γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 2, 2012, Pages 330-338

  Nowak, Grazyna ^a   Bakajsova, Diana ^a   Hayes, Corey ^a   Hauer Jensen, Martin ^a,b   Compadre, Cesar M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL; GAMMA TOCOTRIENOL; LACTATE DEHYDROGENASE; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; FEMALE; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE COUPLING; OXIDATIVE STRESS; POLARIZATION; PRIORITY JOURNAL; RENAL PROTECTION; RESPIRATION CONTROL;

ADENOSINE TRIPHOSPHATE; ALPHA-TOCOPHEROL; ANIMALS; APOPTOSIS; CELL DEATH; CELL RESPIRATION; CELL SURVIVAL; CELLS, CULTURED; CHROMANS; EPITHELIAL CELLS; FEMALE; KIDNEY TUBULES, PROXIMAL; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OLIGOMYCINS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTON-TRANSLOCATING ATPASES; RABBITS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROPEROXIDE; VITAMIN E;

EID: 84856024044     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.186882     Document Type: Article

References (41)

1. Abid MR, Razzaque MS, and Taguchi T (2005) Oxidant stress in renal pathophysiology. Contrib Nephrol 148:135-153. (Pubitemid 43264927)
2. Aggarwal BB, Sundaram C, Prasad S, and Kannappan R (2010) Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol 80:1613-1631.
3. Berbée M, Fu Q, Garg S, Kulkarni S, Kumar KS, and Hauer-Jensen M (2011) Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems. Radiat Res 175:297-306.
4. Bichay TJ and Roy RM (1986) Modification of survival and hematopoiesis in mice by tocopherol injection following irradiation. Strahlenther Onkol 162:391-399. (Pubitemid 17014786)
5. Boerma M, Roberto KA, and Hauer-Jensen M (2008) Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and α-tocopherol. Int J Radiat Oncol Biol Phys 72:170-177.
6. Brigelius-Flohé R and Traber MG (1999) Vitamin E: function and metabolism. FASEB J 13:1145-1155. (Pubitemid 29300361)
7. Cachofeiro V, Goicochea M, de Vinuesa SG, Oubina P, Lahera V, and Luno J (2008) Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl (111):S4-S9.
8. Cottrell RC (1991) Introduction: nutritional aspects of palm oil. Am J Clin Nutr 53 (Suppl 4):989S-1009S.
9. Das S, Lekli I, Das M, Szabo G, Varadi J, Juhasz B, Bak I, Nesaretam K, Tosaki A, Powell SR, et al. (2008) Cardioprotection with palm oil tocotrienols: comparision of different isomers. Am J Physiol Heart Circ Physiol 294:H970-H978. (Pubitemid 351253310)
10. Elson CE (1995) Suppression of mevalonate pathway activities by dietary isoprenoids: protective roles in cancer and cardiovascular disease. J Nutr 125:1666S-1672S.
11. Felemovicius I, Bonsack ME, Baptista ML, and Delaney JP (1995) Intestinal radioprotection by vitamin E (α-tocopherol). Ann Surg 222:504-508; discussion 508-510.
12. Ghosh SP, Kulkarni S, Hieber K, Toles R, Romanyukha L, Kao TC, Hauer-Jensen M, and Kumar KS (2009) γ-Tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol 85:598-606.
13. Goh SH, Hew NF, Norhanom AW, and Yadav M (1994) Inhibition of tumour promotion by various palm-oil tocotrienols. Int J Cancer 57:529-531. (Pubitemid 24173098)
14. Kamat JP and Devasagayam TP (1995) Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 195:179-182.
15. 7)-induced acute renal injury in rats. Chem Biol Interact 186:228-238.
16. Khor HT, Chieng DY, and Ong KK (1995) Tocotrienols inhibit liver HMG CoA reductase activity in the guinea pig. Nutr Res 15:537-544.
17. Koyner JL, Sher Ali R, and Murray PT (2008) Antioxidants. Do they have a place in the prevention or therapy of acute kidney injury? Nephron Exp Nephrol 109:e109-e117.
18. Kulkarni S, Ghosh SP, Satyamitra M, Mog S, Hieber K, Romanyukha L, Gambles K, Toles R, Kao TC, Hauer-Jensen M, et al. (2010) γ-Tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation. Radiat Res 173:738-747.
