Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14723-14728

  Cai, Erica P ^a,c   Wu, Xiaohong ^d   Schroer, Stephanie A ^a   Elia, Andrew J ^c,e   Nostro, M Cristina ^a,b   Zacksenhaus, Eldad ^a   Woo, Minna ^a,c  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NANJING MEDICAL UNIVERSITY   (China)

^e PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Cell cycle; Diabetes mellitus; E2f; Glucagon; Insulin

Indexed keywords

GLUCOSE; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR NKX6.1; ARX PROTEIN, MOUSE; E2F1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE DELETION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREATIC STEM CELL; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL; ANIMAL; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; METABOLISM; NEWBORN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

MURINAE;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; E2F1 TRANSCRIPTION FACTOR; FEMALE; GLUCAGON-SECRETING CELLS; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE HOMOLOGY, NUCLEIC ACID; STEM CELLS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84883399054     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303386110     Document Type: Article

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