Applications of nanostructured calcium phosphate in tissue engineering

Biomaterials Science

Volumn 1, Issue 10, 2013, Pages 1012-1028

  Zhou, Changchun ^a   Hong, Youliang ^a   Zhang, Xingdong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EFFECTS; HARD TISSUES; INFLAMMATORY RESPONSE; NANO-STRUCTURED; NERVE REPAIR; RECENT RESEARCHES; SOFT TISSUE;

BIOLOGICAL MATERIALS; BLOOD VESSELS; REPAIR; TISSUE ENGINEERING;

CALCIUM PHOSPHATE;

EID: 84883333078     PISSN: 20474830     EISSN: 20474849     Source Type: Journal    
DOI: 10.1039/c3bm60058k     Document Type: Article

References (172)

1. L. L. Hench J. M. Polak Third-generation biomedical materials Science 2002 295 1014
2. A. Veis Materials science. A window on biomineralization Science 2005 307 1419
3. Y. Cai Y. Liu W. Yan Q. Hu J. Tao M. Zhang Z. Shi R. Tang Role of hydroxyapatite nanoparticle size in bone cell proliferation J. Mater. Chem. 2007 17 3780
4. P. N. Kumta C. Sfeir D. H. Lee D. Olton D. Choi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization Acta Biomater. 2005 1 65
5. F. Qiang M. N. Rahaman Z. Nai H. Wenhai W. Deping Z. Liying L. Haifeng In vitro study on different cell response to spherical hydroxyapatite nanoparticles J. Biomater. Appl. 2008 23 37
6. S. H. Chu D. F. Feng Y. B. Ma Z. Q. Li Hydroxyapatite nanoparticles inhibit the growth of human glioma cells in vitro and in vivo Int. J. Nanomed. 2012 7 3659
7. X. Zhao B. C. Heng S. Xiong J. Guo T. T. Tan F. Y. Boey K. W. Ng J. S. Loo In vitro assessment of cellular responses to rod-shaped hydroxyapatite nanoparticles of varying lengths and surface areas Nanotoxicology 2011 5 182
8. G. Xie J. Sun G. Zhong C. Liu J. Wei Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro J. Mater. Sci.: Mater. Med. 2010 21 1875
9. K. Kandori T. Kuroda S. Togashi E. Katayama Preparation of calcium hydroxyapatite nanoparticles using microreactor and their characteristics of protein adsorption J. Phys. Chem. B 2011 115 653
10. S. V. Dorozhkin Nanosized and nanocrystalline calcium orthophosphates Acta Biomater. 2010 6 715
11. M. Nelson G. Balasundaram T. J. Webster Increased osteoblast adhesion on nanoparticulate crystalline hydroxyapatite functionalized with krsr Int. J. Nanomed. 2006 1 339
12. S. W. Choi Y. Zhang S. Thomopoulos Y. Xia In vitro mineralization by preosteoblasts in poly(dl-lactide-co-glycolide) inverse opal scaffolds reinforced with hydroxyapatite nanoparticles Langmuir 2010 26 12126
13. M. Nagano T. Nakamura T. Kokubo M. Tanahashi M. Ogawa Differences of bone bonding ability and degradation behaviour in vivo between amorphous calcium phosphate and highly crystalline hydroxyapatite coating Biomaterials 1996 17 1771
14. P. T. F. Frayssinet N. Rouquet P. Conte C. Delga G. Bonel Comparative biological properties of HA plasma-sprayed coatings having different crystallinities J. Mater. Sci.: Mater. Med. 1994 5 11
15. M. Arnold E. A. Cavalcanti-Adam R. Glass J. Blummel W. Eck M. Kantlehner H. Kessler J. P. Spatz Activation of integrin function by nanopatterned adhesive interfaces ChemPhysChem 2004 5 383
16. G. Balasundaram M. Sato T. J. Webster Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD Biomaterials 2006 27 2798
17. S. Ozkan D. M. Kalyon X. Yu Functionally graded beta-TCP/PCL nanocomposite scaffolds: in vitro evaluation with human fetal osteoblast cells for bone tissue engineering J. Biomed. Mater. Res., Part A 2010 92 100
18. S. K. Misra T. Ansari D. Mohn S. P. Valappil T. J. Brunner W. J. Stark I. Roy J. C. Knowles P. D. Sibbons E. V. Jones A. R. Boccaccini V. Salih Effect of nanoparticulate bioactive glass particles on bioactivity and cytocompatibility of poly(3-hydroxybutyrate) composites J. R. Soc. Interface 2010 7 453
19. S. Jeanne S. Tricot-Doleux P. Pellen-Mussi F. Perez H. Oudadesse G. Cathelineau Effect of hydroxyapatite and beta-tricalcium phosphate nanoparticles on promonocytic U937 cells J. Biomed. Nanotechnol. 2010 6 158
