메뉴 건너뛰기




Volumn 110, Issue 35, 2013, Pages

Growth hormone is a cellular senescence target in pituitary and nonpituitary cells

Author keywords

Acromegaly; Pituitary hormone

Indexed keywords

GROWTH HORMONE; PROTEIN P21; PROTEIN P53; CAYLIN2; ETOPOSIDE; IMIDAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE;

EID: 84883334461     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310589110     Document Type: Article
Times cited : (61)

References (77)
  • 1
    • 23244452684 scopus 로고    scopus 로고
    • Suppressing cancer: The importance of being senescent
    • Campisi J (2005) Suppressing cancer: The importance of being senescent. Science 309(5736):886-887.
    • (2005) Science , vol.309 , Issue.5736 , pp. 886-887
    • Campisi, J.1
  • 2
    • 85047689866 scopus 로고    scopus 로고
    • Telomeres, stem cells, senescence, and cancer
    • Sharpless NE, DePinho RA (2004) Telomeres, stem cells, senescence, and cancer. J Clin Invest 113(2):160-168.
    • (2004) J Clin Invest , vol.113 , Issue.2 , pp. 160-168
    • Sharpless, N.E.1    Depinho, R.A.2
  • 4
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593-602.
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 5
    • 77949458344 scopus 로고    scopus 로고
    • A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen
    • Coppé JP, et al. (2010) A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS ONE 5(2): e9188.
    • (2010) PLoS ONE , vol.5 , Issue.2
    • Coppé, J.P.1
  • 6
    • 0038054561 scopus 로고    scopus 로고
    • Molecular defects in the pathogenesis of pituitary tumours
    • Levy A, Lightman S (2003) Molecular defects in the pathogenesis of pituitary tumours. Front Neuroendocrinol 24(2):94-127.
    • (2003) Front Neuroendocrinol , vol.24 , Issue.2 , pp. 94-127
    • Levy, A.1    Lightman, S.2
  • 7
    • 33751097773 scopus 로고    scopus 로고
    • Pituitary tumours: Findings from whole genome analyses
    • Farrell WE (2006) Pituitary tumours: Findings from whole genome analyses. Endocr Relat Cancer 13(3):707-716.
    • (2006) Endocr Relat Cancer , vol.13 , Issue.3 , pp. 707-716
    • Farrell, W.E.1
  • 8
    • 0037937433 scopus 로고    scopus 로고
    • Epigenetic change in pituitary tumorigenesis
    • Farrell WE, Clayton RN (2003) Epigenetic change in pituitary tumorigenesis. Endocr Relat Cancer 10(2):323-330.
    • (2003) Endocr Relat Cancer , vol.10 , Issue.2 , pp. 323-330
    • Farrell, W.E.1    Clayton, R.N.2
  • 9
    • 0347951038 scopus 로고    scopus 로고
    • Mechanisms for pituitary tumorigenesis: The plastic pituitary
    • Melmed S (2003) Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112(11):1603-1618.
    • (2003) J Clin Invest , vol.112 , Issue.11 , pp. 1603-1618
    • Melmed, S.1
  • 10
    • 79955093923 scopus 로고    scopus 로고
    • Pathogenesis of pituitary tumors
    • Melmed S (2011) Pathogenesis of pituitary tumors. Nat Rev Endocrinol 7(5):257-266.
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.5 , pp. 257-266
    • Melmed, S.1
  • 11
    • 77955319259 scopus 로고    scopus 로고
    • Proliferation markers of human pituitary tumors: Contribution of a genome-wide transcriptome approach
    • Wierinckx A, et al. (2010) Proliferation markers of human pituitary tumors: Contribution of a genome-wide transcriptome approach. Mol Cell Endocrinol 326(1-2):30-39.
    • (2010) Mol Cell Endocrinol , vol.326 , Issue.1-2 , pp. 30-39
    • Wierinckx, A.1
  • 12
    • 0035183046 scopus 로고    scopus 로고
    • Classification of pituitary adenomas
    • Kovacs K, Horvath E, Vidal S (2001) Classification of pituitary adenomas. J Neurooncol 54(2):121-127.
