The role of T-lymphocytes and cytokines in rheumatoid arthritis

Scandinavian Journal of Rheumatology

Volumn 25, Issue 1, 1996, Pages 1-4

  Smolen, J S ^a,b,e   Tohidast Akrad, M ^b   Gal, A ^c   Kunaver, M ^a   Eberl, G ^a   Zenz, P ^d   Falus, A ^c   Steiner, G ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c National Rheumatology and Physiotherapy Institute   (Hungary)

^d Hospital Baumgartner Hohe   (Austria)

^e GENERAL HOSPITAL LINZ   (Austria)

Author keywords

Cytokines; Gamma interferon; Osteoarthritis; Rheumatoid arthritis; T cells

Indexed keywords

CYTOKINE; GAMMA INTERFERON;

CLINICAL TRIAL; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

EID: 0030021790     PISSN: 03009742     EISSN: None     Source Type: Journal    
DOI: 10.3109/03009749609082660     Document Type: Review

References (34)

1. Zvaifler NJ, Firestein GS. Pannus and pannocytes. Arthritis Rheum 1994; 37: 783-9.
2. Feldmann M, Brennan FM, Field M, Maini RN. Pathogenesis of rheumatoid arthritis: cellular and cytokine interactions. In: Smolen JS, Kalden JR, Maini RN, eds. Rheumatoid Arthritis. Berlin-Heidelberg; Springer Verlag. 1992: 42-54.
3. Kurosaka M, Ziff M. Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med 1983; 158: 1191-210.
4. Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum 1990; 33: 768-73.
5. Haynes BF, Grover BJ, Whichard LP, et al. Synovial microenvironment T cell interactions. Human T cells bind to fibroblast-like synovial cells in vitro. Arthritis Rheum 1988; 31: 947-55.
6. Panayi GS. The immunopathogenesis of rheumatoid arthritis. Br J Rheumatol 1993; 32 (Suppl 1): 4-14.
7. Horneff G, Burmester GR, Emmrich F, Kalden JR. Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody. Arthritis Rheum 1991; 34: 129-37.
8. Lubbe PAvd, Dijkmans BAC, Markusse HM, Nässander U, Breedveld FC. Lack of clinical effect of CD4 monoclonal antibody therapy in early rheumatoid arthritis: a placebo controlled trial. Arthritis Rheum 1994; 37: S294.
9. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Koussis D, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991; 10: 4023-31.
10. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
11. Brown JH, Jardetzky T, Saper MA, Samraoui B, Bjorkman PJ, Wiley DC. A hypothetical model of the foreign antigen binding site of class II Histocompatibility molecules. Nature 1988; 332: 845-50.
12. Dougados M, Awada H, Amor B. Cyclosporin in rheumatoid arthritis: a double blind, placebo controlled study in 52 patients. Ann Rheum Dis 1988; 47: 127-33.
13. Calabrese LH, Wilke WS, Perkins AD, Tubbs RR. RA complicated by infection with the HIV and the development of Sjögren's syndrome. Arthritis Rheum 1989; 32: 1453-7.
14. Holter W, Majdic O, Liszka K, Stockinger H, Knapp W. Kinetics of activation antigen expression by in vitro stimulated human T lymphocytes. Cell Immunol 1985; 90: 322-30.
15. Pitzalis C, Kingsley GH, Lanchbury JSS, Murphy J, Panayi GS. Expression of HLA DR, DQ, DP antigens and interleukin 2 receptor on synovial fluid T lymphocyte subsets in rheumatoid arthritis: Evidence for 'frustrated' rheumatoid arthritis. J Rheumatol 1987; 14: 660-6.
16. Pitzalis C, Kingsley GH, Murphy J, Panayi GS. Abnormal distribution of the helper-inducer and suppressor-inducer T lymphocyte subsets in the rheumatoid joint. Clin Immunol Immunopathol 1987; 45: 252-8.
