B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation

European Journal of Immunology

Volumn 39, Issue 5, 2009, Pages 1271-1279

  Ittah, Marc ^a   Miceli Richard, Corrine ^a   Gottenberg, Jaques Eric ^a   Sellam, Jérémie ^a   Lepajolec, Christine ^a   Mariette, Xavier ^a  

^a BICÊTRE HOSPITAL   (France)

Author keywords

B cell activating factor; NF B; RNA activated protein kinase; Sj gren's syndrome; TLR

Indexed keywords

2 AMINOPURINE; B CELL ACTIVATING FACTOR; DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 24; INTERLEUKIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYCYTIDYLIC ACID; PROTEIN KINASE; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; IFIH1 PROTEIN, HUMAN; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE R; SMALL INTERFERING RNA; TLR3 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TNFSF13B PROTEIN, HUMAN;

ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOSOME; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REOVIRUS; RNA REPLICATION; RNA SYNTHESIS; SALIVARY GLAND; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS INFECTION; AUTOIMMUNE DISEASE; BIOSYNTHESIS; BLOOD; CELL STRAIN K 562; DRUG ANTAGONISM; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA VIRUS; RNA VIRUS INFECTION;

AUTOIMMUNE DISEASES; B-CELL ACTIVATING FACTOR; DEAD-BOX RNA HELICASES; EIF-2 KINASE; ENZYME ACTIVATION; HUMANS; K562 CELLS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY I-C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA VIRUS INFECTIONS; RNA VIRUSES; RNA, DOUBLE-STRANDED; RNA, MESSENGER; RNA, SMALL INTERFERING; SALIVARY GLANDS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 7; TRANSFECTION;

EID: 67649948121     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200839086     Document Type: Article

References (35)

1. Schneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer, J. L., Holler, N., Ambrose, C. et al., BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 1999. 189: 1747-1756.
2. Lesley, R., Xu, Y., Kalled, S. L., Hess, D. M., Schwab, S. R., Shu, H. B. and Cyster, J. G., Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 2004. 20: 441-453.
3. Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C., Baetscher, M., Schneider, P., Tschopp, J. and Browning, J. L., Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J. Exp. Med. 1999. 190: 1697-1710.
4. Stohl, W., Metyas, S., Tan, S. M., Cheema, G. S., Oamar, B., Xu, D., Roschke, V. et al., B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: Longitudinal observations. Arthritis Rheum. 2003. 48: 3475-3486.
5. Mariette, X., Roux, S., Zhang, J., Bengoufa, D., Lavie, F., Zhou, T. and Kimberly, R., The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjogren's syndrome. Ann. Rheum. Dis. 2003. 62: 168-171.
6. Ohata, J., Zvaifler, N. J., Nishio, M., Boyle, D. L., Kalled, S. L., Carson, D. A. and Kipps, T. J., Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J. Immunol. 2005. 174: 864-870.
7. Krumbholz, M., Theil, D., Derfuss, T., Rosenwald, A., Schrader, F., Monoranu, C. M., Kalled, S. L. et al., BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J. Exp. Med. 2005. 201: 195-200.
8. Ittah, M., Miceli-Richard, C., Eric Gottenberg, J., Lavie, F., Lazure, T., Ba, N., Sellam, J. et al., B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjogren's syndrome. Arthritis Res. Ther. 2006. 8: R51.
9. Theander, E., Henriksson, G., Ljungberg, O., Mandl, T., Manthorpe, R. and Jacobsson, L. T., Lymphoma and other malignancies in primary Sjogren's syndrome: A cohort study on cancer incidence and lymphoma predictors. Ann. Rheum. Dis. 2006. 65: 796-803.
10. Kirou, K. A., Lee, C., George, S., Louca, K., Papagiannis, I. G., Peterson, M. G., Ly, N. et al., Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus. Arthritis Rheum. 2004. 50: 3958-3967.
11. Gottenberg, J. E., Cagnard, N., Lucchesi, C., Letourneur, F., Mistou, S., Lazure, T., Jacques, S. et al., Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjogren's syndrome. Proc. Natl. Acad. Sci. USA 2006. 103: 2770-2775.
12. Hjelmervik, T. O., Petersen, K., Jonassen, I., Jonsson, R. and Bolstad, A. I., Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren's syndrome patients from healthy control subjects. Arthritis Rheum. 2005. 52: 1534-1544.
13. Bave, U., Nordmark, G., Lovgren, T., Ronnelid, J., Cajander, S., Eloranta, M. L., Alm, G. V. and Ronnblom, L., Activation of the type I interferon system in primary Sjogren's syndrome: A possible etiopathogenic mechanism. Arthritis Rheum. 2005. 52: 1185-1195.
14. Ittah, M., Miceli-Richard, C., Gottenberg, J. E., Sellam, J., Eid, P., Lebon, P., Pallier, C. et al., Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways. Eur. J. Immunol. 2008. 38: 1058-1064.
15. Hornung, V., Ellegast, J., Kim, S., Brzozka, K., Jung, A., Kato, H., Poeck, H. et al., 5′-Triphosphate RNA is the ligand for RIG-I. Science 2006. 314: 994-997.
16. Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A. et al., Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 2008. 205: 1601-1610.
17. Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S. et al., Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006. 441: 101-105.
18. Williams, B. R., PKR; a sentinel kinase for cellular stress. Oncogene 1999. 18: 6112-6120.
19. Spachidou, M. P., Bourazopoulou, E., Maratheftis, C. I., Kapsogeorgou, E. K., Moutsopoulos, H. M., Tzioufas, A. G. and Manoussakis, M. N., Expression of functional Toll-like receptors by salivary gland epithelial cells: Increased mRNA expression in cells derived from patients with primary Sjogren's syndrome. Clin. Exp. Immunol. 2007. 147: 497-503.
20. Jiang, Z., Zamanian-Daryoush, M., Nie, H., Silva, A. M., Williams, B. R. and Li, X., Poly(I-C)-induced toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J. Biol. Chem. 2003. 278: 16713-16719.
21. Hardenberg, G., Planelles, L., Schwarte, C. M., van Bostelen, L., Le Huong, T., Hahne, M. and Medema, J. P., Specific TLR ligands regulate APRIL secretion by dendritic cells in a PKR-dependent manner. Eur. J. Immunol. 2007. 37: 2900-2911.
22. Litinskiy, M. B., Nardelli, B., Hilbert, D. M., He, B., Schaffer, A., Casali, P. and Cerutti, A., DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat. Immunol. 2002. 3: 822-829.
23. Yoshimoto, K., Takahashi, Y., Ogasawara, M., Setoyama, Y., Suzuki, K., Tsuzaka, K., Abe, T. and Takeuchi, T., Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy. Int. Immunol. 2006. 18: 1189-1196.
24. Clarke, P., Meintzer, S. M., Widmann, C., Johnson, G. L. and Tyler, K. L., Reovirus infection activates JNK and the JNK-dependent transcription factor c-Jun. J. Virol. 2001. 75: 11275-11283.
25. Clarke, P., Debiasi, R. L., Goody, R., Hoyt, C. C., Richardson-Burns, S. and Tyler, K. L., Mechanisms of reovirus-induced cell death and tissue injury: Role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 2005. 18: 89-115.
26. Meusel, T. R. and Imani, F., Viral induction of inflammatory cytokines in human epithelial cells follows a p38 mitogen-activated protein kinase-dependent but NF-kappa B-independent pathway. J. Immunol. 2003. 171: 3768-3774.
27. Fagarasan, S. and Honjo, T., T-Independent immune response: New aspects of B cell biology. Science 2000. 290: 89-92.
28. Macpherson, A. J. and Lamarre, A., BLySsful interactions between DCs and B cells. Nat. Immunol. 2002. 3: 798-800.
29. Xu, W., Santini, P. A., Matthews, A. J., Chiu, A., Plebani, A., He, B., Chen, K. and Cerutti, A., Viral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF. J. Immunol. 2008. 181: 276-287.
30. Kato, A., Truong-Tran, A. Q., Scott, A. L., Matsumoto, K. and Schleimer, R. P., Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism. J. Immunol. 2006. 177: 7164-7172.
31. Xu, W., He, B., Chiu, A., Chadburn, A., Shan, M., Buldys, M., Ding, A. et al., Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nat. Immunol. 2007. 8: 294-303.
32. Lerner, M. R. and Steitz, J. A., Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 1979. 76: 5495-5499.
33. Craft, J., Antibodies to snRNPs in systemic lupus erythematosus. Rheum. Dis. Clin. North Am. 1992. 18: 311-335.
34. Kelly, K. M., Zhuang, H., Nacionales, D. C., Scumpia, P. O., Lyons, R., Akaogi, J., Lee, P. et al., "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60. Arthritis Rheum. 2006. 54: 1557-1567.
35. Dimitriou, I. D., Kapsogeorgou, E. K., Abu-Helu, R. F., Moutsopoulos, H. M. and Manoussakis, M. N., Establishment of a convenient system for the long-term culture and study of non-neoplastic human salivary gland epithelial cells. Eur. J. Oral Sci. 2002. 110: 21-30.