메뉴 건너뛰기




Volumn 36, Issue 4, 2013, Pages 203-208

The IL-23/IL-17 axis as a therapeutic target

Author keywords

IL 17; IL 23; Th17; Ustekinumab

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 23;

EID: 84883407518     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.36.203     Document Type: Review
Times cited : (4)

References (51)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T.R., et al.: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1
  • 2
    • 0030021790 scopus 로고    scopus 로고
    • The role of T-lymphocytes and cytokines in rheumatoid arthritis
    • Smolen, J.S., et al.: The role of T-lymphocytes and cytokines in rheumatoid arthritis. Scand J Rheumatol 25: 1-4, 1996.
    • (1996) Scand J Rheumatol , vol.25 , pp. 1-4
    • Smolen, J.S.1
  • 3
    • 0031159108 scopus 로고    scopus 로고
    • High susceptibility to collagen-induced arthritis in mice lacking IFN-g receptors
    • Manoury-Schwartz, B., et al.: High susceptibility to collagen-induced arthritis in mice lacking IFN-g receptors. J Immunol 158: 5501-5506, 1997.
    • (1997) J Immunol , vol.158 , pp. 5501-5506
    • Manoury-Schwartz, B.1
  • 4
    • 0031156936 scopus 로고    scopus 로고
    • Accelerated collagen-induced arthritis in IFN-g receptor-deficient mice
    • Vermeire, K., et al.: Accelerated collagen-induced arthritis in IFN-g receptor-deficient mice. J Immunol 158: 5507-5513, 1997.
    • (1997) J Immunol , vol.158 , pp. 5507-5513
    • Vermeire, K.1
  • 5
    • 0034762869 scopus 로고    scopus 로고
    • Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collageninduced arthritis in a nonsusceptible mouse strain
    • Guedez, Y.B., et al.: Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collageninduced arthritis in a nonsusceptible mouse strain. Arthritis Rheum 44: 2413-2424, 2001.
    • (2001) Arthritis Rheum , vol.44 , pp. 2413-2424
    • Guedez, Y.B.1
  • 6
    • 0023879766 scopus 로고
    • Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma
    • Billiau, A., et al.: Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J Immunol 140: 1506-1510, 1988.
    • (1988) J Immunol , vol.140 , pp. 1506-1510
    • Billiau, A.1
  • 7
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFNgamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber, I.A., et al.: Mice with a disrupted IFNgamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 156: 5-7, 1996.
    • (1996) J Immunol , vol.156 , pp. 5-7
    • Ferber, I.A.1
  • 8
    • 0029957071 scopus 로고    scopus 로고
    • Interferon-gamma confers resistance to experimental allergic encephalomyelitis
    • Krakowski, M., Owens, T.: Interferon-gamma confers resistance to experimental allergic encephalomyelitis. Eur J Immunol 26: 1641-1646, 1996.
    • (1996) Eur J Immunol , vol.26 , pp. 1641-1646
    • Krakowski, M.1    Owens, T.2
  • 9
    • 0025293228 scopus 로고
    • Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferongamma in Lewis rats
    • Voorthuis, J.A., et al.: Suppression of experimental allergic encephalomyelitis by intraventricular administration of interferongamma in Lewis rats. Clin Exp Immunol 81: 183-188, 1990.
    • (1990) Clin Exp Immunol , vol.81 , pp. 183-188
    • Voorthuis, J.A.1
  • 10
    • 0030587910 scopus 로고    scopus 로고
    • IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Willenborg, D.O., et al.: IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 157: 3223-3227, 1996.
    • (1996) J Immunol , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1
  • 11
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L.E., et al.: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132, 2005.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 12
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H., et al.: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6: 1133-1141, 2005.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1
  • 13
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B., et al.: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725, 2000.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 14
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D.J., et al.: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748, 2003.
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 15
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., et al.: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278: 1910-1914, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1
  • 16
    • 0033134608 scopus 로고    scopus 로고
    • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    • Kotake, S., et al.: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103: 1345-1352, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 1345-1352
