-
1
-
-
0022640843
-
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann, T.R., et al.: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986.
-
(1986)
J Immunol
, vol.136
, pp. 2348-2357
-
-
Mosmann, T.R.1
-
2
-
-
0030021790
-
The role of T-lymphocytes and cytokines in rheumatoid arthritis
-
Smolen, J.S., et al.: The role of T-lymphocytes and cytokines in rheumatoid arthritis. Scand J Rheumatol 25: 1-4, 1996.
-
(1996)
Scand J Rheumatol
, vol.25
, pp. 1-4
-
-
Smolen, J.S.1
-
3
-
-
0031159108
-
High susceptibility to collagen-induced arthritis in mice lacking IFN-g receptors
-
Manoury-Schwartz, B., et al.: High susceptibility to collagen-induced arthritis in mice lacking IFN-g receptors. J Immunol 158: 5501-5506, 1997.
-
(1997)
J Immunol
, vol.158
, pp. 5501-5506
-
-
Manoury-Schwartz, B.1
-
4
-
-
0031156936
-
Accelerated collagen-induced arthritis in IFN-g receptor-deficient mice
-
Vermeire, K., et al.: Accelerated collagen-induced arthritis in IFN-g receptor-deficient mice. J Immunol 158: 5507-5513, 1997.
-
(1997)
J Immunol
, vol.158
, pp. 5507-5513
-
-
Vermeire, K.1
-
5
-
-
0034762869
-
Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collageninduced arthritis in a nonsusceptible mouse strain
-
Guedez, Y.B., et al.: Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collageninduced arthritis in a nonsusceptible mouse strain. Arthritis Rheum 44: 2413-2424, 2001.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 2413-2424
-
-
Guedez, Y.B.1
-
6
-
-
0023879766
-
Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma
-
Billiau, A., et al.: Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J Immunol 140: 1506-1510, 1988.
-
(1988)
J Immunol
, vol.140
, pp. 1506-1510
-
-
Billiau, A.1
-
7
-
-
0029671318
-
Mice with a disrupted IFNgamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
-
Ferber, I.A., et al.: Mice with a disrupted IFNgamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156: 5-7, 1996.
-
(1996)
J Immunol
, vol.156
, pp. 5-7
-
-
Ferber, I.A.1
-
8
-
-
0029957071
-
Interferon-gamma confers resistance to experimental allergic encephalomyelitis
-
Krakowski, M., Owens, T.: Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 26: 1641-1646, 1996.
-
(1996)
Eur J Immunol
, vol.26
, pp. 1641-1646
-
-
Krakowski, M.1
Owens, T.2
-
9
-
-
0025293228
-
Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferongamma in Lewis rats
-
Voorthuis, J.A., et al.: Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferongamma in Lewis rats. Clin Exp Immunol 81: 183-188, 1990.
-
(1990)
Clin Exp Immunol
, vol.81
, pp. 183-188
-
-
Voorthuis, J.A.1
-
10
-
-
0030587910
-
IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
Willenborg, D.O., et al.: IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 157: 3223-3227, 1996.
-
(1996)
J Immunol
, vol.157
, pp. 3223-3227
-
-
Willenborg, D.O.1
-
11
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington, L.E., et al.: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132, 2005.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
-
12
-
-
27544465354
-
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
-
Park, H., et al.: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6: 1133-1141, 2005.
-
(2005)
Nat Immunol
, vol.6
, pp. 1133-1141
-
-
Park, H.1
-
13
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B., et al.: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725, 2000.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
-
14
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D.J., et al.: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748, 2003.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
-
15
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
Aggarwal, S., et al.: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278: 1910-1914, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 1910-1914
-
-
Aggarwal, S.1
-
16
-
-
0033134608
-
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
-
Kotake, S., et al.: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103: 1345-1352, 1999.
-
(1999)
J Clin Invest
, vol.103
, pp. 1345-1352
-
-
Kotake, S.1
-
17
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells
-
Bettelli, E., et al.: Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 441: 235-238, 2006.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
-
18
-
-
33646560950
-
Transforming growth factor-b induces development of the Th17 lineage
-
Mangan, P.R., et al.: Transforming growth factor-b induces development of the Th17 lineage. Nature 441: 231-234, 2006.
