Allelic origin of protease-sensitive and protease-resistant prion protein isoforms in gerstmann-sträussler-scheinker disease with the p102l mutation

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Monaco, Salvatore ^a   Fiorini, Michele ^a   Farinazzo, Alessia ^a   Ferrari, Sergio ^a   Gelati, Matteo ^a   Piccardo, Pedro ^b,c   Zanusso, Gianluigi ^a   Ghetti, Bernardino ^c  

^a UNIVERSITY OF VERONA   (Italy)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; PRION PROTEIN; PROTEASE RESISTANT PRION PROTEIN ISOFORM; PROTEASE SENSITIVE PRION PROTEIN ISOFORM; UNCLASSIFIED DRUG; PEPTIDE HYDROLASE; SUCROSE;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENOMIC FRAGMENT; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR BIOLOGY; NERVE DEGENERATION; NEUROPATHOLOGY; PARAFFIN EMBEDDED TISSUE BLOT; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN CONFORMATION; SENSITIVITY ANALYSIS; TISSUE DISTRIBUTION; TISSUE PREPARATION; WESTERN BLOTTING; AGED; BIOLOGICAL MODEL; CHEMISTRY; DENSITY GRADIENT CENTRIFUGATION; GENETICS; ISOELECTRIC FOCUSING; METABOLISM; METHODOLOGY; MIDDLE AGED; POINT MUTATION; POSITRON EMISSION TOMOGRAPHY; PROTEIN DEGRADATION;

ADULT; AGED; ALLELES; CENTRIFUGATION, DENSITY GRADIENT; FEMALE; GERSTMANN-STRAUSSLER-SCHEINKER DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOELECTRIC FOCUSING; MALE; MIDDLE AGED; MODELS, GENETIC; PEPTIDE HYDROLASES; PHENOTYPE; POINT MUTATION; POSITRON-EMISSION TOMOGRAPHY; PROTEIN CONFORMATION; PROTEOLYSIS; PRPSC PROTEINS; SUCROSE;

EID: 84857517525     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032382     Document Type: Article

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