20. A. K. Guha S. Singh R. Kumaresan S. Nayar A. Sinha Mesenchymal cell response to nanosized biphasic calcium phosphate composites Colloids Surf., B 2009 73 146
21. K. Tan P. Cheang I. A. Ho P. Y. Lam K. M. Hui Nanosized bioceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen Gene Ther. 2007 14 828
22. S. C. Loo T. Moore B. Banik F. Alexis Biomedical applications of hydroxyapatite nanoparticles Curr. Pharm. Biotechnol. 2010 11 333
23. M. Kamitakahara K. Kimura K. Ioku Synthesis of nanosized porous hydroxyapatite granules in hydrogel by electrophoresis Colloids Surf., B 2012 97 236
24. R. A. Perez G. Altankov E. Jorge-Herrero M. P. Ginebra Micro- and nanostructured hydroxyapatite-collagen microcarriers for bone tissue-engineering applications J. Tissue Eng. Regener. Med. 2013 7 353
25. X. Zhu H. Zhang D. Li H. Fan X. Zhang Study on the enhanced protein adsorption of microwave sintered hydroxyapatite nanoceramic particles: Role of microstructure J. Biomed. Mater. Res., Part B 2012 100B 516
26. Y. Cai R. Tang Calcium phosphate nanoparticles in biomineralization and biomaterials J. Mater. Chem. 2008 18 3775
27. M. J. Olszta X. Cheng S. S. Jee R. Kumar Y.-Y. Kim M. J. Kaufman E. P. Douglas L. B. Gower Bone structure and formation: a new perspective Mater. Sci. Eng., R 2007 58 77
28. R. Tang L. Wang C. A. Orme T. Bonstein P. J. Bush G. H. Nancollas Dissolution at the nanoscale: Self-preservation of biominerals Angew. Chem., Int. Ed. 2004 43 2697
29. T. Hassenkam G. E. Fantner J. A. Cutroni J. C. Weaver D. E. Morse P. K. Hansma High-resolution afm imaging of intact and fractured trabecular bone Bone 2004 35 4
30. L. Zhang T. J. Webster Nanotechnology and nanomaterials: Promises for improved tissue regeneration Nano Today 2009 4 66
31. Z. Shi X. Huang Y. Cai R. Tang D. Yang Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells Acta Biomater. 2009 5 338
32. A. P. Alivisatos Biomineralization. Naturally aligned nanocrystals Science 2000 289 736
33. A. L. Boskey Biomineralization: An overview Connect. Tissue Res. 2003 44 Suppl 1 5
34. D. W. Kim I. S. Cho J. Y. Kim H. L. Jang G. S. Han H. S. Ryu H. Shin H. S. Jung H. Kim K. S. Hong Simple large-scale synthesis of hydroxyapatite nanoparticles: in situ observation of crystallization process Langmuir 2010 26 384
35. T. Yuasa Y. Miyamoto K. Ishikawa M. Takechi Y. Momota S. Tatehara M. Nagayama Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro Biomaterials 2004 25 1159
36. L. Cerroni R. Filocamo M. Fabbri C. Piconi S. Caropreso S. G. Condo Growth of osteoblast-like cells on porous hydroxyapatite ceramics: An in vitro study Biomol. Eng. 2002 19 119
37. I. Zizak P. Roschger O. Paris B. M. Misof A. Berzlanovich S. Bernstorff H. Amenitsch K. Klaushofer P. Fratzl Characteristics of mineral particles in the human bone/cartilage interface J. Struct. Biol. 2003 141 208
38. Y. Pan D. Xiong F. Gao Viscoelastic behavior of nano-hydroxyapatite reinforced poly(vinyl alcohol) gel biocomposites as an articular cartilage J. Mater. Sci.: Mater. Med. 2008 19 1963
39. K. Yudoh K. Shishido H. Murayama M. Yano K. Matsubayashi Water-soluble C60 fullerene prevents degeneration of articular cartilage in osteoarthritis via down-regulation of chondrocyte catabolic activity and inhibition of cartilage degeneration during disease development Arthritis Rheum. 2007 56 3307
40. E. Wernike M. O. Montjovent Y. Liu D. Wismeijer E. B. Hunziker K. A. Siebenrock W. Hofstetter F. M. Klenke VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo Eur. Cell Mater. 2010 19 30
41. F. C. Cackowski J. L. Anderson K. D. Patrene R. J. Choksi S. D. Shapiro J. J. Windle H. C. Blair G. D. Roodman Osteoclasts are important for bone angiogenesis Blood 2010 115 140
42. S. Pezzatini L. Morbidelli R. Solito E. Paccagnini E. Boanini A. Bigi M. Ziche Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis Bone 2007 41 523