19. Kumar KS, Raghavan M, Hieber K, Ege C, Mog S, Parra N, Hildabrand A, Singh V, Srinivasan V, Toles R, et al. (2006) Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant γ-tocotrienol. Life Sci 78:2099-2104.
20. Lekli I, Ray D, Mukherjee S, Gurusamy N, Ahsan MK, Juhasz B, Bak I, Tosaki A, Gherghiceanu M, Popescu LM, et al. (2010) Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection. J Cell Mol Med 14:2506-2518.
21. Liu X, Godwin ML, and Nowak G (2004) Protein kinase C-α inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells. Am J Physiol Renal Physiol 287:F64-F73. (Pubitemid 38780584)
22. Mazlan M, Sue Mian T, Mat Top G, and Zurinah Wan Ngah W (2006) Comparative effects of α-tocopherol and γ-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. J Neurol Sci 243:5-12.
23. McIntyre BS, Briski KP, Tirmenstein MA, Fariss MW, Gapor A, and Sylvester PW (2000) Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells. Lipids 35:171-180. (Pubitemid 30183648)
24. + transport, and cisplatin-induced apoptosis in renal cells. J Biol Chem 277:43377-43388.
25. + transport after oxidant injury in renal cells. Am J Physiol Renal Physiol 286:F307-F316.
26. Nowak G, Bakajsova D, and Samarel AM (2011) Protein kinase C-ε activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules. Am J Physiol Renal Physiol 301:F197-F208.
27. Nowak G, Clifton GL, Godwin ML, and Bakajsova D (2006) Activation of ERK1/2 pathway mediates oxidant-induced decreases in mitochondrial function in renal cells. Am J Physiol Renal Physiol 291:F840-F55.
28. Nowak G and Schnellmann RG (1996) L-Ascorbic acid regulates growth and metabolism of renal cells: improvements in cell culture. Am J Physiol Cell Physiol 271:C2072-C2080.
29. Pearce BC, Parker RA, Deason ME, Qureshi AA, and Wright JJ (1992) Hypocholesterolemic activity of synthetic and natural tocotrienols. J Med Chem 35:3595-3606.
30. Qureshi AA, Bradlow BA, Brace L, Manganello J, Peterson DM, Pearce BC, Wright JJ, Gapor A, and Elson CE (1995) Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-1177.
31. Qureshi N and Qureshi AA (1993) Tocotrienols: novel hypocholesterolemic agents with antioxidant properties, in Vitamin E in Health and Disease (Packer L and Fuchs J eds) pp 247-268, Marcel Dekker, Inc., New York.
32. Sen CK, Gordillo GM, Khanna S, and Roy S (2009) Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res 46:527-540.
33. Sen CK, Khanna S, Roy S, and Packer L (2000) Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem 275:13049-13055. (Pubitemid 30241466)
34. Shaik ZP, Fifer EK, and Nowak G (2008) Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury. Am J Physiol Renal Physiol 294:F423-F432. (Pubitemid 351199408)
35. Singh VK, Shafran RL, Jackson WE 3rd, Seed TM, and Kumar KS (2006) Induction of cytokines by radioprotective tocopherol analogs. Exp Mol Pathol 81:55-61. (Pubitemid 43946856)
36. Song BL and DeBose-Boyd RA (2006) Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase stimulated by δ- and γ-tocotrienols. J Biol Chem 281:25054-25061.
37. Sun W, Xu W, Liu H, Liu J, Wang Q, Zhou J, Dong F, and Chen B (2009) γ-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J Nutr Biochem 20:276-284.
38. Sylvester PW, Shah SJ, and Samant GV (2005) Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of γ-tocotrienol in neoplastic mammary epithelial cells. J Plant Physiol 162:803-810. (Pubitemid 40772096)
39. Takahashi K and Loo G (2004) Disruption of mitochondria during tocotrienol-induced apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmacol 67:315-324. (Pubitemid 38112762)
40. Then SM, Mazlan M, Mat Top G, and Wan Ngah WZ (2009) Is vitamin E toxic to neuron cells? Cell Mol Neurobiol 29:485-496.
41. Theriault A, Chao JT, Wang Q, Gapor A, and Adeli K (1999) Tocotrienol: a review of its therapeutic potential. Clin Biochem 32:309-319. (Pubitemid 29416720)