17. Maurer D, Felzmann T, Holter W, Petera P, Smolen J, Knapp W. Evidence for the presence of activated CD4 T cells with naive phenotype in the peripheral blood of patients with rheumatoid arthritis. Clin Exp Immunol 1992; 87: 429-34.
18. Feldmann M, Brennan FM, Field M, Maini RN. Pathogenesis of rheumatoid arthritis: cellular and cytokine interactions. In: Smolen JS, Kalden JR, Maini RN, eds. Rheumatoid arthritis. Recent research advances. Berlin-Heidelberg-New York; Springer Verlag, 1992; 41-54.
19. Steiner G, Witzmann G, Studnicka-Benke A, Höfler E, Partsch G, Smolen J. Cytokines in sera and synovial fluids from patients with inflammatory arthritides. Clin Rheumatol 1992; 11: 141.
20. Firestein GS, Zvaifler NJ. Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that y-interferon is not the primary mactophage activating factor. Arthritis Rheum 1987; 30: 864-71.
21. Kunaver M, Steiner G, Gal A, Wessely M. Zenz P, Smolen J. Immunohistochemical localization of IL6, TNFa, IL2 and IFN-y in rheumatoid arthritis synovial membrane. Clin Rheumatol 1993; 12: 121.
22. Steiner G, Tohidast-Akrad M, Kunaver M, Gal A, Smolen J. Production of cytokines by T cells in RA synovial membranes. Clin Rheumatol 1995; 14: 236.
23. Simon AK, Seipelt E, Sieper J. Divergent T-cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci USA 1994; 91: 8562-6.
24. Chomarat P, Kjeldsen-Kragh J, Quayle AJ, Natvig JB, Miossec P. Different cytokine production profiles of gamma delta T cell clones: relation to inflammatory arthritis. Eur J Immunol 1994; 24: 2087-91.
25. Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin-10 in rheumatoid arthritis. J Exp Med 1994; 179: 1517-27.
26. Andrews HJ, Bunning RAD, Plumpton TA, Clark IM, Russel RGG, Cawston TE. Inhibition of interleukin-1-induced collagenase production in human articular chondrocytes in vitro by recombinant human interferon-gamma. Arthritis Rheum 1990; 33: 1733-8.
27. Machold KP, Neumann K, Smolen JS. Rcombinant human interferon gamma in the treatment of rheumatoid arthritis: double blind placebo controlled study. Ann Rheum Dis 1992; 51: 1039-43.
28. Lemmel EM, Gaus W, Hofschneider PH. Multicenter double-blind trial of interferon-gamma versus placebo in the treatment of rheumatoid arthritis. Arthritis Rheum 1991; 34: 1621-2.
29. Bowness P, Bell J. T cell receptors and rheumatic disease: an approach to repertoire analysis. Br J Rheumatol 1992; 31: 3-8.
30. Saxne TM, Palladino MA, Heinegard D, Talal N, Wollheim FA. Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluids and serum. Arthritis Rheum 1988; 31: 1041-4.
31. Buchan G, Barrett K, Turner M, Chantry D, Maini RN, Feldmann M. Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged prodcution of IL-1 alpha. Clin Exp Immunol 1988; 73: 449-55.
32. Gadd SJ, Felzmann T, Majdic O, Maurer D, Petera P, Smolen J, et al. Phenotypic analysis of functionally associated molecules on peripheral blood and synovial fluid monocytes from arthritis patients. Rheumatol Int 1992; 12: 153-7.
33. Felzmann T, Gadd S, Majdic O, Maurer D, Petera P, Smolen J, et al. Analysis of function associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid arthritis. J Clin Immunol 1991; 11: 205-12.
34. Elliott MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen JS, et al. Treatment with a chimaeric monoclonal entibody to tumour necrosis factor alpha suppresses disease activity in rheumatoid arthritis. Lancet 1994; 344: 1105-10.