43. X. Tang Q. Zhang S. Shi Y. Yen X. Li Y. Zhang K. Zhou A. D. Le Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells Int. J. Cancer 2010 126 90
44. M. Liu G. Zhou W. Song P. Li H. Liu X. Niu Y. Fan Effect of nano-hydroxyapatite on the axonal guidance growth of rat cortical neurons Nanoscale 2012 4 3201
45. T. A. Fulga I. Elson-Schwab V. Khurana M. L. Steinhilb T. L. Spires B. T. Hyman M. B. Feany Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo Nat. Cell Biol. 2007 9 139
46. X. Liu D. Fan J. Zhang J. Zheng T. Ma Comparison of distributions of muscle injection and intravenous administration of human mesenchymal stem cells in denervated muscles of the sciatic nerve injured rats Beijing Da Xue Xue Bao 2008 40 185
47. Y. J. Han S. C. Loo J. Lee J. Ma Investigation of the bioactivity and biocompatibility of different glass interfaces with hydroxyapatite, fluorohydroxyapatite and 58 s bioactive glass BioFactors 2007 30 205
48. Y. Yuan C. Liu J. Qian J. Wang Y. Zhang Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HEPG2 cells Biomaterials 2010 31 730
49. M. Motskin D. M. Wright K. Muller N. Kyle T. G. Gard A. E. Porter J. N. Skepper Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability Biomaterials 2009 30 3307
50. C. Albrecht A. M. Scherbart D. van Berlo C. M. Braunbarth R. P. Schins J. Scheel Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary macrophages Toxicol. in Vitro 2009 23 520
51. J. Huang S. M. Best W. Bonfield R. A. Brooks N. Rushton S. N. Jayasinghe M. J. Edirisinghe In vitro assessment of the biological response to nano-sized hydroxyapatite J. Mater. Sci.: Mater. Med. 2004 15 441
52. X. Zhao S. Ng B. C. Heng J. Guo L. Ma T. T. Tan K. W. Ng S. C. Loo Cytotoxicity of hydroxyapatite nanoparticles is shape and cell dependent Arch. Toxicol. 2013 87 1037
53. L. Zhang J. Rodriguez J. Raez A. J. Myles H. Fenniri T. J. Webster Biologically inspired rosette nanotubes and nanocrystalline hydroxyapatite hydrogel nanocomposites as improved bone substitutes Nanotechnology 2009 20 175101
54. S. Sanchez-Salcedo I. Izquierdo-Barba D. Arcos M. Vallet-Regi In vitro evaluation of potential calcium phosphate scaffolds for tissue engineering Tissue Eng. 2006 12 279
55. F. Chen Y. Zhu J. Wu P. Huang D. Cui Nanostructured calcium phosphates: Preparation and their application in biomedicine Nano Biomed. Eng. 2012 4 41
56. M. Epple K. Ganesan R. Heumann J. Klesing A. Kovtun S. Neumann V. Sokolova Application of calcium phosphate nanoparticles in biomedicine J. Mater. Chem. 2010 20 18
57. B. Kateb K. Chiu K. L. Black V. Yamamoto B. Khalsa J. Y. Ljubimova Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: What should be the policy? NeuroImage 2011 54 Suppl 1 S106
58. S. V. Dorozhkin Bioceramics of calcium orthophosphates Biomaterials 2010 31 1465
59. D. Williams The relationship between biomaterials and nanotechnology Biomaterials 2008 29 1737
60. P. Moriarty Nanostructured materials Rep. Prog. Phys. 2001 64 297
61. T. J. Webster E. S. Ahn Nanostructured biomaterials for tissue engineering bone Adv. Biochem. Eng. Biotechnol. 2007 103 275
62. R. M. Streicher M. Schmidt S. Fiorito Nanosurfaces and nanostructures for artificial orthopedic implants Nanomedicine 2007 2 861
63. E. Commission, Scientific committee on emerging and newly identified health risks (SCENIHR). Opinion on "the scientific aspects of the existing and proposed definitions relating to products of nanoscience and nanotechnologies", Springer, Berlin, 2007
64. S. C. Leeuwenburgh J. A. Jansen A. G. Mikos Functionalization of oligo(poly(ethylene glycol)fumarate) hydrogels with finely dispersed calcium phosphate nanocrystals for bone-substituting purposes J. Biomater. Sci. Polym. Ed. 2007 18 1547
65. J. E. Barralet K. J. Lilley L. M. Grover D. F. Farrar C. Ansell U. Gbureck Cements from nanocrystalline hydroxyapatite J. Mater. Sci.: Mater. Med. 2004 15 407
