 (2011).
    • (2011) Autoimmun. Rev. , vol.10 , pp. 299-304
    • Dong, W.1    Zhu, P.2    Wang, Y.3    Wang, Z.4
  • 62
    • 27844511909 scopus 로고    scopus 로고
    • The risk of lymphoma development in autoimmune diseases: A meta-analysis
    • Zintzaras, E., Voulgarelis, M. & Moutsopoulos, H. M. The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch. Intern. Med. 165, 2337-2344 (2005).
    • (2005) Arch. Intern. Med. , vol.165 , pp. 2337-2344
    • Zintzaras, E.1    Voulgarelis, M.2    Moutsopoulos, H.M.3
  • 63
    • 33744503669 scopus 로고    scopus 로고
    • Lymphoma and other malignancies in primary Sjögren's syndrome: A cohort study on cancer incidence and lymphoma predictors
    • Theander, E. et al. Lymphoma and other malignancies in primary Sjögren's syndrome: a cohort study on cancer incidence and lymphoma predictors. Ann. Rheum. Dis. 65, 796-803 (2006).
    • (2006) Ann. Rheum. Dis. , vol.65 , pp. 796-803
    • Theander, E.1
  • 64
    • 30344479938 scopus 로고    scopus 로고
    • Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype
    • Smedby, K. E. et al. Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype. J. Natl Cancer Inst. 98, 51-60 (2006).
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 51-60
    • Smedby, K.E.1
  • 65
    • 84857913542 scopus 로고    scopus 로고
    • Incidence of cancer in a nationwide population cohort of 7,852 patients with primary Sjögren's syndrome in Taiwan
    • Weng, M. Y., Huang, Y. T., Liu, M. F. & Lu, T. H. Incidence of cancer in a nationwide population cohort of 7,852 patients with primary Sjögren's syndrome in Taiwan. Ann. Rheum. Dis. 71, 524-527 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 524-527
    • Weng, M.Y.1    Huang, Y.T.2    Liu, M.F.3    Lu, T.H.4
  • 66
    • 84876708705 scopus 로고    scopus 로고
    • Risk of non-hodgkin's lymphoma in primary Sjögren's syndrome: A population-based study
    • Johnsen, S. J. et al. Risk of non-hodgkin's lymphoma in primary Sjögren's syndrome: a population-based study. Arthritis Care Res. (Hoboken) 65, 816-821 (2013).
    • (2013) Arthritis Care Res. (Hoboken) , vol.65 , pp. 816-821
    • Johnsen, S.J.1
  • 67
    • 0030872542 scopus 로고    scopus 로고
    • Lymphomas in patients with Sjögren's syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses
    • Royer, B. et al. Lymphomas in patients with Sjögren's syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses. Blood 90, 766-775 (1997).
    • (1997) Blood , vol.90 , pp. 766-775
    • Royer, B.1
  • 68
    • 84855347439 scopus 로고    scopus 로고
    • Prognosis and outcome of non-Hodgkin lymphoma in primary Sjögren syndrome
    • Voulgarelis, M. et al. Prognosis and outcome of non-Hodgkin lymphoma in primary Sjögren syndrome. Medicine (Baltimore) 91, 1-9 (2012).
    • (2012) Medicine (Baltimore) , vol.91 , pp. 1-9
    • Voulgarelis, M.1
  • 69
    • 0029989203 scopus 로고    scopus 로고
    • Clinicopathological factors relating malignant lymphoma with Sjögren's syndrome
    • Anaya, J. M., McGuff, H. S., Banks, P. M. & Talal, N. Clinicopathological factors relating malignant lymphoma with Sjögren's syndrome. Semin. Arthritis Rheum. 25, 337-346 (1996).
    • (1996) Semin. Arthritis Rheum. , vol.25 , pp. 337-346
    • Anaya, J.M.1    McGuff, H.S.2    Banks, P.M.3    Talal, N.4
  • 70
    • 82955163284 scopus 로고    scopus 로고
    • Risk, predictors, and clinical characteristics of lymphoma development in primary Sjögren's syndrome
    • Solans-Laque, R. et al. Risk, predictors, and clinical characteristics of lymphoma development in primary Sjögren's syndrome. Semin. Arthritis Rheum. 41, 415-423 (2011).
