Molecular mechanism of selective recruitment of Syk kinases by the membrane antigen-receptor complex

Journal of Biological Chemistry

Volumn 286, Issue 29, 2011, Pages 25872-25881

  Bond, Peter J ^a,b   Faraldo Gómez, José D ^a  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN RECEPTORS; ATOMIC RESOLUTION; CATALYTIC DOMAINS; FREE-ENERGY CALCULATIONS; KINASE ACTIVATION; MICROSCOPIC MECHANISMS; MOLECULAR MECHANISM; SELECTIVE RECRUITMENT; SH2 DOMAIN; SIMULATION TIME; STRUCTURAL CHANGE; THEORETICAL STUDY; TYROSINE KINASE;

AMINO ACIDS; ANTIGENS; CHEMICAL ACTIVATION; FREE ENERGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ENZYMES;

LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN KINASE SYK; PROTEIN KINASE ZAP 70; PROTEIN SH2; T CELL RECEPTOR CD3 EPSILON CHAIN; T CELL RECEPTOR CD3 ZETA CHAIN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CALCULATION; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENERGY; FREE ENERGY; HYDROGEN BOND; ITAM MOTIF; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN REFOLDING; PROTEIN STRUCTURE; SIMULATION; THEORETICAL STUDY;

AMINO ACID MOTIFS; CELL MEMBRANE; ENZYME STABILITY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 79960401699     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.223321     Document Type: Article

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