66. F. Barrere M. M. Snel C. A. van Blitterswijk K. de Groot P. Layrolle Nano-scale study of the nucleation and growth of calcium phosphate coating on titanium implants Biomaterials 2004 25 2901
67. J. S. Bow S. C. Liou S. Y. Chen Structural characterization of room-temperature synthesized nano-sized beta-tricalcium phosphate Biomaterials 2004 25 3155
68. M. C. Chang C. C. Ko W. H. Douglas Preparation of hydroxyapatite-gelatin nanocomposite Biomaterials 2003 24 2853
69. D. O. Costa S. J. Dixon A. S. Rizkalla One- and three-dimensional growth of hydroxyapatite nanowires during sol-gel-hydrothermal synthesis ACS Appl. Mater. Interfaces 2012 4 1490
70. S. Hayakawa Y. Li K. Tsuru A. Osaka E. Fujii K. Kawabata Preparation of nanometer-scale rod array of hydroxyapatite crystal Acta Biomater. 2009 5 2152
71. F. Chen Y. J. Zhu K. W. Wang K. L. Zhao Surfactant-free solvothermal synthesis of hydroxyapatite nanowire/nanotube ordered arrays with biomimetic structures CrystEngComm 2011 13 1858
72. Y. Hong H. Fan B. Li B. Guo M. Liu X. Zhang Fabrication, biological effects, and medical applications of calcium phosphate nanoceramics Mater. Sci. Eng., R 2010 70 225
73. F. Chen Y. Zhu J. Wu P. Huang D. Cui Nanostructured calcium phosphates: Preparation and their application in biomedicine Nano Biomed. Eng. 2012 4 41
74. C. Zhang J. Yang Z. Quan P. Yang C. Li Z. Hou J. Lin Hydroxyapatite nano- and microcrystals with multiform morphologies controllable synthesis and luminescence properties Cryst. Growth Des. 2009 9 2725
75. C. K. Chan T. S. Kumar S. Liao R. Murugan M. Ngiam S. Ramakrishnan Biomimetic nanocomposites for bone graft applications Nanomedicine 2006 1 177
76. E. Kon M. Delcogliano G. Filardo D. Pressato M. Busacca B. Grigolo G. Desando M. Marcacci A novel nano-composite multi-layered biomaterial for treatment of osteochondral lesions: Technique note and an early stability pilot clinical trial Injury 2010 41 693
77. R. Detsch D. Hagmeyer M. Neumann S. Schaefer A. Vortkamp M. Wuelling G. Zieglera M. Epple The resorption of nanocrystalline calcium phosphates by osteoclast-like cells Acta Biomater. 2010 6 3223
78. R. Z. LeGeros Biodegradation and bioresorption of calcium phosphate ceramics Clin. Mater. 1993 14 65
79. H. Zhou J. Lee Nanoscale hydroxyapatite particles for bone tissue engineering Acta Biomater. 2011 7 2769
80. A. Kasaj B. Willershausen C. Reichert B. Rohrig R. Smeets M. Schmidt Ability of nanocrystalline hydroxyapatite paste to promote human periodontal ligament cell proliferation J. Oral Sci. 2008 50 279
81. S. Bose S. Dasgupta S. Tarafder A. Bandyopadhyay Microwave-processed nanocrystalline hydroxyapatite: simultaneous enhancement of mechanical and biological properties Acta Biomater. 2010 6 3782
82. A. Kasaj B. Willershausen R. Junker S. I. Stratul M. Schmidt Human periodontal ligament fibroblasts stimulated by nanocrystalline hydroxyapatite paste or enamel matrix derivative. An in vitro assessment of pdl attachment, migration, and proliferation Clin. Oral Invest. 2012 16 745
83. O. Kilian V. Alt C. Heiss T. Jonuleit E. Dingeldein I. Flesch U. Fidorra S. Wenisch R. Schnettler New blood vessel formation and expression of vegf receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite Growth Factors 2005 23 125
84. M. Rogel H. Qiu G. Ameer The role of nanocomposites in bone regeneration J. Mater. Chem. 2008 18 4233
85. L. Wang G. H. Nancollas Z. J. Henneman E. Klein S. Weiner Nanosized particles in bone and dissolution insensitivity of bone mineral Biointerphases 2006 1 106
86. B. Adele Bone mineral crystal size Osteoporos Int. 2003 14 Suppl 5 S16 S20
87. M. P. Ginebra F. C. M. Driessens J. A. Planell Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis Biomaterials 2004 25 3453
88. E. Engel S. D. Valle C. Aparicio G. Altankov L. Sain J. A. Planell M. P. Ginebra Discerning the Role of Topography and Ion Exchange in Cell Response of Bioactive Tissue Engineering Scaffolds Tissue Eng. A 2008 14 1341