    • (2001) J Neurooncol , vol.54 , Issue.2 , pp. 121-127
    • Kovacs, K.1    Horvath, E.2    Vidal, S.3
  • 13
    • 35948990011 scopus 로고    scopus 로고
    • Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth
    • Chesnokova V, et al. (2007) Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res 67(21):10564-10572.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10564-10572
    • Chesnokova, V.1
  • 14
    • 56249140465 scopus 로고    scopus 로고
    • P21(Cip1) restrains pituitary tumor growth
    • Chesnokova V, et al. (2008) p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci USA 105(45):17498-17503.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.45 , pp. 17498-17503
    • Chesnokova, V.1
  • 15
    • 17844400784 scopus 로고    scopus 로고
    • Early multipotential pituitary focal hyperplasia in the alphasubunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice
    • Abbud RA, et al. (2005) Early multipotential pituitary focal hyperplasia in the alphasubunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol 19(5):1383-1391.
    • (2005) Mol Endocrinol , vol.19 , Issue.5 , pp. 1383-1391
    • Abbud, R.A.1
  • 16
    • 0242468471 scopus 로고    scopus 로고
    • Overexpressed pituitary tumortransforming gene causes aneuploidy in live human cells
    • Yu R, Lu W, Chen J, McCabe CJ, Melmed S (2003) Overexpressed pituitary tumortransforming gene causes aneuploidy in live human cells. Endocrinology 144(11): 4991-4998.
    • (2003) Endocrinology , vol.144 , Issue.11 , pp. 4991-4998
    • Yu, R.1    Lu, W.2    Chen, J.3    McCabe, C.J.4    Melmed, S.5
  • 17
    • 33748740748 scopus 로고    scopus 로고
    • Pituitary tumor transforming gene overexpression facilitates pituitary tumor development
    • Donangelo I, et al. (2006) Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology 147(10):4781-4791.
    • (2006) Endocrinology , vol.147 , Issue.10 , pp. 4781-4791
    • Donangelo, I.1
  • 18
    • 0029917618 scopus 로고    scopus 로고
    • P53 expression in pituitary adenomas and carcinomas: Correlation with invasiveness and tumor growth fractions
    • discussion 770-771
    • Thapar K, Scheithauer BW, Kovacs K, Pernicone PJ, Laws ER, Jr. (1996) p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumor growth fractions. Neurosurgery 38(4):765-770, discussion 770-771.
    • (1996) Neurosurgery , vol.38 , Issue.4 , pp. 765-770
    • Thapar, K.1    Scheithauer, B.W.2    Kovacs, K.3    Pernicone, P.J.4    Laws Jr., E.R.5
  • 19
    • 35948972215 scopus 로고    scopus 로고
    • A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors
    • Wierinckx A, et al. (2007) A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Endocr Relat Cancer 14(3):887-900.
    • (2007) Endocr Relat Cancer , vol.14 , Issue.3 , pp. 887-900
    • Wierinckx, A.1
  • 20
    • 33748295612 scopus 로고    scopus 로고
    • Pathobiology of pituitary adenomas and carcinomas
    • discussion 341-353
    • Scheithauer BW, et al. (2006) Pathobiology of pituitary adenomas and carcinomas. Neurosurgery 59(2):341-353, discussion 341-353.
    • (2006) Neurosurgery , vol.59 , Issue.2 , pp. 341-353
    • Scheithauer, B.W.1
  • 21
    • 0035068301 scopus 로고    scopus 로고
    • Mdm2 and the p53 pathway in human pituitary adenomas
    • Suliman M, et al. (2001) Mdm2 and the p53 pathway in human pituitary adenomas. Clin Endocrinol (Oxf) 54(3):317-325.
    • (2001) Clin Endocrinol (Oxf) , vol.54 , Issue.3 , pp. 317-325
    • Suliman, M.1
  • 22
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden KH, Prives C (2009) Blinded by the light: The growing complexity of p53. Cell 137(3):413-431.