    • (2011) Semin. Arthritis Rheum. , vol.41 , pp. 415-423
    • Solans-Laque, R.1
  • 71
    • 0029914461 scopus 로고    scopus 로고
    • Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sjögren's syndrome
    • Tzioufas, A. G., Boumba, D. S., Skopouli, F. N. & Moutsopoulos, H. M. Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sjögren's syndrome. Arthritis Rheum. 39, 767-772 (1996).
    • (1996) Arthritis Rheum. , vol.39 , pp. 767-772
    • Tzioufas, A.G.1    Boumba, D.S.2    Skopouli, F.N.3    Moutsopoulos, H.M.4
  • 72
    • 0033496363 scopus 로고    scopus 로고
    • Malignant lymphoma in primary Sjogren's syndrome: A multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's Syndrome
    • Voulgarelis, M., Dafni, U. G., Isenberg, D. A. & Moutsopoulos, H. M. Malignant lymphoma in primary Sjogren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's Syndrome. Arthritis Rheum. 42, 1765-1772 (1999).
    • (1999) Arthritis Rheum , vol.42 , pp. 1765-1772
    • Voulgarelis, M.1    Dafni, U.G.2    Isenberg, D.A.3    Moutsopoulos, H.M.4
  • 73
    • 0033865077 scopus 로고    scopus 로고
    • Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells
    • Martin, T. et al. Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells. Arthritis Rheum. 43, 908-916 (2000).
    • (2000) Arthritis Rheum , vol.43 , pp. 908-916
    • Martin, T.1
  • 74
    • 18244385722 scopus 로고    scopus 로고
    • Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
    • Bende, R. J. et al. Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J. Exp. Med. 201, 1229-1241 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1229-1241
    • Bende, R.J.1
  • 75
    • 79959799977 scopus 로고    scopus 로고
    • Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome
    • Theander, E. et al. Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome. Ann. Rheum. Dis. 70, 1363-1368 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1363-1368
    • Theander, E.1
  • 76
    • 84865134897 scopus 로고    scopus 로고
    • C-X-C chemokine receptor type 5 gene polymorphisms are associated with non-Hodgkin lymphoma
    • Song, H., Tong, D., Cha, Z. & Bai, J. C-X-C chemokine receptor type 5 gene polymorphisms are associated with non-Hodgkin lymphoma. Mol. Biol. Rep. 39, 8629-8635 (2012).
    • (2012) Mol. Biol. Rep. , vol.39 , pp. 8629-8635
    • Song, H.1    Tong, D.2    Cha, Z.3    Bai, J.4
  • 77
    • 84878118827 scopus 로고    scopus 로고
    • Serum levels of beta2-microglobulin and free light chains of immunoglobulins are associated with systemic disease activity in primary Sjögren's syndrome. Data at enrollment in the prospective ASSESS cohort
    • Gottenberg, J. E. et al. Serum levels of beta2-microglobulin and free light chains of immunoglobulins are associated with systemic disease activity in primary Sjögren's syndrome. Data at enrollment in the prospective ASSESS cohort. PLoS ONE 8, e59868 (2013).
    • (2013) PLoS ONE , vol.8
    • Gottenberg, J.E.1
  • 78
    • 84875684077 scopus 로고    scopus 로고
    • BLyS upregulation in Sjögren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands
    • Quartuccio, L. et al. BLyS upregulation in Sjögren's syndrome associated with lymphoproliferative disorders, higher ESSDAI score and B-cell clonal expansion in the salivary glands. Rheumatology (Oxford) 52, 276-281 (2013).
    • (2013) Rheumatology (Oxford) , vol.52 , pp. 276-281
    • Quartuccio, L.1
  • 79
    • 0034774757 scopus 로고    scopus 로고
    • Lymphomas complicating Sjögren's syndrome and hepatitis C virus infection may share a common pathogenesis: Chronic stimulation of rheumatoid factor B cells
    • Mariette, X. Lymphomas complicating Sjögren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells. Ann. Rheum. Dis. 60, 1007-1010 (2001).