89. 2 bioceramics prepared using nano-size powders Ceram. Int. 2007 33 979
90. G. L. Yang F. M. He J. A. Hu X. X. Wang S. F. Zhao Effects of biomimetically and electrochemically deposited nano-hydroxyapatite coatings on osseointegration of porous titanium implants Oral Surg., Oral Med., Oral Pathol., Oral Radiol. Endodontol. 2009 107 782
91. H. Autefage F. Briand-Mesange S. Cazalbou C. Drouet D. Fourmy S. Goncalves J. P. Salles C. Combes P. Swider C. Rey Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/beta- tricalcium phosphate porous ceramics J. Biomed. Mater. Res., Part B 2009 91 706
92. S. M. Shibli A. C. Jayalekshmi A novel nano hydroxyapatite-incorporated ni-p coating as an effective inter layer for biological applications J. Mater. Sci.: Mater. Med. 2009 20 711
93. Y. P. Lu Y. M. Chen S. T. Li J. H. Wang Surface nanocrystallization of hydroxyapatite coating Acta Biomater. 2008 4 1865
94. S. I. Roohani-Esfahani S. Nouri-Khorasani Z. F. Lu R. C. Appleyard H. Zreiqat Effects of bioactive glass nanoparticles on the mechanical and biological behavior of composite coated scaffolds Acta Biomater. 2011 7 1307
95. Y. Zhao Y. Zhang Y. Zhao S. Hou P. K. Chu Synthesis and cellular biocompatibility of two nanophase hydroxyapatite with different Ca/P ratio J. Nanosci. Nanotechnol. 2011 11 11069
96. Q. Hu Z. Tan Y. Liu J. Tao M. Zhang H. Pan X. Xu R. Tang Effect of crystallinity of calcium phosphate nanoparticles on adhesion, proliferation, and differentiation of bone marrow mesenchymal stem cells J. Mater. Chem. 2007 17 4690
97. X. Liu M. Zhao J. Lu J. Ma J. Wei S. Wei Cell responses to two kinds of nanohydroxyapatite with different sizes and crystallinities Int. J. Nanomed. 2012 7 1239
98. Y. Huang G. Zhou L. Zheng H. Liu X. Niu Y. Fan Micro-/nano-sized hydroxyapatite directs differentiation of rat bone marrow derived mesenchymal stem cells towards an osteoblast lineage Nanoscale 2012 4 2484
99. J. L. Xu K. A. Khor J. J. Sui J. H. Zhang W. N. Chen Protein expression profiles in osteoblasts in response to differentially shaped hydroxyapatite nanoparticles Biomaterials 2009 30 5385
100. M. J. Phillips J. A. Darr Z. B. Luklinska I. Rehman Synthesis and characterization of nano-biomaterials with potential osteological applications J. Mater. Sci.: Mater. Med. 2003 14 875
101. S. A. Catledge M. D. Fries Y. K. Vohra W. R. Lacefield J. E. Lemons S. Woodard R. Venugopalan Nanostructured ceramics for biomedical implants J. Nanosci. Nanotechnol. 2002 2 293
102. M. M. Stevens J. H. George Exploring and engineering the cell surface interface Science 2005 310 1135
103. A. K. Gupta M. Gupta S. J. Yarwood A. S. Curtis Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts J. Controlled Release 2004 95 197
104. M. Bongio J. J. van den Beucken M. R. Nejadnik S. C. Leeuwenburgh L. A. Kinard F. K. Kasper A. G. Mikos J. A. Jansen Biomimetic modification of synthetic hydrogels by incorporation of adhesive peptides and calcium phosphate nanoparticles: in vitro evaluation of cell behavior Eur. Cell Mater. 2011 22 359
105. N. Aboudzadeh M. Imani M. A. Shokrgozar A. Khavandi J. Javadpour Y. Shafieyan M. Farokhi Fabrication and characterization of poly(d,l-lactide-co- glycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration J. Biomed. Mater. Res., Part A 2010 94 137
106. Y. Cui Y. Liu Y. Cui X. Jing P. Zhang X. Chen The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with l-lactic acid oligomer for bone repair Acta Biomater. 2009 5 2680
107. S. Zeng S. Fu G. Guo H. Liang Z. Qian X. Tang F. Luo Preparation and characterization of nano-hydroxyapatite/poly(vinyl alcohol) composite membranes for guided bone regeneration J. Biomed. Nanotechnol. 2011 7 549
108. N. Ribeiro S. R. Sousa F. J. Monteiro Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion and morphology J. Colloid Interface Sci. 2010 351 398
