Functionally graded β-TCP/PCL nanocomposite scaffolds: In vitro evaluation with human fetal osteoblast cells for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 92, Issue 3, 2010, Pages 1007-1018

  Ozkan, Seher ^a   Kalyon, Dilhan M ^a   Yu, Xiaojun ^a  

^a STEVENS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Extrusion; Functionally graded; Nanocomposite; Osteoblast; Scaffold; Tissue engineering

Indexed keywords

BIODEGRADABLE SCAFFOLD; BONE TISSUE ENGINEERING; COMPRESSIVE PROPERTIES; DEGREE OF FREEDOM; FUNCTIONALLY GRADED; IN-VITRO; IN-VITRO EVALUATION; INTERCONNECTED POROSITY; NANOPARTICLE CONCENTRATIONS; OSTEOBLAST CELLS; PHYSICAL AND CHEMICAL PROPERTIES; POROGENS; POROUS SCAFFOLD; TRICALCIUM PHOSPHATES;

BIOMIMETICS; CELL PROLIFERATION; CHEMICAL PROPERTIES; EXTRUSION; NANOCOMPOSITES; NANOPARTICLES; POLYCAPROLACTONE; PORE SIZE; TISSUE; TISSUE ENGINEERING; TRANSMISSION CONTROL PROTOCOL;

SCAFFOLDS;

CALCIUM PHOSPHATE; NANOCOMPOSITE; NANOPARTICLE; POLYCAPROLACTONE; SODIUM CHLORIDE;

ARTICLE; BONE TISSUE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOBLAST; TISSUE ENGINEERING;

CALCIUM PHOSPHATES; CALORIMETRY, DIFFERENTIAL SCANNING; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; NANOCOMPOSITES; POLYESTERS; TISSUE ENGINEERING;

EID: 75749089257     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32425     Document Type: Article