    • (2001) Ann. Rheum. Dis. , vol.60 , pp. 1007-1010
    • Mariette, X.1
  • 80
    • 84881573740 scopus 로고    scopus 로고
    • Germinal and somatic abnormalities of the TNFAIP3 gene support a two-hit hypothesis of lymphomagenesis in autoimmune disease [abstract]
    • Mariette, X. et al. Germinal and somatic abnormalities of the TNFAIP3 gene support a two-hit hypothesis of lymphomagenesis in autoimmune disease [abstract]. Arthritis Rheum. 63 (Suppl. 10), 161 (2011).
    • (2011) Arthritis Rheum. , vol.63 , Issue.SUPPL. 10 , pp. 161
    • Mariette, X.1
  • 81
    • 79955471681 scopus 로고    scopus 로고
    • Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases
    • Musone, S. L. et al. Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases. Genes Immun. 12, 176-182 (2011).
    • (2011) Genes Immun , vol.12 , pp. 176-182
    • Musone, S.L.1
  • 82
    • 84862134821 scopus 로고    scopus 로고
    • A20 inactivation in ocular adnexal MALT lymphoma
    • Bi, Y. et al. A20 inactivation in ocular adnexal MALT lymphoma. Haematologica 97, 926-930 (2011).
    • (2011) Haematologica , vol.97 , pp. 926-930
    • Bi, Y.1
  • 83
    • 70350504882 scopus 로고    scopus 로고
    • TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    • Honma, K. et al. TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood 114, 2467-2475 (2009).
    • (2009) Blood , vol.114 , pp. 2467-2475
    • Honma, K.1
  • 84
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B-cell lymphomas
    • Kato, M. et al. Frequent inactivation of A20 in B-cell lymphomas. Nature 459, 712-716 (2009).
    • (2009) Nature , vol.459 , pp. 712-716
    • Kato, M.1
  • 85
    • 66549086135 scopus 로고    scopus 로고
    • The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    • Novak, U. et al. The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas. Blood 113, 4918-4921 (2009).
    • (2009) Blood , vol.113 , pp. 4918-4921
    • Novak, U.1
  • 86
    • 84883457100 scopus 로고    scopus 로고
    • Germinal and somatic genetic variants of TNFAIP3 promote lymphomagenesis process complicating primary Sjögren's syndrome [abstract OP0023]
    • Nocturne, G. et al. Germinal and somatic genetic variants of TNFAIP3 promote lymphomagenesis process complicating primary Sjögren's syndrome [abstract OP0023]. Ann. Rheum. Dis. 72 (Suppl. 3), 55 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , Issue.SUPPL. 3 , pp. 55
    • Nocturne, G.1
  • 87
    • 84857061990 scopus 로고    scopus 로고
    • HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies
    • Cruz-Tapias, P., Rojas-Villarraga, A., Maier-Moore, S. & Anaya, J. M. HLA and Sjögren's syndrome susceptibility. A meta-analysis of worldwide studies. Autoimmun. Rev. 11, 281-287 (2012).
    • (2012) Autoimmun. Rev. , vol.11 , pp. 281-287
    • Cruz-Tapias, P.1    Rojas-Villarraga, A.2    Maier-Moore, S.3    Anaya, J.M.4
  • 88
    • 0031975394 scopus 로고    scopus 로고
    • Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome
    • Hagiwara, E., Pando, J., Ishigatsubo, Y. & Klinman, D. M. Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J. Rheumatol. 25, 89-93 (1998).
    • (1998) J. Rheumatol. , vol.25 , pp. 89-93
    • Hagiwara, E.1    Pando, J.2    Ishigatsubo, Y.3    Klinman, D.M.4
  • 89
    • 10844279142 scopus 로고    scopus 로고
    • A dual role for interferon-γ in the pathogenesis of Sjögren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse
    • Cha, S. et al. A dual role for interferon-γ in the pathogenesis of Sjögren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse. Scand. J. Immunol. 60, 552-565 (2004).
    • (2004) Scand. J. Immunol. , vol.60 , pp. 552-565
    • Cha, S.1
  • 90
    • 79953160463 scopus 로고    scopus 로고
    • Location of immunization and interferon-γ are central to induction of salivary gland dysfunction in Ro60 peptide immunized model of Sjögren's syndrome
    • Yin, H. et al. Location of immunization and interferon-γ are central to induction of salivary gland dysfunction in Ro60 peptide immunized model of Sjögren's syndrome. PLoS ONE 6, e18003 (2011).
