The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression

Molecular Endocrinology

Volumn 25, Issue 5, 2011, Pages 877-884

  Ho, Yugong ^a   Liebhaber, Stephen A ^a   Cooke, Nancy E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; HUMAN GROWTH HORMONE; TRANSCRIPTION FACTOR PIT 1;

ANIMAL CELL; ARTICLE; CELL EXPANSION; CELL TYPE; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; HUMAN; HYPOPHYSIS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; TRANSGENE;

ANIMALS; DEOXYRIBONUCLEASES, TYPE I SITE-SPECIFIC; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; HUMAN GROWTH HORMONE; LOCUS CONTROL REGION; MALE; MICE; MICE, TRANSGENIC; PROLACTIN; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; SOMATOTROPHS; THYROTROPIN, BETA SUBUNIT; TRANSCRIPTION FACTOR PIT-1;

MAMMALIA;

EID: 79955781676     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0411     Document Type: Article

References (26)

1. Zhu X, Gleiberman AS, Rosenfeld MG 2007 Molecular physiology of pituitary development: signaling and transcriptional networks. Physiol Rev 87:933-963
2. Li S, Crenshaw 3rd EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG 1990 Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature 347:528-533
3. Camper SA, Saunders TL, Katz RW, Reeves RH 1990 The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation. Genomics 8:586-590
4. Dasen JS, Rosenfeld MG 1999 Signaling mechanisms in pituitary morphogenesis and cell fate determination. Curr Opin Cell Biol 11:669-677
5. Chen EY, Liao YC, Smith DH, Barrera-Saldaña HA, Gelinas RE, Seeburg PH 1989 The human growth hormone locus: nucleotide sequence, biology, and evolution. Genomics 4:479-497
6. Jones BK, Monks BR, Liebhaber SA, Cooke NE 1995 The human growth hormone gene is regulated by a multicomponent locus con- trol region. Mol Cell Biol 15:7010-7021
7. Su Y, Liebhaber SA, Cooke NE 2000 The human growth hormone gene cluster locus control region supports position-independent pi- tuitary- and placenta-specific expression in the transgenic mouse. J Biol Chem 275:7902-7909
8. Bennani-Baïti IM, Asa SL, Song D, Iratni R, Liebhaber SA, Cooke NE 1998 DNase I-hypersensitive sites I and II of the human growth hormone locus control region are a major developmental activator of somatotrope gene expression. Proc Natl Acad Sci USA 95: 10655-10660
9. Shewchuk BM, Asa SL, Cooke NE, Liebhaber SA 1999 Pit-1 bind-ing sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation. J Biol Chem 274:35725-35733
10. Ho Y, Elefant F, Cooke N, Liebhaber S 2002 A defined locus con-trol region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell 9:291-302
11. Ho Y, Elefant F, Liebhaber SA, Cooke NE 2006 Locus control region transcription plays an active role in long-range gene activa- tion. Mol Cell 23:365-375
12. Ho Y, Tadevosyan A, Liebhaber SA, Cooke NE 2008 The juxta-position of a promoter with a locus control region transcriptional domain activates gene expression. EMBO Rep 9:891-898
13. Shewchuk BM, Liebhaber SA, Cooke NE 2002 Specification of unique Pit-1 activity in the hGH locus control region. Proc Natl Acad Sci USA 99:11784-11789
14. Magoulas C, McGuinness L, Balthasar N, Carmignac DF, Sesay AK, Mathers KE, Christian H, Candeil L, Bonnefont X, Mollard P, Robinson IC 2000 A secreted fluorescent reporter targeted to pitu- itary growth hormone cells in transgenic mice. Endocrinology 141: 4681-4689
15. Jin Y, Lu SY, Fresnoza A, Detillieux KA, Duckworth ML, Cattini PA 2009 Differential placental hormone gene expression during preg- nancy in a transgenic mouse containing the human growth hormone/ chorionic somatomammotropin locus. Placenta 30:226-235
16. Shewchuk BM, Ho Y, Liebhaber SA, Cooke NE 2006 A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and func- tions. Mol Cell Biol 26:6535-6546
17. Asa SL, Ezzat S 1999 Molecular determinants of pituitary cytodif- ferentiation. Pituitary 1:159-168
18. Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carriere C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG 2000 Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 290:1127-1131
19. Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG 2007 Op- posing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446:882-887
20. Jing H, Vakoc CR, Ying L, Mandat S, Wang H, Zheng X, Blobel GA 2008 Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell 29:232-242
21. Horike S, Cai S, Miyano M, Cheng JF, Kohwi-Shigematsu T 2005 Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet 37:31-40
22. Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH 2010 Transcriptional silencing of -globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes Dev 24:783-798
23. Sizova D, Ho Y, Cooke NE, Liebhaber SA 2010 Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage. Mol Endocrinol 24:2232-2240
24. Kendall SK, Saunders TL, Jin L, Lloyd RV, Glode LM, Nett TM, Keri RA, Nilson JH, Camper SA 1991 Targeted ablation of pituitary go- nadotropes in transgenic mice. Mol Endocrinol 5:2025-2036
25. Gage PJ, Roller ML, Saunders TL, Scarlett LM, Camper SA 1996 Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion. Development 122:151-160
26. Villalobos C, Núñez L, García-Sancho J 2004 Anterior pituitary thyrotropes are multifunctional cells. Am J Physiol Endocrinol Metab 287:E1166-1170