References (53)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
2. Mikos AG, Herring SW, Ochareon P, Elisseeff J, Lu HH, Kandel R, Schoen FJ, Toner M, Mooney D, Atala A, Van Dyke ME, Kaplan D, Novakovic GV. Engineering complex tissues. Tissue Eng 2006;12:3307-3339.
3. Causa F, Netti PA, Ambrosio L. A multi-functional scaffold for tissue regeneration: The need to engineer a tissue analogue. Biomaterials 2007;28:5093-5099.
4. Sands RW, Mooney DJ. Polymers to direct cell fate by controlling the microenvironment. Curr Opin Biotechnol 2007;18:448-453.
5. Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 2005;23:47-55.
6. Leong KF, Chua CK, Sudarmadji N, Yeong WY. Engineering functionally graded tissue engineering scaffolds. J Mech Behav Biomed Mater 2008;1:140-152.
7. Pompe W, Worch H, Epple M, Friess W, Gelinsky M, Greil P, Hempel U, Scharnweber D, Schulte K. Functionally graded materials for biomedical applications. Mater Sci Eng A 2003;362:40-60.
8. Xu HH, Burguera EF, Carey LE. Strong, macroporous, and in situ-setting calcium phosphate cement-layered structures. Biomaterials 2007;28:3786-3796.
9. Lawrence BJ, Maase EL, Lin HK, Madihally SV. Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa. J Biomed Mater Res A 2009;88:634-643.
10. Wan Y, Feng G, Shen FH, Laurencin CT, Li X. Biphasic scaffold for annulus fibrosus tissue regeneration. Biomaterials 2008;29:643-652.
11. Ryu W, Min SW, Hammerick KE, Vyakarnam M, Greco RS, Prinz FB, Fasching RJ. The construction of three-dimensional micro-fluidic scaffolds of biodegradable polymers by solvent vapor based bonding of micro-molded layers. Biomaterials 2007;28:1174-1184.
12. Thomas V, Zhang X, Catledge SA, Vohra YK. Functionally graded electrospun scaffolds with tunable mechanical properties for vascular tissue regeneration. Biomed Mater. 2007;2:224-232.
13. Oh SH, Park IK, Kim JM, Lee JH. In vitro and in vivo characteristics of PCL scaffolds with pore size gradient fabricated by a centrifugation method. Biomaterials 2007;28:1664-1671.
14. Chen RR, Silva EA, Yuen WW, Mooney DJ. Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res 2007;24:258-264.
15. Sherwood JK, Riley SL, Palazzolo R, Brown SC, Monkhouse DC, Coates M, Griffith LG, Landeen LK, Ratcliffe A. A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 2002;23:4739-4751.
16. Shao XX, Hutmacher DW, Ho ST, Goh JC, Lee EH. Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits. Biomaterials 2006;27:1071-1080.
17. Kalita SJ, Bose S, Hosick HL, Bandyopadhyay A. Development of controlled porosity polymer-ceramic composite scaffolds via fused deposition modeling. Mater Sci Eng C 2003;23:611-620.
18. Erisken C, Kalyon DM, Wang H. A hybrid twin screw extrusion/ electrospinning method to process nanoparticle-incorporated electrospun nanofibers. Nanotechnology 2008;19:165302.
19. Erisken C, Kalyon DM, Wang H. Functionally graded electrospun polycaprolactone and β-tricalcium phosphate nanocomposites for tissue engineering applications. Biomaterials 2008;29:4065-4073.
20. 13C solid state NMR. Polymer 2002;43:1357-1364.
21. Yu X, Botchwey EA, Levine EM, Pollack SR, Laurencin CT. Bioreactor-based bone tissue engineering: The influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization. PNAS 2004;101:11203-11208.
22. Popat KC, Leary Swan EE, Mukhatyar V, Chatvanichkul KI, Mor GK, Grimes CA, Desai TA. Influence of nanoporous alumina membranes on long-term osteoblast response. Biomaterials 2005;26:4516-4522.
23. Ignatius A, Blessing H, Liedert A, Schmidt C, Neidlinger-Wilke C, Kaspar D, Friemert B, Claes L. Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices. Biomaterials 2005;26:311-318.
24. Jones JR, Tsigkou O, Coates EE, Stevens MM, Polak JM, Hench LL. Extracellular matrix formation and mineralization on a phosphate-free porous bioactive glass scaffold using primary human osteoblast (HOB) cells. Biomaterials 2007;28:1653-1663.
25. Skelton KL, Glenn JV, Clarke SA, Georgiou G, Valappil SP, Knowles JC, Nazhat SN, Jordan GR. Effect of ternary phosphate-based glass compositions on osteoblast and osteoblastlike proliferation, differentiation and death in vitro. Acta Biomater 2007;3:563-672.
26. Cuddihy MJ, Kotov NA. Poly(lactic-co-glycolic acid) bone scaffolds with inverted colloidal crystal geometry. Tissue Eng Part A 2008;14:1639-1649.
27. Subramaniam M, Jalal SM, Rickard DJ, Harris SA, Bolander ME, Spelsberg TC. Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER alpha cells: bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization. J Cell Biochem 2002;87:9-15.