    • (2009) Cell , vol.137 , Issue.3 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 23
    • 70349438905 scopus 로고    scopus 로고
    • The expanding universe of p53 targets
    • Menendez D, Inga A, Resnick MA (2009) The expanding universe of p53 targets. Nat Rev Cancer 9(10):724-737.
    • (2009) Nat Rev Cancer , vol.9 , Issue.10 , pp. 724-737
    • Menendez, D.1    Inga, A.2    Resnick, M.A.3
  • 24
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, et al. (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303(5659):844-848.
    • (2004) Science , vol.303 , Issue.5659 , pp. 844-848
    • Vassilev, L.T.1
  • 25
    • 6344284118 scopus 로고    scopus 로고
    • The oncogenic potential of autocrine human growth hormone in breast cancer
    • Waters MJ, Conway-Campbell BL (2004) The oncogenic potential of autocrine human growth hormone in breast cancer. Proc Natl Acad Sci USA 101(42):14992-14993.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.42 , pp. 14992-14993
    • Waters, M.J.1    Conway-Campbell, B.L.2
  • 26
    • 62749110757 scopus 로고    scopus 로고
    • Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma
    • Brunet-Dunand SE, et al. (2009) Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma. Endocrinology 150(3):1341-1352.
    • (2009) Endocrinology , vol.150 , Issue.3 , pp. 1341-1352
    • Brunet-Dunand, S.E.1
  • 29
    • 85047690242 scopus 로고    scopus 로고
    • The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity
    • Clemmons DR (2004) The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity. J Clin Invest 113(1):25-27.
    • (2004) J Clin Invest , vol.113 , Issue.1 , pp. 25-27
    • Clemmons, D.R.1
  • 30
    • 49549111375 scopus 로고    scopus 로고
    • Growth hormone, insulin-like growth factors, and the skeleton
    • Giustina A, Mazziotti G, Canalis E (2008) Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29(5):535-559.
    • (2008) Endocr Rev , vol.29 , Issue.5 , pp. 535-559
    • Giustina, A.1    Mazziotti, G.2    Canalis, E.3
  • 31
    • 79960089146 scopus 로고    scopus 로고
    • Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: A gene expression study in hypopituitary men
    • Zhao JT, et al. (2011) Identification of novel GH-regulated pathway of lipid metabolism in adipose tissue: A gene expression study in hypopituitary men. J Clin Endocrinol Metab 96(7):E1188-E1196.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.7
    • Zhao, J.T.1
  • 32
    • 32244446245 scopus 로고    scopus 로고
    • Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines
    • Liu Y, Bodmer WF (2006) Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines. Proc Natl Acad Sci USA 103(4):976-981.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.4 , pp. 976-981
    • Liu, Y.1    Bodmer, W.F.2
  • 33
    • 0027246716 scopus 로고
    • Regulation of p53 protein expression in human breast cancer cell lines
    • Vojtěsek B, Lane DP (1993) Regulation of p53 protein expression in human breast cancer cell lines. J Cell Sci 105(Pt 3):607-612.
    • (1993) J Cell Sci , vol.105 , Issue.PART 3 , pp. 607-612
    • Vojtěsek, B.1    Lane, D.P.2
  • 34
    • 0019758979 scopus 로고
    • Growth hormone-like material in normal human tissues
    • Kyle CV, Evans MC, Odell WD (1981) Growth hormone-like material in normal human tissues. J Clin Endocrinol Metab 53(6):1138-1144.
    • (1981) J Clin Endocrinol Metab , vol.53 , Issue.6 , pp. 1138-1144
    • Kyle, C.V.1    Evans, M.C.2    Odell, W.D.3
  • 35
    • 80053015725 scopus 로고    scopus 로고
    • P53 isoforms: An intracellular microprocessor?
    • Khoury MP, Bourdon JC (2011) p53 isoforms: An intracellular microprocessor? Genes Cancer 2(4):453-465.
