Functional expression of a costimulatory B7.2 (CD86) protein on human salivary gland epithelial cells that interacts with the CD28 receptor, but has reduced binding to CTLA4

Journal of Immunology

Volumn 166, Issue 5, 2001, Pages 3107-3113

  Kapsogeorgou, E K ^a   Moutsopoulos, H M ^a   Manoussakis, M N ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GROWTH FACTOR; INTERLEUKIN 2; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND; SJOEGREN SYNDROME; T LYMPHOCYTE;

EID: 0035284814     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.5.3107     Document Type: Article

References (48)

1. CD28/B7 system of T cell costimulation
2. The role of B7-1/B7-2: CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response
3. + T cells
4. Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
5. Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 costimulatory molecules
6. Costimulation and autoimmunity
7. Transplantation of anergic histoincompatible bone marrow allografts
8. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic cells
9. B70 antigen is a second ligand for CTLA-4 and CD28
10. Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
11. Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation
12. The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor
13. Human muscle cells express a functional costimulatory molecule distinct from B7.1 (CD80) and B7.2 (CD86) in vitro and in inflammatory lesions
14. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα
15. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
16. CTLA-4 is a second receptor for the B cell activation antigen B7
17. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
18. CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics
19. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
20. CTLA-4 ligation blocks CD28-dependent T cell activation
21. Functional expression of B7/BB1 on activated T lymphocytes
22. Expression of a hypoglycosylated form of CD86 (B7.2) on human T cells with altered binding properties to CD28 and CTLA-4
23. + T cell activation during Helicobacter pylori infection
24. Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa
25. Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells: Cloning, sequencing, and functional expression in human endothelial cells
26. Primary porcine endothelial cells express membrane-bound B7-2 (CD86) and a soluble factor that co-stimulate cyclosporin-A-resistant and CD28-dependent human T cell proliferation
27. Potential roles of the B7 and CD28 receptors families in autoimmunity and immune evasion
28. The CD28-B7 costimulatory pathway and its role in autoimmune disease
29. B7-2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: Implications for induction of antitumor immunity to T cell tumors
30. In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation
31. Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sjögren's syndrome
32. Preliminary criteria for the classification of Sjögren's syndrome: Results of the EEC prospective concerted action
33. Secretion of α-amylase in human parotid gland epithelial cell culture
34. Differential expression of alternate mB7-2 transcripts
35. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines
36. + T lymphocytes from interleukin-2-deficient mice by costimulatory B7 molecules
37. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent IL-2-independent mechanism
38. IL-2-independent activation and proliferation in human T cells induced by CD28
39. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
40. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin-2
41. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation interleukin 2 mRNA accumulation
42. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon γ production
43. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
44. Detection of a soluble form of B7-1 (CD80) in synovial fluid from patients with arthritis using monoclonal antibodies against distinct epitopes of human B7-1
45. Primary structure and functional characterization of a soluble, alternatively spliced form of B7-1
46. Sjögren's syndrome: Autoimmune epithelitis
47. Sjögren's syndrome: Autoimmune epithelitis
48. Soluble CD86 is a costimulatory molecule for human T lymphocytes