109. S. Sethuraman L. S. Nair S. El-Amin M. T. Nguyen Y. E. Greish J. D. Bender P. W. Brown H. R. Allcock C. T. Laurencin Novel low temperature setting nanocrystalline calcium phosphate cements for bone repair: osteoblast cellular response and gene expression studies J. Biomed. Mater. Res., Part A 2007 82 884
110. E. B. Hunziker Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? Osteoarthritis Cartilage 1999 7 15
111. G. D. Smith G. Knutsen J. B. Richardson A clinical review of cartilage repair techniques J. Bone Joint Surg. Br. 2005 87 445
112. L. Hangody G. Vasarhelyi L. R. Hangody Z. Sukosd G. Tibay L. Bartha G. Bodo Autologous osteochondral grafting - technique and long-term results Injury 2008 39 Suppl 1 S32
113. J. Yang G. Shi J. Bei S. Wang Y. Cao Q. Shang G. Yang W. Wang Fabrication and surface modification of macroporous poly(l-lactic acid) and poly(l-lactic-co-glycolic acid) (70/30) cell scaffolds for human skin fibroblast cell culture J. Biomed. Mater. Res. 2002 62 438
114. M. Kobayashi Y. S. Chang M. Oka A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus Biomaterials 2005 26 3243
115. T. Noguchi T. Yamamuro M. Oka P. Kumar Y. Kotoura S. Hyon Y. Ikada Poly(vinyl alcohol) hydrogel as an artificial articular cartilage: evaluation of biocompatibility J. Appl. Biomater. 1991 2 101
116. N. Tamai A. Myoui M. Hirao T. Kaito T. Ochi J. Tanaka K. Takaoka H. Yoshikawa A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2) Osteoarthritis Cartilage 2005 13 405
117. X. B. Jin Y. S. Sun K. Zhang J. Wang T. P. Shi X. D. Ju S. Q. Lou Tissue engineered cartilage from htgf beta2 transduced human adipose derived stem cells seeded in PLGA/alginate compound in vitro and in vivo J. Biomed. Mater. Res., Part A 2008 86 1077
118. Y. Pan D. Xiong Study on compressive mechanical properties of nanohydroxyapatite reinforced poly(vinyl alcohol) gel composites as biomaterial J. Mater. Sci.: Mater. Med. 2009 20 1291
119. L. Cheng S. M. Zhang P. P. Chen S. L. Huang R. R. Cao W. Zhou J. Liu Q. Luo Fabrication and characterization of nano-hydroxyapatite/poly(d,l-lactide) composite porous scaffolds for human cartilage tissue engineering Key Eng. Mater. 2006 18 943
120. D. Xue Q. Zheng C. Zong Q. Li H. Li S. Qian B. Zhang L. Yu Z. Pan Osteochondral repair using porous poly(lactide-co-glycolide)/nano-hydroxyapatite hybrid scaffolds with undifferentiated mesenchymal stem cells in a rat model J. Biomed. Mater. Res., Part A 2010 94 259
121. S. C. Rizzi D. J. Heath A. G. Coombes N. Bock M. Textor S. Downes Biodegradable polymer/hydroxyapatite composites: Surface analysis and initial attachment of human osteoblasts J. Biomed. Mater. Res. 2001 55 475
122. R. J. Covert R. D. Ott D. N. Ku Friction characteristics of a potential articular cartilage biomaterial Wear 2003 255 1064
123. Y. S. D. Pan S. Xiong R. Y. Ma A study on the friction properties of poly(vinyl alcohol) hydrogel as articular cartilage against titanium alloy Wear 2007 262 1021
124. Y. Pan D. Xiong Stress relaxation behavior of nano-hydroxyapatite reinforced poly(vinyl alcohol) gel composites as biomaterial J. Mater. Sci. 2010 45 5495
125. N. Tudorachi A. P. Chiriac Poly(vinyl alcohol-co-lactic acid)/hydroxyapatite composites: synthesis and characterization J. Polym. Environ. 2011 19 546
126. Y. Pan D. Xiong X. Chen Mechanical properties of nanohydroxyapatite reinforced poly(vinyl alcohol) gel composites as biomaterial J. Mater. Sci. 2007 42 5129
127. M. W. Laschke K. Witt T. Pohlemann M. D. Menger Injectable nanocrystalline hydroxyapatite paste for bone substitution: In vivo analysis of biocompatibility and vascularization J. Biomed. Mater. Res., Part B 2007 82 494
128. S. Pezzatini R. Solito L. Morbidelli S. Lamponi E. Boanini A. Bigi M. Ziche The effect of hydroxyapatite nanocrystals on microvascular endothelial cell viability and functions J. Biomed. Mater. Res., Part A 2006 76 656
