Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages

  Corbi Verge, Carles ^a   Marinelli, Fabrizio ^b,c   Zafra Ruano, Ana ^a   Ruiz Sanz, Javier ^a   Luque, Irene ^a   Faraldo Ǵomez, José D ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Allosteric inhibitors; Leukemia; Macromolecular assembly; Population shift; Protein protein interactions

Indexed keywords

ABELSON KINASE; AMINO ACID; PROTEIN SH2; PROTEIN SH3;

ALLOSTERISM; ARTICLE; ATOM; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME ACTIVE SITE; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS; ALGORITHM; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; SRC HOMOLOGY DOMAIN; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; ALLOSTERIC REGULATION; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ABL; SRC HOMOLOGY DOMAINS; THERMODYNAMICS;

EID: 84883405702     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303966110     Document Type: Article

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