    • (2011) PLoS ONE , vol.6
    • Yin, H.1
  • 91
    • 33749370410 scopus 로고    scopus 로고
    • IL-12 overexpression in mice as a model for Sjögren lung disease
    • McGrath-Morrow, S. et al. IL-12 overexpression in mice as a model for Sjögren lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 291, L837-L846 (2006).
    • (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.291
    • McGrath-Morrow, S.1
  • 92
    • 73249151654 scopus 로고    scopus 로고
    • Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome
    • Vosters, J. L. et al. Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome. Arthritis Rheum. 60, 3633-3641 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 3633-3641
    • Vosters, J.L.1
  • 93
    • 84867907920 scopus 로고    scopus 로고
    • Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases
    • Hall, J. C. et al. Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases. Proc. Natl Acad. Sci. USA 109, 17609-17614 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 17609-17614
    • Hall, J.C.1
  • 94
    • 59849096879 scopus 로고    scopus 로고
    • Cutting edge: Autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-α in lupus patients in vivo
    • Kariuki, S. N. et al. Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-α in lupus patients in vivo. J. Immunol. 182, 34-38 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 34-38
    • Kariuki, S.N.1
  • 95
    • 84883460682 scopus 로고    scopus 로고
    • Interleukin 12 is involved in an interferon type i signature through crosstalk of CD4+ T cells and plasmacytoid dendritic cells [abstract 2321]
    • Miceli-Richard, C. et al. Interleukin 12 is involved in an interferon type I signature through crosstalk of CD4+ T cells and plasmacytoid dendritic cells [abstract 2321]. Arthritis Rheum. 64 (Suppl. 10), S980 (2012).
    • (2012) Arthritis Rheum. , vol.64 , Issue.SUPPL. 10
    • Miceli-Richard, C.1
  • 96
    • 0035905477 scopus 로고    scopus 로고
    • Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4+ T cells
    • Geginat, J., Sallusto, F. & Lanzavecchia, A. Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4+ T cells. J. Exp. Med. 194, 1711-1719 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1711-1719
    • Geginat, J.1    Sallusto, F.2    Lanzavecchia, A.3
  • 97
    • 77950536542 scopus 로고    scopus 로고
    • Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation
    • Bikker, A. et al. Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation. Arthritis Rheum. 62, 969-977 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 969-977
    • Bikker, A.1
  • 98
    • 84860917111 scopus 로고    scopus 로고
    • Increased interleukin (IL)-7Rα expression in salivary glands of patients with primary Sjögren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity
    • Bikker, A. et al. Increased interleukin (IL)-7Rα expression in salivary glands of patients with primary Sjögren's syndrome is restricted to T cells and correlates with IL-7 expression, lymphocyte numbers and activity. Ann. Rheum. Dis. 71, 1027-1033 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1027-1033
    • Bikker, A.1
  • 99
    • 84868377611 scopus 로고    scopus 로고
    • Clinical efficacy of leflunomide in primary Sjögren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor alpha expression
    • Bikker, A. et al. Clinical efficacy of leflunomide in primary Sjögren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor alpha expression. Ann. Rheum. Dis. 71, 1934-1941 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 1934-1941
    • Bikker, A.1
  • 100
    • 70349244787 scopus 로고    scopus 로고
    • Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis
    • Katsifis, G. E., Rekka, S., Moutsopoulos, N. M., Pillemer, S. & Wahl, S. M. Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis. Am. J. Pathol. 175, 1167-1177 (2009).
    • (2009) Am. J. Pathol. , vol.175 , pp. 1167-1177
    • Katsifis, G.E.1    Rekka, S.2    Moutsopoulos, N.M.3    Pillemer, S.4    Wahl, S.M.5
  • 101
    • 53149131365 scopus 로고    scopus 로고
    • Identification of IL-18 and TH17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18
    • Sakai, A., Sugawara, Y., Kuroishi, T., Sasano, T. & Sugawara, S. Identification of IL-18 and TH17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J. Immunol. 181, 2898-2906 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 2898-2906
    • Sakai, A.1    Sugawara, Y.2    Kuroishi, T.3    Sasano, T.4    Sugawara, S.5
  • 102
    • 55349085462 scopus 로고    scopus 로고
    • Foxp3+ T-regulatory cells in Sjögren's syndrome: Correlation with the grade of the autoimmune lesion and certain adverse prognostic factors
    • Christodoulou, M. I., Kapsogeorgou, E. K., Moutsopoulos, N. M. & Moutsopoulos, H. M. Foxp3+ T-regulatory cells in Sjögren's syndrome: correlation with the grade of the autoimmune lesion and certain adverse prognostic factors. Am. J. Pathol. 173, 1389-1396 (2008).