    • (2011) Genes Cancer , vol.2 , Issue.4 , pp. 453-465
    • Khoury, M.P.1    Bourdon, J.C.2
  • 36
    • 84872478616 scopus 로고    scopus 로고
    • Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis
    • Pan D, et al. (2013) Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis. PLoS ONE 8(1):e54006.
    • (2013) PLoS ONE , vol.8 , Issue.1
    • Pan, D.1
  • 37
    • 0032553485 scopus 로고    scopus 로고
    • Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    • Bunz F, et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282(5393):1497-1501.
    • (1998) Science , vol.282 , Issue.5393 , pp. 1497-1501
    • Bunz, F.1
  • 38
    • 0033730616 scopus 로고    scopus 로고
    • Senescence-associated (beta)- galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    • Kurz DJ, Decary S, Hong Y, Erusalimsky JD (2000) Senescence-associated (beta)- galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113(Pt 20):3613-3622.
    • (2000) J Cell Sci , vol.113 , Issue.PART 20 , pp. 3613-3622
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Erusalimsky, J.D.4
  • 39
    • 1842611115 scopus 로고    scopus 로고
    • The inhibition of apoptosis in EL4 lymphoma cells overexpressing growth hormone
    • Arnold RE, Weigent DA (2004) The inhibition of apoptosis in EL4 lymphoma cells overexpressing growth hormone. Neuroimmunomodulation 11(3):149-159.
    • (2004) Neuroimmunomodulation , vol.11 , Issue.3 , pp. 149-159
    • Arnold, R.E.1    Weigent, D.A.2
  • 40
    • 44449148971 scopus 로고    scopus 로고
    • Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures
    • Svensson AL, Bucht N, Hallberg M, Nyberg F (2008) Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures. Proc Natl Acad Sci USA 105(20):7304-7308.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.20 , pp. 7304-7308
    • Svensson, A.L.1    Bucht, N.2    Hallberg, M.3    Nyberg, F.4
  • 41
    • 0024497109 scopus 로고
    • Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor
    • Brent GA, Larsen PR, Harney JW, Koenig RJ, Moore DD (1989) Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem 264(1):178-182.
    • (1989) J Biol Chem , vol.264 , Issue.1 , pp. 178-182
    • Brent, G.A.1    Larsen, P.R.2    Harney, J.W.3    Koenig, R.J.4    Moore, D.D.5
  • 42
    • 0029810025 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells
    • Schaufele F (1996) CCAAT/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells. J Biol Chem 271(35): 21484-21489.
    • (1996) J Biol Chem , vol.271 , Issue.35 , pp. 21484-21489
    • Schaufele, F.1
  • 43
    • 0025131065 scopus 로고
    • The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters
    • Fox SR, et al. (1990) The homeodomain protein, Pit-1/GHF-1, is capable of binding to and activating cell-specific elements of both the growth hormone and prolactin gene promoters. Mol Endocrinol 4(7):1069-1080.
    • (1990) Mol Endocrinol , vol.4 , Issue.7 , pp. 1069-1080
    • Fox, S.R.1
  • 44
    • 0024506672 scopus 로고
    • Identification of an adenosine 3′,5′-monophosphate (cAMP)-responsive region in the rat growth hormone gene: Evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression
    • Copp RP, Samuels HH (1989) Identification of an adenosine 3′,5′-monophosphate (cAMP)-responsive region in the rat growth hormone gene: evidence for independent and synergistic effects of cAMP and thyroid hormone on gene expression. Mol Endocrinol 3(5):790-796.
    • (1989) Mol Endocrinol , vol.3 , Issue.5 , pp. 790-796
    • Copp, R.P.1    Samuels, H.H.2
  • 45
    • 79955781676 scopus 로고    scopus 로고
    • The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression
    • Ho Y, Liebhaber SA, Cooke NE (2011) The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression. Mol Endocrinol 25(5):877-884.