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
-
19
-
-
34548125305
-
Interleukins 1b and 6 but not transforming growth factor-b are essential for the differentiation of interleukin 17-producing human T helper cells
-
Acosta-Rodriguez, E.V., et al.: Interleukins 1b and 6 but not transforming growth factor-b are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8: 942-949, 2007.
-
(2007)
Nat Immunol
, vol.8
, pp. 942-949
-
-
Acosta-Rodriguez, E.V.1
-
20
-
-
34548133583
-
Development, cytokine profile and function of human interleukin 17-producing helper T cells
-
Wilson, N.J., et al.: Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8: 950-957, 2007.
-
(2007)
Nat Immunol
, vol.8
, pp. 950-957
-
-
Wilson, N.J.1
-
21
-
-
44049104564
-
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
-
Manel, N., et al.: The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9: 641-649, 2008.
-
(2008)
Nat Immunol
, vol.9
, pp. 641-649
-
-
Manel, N.1
-
22
-
-
44049102724
-
A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
-
Volpe, E., et al.: A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9: 650-657, 2008.
-
(2008)
Nat Immunol
, vol.9
, pp. 650-657
-
-
Volpe, E.1
-
23
-
-
36248965294
-
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
-
McGeachy, M.J., et al.: TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8: 1390-1397, 2007.
-
(2007)
Nat Immunol
, vol.8
, pp. 1390-1397
-
-
McGeachy, M.J.1
-
24
-
-
33748588423
-
The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, I.I., et al.: The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133, 2006.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
-
25
-
-
47749107262
-
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
-
Kimura, A., et al.: Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci USA 105: 9721-9726, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9721-9726
-
-
Kimura, A.1
-
26
-
-
42649106556
-
The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins
-
Veldhoen, M., et al.: The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins. Nature 453: 106-109, 2008.
-
(2008)
Nature
, vol.453
, pp. 106-109
-
-
Veldhoen, M.1
-
27
-
-
0034541221
-
Microbial lipopeptides induce the production of IL-17 in Th cells
-
Infante-Duarte, C., et al.: Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 165: 6107-6115, 2000.
-
(2000)
J Immunol
, vol.165
, pp. 6107-6115
-
-
Infante-Duarte, C.1
-
28
-
-
69349093225
-
Interleukin-17 and type 17 helper T cells
-
Miossec, P., et al.: Interleukin-17 and type 17 helper T cells. N Engl J Med 361: 888-898, 2009.
-
(2009)
N Engl J Med
, vol.361
, pp. 888-898
-
-
Miossec, P.1
-
29
-
-
17944364849
-
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
-
Ye, P., et al.: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 194: 519-527, 2001.
-
(2001)
J Exp Med
, vol.194
, pp. 519-527
-
-
Ye, P.1
-
30
-
-
3242814586
-
Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice
-
Huang, W., et al.: Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190: 624-631, 2004.
-
(2004)
J Infect Dis
, vol.190
, pp. 624-631
-
-
Huang, W.1
-
31
-
-
0344585384
-
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
-
Nakae, S., et al.: Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 171: 6173-6177, 2003.
-
(2003)
J Immunol
, vol.171
, pp. 6173-6177
-
-
Nakae, S.1
-
32
-
-
77950535421
-
LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-ofconcept study
-
Genovese, M.C., et al.: LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-ofconcept study. Arthritis Rheum 62: 929-939, 2010.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 929-939
-
-
Genovese, M.C.1
-
33
-
-
74249094930
-
Comparison of ustekinumab and etanercept for moderate-tosevere psoriasis
-
Grieffiths, C.E., et al.: Comparison of ustekinumab and etanercept for moderate-tosevere psoriasis. N Engl J Med 362: 118-128, 2010.
-
(2010)
N Engl J Med
, vol.362
, pp. 118-128
-
-
Grieffiths, C.E.1
-
34
-
-
0347285359
-
Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
-
Lee, E., et al.: Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199: 125-130, 2004.
-
(2004)
J Exp Med
, vol.199
, pp. 125-130
-
-
Lee, E.1
-
35
-
-
77957952423
-
Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques
-
Johnson-Huang, L.M., et al.: Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques. J Invest Dermatol 130: 2654-2663, 2010.