    • (2008) Am. J. Pathol. , vol.173 , pp. 1389-1396
    • Christodoulou, M.I.1    Kapsogeorgou, E.K.2    Moutsopoulos, N.M.3    Moutsopoulos, H.M.4
  • 103
    • 76049096595 scopus 로고    scopus 로고
    • The numbers of Foxp3+ TREG cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjögren's syndrome
    • Sarigul, M. et al. The numbers of Foxp3+ TREG cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjögren's syndrome. Lupus 19, 138-145 (2010).
    • (2010) Lupus , vol.19 , pp. 138-145
    • Sarigul, M.1
  • 104
    • 17444366917 scopus 로고    scopus 로고
    • CD4 CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndrome
    • Gottenberg, J. E. et al. CD4 CD25high regulatory T cells are not impaired in patients with primary Sjögren's syndrome. J. Autoimmun. 24, 235-242 (2005).
    • (2005) J. Autoimmun. , vol.24 , pp. 235-242
    • Gottenberg, J.E.1
  • 105
    • 84855350256 scopus 로고    scopus 로고
    • Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome
    • Ciccia, F. et al. Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome. Ann. Rheum. Dis. 71, 295-301 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 295-301
    • Ciccia, F.1
  • 106
    • 77954627022 scopus 로고    scopus 로고
    • Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity
    • Cella, M., Otero, K. & Colonna, M. Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity. Proc. Natl Acad. Sci. USA 107, 10961-10966 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10961-10966
    • Cella, M.1    Otero, K.2    Colonna, M.3
  • 107
    • 84883460952 scopus 로고    scopus 로고
    • Genetic variation at the NCR3 locus is associated with risk of primary Sjögren's syndrome and implicates a role for NK cells in this autoimmune disease [abstract]
    • Miceli-Richard, C. et al. Genetic variation at the NCR3 locus is associated with risk of primary Sjögren's syndrome and implicates a role for NK cells in this autoimmune disease [abstract]. Ann. Rheum. Dis. 70 (Suppl. 3), 212 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , Issue.SUPPL. 3 , pp. 212
    • Miceli-Richard, C.1
  • 108
    • 84883455702 scopus 로고    scopus 로고
    • Genetic and functional analyses implicate NCR3NKp30 in the pathogenesis of primary sjögren's syndrome
    • in press
    • Nocturne, G. et al. Genetic and functional analyses implicate NCR3/NKp30 in the pathogenesis of primary Sjögren's syndrome. Sci. Transl. Med. (in press).
    • Sci. Transl. Med.
    • Nocturne, G.1
  • 109
    • 84883462313 scopus 로고    scopus 로고
    • Genetic variation in the NCR3 locus is associated with anti-SSA/SSB positive primary Sjögren's syndrome in Scandinavian samples [abstract 522]
    • Nordmark, G. et al. Genetic variation in the NCR3 locus is associated with anti-SSA/SSB positive primary Sjögren's syndrome in Scandinavian samples [abstract 522]. Arthritis Rheum. 64 (Suppl. 10), S228 (2012).
    • (2012) Arthritis Rheum. , vol.64 , Issue.SUPPL. 10
    • Nordmark, G.1
  • 110
    • 34447636217 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis function in Sjögren's syndrome: Mechanisms of neuroendocrine and immune system homeostasis
    • Johnson, E. O., Kostandi, M. & Moutsopoulos, H. M. Hypothalamic-pituitary-adrenal axis function in Sjögren's syndrome: mechanisms of neuroendocrine and immune system homeostasis. Ann. NY Acad. Sci. 1088, 41-51 (2006).