    • (2011) Mol Endocrinol , vol.25 , Issue.5 , pp. 877-884
    • Ho, Y.1    Liebhaber, S.A.2    Cooke, N.E.3
  • 46
    • 79953067459 scopus 로고    scopus 로고
    • Lineage-specific restraint of pituitary gonadotroph cell adenoma growth
    • Chesnokova V, et al. (2011) Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS ONE 6(3):e17924.
    • (2011) PLoS ONE , vol.6 , Issue.3
    • Chesnokova, V.1
  • 47
    • 0026666502 scopus 로고
    • Differences in pathological findings and growth hormone responses in patients with growth hormone-producing pituitary adenoma
    • Bando H, et al. (1992) Differences in pathological findings and growth hormone responses in patients with growth hormone-producing pituitary adenoma. Endocrinol Jpn 39(4):355-363.
    • (1992) Endocrinol Jpn , vol.39 , Issue.4 , pp. 355-363
    • Bando, H.1
  • 48
    • 0027247930 scopus 로고
    • Growth hormone-producing pituitary adenomas: Correlations between clinical characteristics and morphology
    • Yamada S, et al. (1993) Growth hormone-producing pituitary adenomas: Correlations between clinical characteristics and morphology. Neurosurgery 33(1):20-27.
    • (1993) Neurosurgery , vol.33 , Issue.1 , pp. 20-27
    • Yamada, S.1
  • 49
    • 0034947312 scopus 로고    scopus 로고
    • Prognostic relevance of intracytoplasmic cytokeratin pattern, hormone expression profile, and cell proliferation in pituitary adenomas of acromegalic patients
    • Mazal PR, et al. (2001) Prognostic relevance of intracytoplasmic cytokeratin pattern, hormone expression profile, and cell proliferation in pituitary adenomas of acromegalic patients. Clin Neuropathol 20(4):163-171.
    • (2001) Clin Neuropathol , vol.20 , Issue.4 , pp. 163-171
    • Mazal, P.R.1
  • 50
    • 55249120008 scopus 로고    scopus 로고
    • Clinicopathological features of growth hormone-producing pituitary adenomas: Difference among various types defined by cytokeratin distribution pattern including a transitional form
    • Obari A, et al. (2008) Clinicopathological features of growth hormone-producing pituitary adenomas: Difference among various types defined by cytokeratin distribution pattern including a transitional form. Endocr Pathol 19(2):82-91.
    • (2008) Endocr Pathol , vol.19 , Issue.2 , pp. 82-91
    • Obari, A.1
  • 51
    • 84865036732 scopus 로고    scopus 로고
    • Clinical implications of growth hormone-secreting tumor subtypes
    • Kiseljak-Vassiliades K, et al. (2012) Clinical implications of growth hormone-secreting tumor subtypes. Endocrine 42(1):18-28.
    • (2012) Endocrine , vol.42 , Issue.1 , pp. 18-28
    • Kiseljak-Vassiliades, K.1
  • 52
    • 57149130799 scopus 로고    scopus 로고
    • IGF-I, GH, and sex steroid effects in normal mammary gland development
    • Kleinberg DL, Ruan W (2008) IGF-I, GH, and sex steroid effects in normal mammary gland development. J Mammary Gland Biol Neoplasia 13(4):353-360.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , Issue.4 , pp. 353-360
    • Kleinberg, D.L.1    Ruan, W.2
  • 53
    • 0033306843 scopus 로고    scopus 로고
    • Evidence that insulin-like growth factor i and growth hormone are required for prostate gland development
    • Ruan W, Powell-Braxton L, Kopchick JJ, Kleinberg DL (1999) Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development. Endocrinology 140(5):1984-1989.
    • (1999) Endocrinology , vol.140 , Issue.5 , pp. 1984-1989
    • Ruan, W.1    Powell-Braxton, L.2    Kopchick, J.J.3    Kleinberg, D.L.4
  • 54
    • 0033785320 scopus 로고    scopus 로고
    • Growth hormone in the brain: Characteristics of specific brain targets for the hormone and their functional significance
    • Nyberg F (2000) Growth hormone in the brain: Characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 21(4): 330-348.