-
(2010)
J Invest Dermatol
, vol.130
, pp. 2654-2663
-
-
Johnson-Huang, L.M.1
-
36
-
-
37549011317
-
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
-
Zaba, L.C., et al.: Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 204: 3183-3194, 2007.
-
(2007)
J Exp Med
, vol.204
, pp. 3183-3194
-
-
Zaba, L.C.1
-
37
-
-
33751546237
-
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
-
Chan, J.R., et al.: IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med 203: 2577-2587, 2006.
-
(2006)
J Exp Med
, vol.203
, pp. 2577-2587
-
-
Chan, J.R.1
-
38
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal in-flammation and acanthosis
-
Zheng, Y., et al.: Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal in-flammation and acanthosis. Nature 445: 648-651, 2007.
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
-
39
-
-
84859017988
-
Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
-
Papp, K.A., et al.: Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med 366: 1181-1189, 2012.
-
(2012)
N Engl J Med
, vol.366
, pp. 1181-1189
-
-
Papp, K.A.1
-
40
-
-
84859073115
-
Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
-
Leonardi, C., et al.: Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl JMed 366: 1190-1199, 2012.
-
(2012)
N Engl JMed
, vol.366
, pp. 1190-1199
-
-
Leonardi, C.1
-
41
-
-
79955526989
-
Suppression of Th17 differentiation and autoimmunity by a synthetic ROR ligand
-
Solt, L.A., et al.: Suppression of Th17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472: 491-494, 2011.
-
(2011)
Nature
, vol.472
, pp. 491-494
-
-
Solt, L.A.1
-
42
-
-
79955538365
-
Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgammat activity
-
Huh, J.R., et al.: Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgammat activity. Nature 472: 486-490, 2011.
-
(2011)
Nature
, vol.472
, pp. 486-490
-
-
Huh, J.R.1
-
43
-
-
77951636478
-
Mast cells express IL-17A in rheumatoid arthritis synovium
-
Hueber, A.J., et al.: Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol 184: 3336-3340, 2010.
-
(2010)
J Immunol
, vol.184
, pp. 3336-3340
-
-
Hueber, A.J.1
-
44
-
-
80053172579
-
Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and-negative rheumatoid arthritis and osteoarthritis synovium
-
Suurmond, J., et al.: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and-negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther 13: R150, 2011.
-
(2011)
Arthritis Res Ther
, vol.13
-
-
Suurmond, J.1
-
45
-
-
45449084802
-
Gammadelta T cells: An important source of IL-17
-
Roark, C.L., et al.: gammadelta T cells: an important source of IL-17. Curr Opin Immunol 20: 353-357, 2008.
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 353-357
-
-
Roark, C.L.1
-
46
-
-
80755180843
-
Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation
-
Cai, Y., et al.: Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35: 596-610, 2011.
-
(2011)
Immunity
, vol.35
, pp. 596-610
-
-
Cai, Y.1
-
47
-
-
84861801523
-
Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice
-
Pantelyushin, S., et al.: Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J Clin Invest 122: 2252-2256, 2012.
-
(2012)
J Clin Invest
, vol.122
, pp. 2252-2256
-
-
Pantelyushin, S.1
-
48
-
-
79959584686
-
Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
-
Lin, A.M., et al.: Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 187: 490-500, 2011.
-
(2011)
J Immunol
, vol.187
, pp. 490-500
-
-
Lin, A.M.1
-
49
-
-
84871701834
-
Ustekinumab induction and maintenance therapy in refractory Crohn's disease
-
Sandborn, W.J., et al.: Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 367: 1519-1528, 2012.
-
(2012)
N Engl J Med
, vol.367
, pp. 1519-1528
-
-
Sandborn, W.J.1
-
50
-
-
79951677394
-
Fate mapping of IL-17-producing T cells in inflammatory responses
-
Hirota, K., et al.: Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12: 255-263, 2011.
-
(2011)
Nat Immunol
, vol.12
, pp. 255-263
-
-
Hirota, K.1
-
51
-
-
84875473675
-
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses
-
Hirota, K., et al.: Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 14: 372-379, 2013.
-
(2013)
Nat Immunol
, vol.14
, pp. 372-379
-
-
Hirota, K.1
|