    • (2006) Ann. NY Acad. Sci. , vol.1088 , pp. 41-51
    • Johnson, E.O.1    Kostandi, M.2    Moutsopoulos, H.M.3
  • 113
    • 0141425633 scopus 로고    scopus 로고
    • Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background
    • Ishimaru, N. et al. Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background. Am. J. Pathol. 163, 1481-1490 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 1481-1490
    • Ishimaru, N.1
  • 114
    • 58149288276 scopus 로고    scopus 로고
    • Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy
    • Ishimaru, N. et al. Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy. J. Exp. Med. 205, 2915-2927 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2915-2927
    • Ishimaru, N.1
  • 115
    • 70349220968 scopus 로고    scopus 로고
    • Functional estrogen receptors alpha and beta are expressed in normal human salivary gland epithelium and apparently mediate immunomodulatory effects
    • Tsinti, M. et al. Functional estrogen receptors alpha and beta are expressed in normal human salivary gland epithelium and apparently mediate immunomodulatory effects. Eur. J. Oral Sci. 117, 498-505 (2009).
    • (2009) Eur. J. Oral Sci. , vol.117 , pp. 498-505
    • Tsinti, M.1
  • 116
    • 0028170135 scopus 로고
    • Sjögren's syndrome: Autoimmune epithelitis
    • Moutsopoulos, H. M. Sjögren's syndrome: autoimmune epithelitis. Clin. Immunol. Immunopathol. 72, 162-165 (1994).
    • (1994) Clin. Immunol. Immunopathol. , vol.72 , pp. 162-165
    • Moutsopoulos, H.M.1
  • 117
    • 0029892213 scopus 로고    scopus 로고
    • Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-SCID mouse in the absence of detectable lymphocytic infiltration: A potential trigger for sialoadenitis of NOD mice
    • Robinson, C. P., Yamamoto, H., Peck, A. B. & Humphreys-Beher, M. G. Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-SCID mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice. Clin. Immunol. Immunopathol. 79, 50-59 (1996).
    • (1996) Clin. Immunol. Immunopathol. , vol.79 , pp. 50-59
    • Robinson, C.P.1    Yamamoto, H.2    Peck, A.B.3    Humphreys-Beher, M.G.4
  • 118
    • 0035284814 scopus 로고    scopus 로고
    • Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4
    • Kapsogeorgou, E. K., Moutsopoulos, H. M. & Manoussakis, M. N. Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4. J. Immunol. 166, 3107-3113 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3107-3113
    • Kapsogeorgou, E.K.1    Moutsopoulos, H.M.2    Manoussakis, M.N.3
  • 119
    • 0033045115 scopus 로고    scopus 로고
    • Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sjögren's syndrome
    • Manoussakis, M. N. et al. Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sjögren's syndrome. Arthritis Rheum. 42, 229-239 (1999).
    • (1999) Arthritis Rheum , vol.42 , pp. 229-239
    • Manoussakis, M.N.1
  • 120
    • 70350612907 scopus 로고    scopus 로고
    • B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome
    • Ittah, M. et al. B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome. Arthritis Res. Ther. 8, R51 (2006).
    • (2006) Arthritis Res. Ther. , vol.8
    • Ittah, M.1
  • 121
    • 0029618990 scopus 로고
    • Ribonucleoprotein complexes as autoantigens
    • van Venrooij, W. J. & Pruijn, G. J. Ribonucleoprotein complexes as autoantigens. Curr. Opin. Immunol. 7, 819-824 (1995).
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 819-824
    • Van Venrooij, W.J.1    Pruijn, G.J.2
  • 122
    • 18644377363 scopus 로고    scopus 로고
    • Salivary gland epithelial cell exosomes: A source of autoantigenic ribonucleoproteins
    • Kapsogeorgou, E. K., Abu-Helu, R. F., Moutsopoulos, H. M. & Manoussakis, M. N. Salivary gland epithelial cell exosomes: A source of autoantigenic ribonucleoproteins. Arthritis Rheum. 52, 1517-1521 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1517-1521
    • Kapsogeorgou, E.K.1    Abu-Helu, R.F.2    Moutsopoulos, H.M.3    Manoussakis, M.N.4
  • 123
    • 54349116244 scopus 로고    scopus 로고
    • Reduction of fatigue in Sjögren syndrome with rituximab: Results of a randomised, double-blind, placebo-controlled pilot study
    • Dass, S. et al. Reduction of fatigue in Sjögren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study. Ann. Rheum. Dis. 67, 1541-1544 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1541-1544
    • Dass, S.1
  • 124
    • 77950538947 scopus 로고    scopus 로고
    • Effectiveness of rituximab treatment in primary Sjögren's syndrome: A randomized, double-blind, placebo-controlled trial
    • Meijer, J. M. et al. Effectiveness of rituximab treatment in primary Sjögren's syndrome: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 62, 960-968 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 960-968
    • Meijer, J.M.1
  • 125
    • 34047177483 scopus 로고    scopus 로고
    • Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjögren's syndrome
    • Seror, R. et al. Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjögren's syndrome. Ann. Rheum. Dis. 66, 351-357 (2007).