    • (2000) Front Neuroendocrinol , vol.21 , Issue.4 , pp. 330-348
    • Nyberg, F.1
  • 55
    • 0032239547 scopus 로고    scopus 로고
    • Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human
    • Giustina A, Veldhuis JD (1998) Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 19(6): 717-797.
    • (1998) Endocr Rev , vol.19 , Issue.6 , pp. 717-797
    • Giustina, A.1    Veldhuis, J.D.2
  • 56
    • 77955921088 scopus 로고    scopus 로고
    • The growth hormone receptor: Mechanism of activation and clinical implications
    • Brooks AJ, Waters MJ (2010) The growth hormone receptor: Mechanism of activation and clinical implications. Nat Rev Endocrinol 6(9):515-525.
    • (2010) Nat Rev Endocrinol , vol.6 , Issue.9 , pp. 515-525
    • Brooks, A.J.1    Waters, M.J.2
  • 57
    • 33846213670 scopus 로고    scopus 로고
    • Multiple mechanisms of growth hormone-regulated gene transcription
    • Ceseña TI, et al. (2007) Multiple mechanisms of growth hormone-regulated gene transcription. Mol Genet Metab 90(2):126-133.
    • (2007) Mol Genet Metab , vol.90 , Issue.2 , pp. 126-133
    • Ceseña, T.I.1
  • 58
    • 35748958108 scopus 로고    scopus 로고
    • Mode of growth hormone action in osteoblasts
    • DiGirolamo DJ, et al. (2007) Mode of growth hormone action in osteoblasts. J Biol Chem 282(43):31666-31674.
    • (2007) J Biol Chem , vol.282 , Issue.43 , pp. 31666-31674
    • Digirolamo, D.J.1
  • 59
    • 78149366451 scopus 로고    scopus 로고
    • The GH/IGF-1 axis in growth and development: New insights derived from animal models
    • Cannata D, Vijayakumar A, Fierz Y, LeRoith D (2010) The GH/IGF-1 axis in growth and development: New insights derived from animal models. Adv Pediatr 57(1):331-351.
    • (2010) Adv Pediatr , vol.57 , Issue.1 , pp. 331-351
    • Cannata, D.1    Vijayakumar, A.2    Fierz, Y.3    Leroith, D.4
  • 60
    • 79958243025 scopus 로고    scopus 로고
    • Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse
    • List EO, et al. (2011) Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse. Endocr Rev 32(3):356-386.
    • (2011) Endocr Rev , vol.32 , Issue.3 , pp. 356-386
    • List, E.O.1
  • 61
    • 73549121928 scopus 로고    scopus 로고
    • In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2
    • Barclay JL, et al. (2010) In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2. Mol Endocrinol 24(1):204-217.
    • (2010) Mol Endocrinol , vol.24 , Issue.1 , pp. 204-217
    • Barclay, J.L.1
  • 63
    • 0029844028 scopus 로고    scopus 로고
    • Constitutive nuclear localization of Janus kinases 1 and 2
    • Lobie PE, et al. (1996) Constitutive nuclear localization of Janus kinases 1 and 2. Endocrinology 137(9):4037-4045.
    • (1996) Endocrinology , vol.137 , Issue.9 , pp. 4037-4045
    • Lobie, P.E.1
  • 64
    • 21244457302 scopus 로고    scopus 로고
    • Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma
    • Xu XQ, et al. (2005) Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma. J Biol Chem 280(25):23987-24003.
    • (2005) J Biol Chem , vol.280 , Issue.25 , pp. 23987-24003
    • Xu, X.Q.1
  • 65
    • 33845491265 scopus 로고    scopus 로고
    • Medical progress: Acromegaly
    • Melmed S (2006) Medical progress: Acromegaly. N Engl J Med 355(24):2558-2573.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2558-2573
    • Melmed, S.1
  • 66
    • 11244313444 scopus 로고    scopus 로고
    • Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone
    • Zhu T, et al. (2005) Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res 65(1):317-324.