    • Kotake, S.1
  • 17
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells
    • Bettelli, E., et al.: Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 441: 235-238, 2006.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1
  • 18
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-b induces development of the Th17 lineage
    • Mangan, P.R., et al.: Transforming growth factor-b induces development of the Th17 lineage. Nature 441: 231-234, 2006.
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1
  • 19
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1b and 6 but not transforming growth factor-b are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez, E.V., et al.: Interleukins 1b and 6 but not transforming growth factor-b are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8: 942-949, 2007.
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1
  • 20
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson, N.J., et al.: Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8: 950-957, 2007.
    • (2007) Nat Immunol , vol.8 , pp. 950-957
    • Wilson, N.J.1
  • 21
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    • Manel, N., et al.: The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 9: 641-649, 2008.
    • (2008) Nat Immunol , vol.9 , pp. 641-649
    • Manel, N.1
  • 22
    • 44049102724 scopus 로고    scopus 로고
    • A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses
    • Volpe, E., et al.: A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9: 650-657, 2008.
    • (2008) Nat Immunol , vol.9 , pp. 650-657
    • Volpe, E.1
  • 23
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy, M.J., et al.: TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 8: 1390-1397, 2007.
    • (2007) Nat Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1
  • 24
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov, I.I., et al.: The orphan nuclear receptor RORgt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133, 2006.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1
  • 25
    • 47749107262 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
    • Kimura, A., et al.: Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci USA 105: 9721-9726, 2008.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9721-9726
    • Kimura, A.1
  • 26
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins
    • Veldhoen, M., et al.: The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins. Nature 453: 106-109, 2008.
    • (2008) Nature , vol.453 , pp. 106-109
    • Veldhoen, M.1
  • 27
    • 0034541221 scopus 로고    scopus 로고
    • Microbial lipopeptides induce the production of IL-17 in Th cells
    • Infante-Duarte, C., et al.: Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 165: 6107-6115, 2000.
    • (2000) J Immunol , vol.165 , pp. 6107-6115
    • Infante-Duarte, C.1
  • 28
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec, P., et al.: Interleukin-17 and type 17 helper T cells. N Engl J Med 361: 888-898, 2009.
    • (2009) N Engl J Med , vol.361 , pp. 888-898
    • Miossec, P.1
  • 29
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye, P., et al.: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 194: 519-527, 2001.
    • (2001) J Exp Med , vol.194 , pp. 519-527
    • Ye, P.1
  • 30
    • 3242814586 scopus 로고    scopus 로고
    • Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice
    • Huang, W., et al.: Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190: 624-631, 2004.
    • (2004) J Infect Dis , vol.190 , pp. 624-631
    • Huang, W.1
  • 31
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae, S., et al.: Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 171: 6173-6177, 2003.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1
  • 32
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-ofconcept study
    • Genovese, M.C., et al.: LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-ofconcept study. Arthritis Rheum 62: 929-939, 2010.
    • (2010) Arthritis Rheum , vol.62 , pp. 929-939
    • Genovese, M.C.1
  • 33
    • 74249094930 scopus 로고    scopus 로고
    • Comparison of ustekinumab and etanercept for moderate-tosevere psoriasis
    • Grieffiths, C.E., et al.: Comparison of ustekinumab and etanercept for moderate-tosevere psoriasis. N Engl J Med 362: 118-128, 2010.
    • (2010) N Engl J Med , vol.362 , pp. 118-128
    • Grieffiths, C.E.1
  • 34
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee, E., et al.: Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med 199: 125-130, 2004.
    • (2004) J Exp Med , vol.199 , pp. 125-130
    • Lee, E.1
  • 35
    • 77957952423 scopus 로고    scopus 로고
    • Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques
    • Johnson-Huang, L.M., et al.: Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques. J Invest Dermatol 130: 2654-2663, 2010.
    • (2010) J Invest Dermatol , vol.130 , pp. 2654-2663
    • Johnson-Huang, L.M.1
  • 36
    • 37549011317 scopus 로고    scopus 로고
    • Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    • Zaba, L.C., et al.: Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med 204: 3183-3194, 2007.
    • (2007) J Exp Med , vol.204 , pp. 3183-3194
    • Zaba, L.C.1
  • 37
    • 33751546237 scopus 로고    scopus 로고
    • IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    • Chan, J.R., et al.: IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med 203: 2577-2587, 2006.
    • (2006) J Exp Med , vol.203 , pp. 2577-2587
    • Chan, J.R.1
  • 38
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal in-flammation and acanthosis
    • Zheng, Y., et al.: Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal in-flammation and acanthosis. Nature 445: 648-651, 2007.
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1
  • 39
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp, K.A., et al.: Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med 366: 1181-1189, 2012.
    • (2012) N Engl J Med , vol.366 , pp. 1181-1189
    • Papp, K.A.1
  • 40
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi, C., et al.: Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl JMed 366: 1190-1199, 2012.
    • (2012) N Engl JMed , vol.366 , pp. 1190-1199
    • Leonardi, C.1
  • 41
    • 79955526989 scopus 로고    scopus 로고
    • Suppression of Th17 differentiation and autoimmunity by a synthetic ROR ligand
    • Solt, L.A., et al.: Suppression of Th17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472: 491-494, 2011.
    • (2011) Nature , vol.472 , pp. 491-494
    • Solt, L.A.1
  • 42
    • 79955538365 scopus 로고    scopus 로고
    • Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgammat activity
    • Huh, J.R., et al.: Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORgammat activity. Nature 472: 486-490, 2011.
    • (2011) Nature , vol.472 , pp. 486-490
    • Huh, J.R.1
  • 43
    • 77951636478 scopus 로고    scopus 로고
    • Mast cells express IL-17A in rheumatoid arthritis synovium
    • Hueber, A.J., et al.: Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol 184: 3336-3340, 2010.
    • (2010) J Immunol , vol.184 , pp. 3336-3340
    • Hueber, A.J.1
  • 44
    • 80053172579 scopus 로고    scopus 로고
    • Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and-negative rheumatoid arthritis and osteoarthritis synovium
    • Suurmond, J., et al.: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and-negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther 13: R150, 2011.
    • (2011) Arthritis Res Ther , vol.13
    • Suurmond, J.1
  • 45
    • 45449084802 scopus 로고    scopus 로고
    • Gammadelta T cells: An important source of IL-17
    • Roark, C.L., et al.: gammadelta T cells: an important source of IL-17. Curr Opin Immunol 20: 353-357, 2008.
    • (2008) Curr Opin Immunol , vol.20 , pp. 353-357
    • Roark, C.L.1
  • 46
    • 80755180843 scopus 로고    scopus 로고
    • Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation
    • Cai, Y., et al.: Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35: 596-610, 2011.
    • (2011) Immunity , vol.35 , pp. 596-610
    • Cai, Y.1
  • 47
    • 84861801523 scopus 로고    scopus 로고
    • Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice
    • Pantelyushin, S., et al.: Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J Clin Invest 122: 2252-2256, 2012.
    • (2012) J Clin Invest , vol.122 , pp. 2252-2256
    • Pantelyushin, S.1
  • 48
    • 79959584686 scopus 로고    scopus 로고
    • Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    • Lin, A.M., et al.: Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol 187: 490-500, 2011.
    • (2011) J Immunol , vol.187 , pp. 490-500
    • Lin, A.M.1
  • 49
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn, W.J., et al.: Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 367: 1519-1528, 2012.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1
  • 50
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • Hirota, K., et al.: Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12: 255-263, 2011.
    • (2011) Nat Immunol , vol.12 , pp. 255-263
    • Hirota, K.1
  • 51
    • 84875473675 scopus 로고    scopus 로고
    • Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses
    • Hirota, K., et al.: Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 14: 372-379, 2013.
    • (2013) Nat Immunol , vol.14 , pp. 372-379
    • Hirota, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.