    • (2007) Ann. Rheum. Dis. , vol.66 , pp. 351-357
    • Seror, R.1
  • 126
    • 84881218563 scopus 로고    scopus 로고
    • Efficacy of belimumab on non-malignant parotid swelling and systemic manifestations of Sjögren's syndrome: Results of the Beliss study [abstract 2189]
    • De Vita, S. et al. Efficacy of belimumab on non-malignant parotid swelling and systemic manifestations of Sjögren's syndrome: results of the Beliss study [abstract 2189]. Arthritis Rheum. 64 (Suppl. 10), S926 (2012).
    • (2012) Arthritis Rheum. , vol.64 , Issue.SUPPL. 10
    • De Vita, S.1
  • 127
    • 0032903599 scopus 로고    scopus 로고
    • Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
    • Fernandez, N. C. et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 5, 405-411 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 405-411
    • Fernandez, N.C.1
  • 128
    • 0037017381 scopus 로고    scopus 로고
    • Reciprocal activating interaction between natural killer cells and dendritic cells
    • Gerosa, F. et al. Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 195, 327-333 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 327-333
    • Gerosa, F.1
  • 129
    • 26844581032 scopus 로고    scopus 로고
    • Natural-killer cells and dendritic cells: "l'union fait la force"
    • Walzer, T., Dalod, M., Robbins, S. H., Zitvogel, L. & Vivier, E. Natural-killer cells and dendritic cells: "l'union fait la force". Blood 106, 2252-2258 (2005).
    • (2005) Blood , vol.106 , pp. 2252-2258
    • Walzer, T.1    Dalod, M.2    Robbins, S.H.3    Zitvogel, L.4    Vivier, E.5
  • 130
    • 84868363350 scopus 로고    scopus 로고
    • Low copy number of the Fc-gamma receptor 3B gene FCGR3B is a risk factor for primary Sjögren's syndrome
    • Nossent, J. C., Rischmueller, M. & Lester, S. Low copy number of the Fc-gamma receptor 3B gene FCGR3B is a risk factor for primary Sjögren's syndrome. J. Rheumatol. 39, 2142-2147 (2012).
    • (2012) J. Rheumatol. , vol.39 , pp. 2142-2147
    • Nossent, J.C.1    Rischmueller, M.2    Lester, S.3
  • 131
    • 84860918960 scopus 로고    scopus 로고
    • Association between genetic variants in the tumour necrosis factor/lymphotoxin alpha/lymphotoxin beta locus and primary Sjögren's syndrome in Scandinavian samples
    • Bolstad, A. I. et al. Association between genetic variants in the tumour necrosis factor/lymphotoxin alpha/lymphotoxin beta locus and primary Sjögren's syndrome in Scandinavian samples. Ann. Rheum. Dis. 71, 981-988 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 981-988
    • Bolstad, A.I.1
  • 132
    • 0035016886 scopus 로고    scopus 로고
    • Polymorphisms of the mannose binding lectin gene in patients with Sjögren's syndrome
    • Wang, Z. Y., Morinobu, A., Kanagawa, S. & Kumagai, S. Polymorphisms of the mannose binding lectin gene in patients with Sjögren's syndrome. Ann. Rheum. Dis. 60, 483-486 (2001).
    • (2001) Ann. Rheum. Dis. , vol.60 , pp. 483-486
    • Wang, Z.Y.1    Morinobu, A.2    Kanagawa, S.3    Kumagai, S.4
  • 133
    • 51349083551 scopus 로고    scopus 로고
    • IκBα promoter polymorphisms in patients with primary Sjögren's syndrome
    • Ou, T. T. et al. IκBα promoter polymorphisms in patients with primary Sjögren's syndrome. J. Clin. Immunol. 28, 440-444 (2008).