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 317-324
    • Zhu, T.1
  • 67
    • 6344234799 scopus 로고    scopus 로고
    • Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone
    • Mukhina S, et al. (2004) Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone. Proc Natl Acad Sci USA 101(42):15166-15171.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.42 , pp. 15166-15171
    • Mukhina, S.1
  • 68
    • 0033303817 scopus 로고    scopus 로고
    • Insulin-like growth factor i is essential for terminal end bud formation and ductal morphogenesis during mammary development
    • Ruan W, Kleinberg DL (1999) Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 140(11):5075-5081.
    • (1999) Endocrinology , vol.140 , Issue.11 , pp. 5075-5081
    • Ruan, W.1    Kleinberg, D.L.2
  • 69
    • 0035834121 scopus 로고    scopus 로고
    • Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
    • Krtolica A, Parrinello S, Lockett S, Desprez PY, Campisi J (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci USA 98(21):12072-12077.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.21 , pp. 12072-12077
    • Krtolica, A.1    Parrinello, S.2    Lockett, S.3    Desprez, P.Y.4    Campisi, J.5
  • 70
    • 31544479046 scopus 로고    scopus 로고
    • The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    • Bavik C, et al. (2006) The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res 66(2):794-802.
    • (2006) Cancer Res , vol.66 , Issue.2 , pp. 794-802
    • Bavik, C.1
  • 71
    • 33750039991 scopus 로고    scopus 로고
    • Predictive markers of pituitary adenoma behavior
    • Kontogeorgos G (2006) Predictive markers of pituitary adenoma behavior. Neuroendocrinology 83(3-4):179-188.
    • (2006) Neuroendocrinology , vol.83 , Issue.3-4 , pp. 179-188
    • Kontogeorgos, G.1
  • 72
    • 0033061851 scopus 로고    scopus 로고
    • Apoptosis in nontumorous and neoplastic human pituitaries: Expression of the Bcl-2 family of proteins
    • Kulig E, et al. (1999) Apoptosis in nontumorous and neoplastic human pituitaries: Expression of the Bcl-2 family of proteins. Am J Pathol 154(3):767-774.
    • (1999) Am J Pathol , vol.154 , Issue.3 , pp. 767-774
    • Kulig, E.1
  • 73
    • 84876256620 scopus 로고    scopus 로고
    • Differential effects of exogenous and autocrine growth hormone on LNCaP prostate cancer cell proliferation and survival
    • Nakonechnaya AO, Jefferson HS, Chen X, Shewchuk BM (2013) Differential effects of exogenous and autocrine growth hormone on LNCaP prostate cancer cell proliferation and survival. J Cell Biochem 114(6):1322-1335.
    • (2013) J Cell Biochem , vol.114 , Issue.6 , pp. 1322-1335
    • Nakonechnaya, A.O.1    Jefferson, H.S.2    Chen, X.3    Shewchuk, B.M.4
  • 74
    • 77955422848 scopus 로고    scopus 로고
    • Human growth hormone: 45-kDa isoform with extraordinarily stable interchain disulfide links has attenuated receptor-binding and cell-proliferative activities
    • Bustamante JJ, et al. (2010) Human growth hormone: 45-kDa isoform with extraordinarily stable interchain disulfide links has attenuated receptor-binding and cell-proliferative activities. Growth Horm IGF Res 20(4):298-304.
    • (2010) Growth Horm IGF Res , vol.20 , Issue.4 , pp. 298-304
    • Bustamante, J.J.1
  • 76
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cellnonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppé JP, et al. (2008) Senescence-associated secretory phenotypes reveal cellnonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853-2868.
    • (2008) PLoS Biol , vol.6 , Issue.12 , pp. 2853-2868
    • Coppé, J.P.1
  • 77
    • 79951701976 scopus 로고    scopus 로고
    • Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells
    • Endo S, et al. (2011) Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Cancer Sci 102(3):605-613.
    • (2011) Cancer Sci , vol.102 , Issue.3 , pp. 605-613
    • Endo, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.