129. J. Harper M. Klagsbrun Cartilage to bone - angiogenesis leads the way Nat. Med. 1999 5 617
130. H. L. Guenther H. Fleisch N. Sorgente Endothelial cells in culture synthesize a potent bone cell active mitogen Endocrinology 1986 119 193
131. M. Samee S. Kasugai H. Kondo K. Ohya H. Shimokawa S. Kuroda Bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) transfection to human periosteal cells enhances osteoblast differentiation and bone formation J. Pharmacol. Sci. 2008 108 18
132. C. N. Cornell J. M. Lane Current understanding of osteoconduction in bone regeneration Clin. Orthop. Relat. Res. 1998 355 Suppl S267
133. J. Street M. Bao L. deGuzman S. Bunting F. V. Peale Jr. N. Ferrara H. Steinmetz J. Hoeffel J. L. Cleland A. Daugherty N. van Bruggen H. P. Redmond R. A. Carano E. H. Filvaroff Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover Proc. Natl. Acad. Sci. U. S. A. 2002 99 9656
134. W. Suchanec M. Yoshimura Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants J. Mater. Res. 1998 13 94
135. S. Donnini M. Ziche Constitutive and inducible nitric oxide synthase: Role in angiogenesis Antioxid. Redox Signaling 2002 4 817
136. L. Morbidelli S. Donnini M. Ziche Role of nitric oxide in the modulation of angiogenesis Curr. Pharm. Des. 2003 9 521
137. M. Ziche L. Morbidelli R. Choudhuri H. T. Zhang S. Donnini H. J. Granger R. Bicknell Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis J. Clin. Invest. 1997 99 2625
138. S. Cantara S. Donnini L. Morbidelli A. Giachetti R. Schulz M. Memo M. Ziche Physiological levels of amyloid peptides stimulate the angiogenic response through FGF-2 FASEB J. 2004 18 1943
139. H. F. Heijnen S. Waaijenborg J. D. Crapo R. P. Bowler J. W. Akkerman J. W. Slot Colocalization of enos and the catalytic subunit of PKA in endothelial cell junctions: A clue for regulated no production J. Histochem. Cytochem. 2004 52 1277
140. M. Renko N. Quarto T. Morimoto D. B. Rifkin Nuclear and cytoplasmic localization of different basic fibroblast growth factor species J. Cell. Physiol. 1990 144 108
141. J. E. Greer M. J. McGinn J. T. Povlishock Diffuse traumatic axonal injury in the mouse induces atrophy, c-jun activation, and axonal outgrowth in the axotomized neuronal population J. Neurosci. 2011 31 5089
142. D. H. Smith D. F. Meaney W. H. Shull Diffuse axonal injury in head trauma J. Head Trauma Rehabil. 2003 18 307
143. K. D. Barron M. P. Dentinger L. R. Nelson J. E. Mincy Ultrastructure of axonal reaction in red nucleus of cat J. Neuropathol. Exp. Neurol. 1975 34 222
144. V. Pernet S. Joly D. Dalkara O. Schwarz F. Christ D. Schaffer J. G. Flannery M. E. Schwab Neuronal nogo-a upregulation does not contribute to er stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina Cell Death Differ. 2012 19 1096
145. P. G. Richardson M. Delforge M. Beksac P. Wen J. L. Jongen O. Sezer Management of treatment-emergent peripheral neuropathy in multiple myeloma Leukemia 2012 26 595
146. X. R. Xia N. A. Monteiro-Riviere J. E. Riviere An index for characterization of nanomaterials in biological systems Nat. Nanotechnol. 2010 5 671
147. P. Galvan-Garcia E. W. Keefer F. Yang M. Zhang S. Fang A. A. Zakhidov R. H. Baughman M. I. Romero Robust cell migration and neuronal growth on pristine carbon nanotube sheets and yarns J. Biomater. Sci., Polym. Ed. 2007 18 1245
148. G. Z. Jin M. Kim U. S. Shin H. W. Kim Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating Neurosci. Lett. 2011 501 10
149. D. C. Merz H. Zheng M. T. Killeen A. Krizus J. G. Culotti Multiple signaling mechanisms of the Unc-6/netrin receptors Unc-5 and Unc-40/dcc in vivo Genetics 2001 158 1071
150. K. Keleman B. J. Dickson Short- and long-range repulsion by the Drosophila Unc5 netrin receptor Neuron 2001 32 605