    • (2008) J. Clin. Immunol. , vol.28 , pp. 440-444
    • Ou, T.T.1
  • 134
    • 0036301115 scopus 로고    scopus 로고
    • TAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary Sjögren's syndrome
    • Anaya, J. M., Correa, P. A., Mantilla, R. D. & Arcos-Burgos, M. TAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary Sjögren's syndrome. Semin. Arthritis Rheum. 31, 396-405 (2002).
    • (2002) Semin. Arthritis Rheum. , vol.31 , pp. 396-405
    • Anaya, J.M.1    Correa, P.A.2    Mantilla, R.D.3    Arcos-Burgos, M.4
  • 135
    • 79952280367 scopus 로고    scopus 로고
    • Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome
    • Nordmark, G. et al. Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome. Genes Immun. 12, 100-109 (2011).
    • (2011) Genes Immun , vol.12 , pp. 100-109
    • Nordmark, G.1
  • 136
    • 27844441281 scopus 로고    scopus 로고
    • PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases
    • Gomez, L. M. et al. PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases. Genes Immun. 6, 628-631 (2005).
    • (2005) Genes Immun , vol.6 , pp. 628-631
    • Gomez, L.M.1
  • 137
    • 0036709574 scopus 로고    scopus 로고
    • CC chemokine receptor 5 and interleukin-1 receptor antagonist gene polymorphisms in patients with primary Sjögren's syndrome
    • Petrek, M. et al. CC chemokine receptor 5 and interleukin-1 receptor antagonist gene polymorphisms in patients with primary Sjögren's syndrome. Clin. Exp. Rheumatol. 20, 701-703 (2002).
    • (2002) Clin. Exp. Rheumatol. , vol.20 , pp. 701-703
    • Petrek, M.1
  • 138
    • 0035147109 scopus 로고    scopus 로고
    • Genetic association between interleukin-10 promoter region polymorphisms and primary Sjögren's syndrome
    • Hulkkonen, J. et al. Genetic association between interleukin-10 promoter region polymorphisms and primary Sjögren's syndrome. Arthritis Rheum. 44, 176-179 (2001).
    • (2001) Arthritis Rheum , vol.44 , pp. 176-179
    • Hulkkonen, J.1
  • 139
    • 0018220157 scopus 로고
    • Increased risk of lymphoma in sicca syndrome
    • Kassan, S. S. et al. Increased risk of lymphoma in sicca syndrome. Ann. Intern. Med. 89, 888-892 (1978).
    • (1978) Ann. Intern. Med. , vol.89 , pp. 888-892
    • Kassan, S.S.1
  • 140
    • 0031451930 scopus 로고    scopus 로고
    • Differential risk of non-Hodgkin's lymphoma in Italian patients with primary Sjögren's syndrome
    • Valesini, G. et al. Differential risk of non-Hodgkin's lymphoma in Italian patients with primary Sjögren's syndrome. J. Rheumatol. 24, 2376-2380 (1997).
    • (1997) J. Rheumatol. , vol.24 , pp. 2376-2380
    • Valesini, G.1
  • 141
    • 0030942071 scopus 로고    scopus 로고
    • Elevated incidence of hematologic malignancies in patients with Sjögren's syndrome compared with patients with rheumatoid arthritis (Finland)
    • Kauppi, M., Pukkala, E. & Isomaki, H. Elevated incidence of hematologic malignancies in patients with Sjögren's syndrome compared with patients with rheumatoid arthritis (Finland). Cancer Causes Control 8, 201-204 (1997).
    • (1997) Cancer Causes Control , vol.8 , pp. 201-204
    • Kauppi, M.1    Pukkala, E.2    Isomaki, H.3
  • 142
    • 0035023371 scopus 로고    scopus 로고
    • A longitudinal cohort study of Finnish patients with primary Sjögren's syndrome: Clinical, immunological, and epidemiological aspects
    • Pertovaara, M., Pukkala, E., Laippala, P., Miettinen, A. & Pasternack, A. A longitudinal cohort study of Finnish patients with primary Sjögren's syndrome: clinical, immunological, and epidemiological aspects. Ann. Rheum. Dis. 60, 467-472 (2001).
    • (2001) Ann. Rheum. Dis. , vol.60 , pp. 467-472
    • Pertovaara, M.1    Pukkala, E.2    Laippala, P.3    Miettinen, A.4    Pasternack, A.5


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