Allosteric interactions between the myristate- and ATP-site of the Abl kinase

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Iacob, Roxana E ^a   Zhang, Jianming ^b   Gray, Nathanael S ^b   Engen, John R ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; DASATINIB; GNF 5; MYRISTIC ACID; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; 4 METHYL N (3 (4 METHYLIMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)PHENYL) 3 ((4 PYRIDIN 3 YLPYRIMIDIN 2 YL)AMINO)BENZAMIDE; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ALLOSTERISM; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DOWN REGULATION; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MASS SPECTROMETRY; MOLECULAR DYNAMICS; WILD TYPE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

PYRONIA TITHONUS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANTINEOPLASTIC AGENTS; BINDING SITES; HUMANS; MASS SPECTROMETRY; MYRISTIC ACID; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; THIAZOLES;

EID: 79251582163     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015929     Document Type: Article

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