151. H. S. Alghamdi B. AJAvO R. Bosco J. J. van den Beucken A. A. Aldosari S. Anil J. A. Jansen Biological response to titanium implants coated with nanocrystals calcium phosphate or type 1 collagen in a dog model Clin. Oral Implants Res. 2013 24 475
152. C. Schouten G. J. Meijer J. J. van den Beucken S. C. Leeuwenburgh L. T. de Jonge J. G. Wolke P. H. Spauwen J. A. Jansen In vivo bone response and mechanical evaluation of electrosprayed cap nanoparticle coatings using the iliac crest of goats as an implantation model Acta Biomater. 2010 6 2227
153. G. Oberdorster E. Oberdorster J. Oberdorster Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles Environ. Health Perspect. 2005 113 823
154. S. K. Sohaebuddin P. T. Thevenot D. Baker J. W. Eaton L. Tang Nanomaterial cytotoxicity is composition, size, and cell type dependent Part. Fibre Toxicol. 2010 7 22
155. W. H. Suh K. S. Suslick G. D. Stucky Y. H. Suh Nanotechnology, nanotoxicology, and neuroscience Prog. Neurobiol. 2009 87 133
156. B. Li B. Guo H. Fan X. Zhang Preparation of nano-hydroxyapatite particles with different morphology and their response to highly malignant melanoma cell in vitro Appl. Surf. Sci. 2008 255 357
157. A. Nan X. Bai S. J. Son S. B. Lee H. Ghandehari Cellular uptake and cytotoxicity of silica nanotubes Nano Lett. 2008 8 2150
158. B. K. Gaiser T. F. Fernandes M. Jepson J. R. Lead C. R. Tyler V. Stone Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments Environ. Health 2009 8 Suppl 1 S2
159. P. Laquerriere A. Grandjean-Laquerriere E. Jallot G. Balossier P. Frayssinet M. Guenounou Importance of hydroxyapatite particles characteristics on cytokines production by human monocytes in vitro Biomaterials 2003 24 2739
160. A. Grandjean-Laquerriere P. Laquerriere M. Guenounou D. Laurent-Maquin T. M. Phillips Importance of the surface area ratio on cytokines production by human monocytes in vitro induced by various hydroxyapatite particles Biomaterials 2005 26 2361
161. A. Grandjean-Laquerriere P. Laquerriere D. Laurent-Maquin M. Guenounou T. M. Phillips The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro Biomaterials 2004 25 5921
162. T. Blake V. Castranova D. Schwegler-Berry P. Baron G. J. Deye C. Li W. Jones Effect of fiber length on glass microfiber cytotoxicity J. Toxicol. Environ. Health, Part A 1998 54 243
163. G. D. Guthrie Jr. Mineral properties and their contributions to particle toxicity Environ. Health Perspect. 1997 105 Suppl 5 1003
164. T. Xia M. Kovochich J. Brant M. Hotze J. Sempf T. Oberley C. Sioutas J. I. Yeh M. R. Wiesner A. E. Nel Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm Nano Lett. 2006 6 1794
165. S. Syed A. Zubair M. Frieri Immune response to nanomaterials: Implications for medicine and literature review Curr. Allergy Asthma Rep. 2012 13 50
166. L. I. Zon R. T. Peterson In vivo drug discovery in the zebrafish Nat. Rev. Drug Discovery 2005 4 35
167. X. Zhao K. J. Ong J. D. Ede J. L. Stafford K. W. Ng G. G. Goss S. C. Loo Evaluating the toxicity of hydroxyapatite nanoparticles in catfish cells and zebrafish embryos Small 2013 9 1734
168. F. Qing Z. Wang Y. Hong M. Liu B. Guo H. Luo X. Zhang Selective effects of hydroxyapatite nanoparticles on osteosarcoma cells and osteoblasts J. Mater. Sci.: Mater. Med. 2012 23 2245
169. S. Li S. Zhang W. Chen O. Wen Effects of hydroxyapatite ultrafine powder on colony formation and cytoskeletons of MGC-803 cells Bioceramics 1996 9 225
170. Z. S. Liu S. L. Tang Z. L. Ai Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human hepatoma bel-7402 cells World J. Gastroenterol. 2003 9 1968
171. Q. Fu N. Zhou W. Huang D. Wang L. Zhang H. Li Preparation and characterization of a novel bioactive bone cement: Glass based nanoscale hydroxyapatite bone cement J. Mater. Sci.: Mater. Med. 2004 15 1333
172. Q. Fu N. Zhou W. Huang D. Wang L. Zhang H. Li Effects of nano HAP on biological and structural properties of glass bone cement J. Biomed. Mater. Res., Part A 2005 74 156