28. Montjovent MO, Burri N, Mark S, Federici E, Scaletta C, Zambelli PY, Hohlfeld P, Leyvraz PF, Applegate LL, Pioletti DP. Fetal bone cells for tissue engineering. Bone. 2004;35:1323-1333.
29. Botchwey EA, Pollack SR, Levine EM, Laurencin CT. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res 2001;55:242-253.
30. Widmer MS, Gupta PK, Lu L, Meszlenyi RK, Evans GR, Brandt K, Savel T, Gurlek A, Patrick CW Jr, Mikos AG. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials 1998;19:1945-1955.
31. Fiske T, Railkar S, Kalyon DM. Effects of segregation on the packing of spherical and non-spherical particles. Powder Technol 1994;81:57-64.
32. Ouchiyama N, Tanaka T. Porosity estimation for random packings of spherical particles. Ind Eng Chem Fundam 1988;23:490-493.
33. Matsuzaka K, Yoshinari M, Shimono M, Inoue T. Effects of multigrooved surfaces on osteoblast-like cells in vitro: Scanning electron microscopic observation and mRNA expression of osteopontin and osteocalcin. J Biomed Mater Res A 2004;68:227-234.
34. Degirmenbasi N, Ozkan S, Kalyon DM, Yu X. Surface patterning of poly(L-lactide) upon melt processing: in vitro culturing of fibroblasts and osteoblasts on surfaces ranging from highly crystalline with spherulitic protrusions to amorphous with nanoscale indentations. J Biomed Mater Res A 2009;88:94-104.
35. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005;26:5474-5491.
36. Thomson RC, Yaszemski MJ, Powers JM, Mikos AG. Fabrication of biodegradable polymer scaffolds to engineer trabecular bone. J Biomat Sci Polym Ed 1996;7:23-38.
37. Sarazin P, Roy X, Favis BD. Controlled preparation and properties of porous poly(L-lactide) obtained from a co-continuous blend of two biodegradable polymers. Biomaterials 2004;25:5965-5978.
38. Quinn TP, Oreskovic TL, Landis FA, Washburn NR. Material model measurements and predictions for a random pore poly (epsilon-caprolactone) scaffold. J Biomed Mater Res B Appl Biomater 2007;82:205-209.
39. Shor L, Güçeri S, Wen X, Gandhi M, Sun W. Fabrication of three-dimensional polycaprolactone/hydroxyapatite tissue scaffolds and osteoblast-scaffold interactions in vitro. Biomaterials 2007;28:5291-5297.
40. Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004;25:4749-4757.
41. Causa F, Netti PA, Ambrosio L, Ciapetti G, Baldini N, Pagani S, Martini D, Giunti A. Poly-epsilon-caprolactone/hydroxyapatite composites for bone regeneration: In vitro characterization and human osteoblast response. J Biomed Mater Res A 2006;76:151-162.
42. Coombes AG, Rizzi SC, Williamson M, Barralet JE, Downes S, Wallace WA. Precipitation casting of polycaprolactone for applications in tissue engineering and drug delivery. Biomaterials 2004;25:315-325.
43. Nimni ME. Polypeptide growth factors: targeted delivery systems. Biomaterials 1997;18:1201-1225.
44. Ingber DE. Mechanical and chemical determinants of tissue development. In: Lanza RP, Langer R, Vacanti J, editors. Principles of Tissue Engineering. San Diego: Academic Press; 2000. p 101-110.
45. Kunzler TP, Huwiler C, Drobek T, Vörös J, Spencer ND. Systematic study of osteoblast response to nanotopography by means of nanoparticle-density gradients. Biomaterials 2007;28:5000-5006.
46. Liao H, Andersson AS, Sutherland D, Petronis S, Kasemo B, Thomsen P. Response of rat osteoblast-like cells to microstructured model surfaces in vitro. Biomaterials 2003;24:649-654.
47. Lu JX, Flautre B, Anselme K, et al. Study of porous interconnections of bioceramic on cellular rehabitation in vitro and in vivo. In: Sedel L, Rey C, editors.Bioceramics 10. Paris: Pergamon, Elsevier Science, 1997. p 583-586.
48. Ishaug-Riley SL, Crane-Kruger GM, Yaszemski MJ, Mikos AG. Three-dimensional culture of rat calvarial osteoblasts in porous biodegradable polymers. Biomaterials 1998;19:1405-1412.
49. Heinrich L, Freyria AM, Melin M, Tourneur Y, Maksoud R, Bernengo JC, Hartmann DJ. Confocal laser scanning microscopy using dialkylcarbocyanine dyes for cell tracing in hard and soft biomaterials. J Biomed Mater Res B Appl Biomater 2007;81:153-161.
50. Degirmenbasi N, Kalyon DM, Birinci E. Biocomposites of nanohydroxyapatite with collagen and poly(vinyl alcohol). Colloids and Surfaces B Biointerfaces. 2006;48:42-49.
51. Yoshimoto H, Shin YM, Terai H, Vacanti JP. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 2003;24:2077-2082.
52. Wei G, Jin Q, Giannobile WV, Ma PX. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007;28:2087-2096.
53. Malda J, Klein TJ, Upton Z. The roles of hypoxia in the in vitro engineering of tissues. Tissue Eng 2007;13:2153-2162.