Reduction of radiation-induced vascular nitrosative stress by the vitamin e analog γ-tocotrienol: Evidence of a role for tetrahydrobiopterin

International Journal of Radiation Oncology Biology Physics

Volumn 79, Issue 3, 2011, Pages 884-891

  Berbee, Maaike ^a   Fu, Qiang ^a   Boerma, Marjan ^a   Pathak, Rupak ^a   Zhou, Daohong ^a   Kumar, K Sree ^b   Hauer Jensen, Martin ^a,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Endothelial cells; Nitric oxide synthase; Oxidative stress; Radiation; Tetrahydrobiopterin; Vitamin E

Indexed keywords

BENEFICIAL EFFECTS; BIOPTERIN; BONE MARROW; COENZYME A; COFACTORS; COLONY FORMING UNITS; CYCLOHYDROLASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FREE RADICAL PRODUCTIONS; GUANOSINE TRIPHOSPHATE; IN-VITRO; IN-VIVO; NITRIC-OXIDE SYNTHASE; NITROSATIVE STRESS; PEROXYNITRITES; PLEIOTROPIC EFFECTS; POSTIRRADIATION; PROTEIN BINDING; PROTEIN LEVEL; RADIATION-INDUCED; REDUCTASE INHIBITORS; REGULATORY PROTEIN; TETRAHYDROBIOPTERIN; TOCOTRIENOLS; TOTAL BODY IRRADIATION; VASCULAR OXIDATIVE STRESS; VITAMIN E;

BIOCHEMISTRY; BIOLOGICAL ORGANS; BONE; CELL DEATH; COENZYMES; FREE RADICALS; LIQUID CHROMATOGRAPHY; NITRIC OXIDE; OXIDATIVE STRESS; PROTEINS; RADIATION EFFECTS; SELF ASSEMBLY; TRANSCRIPTION; VITAMINS;

ENDOTHELIAL CELLS;

GAMMA TOCOTRIENOL; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PEROXYNITRITE; REGULATOR PROTEIN; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOAVAILABILITY; BLOOD TOXICITY; BONE MARROW; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BINDING; RADIATION RESPONSE; RADIATION SICKNESS; WHOLE BODY RADIATION;

ANIMALS; APOPTOSIS; BIOLOGICAL AVAILABILITY; BIOPTERIN; BONE MARROW CELLS; CHROMANS; COLONY-FORMING UNITS ASSAY; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GTP CYCLOHYDROLASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MALE; MICE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PEROXYNITROUS ACID; PROTEIN BINDING; RADIATION DOSAGE; RANDOM ALLOCATION; TRANSCRIPTION, GENETIC; VITAMIN E; WHOLE-BODY IRRADIATION;

EID: 79551477688     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.08.032     Document Type: Article

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